Comprehensive effects of traditional Chinese medicine treatment on heart failure and changes in B-type natriuretic peptide levels: A meta-analysis

BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious.

Pioneering a New Realm of Human Rights Civilization in the Chinese Path to Modernization——An Overview of the Symposium on“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”

On October 14,2023,a symposium themed“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”was held in Changchun,Jilin Province,China.More than fifty experts,scholars,and researchers from national institutions and universities engaged in discussions and exchanges on human rights on the Chinese path to modernization,including the path,practice,knowledge systems,and civilization forms of human rights.This symposium played a significant role in advancing the construction of the disciplinary system,academic system,and discourse system of human rights in China.

Comprehensive Rehabilitation Therapy of Traditional Chinese Medicine Combined with Modern Rehabilitation Training Improves the Spasticity and Motor Function of Hemiplegia after Stroke

Objective:To analyze the impact of comprehensive rehabilitation therapy of traditional Chinese medicine(TCM)(based on modern rehabilitation training)on the spasticity and motor function in stroke patients with hemiplegia.Methods:Seventy-nine stroke and hemiplegia patients admitted to the hospital from June 2021 to June 2023 were selected and randomly divided into a control group(39 cases)using modern rehabilitation training,and an observation group combined with comprehensive TCM rehabilitation therapy(40 cases),over 1 month.The clinical index data of the two groups were compared.Results:There were differences in the clinical index data between the two groups.The total effective rate after 2 treatment in the observation group(92.50%)was higher than that of the control group(74.36%)(χ^(2)=4.727,P<0.05).All central sensitization inventory(CSI)and stroke quality of life(PRO)scores in both groups were lower after treatment,with the observation group having lower scores as compared to the control group(P<0.05).The scores of FMA(upper limbs,lower limbs),Barthel index scores,and Functional Ambulation Categories(FAC)scores of both groups increased after treatment,with the observation group having higher scores as compared to the control group(P<0.05).Conclusion:Comprehensive TCM rehabilitation therapy had a significant therapeutic effect on patients with hemiplegia after stroke.It improved the patient’s spasticity,limb movement,and walking function.Their daily living abilities and quality of life were also enhanced.

Volatile profile and multivariant analysis of Sanhuang chicken breast in combination with Chinese 5-spice blend and garam masala

Sanhuang chicken is a popular native breed in China and well-known for delicious flavour.Spices could enhance the chicken meat flavour and work well in preservation.Chinese 5-spice blend(CS)and garam masala(GM)are routinely using spices in China and Pakistan,respectively.The flavour profiles of Sanhuang chicken breast(CB)and its blends with CS and GM were obtained by electronic nose(E-nose),solid-phase microextraction gas chromatography-mass spectrometry(SPME GC-MS)and GC-ion mobility spectrometry(GC-IMS).Principal component analysis(PCA)efficiently discriminated the aroma profiles of three chicken formulations.The GC-chromatographs revealed the significant aroma alterations of chicken breast meat after marination with spices.Aldehydes were the major contributors of chicken aroma,while most of the aromatic hydrocarbons were generated by spices.Almost all chicken key-compounds produced by oxidation reaction were either reduced or eliminated by marination,showing the antioxidation capacity of spices leading to meat preservation.GC-IMS is not only a rapid and comprehensive detection method,but also proved to be more sensitive than GC-MS.The substantial role of both traditional spices in enhancing flavour quality of chicken meat,and their exposure as functional ingredients in Chinese and Pakistan cuisines could lead to the cross-cultural meat trade opportunities.

Optimization of CO_2 separation technologies for Chinese refineries based on a fuzzy comprehensive evaluation model

This study aims at determining the optimal CO2 separation technology for Chinese refineries, based on current available technologies, by the method of comprehensive evaluation. Firstly, according to the characteristics of flue gas from Chinese refineries, three feasible CO2 separation technologies are selected. These are pressure swing adsorption （PSA）, chemical absorption （CA）, and membrane absorption （MA）. Secondly, an economic assessment of these three techniques is carried out in accordance with cash flow analysis. The results show that these three techniques all have economic feasibility and the PSA technique is the best. Finally, to further optimize the three techniques, a two-level fuzzy comprehensive evaluation model is established, including economic, technological, and environmental factors. Considering all the factors, PSA is optimal for Chinese refineries, followed by CA and MA. Therefore, to reduce Chinese refineries carbon emission, it is suggested that CO2 should be captured from off-gases using PSA.

Use of Chinese Herbal Medicine Therapies in Comprehensive Hospitals in Central China: A Parallel Survey in Cancer Patients and Clinicians

Summary： Chinese herbal medicine （CHM）, as the largest application category of traditional Chinese medicine （TCM）, is widely accepted among cancer patients in China. Herbal slice （HS） and Chinese patent drug （CPD） are commonly used CHM in China. This study aimed to investigate the utilization of CHM among clinicians and cancer patients in central China. Five hundred and twenty-five patients and 165 clinicians in 35 comprehensive hospitals in central China were asked to complete an anonymous questionnaire that was designed to evaluate the use of CHM. The results showed that 90.74% clinicians and 72.24% cancer patients used CHM during cancer treatment. The educational backgrounds of the clinicians and the age, education level, annual income, and cancer stage of the cancer patients were re- lated to use of CHM. More than 90% clinicians and cancer patients had used CPD. Comparatively, the percentage of HS use was 10% lower than that of CPD use among clinicians and cancer patients. More clinicians preferred to use CHM after surgery than cancer patients did （20.41% vs. 5.37%）. Enhancing physical fitness and improving performance status were regarded as the most potential effect of CHM on cancer treatment （85.71% among clinicians and 94.07% among cancer patients）, in comparison with directly killing tumor cells （24.49% among clinicians and 31.36% among patients）. As for refusal rea- sons, imprecise efficacy was the unanimous （100%） reason for clinicians＇ rejection of CHM, and 95.58% patients objected to using CHM also for this reason. Furthermore, the side effects of CHM were more concerned by clinicians than by patients （33.33% vs. 15.81%）. In conclusion, our survey revealed that CHM was popularly accepted by clinicians and cancer patients in central China. The reasons of use and rejection of CHM were different between clinicians and cancer patients.

Chinese Scientists Have Obtained Great Achievements in Comprehensive Research on the Qinghai-Tibet Plateau

The China Geological Survey carried out 1：250000 regional geological surveys of the Qinghai-Tibet Plateau from 1999 to 2005. With a total investment of 300 million yuan, more than 1000 geologists were involved annually to conduct mapping at a grid of one line to every four km along the Kunlun Mts-Altyn Shan-Tanggula Shah, Kokoxili-Qiangtang, Gangdese, Yalun Zangbu River, and finally to the Himalayan ranges. The extensive mapping culminated in a total of 112 maps covering an area of 152 square kilometers. Based on this success, the China Geological Survey launched another program, the ＂Integration and Comprehensive Study of Basic Geological Survey Result（s） in the Qinghai-Tibet Plateau＂. The program lasted from 2006 to 2010 and has yielded copious research results, making big strides in upgrading our understanding of the Qinghai-Tibet Plateau. The achievements are manifold. Around 100 maps have been drafted, including the 1：1500000 geological map, tectonic, tectono-magmatic, metamorphic rocks, Precambrian geology, lithofacies palaeogeography, Cenozoic geology, geophysical-geochemical maps and others.

Research and Practice on Curriculum Reform of Chinese Pharmaceutical Manufacturing Major against the Backdrop of"Comprehensive Health"

Against the backdrop of Comprehensive Health,the Chinese Pharmaceutical Manufacturing major faces both opportunities and challenges.This paper describes some problems encountered in the development of the Chinese Pharmaceutical Manufacturing major,puts forward some suggestions and measures to adapt to the training of talents of Chinese pharmaceutical manufacturing against the backdrop of Comprehensive Health,and discusses the practical research on curriculum reform.

Occurrence Factors and Comprehensive Prevention and Control of Chinese Rose Black Spot(Actinonema rosae)

In addition to conventional techniques,the prevention and control of Chinese rose black spot(Actinonema rosae)should be strengthened in the management of Chinese rose.The occurrence of Chinese rose black spot is closely related to plant residues,rainfall,cultivation conditions and varieties.On the basis of understanding the symptoms and occurrence regularity of Chinese rose black spot,combination measures of agricultural and chemical prevention and control should be taken.

“Tasks”versus“Disciplines”:The Comprehensive Surveys of Natural Resources by the Chinese Academy of Sciences,and the Politics of Science Policy in the People’s Republic of China

As soon as the Chinese Academy of Sciences(CAS)was founded by the new government of the People’s Republic of China in 1949,the principles of“linking theory with practice”and“conducting research to serve the people”set the framework for its scientific studies.How to balance their obligations to facilitate national economic construction with their desires to advance disciplinary scientific developments posed a knotty problem that frustrated those who organized and engaged in scientific research across the country,and in the CAS in particular.Against this background,the slogan“let tasks lead disciplines”was proposed as an effective solution.However,how exactly to put this into practice became a pressing issue,as CAS scientists and scholars debated the relationship between tasks and advances within scientific disciplines.This paper examines these debates as they were carried out in the case of the comprehensive surveys of natural resources organized by the CAS,focusing especially on different understandings of the relationship between“tasks”and“disciplines”within the CAS in the early 1960s,and examining the impact and legacy of“letting tasks lead disciplinary developments,”with possible lessons for the formulation of scientific plans today.

Clinical Observation on the Prevention and Treatment of Juvenile Mild Myopia with Traditional Chinese Medicine Comprehensive Therapy

Objective:To observe the clinical effect of traditional Chinese medicine on the prevention and treatment ofjuvenile mild myopia.Methods:One hundred and twenty cases of juvenile mild myopia were randomly divided into six groups,with 20 cases in each group:western medicine group,ultrasonic group,acupuncture group,auricular point group,traditional Chinese oral decoction group,and traditional Chinese medicine comprehensive therapy group.The therapeutic effects of the treatment administered to the six groups were compared.Result:In the post-treatment and follow-up stages,the visual acuity of the traditional Chinese medicine comprehensive therapy group significantly improved along with reduced diopter compared to the other groups(p<0.05).However,the axial length of the six groups had no significant change compared with that before treatment(p>0.05).There were no adverse reactions in any of the patients.Conclusion:In the treatment of juvenile mild myopia,traditional Chinese medicine comprehensive therapy has good therapeutic effect without any adverse reactions;thus,it is worthy of clinical promotion.

橘皮竹茹汤对化疗性异食癖大鼠模型5-羟色胺3受体蛋白和mRNA表达的影响

目的观察橘皮竹茹汤对化疗性异食癖大鼠模型止呕作用及对5-羟色胺3受体(5-HT3R)蛋白和mRNA的影响。方法将36只Wistar雄性大鼠随机分为正常对照组、中药对照组(橘皮竹茹汤10.6 g/kg,不造模)、模型组、昂丹司琼组(2.6 mg/kg)、橘皮竹茹汤低剂量组(5.3 g/kg)和橘皮竹茹汤高剂量组(10.6 g/kg),每组6只。各组大鼠给予相应干预措施6 d(每日2次)后,采用腹腔注射顺铂(6 mg/kg)的方式诱导建立化疗性异食癖大鼠模型,观察并记录造模后24 h内大鼠体质量、摄食量和高岭土摄入量的变化。继续干预1 d后,苏木精-伊红(HE)染色观察各组大鼠胃窦、回肠组织形态学变化;实时荧光定量逆转录聚合酶链式反应(RT-qPCR)法检测延髓、回肠组织中5-HT3R、色氨酸羟化酶(TPH)、单胺氧化酶A(MAOA)mRNA表达;Western blot法检测延髓组织中5-HT3R蛋白的表达。结果①与正常对照组比较,模型组大鼠体质量、摄食量降低(P<0.05),高岭土摄入量显著增加(P<0.05);与模型组比较,昂丹司琼组和橘皮竹茹汤低、高剂量组大鼠高岭土摄入量显著降低(P<0.05)。②HE染色显示,与正常对照组比较,模型组胃窦组织上皮细胞受损,固有层腺体排列疏松、紊乱,回肠上皮部分缺失,腺体排列紊乱;与模型组比较,昂丹司琼组和橘皮竹茹汤低、高剂组胃窦和回肠组织病理改变减轻。③RT-qPCR结果显示,与正常对照组比较,模型组大鼠延髓、回肠5-HT3R mRNA表达水平显著升高(P<0.05),回肠MAOA mRNA表达水平显著降低(P<0.05);与模型组比较,橘皮竹茹汤高剂量组大鼠延髓5-HT3R mRNA表达水平明显降低(P<0.05),橘皮竹茹汤低剂量组回肠TPH1 mRNA、橘皮竹茹汤高剂量组延髓TPH2 mRNA表达水平明显降低(P<0.05),昂丹司琼组、橘皮竹茹汤低剂量组、橘皮竹茹汤高剂量组回肠MAOA mRNA表达水平明显升高(P<0.05)。④Western blot结果显示,与正常对照组比较,模型组大鼠延髓5⁃HT3R蛋白表达水平显著升高(P<0.05);与模型组比较,橘皮竹茹汤高剂量组大鼠延髓5-HT3R蛋白表达水平显著降低(P<0.05)。结论橘皮竹茹汤可以通过抑制延髓5-HT3R蛋白和mRNA的表达,调控5-羟色胺合成与代谢相关酶,进而改善化疗导致的恶心呕吐。

Comprehensive evaluation of 5G+smart distribution network based on combined weighting method-cloud model

With the large-scale application of 5G technology in smart distribution networks,the operation effects of distribution networks are not clear.Herein,we propose a comprehensive evaluation model of a 5G+smart distribution network based on the combination weighting and cloud model of the improved Fuzzy Analytic Hierarchy-Entropy Weight Method(FAHP-EWM).First,we establish comprehensive evaluation indexes of a 5G+smart distribution network from five dimensions:reliable operation,economic operation,efficient interaction,technological intelligence,and green emission reduction.Second,by introducing the principle of variance minimization,we propose a combined weighting method based on the improved FAHP-EWM to calculate the comprehensive weight,so as to reduce the defects of subjective arbitrariness and promote objectivity.Finally,a comprehensive evaluation model of 5G+smart distribution network based on cloud model is proposed by considering the uncertainty of distribution network node information and equipment status information.The example analysis indicates that the overall operation of the 5G+smart distribution network project is decent,and the weight value calculated by the combined weighting method is more reasonable and accurate than that calculated by the single weighting method,which verifies the effectiveness and rationality of the proposed evaluation method.Moreover,the proposed evaluation method has a certain guiding role for the large-scale application of 5G communication technology in smart distribution networks.

Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk

The present study was designed to examine the contributions of the fatty acid elongase （ELOVL） gene polymorphisms to the levels of polyunsaturated fatty acids （PUFAs） in breast milk. Two hundred and nine healthy Han Chinese mothers were included in the study. Carriers of minor alleles of SNPs （rs2397142 and rs9357760） in ELOVL5 were associated with higher levels of linoleic acid （LA）, dihomo-γ-linolenic acid （DGLA）, arachidonic acid （AA）, docosatetraenoic acid （DTA）, docosahexenoic acid （DHA）, while in rs209512 of ELOVL5 the carriers of minor alleles had lower levels of DTA compared to major homozygote alleles （P ranged from 0.004-0.046）, and genetically explained variability ranged from 3.2% for eicosapentaenoic acid （EPA） to 6.0% for LA. Our findings demonstrated that common variation in ELOVL5 gene encoding rate-limiting enzymes in the metabolism of PUFAs contribute to the PUFAs in breast milk.

基于政策工具与5W理论二维视角下中医药文化传播政策量化分析

目的:对我国中医药文化传播相关政策文本进行分析,探讨中医药文化传播政策的着重点和存在问题,为后期政策优化提供依据。方法:基于政策工具和5W传播理论的二维视角,对检索出的43份中医药文化传播政策文件进行内容分析。结果:中医药文化传播政策制定中政策工具整体使用较为丰富,但结构分布不均。对传播媒介(110/200,55.00%)的扩展及传播内容(97/102,95.10%)的丰富均依赖资讯性工具,对传播者(63/64,98.44%)的引导与传播受众(14/14,100%)的调动多依赖组织性工具,对传播效果(11/1291.67%)的评估多依赖市场化工具,经济性工具(2/16,12.50%)在5W维度的激励作用均发挥不足。结论:应借助经济性工具激发中医药文化传播主体的积极性与创造性,运用组织性工具兼顾中医药文化传播受众的需求度与差异化,凭借资讯性工具增强中医药传播内容科学性与表达通俗性,依托管制性工具推动中医药文化传播媒介的多元化与整合化发展,利用市场化工具提高中医药文化传播效果的社会效益与经济效益。

纯中医规范化综合治疗短病程突发性聋516例疗效观察

【目的】探讨纯中医规范化综合治疗短病程突发性聋(简称突聋)的临床疗效及其影响因素。【方法】对516例采用纯中医规范化综合治疗的短病程突聋住院患者(中医组)的临床资料进行回顾性分析,并与《中国突发性聋分型治疗的多中心临床研究》的1024例患者(西医组)的疗效进行对照,分析患者性别、耳别、年龄、耳聋程度、听力曲线类型、伴随症状(耳鸣、眩晕、耳闷)及中医证型对疗效的影响。【结果】(1)基线资料比较:与西医组相比,中医组低频下降型占比较低,全聋型占比较高,治疗难度相对较大,而疗程缩短近2/3(12.60 d vs 30.00 d)。(2)疗效分析:中医组516例患者中,痊愈175例,显效121例,有效90例,无效130例,总有效率为74.80%,与西医组1024例相比,无论总体疗效还是按听力曲线分类统计疗效,差异均无统计学意义(P>0.05)。(3)疗效影响因素分析:听力曲线类型与突聋疗效关系密切(P<0.001),低频下降型疗效最好,全聋型疗效最差;耳聋程度越轻,痊愈可能性越大(P<0.001);无眩晕者疗效优于伴眩晕者(P<0.001);青少年患者疗效较中老年好(P<0.05);中医证型与疗效无关(P>0.05)。【结论】纯中医规范化综合治疗短病程突聋疗效较好,与西医常规治疗相比可能具有一定的优势;听力曲线类型、耳聋程度、是否伴随眩晕及年龄是影响疗效的相关因素。

The influence of CYP3A5 ＊ 3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers

Aim The aim of this study was to evaluate the pharmacogenetic variability in the disposition of felodip- ine in healthy Chinese subjects. Methods A single oral dose of 5 mg felodipine was orally administered to 45 healthy Chinese subjects. The serum concentrations of felodipine were measured by using LC/MS/MS. We detected the SNPs of CYP450 enzymes and transporters, which play vital roles in drug metabolism and are with a high fre- quency of mutation in Chinese. Results The area under the plasma concentration - time curve （AUC） within the time points 0 to 72 h （AUC（0-72） ） after felodipine administration was significantly higher in the subjects possessing the CYP3A5 ＊ 1/＊ 3 alleles than in those with the CYP3A5 ＊ 1/＊ 1 alleles （P =0. 021 ）. The BCRP 421A allele was associated with a trend of reduced pharmacokinetic exposure （P = 0. 034）. The mean Tmax in subjects with the CYP3A4 ＊ 1/＊ 18B carriers was longer than in those with the CYP3A4 ＊ 1/＊ 1. The pharmacokinetics charac- teristics of felodipine were not associated with other SNPs we investigated. Conclusion This study showed that the genetic polymorphisms of CYP3A5＊ 3 and BCRPC421A might explain the variability in the pharmacokinetics of felodipine in the Chinese population.

Function Words Analysis——A Reading Comprehension Aid for Chinese Engineers

Background Generally speaking. Chinese college graduates in the fifties and sixties took Russian as their second language, and those who graduated in the seventies had no second language to speak of. Now, in the years of our Open Door Policy, they find they have to learn some English and learn it quickly. They try to learn from radio and TV and many take English courses of 4 to 6 months, with varying degree of success. Their chief stumbling blocks

Digenic heterozygous mutations in EYS/LRP5 in a Chinese family with retinitis pigmentosa

Dear Editor,I am Dr.Ji-Hong Wu,from the Department of Ophthalmology,Eye＆ENT Hospital of Fudan University,China.I write to present a case report of retinitis pigmentosa（RP）caused by novel digenic heterozygous mutations in a Chinese family.