BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,skin changes(POEMS)syndrome is a rare paraneoplastic syndrome that encompass multiple systems.The most common clinical symptoms of POEMS syndrome are pro...BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,skin changes(POEMS)syndrome is a rare paraneoplastic syndrome that encompass multiple systems.The most common clinical symptoms of POEMS syndrome are pro-gressive sensorimotor polyneuropathy,organ enlargement,endocrine disorders,darkening skin,a monoclonal plasma cell proliferative disorder,and lymph node hyperplasia.The organomegaly consists of hepatosplenomegaly and/or lym-phadenopathy;cases of cardiomyopathy are rare.Diagnoses are often delayed because of the atypical nature of the syndrome,exposing patients to possibly severe disability.Therefore,identifying atypical symptoms can improve the prognosis and quality of life among POEMS syndrome patients.lenalidomide and dexamethasone.CONCLUSION When patients with cardiomyopathy have systemic manifestations such as numb limbs and darkening skin,the POEMS syndrome is the most possible diagnosis.展开更多
Mandatory lane change(MLC)is likely to cause traffic oscillations,which have a negative impact on traffic efficiency and safety.There is a rapid increase in research on mandatory lane change decision(MLCD)prediction,w...Mandatory lane change(MLC)is likely to cause traffic oscillations,which have a negative impact on traffic efficiency and safety.There is a rapid increase in research on mandatory lane change decision(MLCD)prediction,which can be categorized into physics-based models and machine-learning models.Both types of models have their advantages and disadvantages.To obtain a more advanced MLCD prediction method,this study proposes a hybrid architecture,which combines the Evolutionary Game Theory(EGT)based model(considering data efficient and interpretable)and the Machine Learning(ML)based model(considering high prediction accuracy)to model the mandatory lane change decision of multi-style drivers(i.e.EGTML framework).Therefore,EGT is utilized to introduce physical information,which can describe the progressive cooperative interactions between drivers and predict the decision-making of multi-style drivers.The generalization of the EGTML method is further validated using four machine learning models:ANN,RF,LightGBM,and XGBoost.The superiority of EGTML is demonstrated using real-world data(i.e.,Next Generation SIMulation,NGSIM).The results of sensitivity analysis show that the EGTML model outperforms the general ML model,especially when the data is sparse.展开更多
BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a plasma cell proliferative disorder.The syndrome is characterized by elevate...BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a plasma cell proliferative disorder.The syndrome is characterized by elevated plasma cells,platelets,and vascular endothelial growth factor levels.Although heart disease rarely occurs in POEMS syndrome,the death rate increases sharply after heart failure.We report a patient who initially presented with an endocrine disease and developed congestive heart failure related to POEMS syndrome 9 years later.CASE SUMMARY A 23-year-old woman with no history of menstruation and a 9-year history of type I diabetes reported feeling breathless after activities.She could not lie down and rest at night.Three months prior,she experienced pain and increased tension in her left thigh accompanied by tenderness and edema in both lower extremities.The chief complaint upon hospital admission was that blood sugar has increased for more than 9 years,pain in the left thigh,and edema in both legs for more than 2 mo.After a multisystem evaluation,she was diagnosed with POEMS syndrome.Her echocardiogram showed left ventricular dilation with systolic dysfunction,and the left ventricular ejection fraction was only 38%with severely elevated brain natriuretic peptide.She received a combination of dexamethasone and thalidomide for 1 mo,but her symptoms did not improve.Therefore,we added a two-per-week bortezomib injection.After 2 wk,the patient’s heart function had improved significantly.CONCLUSION This case provides information about the treatment of POEMS syndrome with complications and highlights the challenges of developing a standardized treatment.展开更多
Governments＇ protection and support are very important for rural enterprises during their birth and development. But, in fact, governments own the rights to control the operation of rural enterprises to a large exten...Governments＇ protection and support are very important for rural enterprises during their birth and development. But, in fact, governments own the rights to control the operation of rural enterprises to a large extent. Govemments encourage and lead the reform of property rights of rural enterprises. Why governments are willing to give up vested interests, and actively promote the reform of property rights of rural enterprises？ This seems to be the key to explain the reform of property rights of rural enterprises. This paper puts forward the hypothesis, uses mathematical models and statistical analyses, and adopts relevant data to verify the needs of governments for fiscal targets, and the rationality of their behavior actively encourages and promotes reconstruction during the reform for maximizing their interests.展开更多
BACKGROUND Polyneuropathy organomegaly endocrinopathy M-protein and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a potential plasma cell tumor.The clinical manifestations of POEMS syndrome a...BACKGROUND Polyneuropathy organomegaly endocrinopathy M-protein and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a potential plasma cell tumor.The clinical manifestations of POEMS syndrome are diverse.Due to the insidious onset and lack of specific early-stage manifestations,POEMS syndrome is easily misdiagnosed or never diagnosed,leading to delayed treatment.Neurological symptoms are usually the first clinical manifestation,while ascites is a rare symptom in patients with POEMS syndrome.CASE SUMMARY A female patient presented with unexplained ascites as an initial symptom,which is a rare early-stage manifestation of the condition.After 1 year,the patient gradually developed progressive renal impairment,anemia,polyserosal effusion,edema,swollen lymph nodes on the neck,armpits,and groin,and decreased muscle strength of the lower extremities.The patient was eventually diagnosed with POEMS syndrome after multidisciplinary team discussion.Treatment comprised bortezomib+dexamethasone,continuous renal replacement therapy,chest and abdominal closed drainage,transfusions of erythrocytes and platelets,and other symptomatic and supportive treatments.The patient’s condition initially improved after treatment.However,then her symptoms worsened,and she succumbed to the illness and died.CONCLUSION Ascites is a potential early manifestation of POEMS syndrome,and this diagnosis should be considered for patients with unexplained ascites.Furthermore,multidisciplinary team discussion is helpful in diagnosing POEMS syndrome.展开更多
The aim of this paper is to reveal the mechanism of compromise and change in coordination where players agree in general but disagree on coordination methods. When players agree on the need to collaborate but are in c...The aim of this paper is to reveal the mechanism of compromise and change in coordination where players agree in general but disagree on coordination methods. When players agree on the need to collaborate but are in conflict regarding the specific method, one player must always compromise. This situation is known as the Battle of the Sexes in game theory. It has ever been believed that if an agreement is reached under such circumstances, the players do not have the incentive to withdraw from the agreement. However, this study shows that this belief is not always true if the players were able to revise the outcome of their negotiations later. The wide-ranging fields use game theories for their analysis frameworks to analyze the success or failure of coordination. However, comparing with the possibility of betrayal illustrated as a well-known Prisoner Dilemma, it has been rare to discuss conflict regarding the specific method of coordination, although such situations are often observed in today＇s interdependent real world. The repeated Battle of the Sexes games presented in this study would be a useful framework to analyze conflict regarding the specific method of coordination.展开更多
It has been reported that a 92-year-old female had got a bruise superficial wound on her right leg one and a half years ago,developing into refractory skin ulcer due to improper management before.A prepared cream,mixe...It has been reported that a 92-year-old female had got a bruise superficial wound on her right leg one and a half years ago,developing into refractory skin ulcer due to improper management before.A prepared cream,mixed royal jelly with berberine for dressing change,was made on the scene through the crush of berberine tablets,working with fresh royal jelly.Topical dressing change with the cream was done every 3 days,and two months later,such the ulcer became clean and was covered fully with fresh granulation tissue.This kind of cream consists of the ingredients of TCM purely,free of antibiotic,and being quite effective clinically,also helpful for proper use of antibiotic.展开更多
Climate protection is a problem of sustaining a public resource. All countries of the world should take action to deal with climate change. However, such an action is actually a game process where each country chooses...Climate protection is a problem of sustaining a public resource. All countries of the world should take action to deal with climate change. However, such an action is actually a game process where each country chooses to cooperate or defect under constrained condition. Here we study the group behavior of countries in dealing with climate change. In our study, the countries of the world are considered as players who are distributed on an assumed spatial network. A new evolution rule is proposed to model the game process among the players. Our extensive experiments demonstrate that under constrained condition, the local psychology of players possibly results in the formation of local group. Some local and global oscillations can be found where part or all of the players change their choices periodically.展开更多
Nowadays many teenagers play online games.Too much violence in online games deeply affects the teenagers' life,makes them act in a violent manner.Actions should be brought for change to protest.
Large yellow croaker(Larimichthys crocea), one of the most important marine fish species in China, can change its abdominal skin color when it is shifted from light to dark or from dark to light, providing us an oppor...Large yellow croaker(Larimichthys crocea), one of the most important marine fish species in China, can change its abdominal skin color when it is shifted from light to dark or from dark to light, providing us an opportunity of investigating the molecular responding mechanism of teleost in light stress. The gene expression profile of fish under light stress is rarely documented. In this research, the transcriptome profiles of the abdominal skin of L. crocea exposed to light or dark for 0 h, 0.5 h and 2 h were produced by next-generation sequencing(NGS). The cluster results demonstrated that stress period, rather than light intensity(e.g., light or dark), is the major influencing factor. Differently expressed genes(DEGs) were identified between 0 h and 0.5 h groups, between 0 h and 2 h groups, between 0.5 h light and 0.5 h dark, and between 2 h light and 2 h dark, respectively. The gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) annotation revealed that the genes relating to immunity, energy metabolism, and cytoskeletal protein binding were significantly enriched. The detailed analysis of transcriptome profiles also revealed regular gene expression trends, indicating that the elaborate gene regulation networks underlined the molecular responses of the fish to light stress. This transcriptome analysis suggested that systematic and complicated regulatory cascades were functionally activated in response to external stress, and coloration change caused by light stress was mainly attributed to the change in the density of chromatophores for L. crocea. This study also provided valuable information for skin coloration or light stress research on other marine fish species.展开更多
The incidence of nonmelanoma skin cancer is rising worldwide.The major cardinogenic factor for most skin cancers is solar ultraviolet light,in particular,the chronic exposure to UVB(280-320nm).In this study,the optica...The incidence of nonmelanoma skin cancer is rising worldwide.The major cardinogenic factor for most skin cancers is solar ultraviolet light,in particular,the chronic exposure to UVB(280-320nm).In this study,the optical characteristics of skin canceration process induced by UVB were analyzed.Optical coherence tomography(OCT)was used for monitoring the morphologic changes and compared with histological analysis.Meanwhile,the optical property,such as the attenuation cofficient(A4)was systematically extracted and analyzed.In addition,characteristic text ures,including energy,entropy and correlation were revealed from OCT images.Results suggest that OCT is a useful tool for monitoring the process of UVB-induced skin cancer and changes of optical property during this process.展开更多
A finite element program with two different soil models is adopted to study the negative skin friction of an unloaded single pile embedded in the settlement trough of a tunnel. The results show that it is necessary to...A finite element program with two different soil models is adopted to study the negative skin friction of an unloaded single pile embedded in the settlement trough of a tunnel. The results show that it is necessary to consider the nonlinear property of soil and to set interface elements between piles and soil in analysis of the negative skin friction of piles. Among a pile group, the pile located above the tunnel centerline bears larger downdrag than the ones far away from tunnel centerline.展开更多
文摘BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,skin changes(POEMS)syndrome is a rare paraneoplastic syndrome that encompass multiple systems.The most common clinical symptoms of POEMS syndrome are pro-gressive sensorimotor polyneuropathy,organ enlargement,endocrine disorders,darkening skin,a monoclonal plasma cell proliferative disorder,and lymph node hyperplasia.The organomegaly consists of hepatosplenomegaly and/or lym-phadenopathy;cases of cardiomyopathy are rare.Diagnoses are often delayed because of the atypical nature of the syndrome,exposing patients to possibly severe disability.Therefore,identifying atypical symptoms can improve the prognosis and quality of life among POEMS syndrome patients.lenalidomide and dexamethasone.CONCLUSION When patients with cardiomyopathy have systemic manifestations such as numb limbs and darkening skin,the POEMS syndrome is the most possible diagnosis.
基金supported by the National Key R&D Program of China(2023YFE0106800)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX24_0100).
文摘Mandatory lane change(MLC)is likely to cause traffic oscillations,which have a negative impact on traffic efficiency and safety.There is a rapid increase in research on mandatory lane change decision(MLCD)prediction,which can be categorized into physics-based models and machine-learning models.Both types of models have their advantages and disadvantages.To obtain a more advanced MLCD prediction method,this study proposes a hybrid architecture,which combines the Evolutionary Game Theory(EGT)based model(considering data efficient and interpretable)and the Machine Learning(ML)based model(considering high prediction accuracy)to model the mandatory lane change decision of multi-style drivers(i.e.EGTML framework).Therefore,EGT is utilized to introduce physical information,which can describe the progressive cooperative interactions between drivers and predict the decision-making of multi-style drivers.The generalization of the EGTML method is further validated using four machine learning models:ANN,RF,LightGBM,and XGBoost.The superiority of EGTML is demonstrated using real-world data(i.e.,Next Generation SIMulation,NGSIM).The results of sensitivity analysis show that the EGTML model outperforms the general ML model,especially when the data is sparse.
文摘BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a plasma cell proliferative disorder.The syndrome is characterized by elevated plasma cells,platelets,and vascular endothelial growth factor levels.Although heart disease rarely occurs in POEMS syndrome,the death rate increases sharply after heart failure.We report a patient who initially presented with an endocrine disease and developed congestive heart failure related to POEMS syndrome 9 years later.CASE SUMMARY A 23-year-old woman with no history of menstruation and a 9-year history of type I diabetes reported feeling breathless after activities.She could not lie down and rest at night.Three months prior,she experienced pain and increased tension in her left thigh accompanied by tenderness and edema in both lower extremities.The chief complaint upon hospital admission was that blood sugar has increased for more than 9 years,pain in the left thigh,and edema in both legs for more than 2 mo.After a multisystem evaluation,she was diagnosed with POEMS syndrome.Her echocardiogram showed left ventricular dilation with systolic dysfunction,and the left ventricular ejection fraction was only 38%with severely elevated brain natriuretic peptide.She received a combination of dexamethasone and thalidomide for 1 mo,but her symptoms did not improve.Therefore,we added a two-per-week bortezomib injection.After 2 wk,the patient’s heart function had improved significantly.CONCLUSION This case provides information about the treatment of POEMS syndrome with complications and highlights the challenges of developing a standardized treatment.
文摘Governments＇ protection and support are very important for rural enterprises during their birth and development. But, in fact, governments own the rights to control the operation of rural enterprises to a large extent. Govemments encourage and lead the reform of property rights of rural enterprises. Why governments are willing to give up vested interests, and actively promote the reform of property rights of rural enterprises？ This seems to be the key to explain the reform of property rights of rural enterprises. This paper puts forward the hypothesis, uses mathematical models and statistical analyses, and adopts relevant data to verify the needs of governments for fiscal targets, and the rationality of their behavior actively encourages and promotes reconstruction during the reform for maximizing their interests.
文摘BACKGROUND Polyneuropathy organomegaly endocrinopathy M-protein and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a potential plasma cell tumor.The clinical manifestations of POEMS syndrome are diverse.Due to the insidious onset and lack of specific early-stage manifestations,POEMS syndrome is easily misdiagnosed or never diagnosed,leading to delayed treatment.Neurological symptoms are usually the first clinical manifestation,while ascites is a rare symptom in patients with POEMS syndrome.CASE SUMMARY A female patient presented with unexplained ascites as an initial symptom,which is a rare early-stage manifestation of the condition.After 1 year,the patient gradually developed progressive renal impairment,anemia,polyserosal effusion,edema,swollen lymph nodes on the neck,armpits,and groin,and decreased muscle strength of the lower extremities.The patient was eventually diagnosed with POEMS syndrome after multidisciplinary team discussion.Treatment comprised bortezomib+dexamethasone,continuous renal replacement therapy,chest and abdominal closed drainage,transfusions of erythrocytes and platelets,and other symptomatic and supportive treatments.The patient’s condition initially improved after treatment.However,then her symptoms worsened,and she succumbed to the illness and died.CONCLUSION Ascites is a potential early manifestation of POEMS syndrome,and this diagnosis should be considered for patients with unexplained ascites.Furthermore,multidisciplinary team discussion is helpful in diagnosing POEMS syndrome.
文摘The aim of this paper is to reveal the mechanism of compromise and change in coordination where players agree in general but disagree on coordination methods. When players agree on the need to collaborate but are in conflict regarding the specific method, one player must always compromise. This situation is known as the Battle of the Sexes in game theory. It has ever been believed that if an agreement is reached under such circumstances, the players do not have the incentive to withdraw from the agreement. However, this study shows that this belief is not always true if the players were able to revise the outcome of their negotiations later. The wide-ranging fields use game theories for their analysis frameworks to analyze the success or failure of coordination. However, comparing with the possibility of betrayal illustrated as a well-known Prisoner Dilemma, it has been rare to discuss conflict regarding the specific method of coordination, although such situations are often observed in today＇s interdependent real world. The repeated Battle of the Sexes games presented in this study would be a useful framework to analyze conflict regarding the specific method of coordination.
文摘It has been reported that a 92-year-old female had got a bruise superficial wound on her right leg one and a half years ago,developing into refractory skin ulcer due to improper management before.A prepared cream,mixed royal jelly with berberine for dressing change,was made on the scene through the crush of berberine tablets,working with fresh royal jelly.Topical dressing change with the cream was done every 3 days,and two months later,such the ulcer became clean and was covered fully with fresh granulation tissue.This kind of cream consists of the ingredients of TCM purely,free of antibiotic,and being quite effective clinically,also helpful for proper use of antibiotic.
基金Supported by the State Key Laboratory of Rail Traffic Control and Safety under Grant Nos.RCS2008ZZ001 and RCS2010ZZ001,Beijing Jiaotong University
文摘Climate protection is a problem of sustaining a public resource. All countries of the world should take action to deal with climate change. However, such an action is actually a game process where each country chooses to cooperate or defect under constrained condition. Here we study the group behavior of countries in dealing with climate change. In our study, the countries of the world are considered as players who are distributed on an assumed spatial network. A new evolution rule is proposed to model the game process among the players. Our extensive experiments demonstrate that under constrained condition, the local psychology of players possibly results in the formation of local group. Some local and global oscillations can be found where part or all of the players change their choices periodically.
文摘Nowadays many teenagers play online games.Too much violence in online games deeply affects the teenagers' life,makes them act in a violent manner.Actions should be brought for change to protest.
基金supported by grants from the National Natural Science Foundation of China (No.U1205122)Key projects of the Xiamen Southern Ocean Research Center (14GZY70NF34)+1 种基金the Natural Science Foundation of Fujian Province (No.2015J05069)‘Li ShangDa’ Foundation and Innovation Research Team Foundation of Jimei University (No.2010A02)
文摘Large yellow croaker(Larimichthys crocea), one of the most important marine fish species in China, can change its abdominal skin color when it is shifted from light to dark or from dark to light, providing us an opportunity of investigating the molecular responding mechanism of teleost in light stress. The gene expression profile of fish under light stress is rarely documented. In this research, the transcriptome profiles of the abdominal skin of L. crocea exposed to light or dark for 0 h, 0.5 h and 2 h were produced by next-generation sequencing(NGS). The cluster results demonstrated that stress period, rather than light intensity(e.g., light or dark), is the major influencing factor. Differently expressed genes(DEGs) were identified between 0 h and 0.5 h groups, between 0 h and 2 h groups, between 0.5 h light and 0.5 h dark, and between 2 h light and 2 h dark, respectively. The gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) annotation revealed that the genes relating to immunity, energy metabolism, and cytoskeletal protein binding were significantly enriched. The detailed analysis of transcriptome profiles also revealed regular gene expression trends, indicating that the elaborate gene regulation networks underlined the molecular responses of the fish to light stress. This transcriptome analysis suggested that systematic and complicated regulatory cascades were functionally activated in response to external stress, and coloration change caused by light stress was mainly attributed to the change in the density of chromatophores for L. crocea. This study also provided valuable information for skin coloration or light stress research on other marine fish species.
基金supported by the National Natural Science Foundation of China(61178089)the Natural Science Foundation of Fujian Province(2014J01226)Foundation of Fujian Educational Committee(JA14093).
文摘The incidence of nonmelanoma skin cancer is rising worldwide.The major cardinogenic factor for most skin cancers is solar ultraviolet light,in particular,the chronic exposure to UVB(280-320nm).In this study,the optical characteristics of skin canceration process induced by UVB were analyzed.Optical coherence tomography(OCT)was used for monitoring the morphologic changes and compared with histological analysis.Meanwhile,the optical property,such as the attenuation cofficient(A4)was systematically extracted and analyzed.In addition,characteristic text ures,including energy,entropy and correlation were revealed from OCT images.Results suggest that OCT is a useful tool for monitoring the process of UVB-induced skin cancer and changes of optical property during this process.
文摘A finite element program with two different soil models is adopted to study the negative skin friction of an unloaded single pile embedded in the settlement trough of a tunnel. The results show that it is necessary to consider the nonlinear property of soil and to set interface elements between piles and soil in analysis of the negative skin friction of piles. Among a pile group, the pile located above the tunnel centerline bears larger downdrag than the ones far away from tunnel centerline.
