Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough v...Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.展开更多
Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and m...Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,展开更多
Background: Complementary and alternative medicines are increasingly used for the treatment of asthma worldwide. A five-herb herbal formula (CUF) has been found to be effective and safe in an animal model of asthma an...Background: Complementary and alternative medicines are increasingly used for the treatment of asthma worldwide. A five-herb herbal formula (CUF) has been found to be effective and safe in an animal model of asthma and in a preliminary clinical study. Objective: The objective of this study was to evaluate the safety and efficacy of CUF in children suffering from asthma. Design: A randomized, double blind, and placebo-controlled, parallel study. Interventions: Subjects received CUF or placebo for 6 months. Efficacy variables included changes in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), Paediatric Asthma Quality of Life Questionnaire (PAQLQ), and steroidal consumption. Results: A total of 100 asthmatic children were enrolled and assigned to two treatment groups. The first group received CUF 6 capsules (3 g/day) and the second group received placebo. There was a statistically significant difference in mean spirometric indexes in CUF group at baseline and follow-up visits. In the CUF group, the activity domain showed significant improvement (p = 0.045). FEV% was significantly improved in the CUF group (p strated. It improved the pulmonary functions of the children, namely, FEV1 and FVC. However, further research on a larger scale is warranted.展开更多
Lou Baiceng 楼百层(Institute of TCM,Zhejiang Province):According to the characteristics ofasthma,is should be kept in mind the basictreatment principle that relieve themanifestive symptoms of the disease at
The article gives Professor Wei’s experience of using theory of mutual reinforce-ing therapies in acupuncture and moxibustion on treating asthma. There are different 8 kinds of thera-pies such as acupuncture, plum-bl...The article gives Professor Wei’s experience of using theory of mutual reinforce-ing therapies in acupuncture and moxibustion on treating asthma. There are different 8 kinds of thera-pies such as acupuncture, plum-blossom needles, embedding of catgut in point, cupping on Ashipoint, external application on points, suppurative moxibustion, injection in points, etc. All of thesemethods have both advantages and backdraws. Prof. Wei tells us how to make full use of them, sothat we are able to improve the curative effect to its possible extend. This theory is important not onlyin acupuncture and moxibustion but also in guiding our practice in other fields of T. C. M.展开更多
Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbos...Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes compared with the 5-FU group （778 ± 202 mm3, both P〈0.05）. The combination group had the highest tumor inhibition rate （47.7%）, followed by the hWRCP group （35.2%） and 5-FU group （28.3%）. The 5-FU group had a lower body weight increase （1.37± 2.06 g versus 5.60± 0.72 g, P〈0.05） and a lower spleen index （4.064 ± 1.774 rag/10 g versus 5.294 ± 1.796 mg/10 g） as compared with the control group, whereas the combination group reversed the changes in the 5-FU group with the body weight increase of 3.52 ± 1.80 g （P〈0.05） and spleen index of 7.036 ± 1.599 mg/10 g （P〈0.05）. The spleen indices in the hWRCP, mWRCP, and IWRCP group were all significantly higher than that in the 5-FU group （P〈0.01 or P〈0.05）. No significant differences in body weight change were observed in WRCP groups compared with the control group （P〉0.05）. Conclusioa： The treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants. KEYWORDS breast cancer, warming and relieving cold phlegm formula, 5-fluorouracil, angiogenesis展开更多
文摘Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.
文摘Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,
文摘Background: Complementary and alternative medicines are increasingly used for the treatment of asthma worldwide. A five-herb herbal formula (CUF) has been found to be effective and safe in an animal model of asthma and in a preliminary clinical study. Objective: The objective of this study was to evaluate the safety and efficacy of CUF in children suffering from asthma. Design: A randomized, double blind, and placebo-controlled, parallel study. Interventions: Subjects received CUF or placebo for 6 months. Efficacy variables included changes in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), Paediatric Asthma Quality of Life Questionnaire (PAQLQ), and steroidal consumption. Results: A total of 100 asthmatic children were enrolled and assigned to two treatment groups. The first group received CUF 6 capsules (3 g/day) and the second group received placebo. There was a statistically significant difference in mean spirometric indexes in CUF group at baseline and follow-up visits. In the CUF group, the activity domain showed significant improvement (p = 0.045). FEV% was significantly improved in the CUF group (p strated. It improved the pulmonary functions of the children, namely, FEV1 and FVC. However, further research on a larger scale is warranted.
文摘Lou Baiceng 楼百层(Institute of TCM,Zhejiang Province):According to the characteristics ofasthma,is should be kept in mind the basictreatment principle that relieve themanifestive symptoms of the disease at
文摘The article gives Professor Wei’s experience of using theory of mutual reinforce-ing therapies in acupuncture and moxibustion on treating asthma. There are different 8 kinds of thera-pies such as acupuncture, plum-blossom needles, embedding of catgut in point, cupping on Ashipoint, external application on points, suppurative moxibustion, injection in points, etc. All of thesemethods have both advantages and backdraws. Prof. Wei tells us how to make full use of them, sothat we are able to improve the curative effect to its possible extend. This theory is important not onlyin acupuncture and moxibustion but also in guiding our practice in other fields of T. C. M.
基金Supported by the National Natural Science Foundation of China (No.30801495)
文摘Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes compared with the 5-FU group （778 ± 202 mm3, both P〈0.05）. The combination group had the highest tumor inhibition rate （47.7%）, followed by the hWRCP group （35.2%） and 5-FU group （28.3%）. The 5-FU group had a lower body weight increase （1.37± 2.06 g versus 5.60± 0.72 g, P〈0.05） and a lower spleen index （4.064 ± 1.774 rag/10 g versus 5.294 ± 1.796 mg/10 g） as compared with the control group, whereas the combination group reversed the changes in the 5-FU group with the body weight increase of 3.52 ± 1.80 g （P〈0.05） and spleen index of 7.036 ± 1.599 mg/10 g （P〈0.05）. The spleen indices in the hWRCP, mWRCP, and IWRCP group were all significantly higher than that in the 5-FU group （P〈0.01 or P〈0.05）. No significant differences in body weight change were observed in WRCP groups compared with the control group （P〉0.05）. Conclusioa： The treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants. KEYWORDS breast cancer, warming and relieving cold phlegm formula, 5-fluorouracil, angiogenesis
