The advent of immunotherapy and the development of immune checkpoint inhibitors(ICIs)are changing the way we think about cancer treatment.ICIs have shown clinical benefits in a variety of tumor types,and ICI-based imm...The advent of immunotherapy and the development of immune checkpoint inhibitors(ICIs)are changing the way we think about cancer treatment.ICIs have shown clinical benefits in a variety of tumor types,and ICI-based immunotherapy has shown effective clinical outcomes in immunologically“hot”tumors.However,for immunologically“cold”tumors such as colorectal cancer(CRC),only a limited number of patients are currently benefiting from ICIs due to limitations such as individual differences and low response rates.In this review,we discuss the classification and differences between hot and cold CRC and the current status of research on cold CRC,and summarize the treatment strategies and challenges of immunotherapy for cold CRC.We also explain the mechanism,biology,and role of immunotherapy for cold CRC,which will help clarify the future development of immunotherapy for cold CRC and discovery of more emerging strategies for the treatment of cold CRC.展开更多
Direct transmission of SARS-CoV-2 involves two main aspects:it can occur by inhaling either droplets or aerosols in the air containing viruses.In addition,viruses can also spread after being deposited on inanimate sur...Direct transmission of SARS-CoV-2 involves two main aspects:it can occur by inhaling either droplets or aerosols in the air containing viruses.In addition,viruses can also spread after being deposited on inanimate surfaces.Recently,there were reports suggested that SARS-CoV-2 can be found in frozen products.The cold chain creates opportunities for the spread of SARS-CoV-2.With the advent of winter,the drop in outside temperature makes the“frozen chain”less likely to be destroyed;thus,the virus will survive longer on frozen products.During the transportation of imported food,there is a greater risk of virus infection.Therefore,we should be vigilant and strengthen the quarantine of each type of imported food.展开更多
Background: 1-3, 1-6 β-glucan derived from Baker’s yeast (Saccharomyces cerevisiae) has been widely studied for its immune stimulatory capabilities and safety. Previous studies found β-glucan to have efficacy at re...Background: 1-3, 1-6 β-glucan derived from Baker’s yeast (Saccharomyces cerevisiae) has been widely studied for its immune stimulatory capabilities and safety. Previous studies found β-glucan to have efficacy at reducing incidence of URTIs as well as being a low risk for negative side effects. The current study aimed to examine the effects of yeast β-glucan (Angel Yeast) on cold and flu incidences and symptoms in healthy adults. Methods: Two hundred and thirty-one males and females aged 18 to 65 years old supplemented with either β-glucan or a placebo for 3-months. Participants completed a general health questionnaire every 4 weeks and in addition, if participants experienced any cold or flu symptoms, these were recorded daily (along with severity) until resolved or up to 2 weeks. Results: Supplementation with β-glucan reduced the self-reported severity of sore throats and improved sleep quality compared to the placebo group. Conclusions: Yeast β-glucan supplementation appears to be able to help reduce certain symptoms experienced during a cold or flu episode and is safe and well tolerated.展开更多
Stomachache is one of the most common diseases of digestive system, among which stomach pain of deficiency cold of spleen and stomach is the most common. Acupuncture and moxibustion therapy as an external treatment of...Stomachache is one of the most common diseases of digestive system, among which stomach pain of deficiency cold of spleen and stomach is the most common. Acupuncture and moxibustion therapy as an external treatment of traditional Chinese medicine for relieving stomach pain due to deficiency of spleen and stomach, has the advantages of convenient operation, small adverse reactions and remarkable curative effect, which is easy for patients to accept. In this paper, acupuncture and moxibustion therapy such as moxibustion and warm acupuncture therapy for stomach pain of spleen and stomach deficiency cold type is summarized to provide evidence-based basis for clinical treatment of stomach pain of spleen and stomach deficiency cold type.展开更多
This paper used potential height field data published by the China National Climate Center and the US NCEP reanalysis data. A study was conducted on a strong cold wave weather process in central and eastern China from...This paper used potential height field data published by the China National Climate Center and the US NCEP reanalysis data. A study was conducted on a strong cold wave weather process in central and eastern China from October 2 to 5, 2022. The results show that this weather process is a cold air weather process of “horizontal trough to vertical” type from the east of Novaya Zemlya Island. Cold air passes through Russia and Mongolia south, controlling northern China. The precipitation process is caused by the combination of high-altitude trough, ground front, warm and humid air flow, and precipitation weather formed by the influence of warm and humid air due to the 700 hPa shear line. The northern Sichuan Basin and the middle and lower reaches of the Yellow River in China can precipitate almost 50 mm. Water vapor is transported from the South China Sea to central and eastern China by the southwest warm and humid air flow along the west side of the West Pacific Subtropical High. Water vapor is concentrated over the precipitation area through horizontal convergence and is the most important source of water vapor causing precipitation.展开更多
The growing interest in energy conservation has inspired companies to seek alternatives to highly polluting fuel electricity generation. This study designed an optimised solar wind power generation system to fulfil th...The growing interest in energy conservation has inspired companies to seek alternatives to highly polluting fuel electricity generation. This study designed an optimised solar wind power generation system to fulfil the energy requirement of a cold chain logistics centre. This study first conducted a thorough analysis of the clarity indicators and daily temperature positions of the cold chain logistics centre, determined the average daily electricity demand, and proposed an effective design scheme. The energy simulation software, RETScreen 8.0, was used to determine the scale of solar photovoltaic and wind power projects that meet the expected energy needs of the cold chain logistics centre. The results indicated that the estimated annual total energy demand was 833689.2 kWh. The annual power generation of 6 kW from solar photovoltaic projects and 150 kW from wind power projects was found to be enough to meet the expected electricity demand. Solar photovoltaic power generation and wind power generation account for 2.44% and 97.56%, respectively. The hybrid energy system achieved a 96.6% reduction in carbon emissions and provides a reasonable payback period of 6.1 years and an electricity generation of 904368.674 kWh per year. The feasibility of the project and the calculated period of investment return are very reasonable. Therefore, this hybrid renewable energy system provides reliable power by combining energy sources.展开更多
This study uses data provided by the National Meteorological Information Center of China, Japan Meteorological Agency (JMA) and National Oceanic Atmospheric Administration (NOAA) Physical Sciences Laboratory of the US...This study uses data provided by the National Meteorological Information Center of China, Japan Meteorological Agency (JMA) and National Oceanic Atmospheric Administration (NOAA) Physical Sciences Laboratory of the USA to analyze a cold air weather process at the beginning of January 2021. Synoptic analysis is mainly used to summarize synoptic laws or patterns based on observational data, and describe and infer weather processes. The main conclusions are as follows: The cold air travels south along the northwest path, affecting most of China. During the cold wave process, the first cold air is weak, which has a certain cooling effect on northern China. The second cold air was guided by the low vortex, the accumulation in the transverse groove of Mongolia was strengthened, and the cooling effect was significant. The southwest jet showed an increasing trend, and the water vapor transport conditions were good. However, due to the relatively gentle southern branch system, the warm and humid air flow was weak and the precipitation level was small. The purpose of this study is to better understand a large-scale cold air weather process in January 2021 in China.展开更多
文摘The advent of immunotherapy and the development of immune checkpoint inhibitors(ICIs)are changing the way we think about cancer treatment.ICIs have shown clinical benefits in a variety of tumor types,and ICI-based immunotherapy has shown effective clinical outcomes in immunologically“hot”tumors.However,for immunologically“cold”tumors such as colorectal cancer(CRC),only a limited number of patients are currently benefiting from ICIs due to limitations such as individual differences and low response rates.In this review,we discuss the classification and differences between hot and cold CRC and the current status of research on cold CRC,and summarize the treatment strategies and challenges of immunotherapy for cold CRC.We also explain the mechanism,biology,and role of immunotherapy for cold CRC,which will help clarify the future development of immunotherapy for cold CRC and discovery of more emerging strategies for the treatment of cold CRC.
文摘Direct transmission of SARS-CoV-2 involves two main aspects:it can occur by inhaling either droplets or aerosols in the air containing viruses.In addition,viruses can also spread after being deposited on inanimate surfaces.Recently,there were reports suggested that SARS-CoV-2 can be found in frozen products.The cold chain creates opportunities for the spread of SARS-CoV-2.With the advent of winter,the drop in outside temperature makes the“frozen chain”less likely to be destroyed;thus,the virus will survive longer on frozen products.During the transportation of imported food,there is a greater risk of virus infection.Therefore,we should be vigilant and strengthen the quarantine of each type of imported food.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences[grant numbers XDA23090102]the National Natural Science Foundation of China[grant numbers 42175078 and 42075040]+1 种基金the Health Meteorological Project of Hebei Province[grant number FW202150]the National Key Research and Development Program of China[grant number 2018YFA0606203].
文摘Background: 1-3, 1-6 β-glucan derived from Baker’s yeast (Saccharomyces cerevisiae) has been widely studied for its immune stimulatory capabilities and safety. Previous studies found β-glucan to have efficacy at reducing incidence of URTIs as well as being a low risk for negative side effects. The current study aimed to examine the effects of yeast β-glucan (Angel Yeast) on cold and flu incidences and symptoms in healthy adults. Methods: Two hundred and thirty-one males and females aged 18 to 65 years old supplemented with either β-glucan or a placebo for 3-months. Participants completed a general health questionnaire every 4 weeks and in addition, if participants experienced any cold or flu symptoms, these were recorded daily (along with severity) until resolved or up to 2 weeks. Results: Supplementation with β-glucan reduced the self-reported severity of sore throats and improved sleep quality compared to the placebo group. Conclusions: Yeast β-glucan supplementation appears to be able to help reduce certain symptoms experienced during a cold or flu episode and is safe and well tolerated.
文摘Stomachache is one of the most common diseases of digestive system, among which stomach pain of deficiency cold of spleen and stomach is the most common. Acupuncture and moxibustion therapy as an external treatment of traditional Chinese medicine for relieving stomach pain due to deficiency of spleen and stomach, has the advantages of convenient operation, small adverse reactions and remarkable curative effect, which is easy for patients to accept. In this paper, acupuncture and moxibustion therapy such as moxibustion and warm acupuncture therapy for stomach pain of spleen and stomach deficiency cold type is summarized to provide evidence-based basis for clinical treatment of stomach pain of spleen and stomach deficiency cold type.
基金the National Natural Science Foundation of China[grant number 42088101]the Postgraduate Research and Practice Innovation Program of Jiangsu Province[grant number KYCX22_1147].
文摘This paper used potential height field data published by the China National Climate Center and the US NCEP reanalysis data. A study was conducted on a strong cold wave weather process in central and eastern China from October 2 to 5, 2022. The results show that this weather process is a cold air weather process of “horizontal trough to vertical” type from the east of Novaya Zemlya Island. Cold air passes through Russia and Mongolia south, controlling northern China. The precipitation process is caused by the combination of high-altitude trough, ground front, warm and humid air flow, and precipitation weather formed by the influence of warm and humid air due to the 700 hPa shear line. The northern Sichuan Basin and the middle and lower reaches of the Yellow River in China can precipitate almost 50 mm. Water vapor is transported from the South China Sea to central and eastern China by the southwest warm and humid air flow along the west side of the West Pacific Subtropical High. Water vapor is concentrated over the precipitation area through horizontal convergence and is the most important source of water vapor causing precipitation.
文摘The growing interest in energy conservation has inspired companies to seek alternatives to highly polluting fuel electricity generation. This study designed an optimised solar wind power generation system to fulfil the energy requirement of a cold chain logistics centre. This study first conducted a thorough analysis of the clarity indicators and daily temperature positions of the cold chain logistics centre, determined the average daily electricity demand, and proposed an effective design scheme. The energy simulation software, RETScreen 8.0, was used to determine the scale of solar photovoltaic and wind power projects that meet the expected energy needs of the cold chain logistics centre. The results indicated that the estimated annual total energy demand was 833689.2 kWh. The annual power generation of 6 kW from solar photovoltaic projects and 150 kW from wind power projects was found to be enough to meet the expected electricity demand. Solar photovoltaic power generation and wind power generation account for 2.44% and 97.56%, respectively. The hybrid energy system achieved a 96.6% reduction in carbon emissions and provides a reasonable payback period of 6.1 years and an electricity generation of 904368.674 kWh per year. The feasibility of the project and the calculated period of investment return are very reasonable. Therefore, this hybrid renewable energy system provides reliable power by combining energy sources.
文摘This study uses data provided by the National Meteorological Information Center of China, Japan Meteorological Agency (JMA) and National Oceanic Atmospheric Administration (NOAA) Physical Sciences Laboratory of the USA to analyze a cold air weather process at the beginning of January 2021. Synoptic analysis is mainly used to summarize synoptic laws or patterns based on observational data, and describe and infer weather processes. The main conclusions are as follows: The cold air travels south along the northwest path, affecting most of China. During the cold wave process, the first cold air is weak, which has a certain cooling effect on northern China. The second cold air was guided by the low vortex, the accumulation in the transverse groove of Mongolia was strengthened, and the cooling effect was significant. The southwest jet showed an increasing trend, and the water vapor transport conditions were good. However, due to the relatively gentle southern branch system, the warm and humid air flow was weak and the precipitation level was small. The purpose of this study is to better understand a large-scale cold air weather process in January 2021 in China.