“Cold”colorectal cancer faces a bottleneck in immunotherapy

The advent of immunotherapy and the development of immune checkpoint inhibitors(ICIs)are changing the way we think about cancer treatment.ICIs have shown clinical benefits in a variety of tumor types,and ICI-based immunotherapy has shown effective clinical outcomes in immunologically“hot”tumors.However,for immunologically“cold”tumors such as colorectal cancer(CRC),only a limited number of patients are currently benefiting from ICIs due to limitations such as individual differences and low response rates.In this review,we discuss the classification and differences between hot and cold CRC and the current status of research on cold CRC,and summarize the treatment strategies and challenges of immunotherapy for cold CRC.We also explain the mechanism,biology,and role of immunotherapy for cold CRC,which will help clarify the future development of immunotherapy for cold CRC and discovery of more emerging strategies for the treatment of cold CRC.

The potential role of the “cold chain” in the spread of SARS-CoV-2

Direct transmission of SARS-CoV-2 involves two main aspects:it can occur by inhaling either droplets or aerosols in the air containing viruses.In addition,viruses can also spread after being deposited on inanimate surfaces.Recently,there were reports suggested that SARS-CoV-2 can be found in frozen products.The cold chain creates opportunities for the spread of SARS-CoV-2.With the advent of winter,the drop in outside temperature makes the“frozen chain”less likely to be destroyed;thus,the virus will survive longer on frozen products.During the transportation of imported food,there is a greater risk of virus infection.Therefore,we should be vigilant and strengthen the quarantine of each type of imported food.

Effect of different cold air intensities and their lagged effects on outpatient visits for respiratory illnesses in Handan in different seasons

本文利用2016年到2019年邯郸市气象要素和呼吸系统疾病门诊数据,分析了不同季节不同强度的冷空气过程及其对呼吸系统疾病的影响,结果显示:尽管呼吸系统疾病在冬季高发,夏季最低,但冷空气对呼吸系统疾病的影响在夏,春季最大,就诊人数分别在冷空气日后两天和五天增加18.4%和13.3%,而冬季就诊人数在冷空气日后三天仅增加3.2%.冷空气对疾病影响的滞后时间在夏,秋和冬季随冷空气强度的增加而减少,而春季的滞后时间总是很长.这些发现可为科学应对气候异常导致的人群健康风险提供针对性依据.

Effect of β-Glucan (Angel Yeast) Compared to a Placebo on Cold and Flu Incidence and Symptoms in an Adult Population—A Double Blind, Randomised Controlled Trial

Background: 1-3, 1-6 β-glucan derived from Baker’s yeast (Saccharomyces cerevisiae) has been widely studied for its immune stimulatory capabilities and safety. Previous studies found β-glucan to have efficacy at reducing incidence of URTIs as well as being a low risk for negative side effects. The current study aimed to examine the effects of yeast β-glucan (Angel Yeast) on cold and flu incidences and symptoms in healthy adults. Methods: Two hundred and thirty-one males and females aged 18 to 65 years old supplemented with either β-glucan or a placebo for 3-months. Participants completed a general health questionnaire every 4 weeks and in addition, if participants experienced any cold or flu symptoms, these were recorded daily (along with severity) until resolved or up to 2 weeks. Results: Supplementation with β-glucan reduced the self-reported severity of sore throats and improved sleep quality compared to the placebo group. Conclusions: Yeast β-glucan supplementation appears to be able to help reduce certain symptoms experienced during a cold or flu episode and is safe and well tolerated.

Recent Situation of Acupuncture and Moxibustion in the Treatment of Stomach Pain with Deficiency and Cold of Spleen and Stomach

Stomachache is one of the most common diseases of digestive system, among which stomach pain of deficiency cold of spleen and stomach is the most common. Acupuncture and moxibustion therapy as an external treatment of traditional Chinese medicine for relieving stomach pain due to deficiency of spleen and stomach, has the advantages of convenient operation, small adverse reactions and remarkable curative effect, which is easy for patients to accept. In this paper, acupuncture and moxibustion therapy such as moxibustion and warm acupuncture therapy for stomach pain of spleen and stomach deficiency cold type is summarized to provide evidence-based basis for clinical treatment of stomach pain of spleen and stomach deficiency cold type.

Subseasonal transition of Barents-Kara sea-ice anomalies in winter related to the reversed warm Arctic-cold Eurasia pattern

“暖北极-冷欧亚”模态(WACE)的次季节反转会触发中国东部冬季的极端冷/暖转换以及春季沙尘暴.在这一显著的高纬度大气模态反转的驱动下,巴伦支海-喀拉海(BKS)的海冰异常也表现出次季节转换.当北极变暖以及乌拉尔山高压增强时,BKS异常向下的湍流热通量和增强的向下红外辐射有利于海冰融化;近地面的异常偏南风使海冰从薄冰区向多年冰区漂移,进一步扩大了开阔洋面.相反的机制出现在WACE反位相,导致BKS海冰异常偏多.当WACE次季节反转时,上述机制分别发生在前冬和后冬,使得BKS海冰异常出现显著的次季节转换.近10年随着WACE反转频率增多,BKS海冰前后冬的次季节变化增强.本文构建了WACE次季节反转的综合示意图,有助于更好地理解和预测中国东部极端气候.

不同土壤条件下秸秆还田量对土壤还原性物质及水稻生长的影响

[目的]在不同土壤上研究水稻秸秆还田后还原性物质的形成及其与水稻生长的关系。[方法]在砂壤土(S1)和粉壤土(S2)上进行2年盆栽试验,模拟低(RL)中(RM)高(RH)产量下秸秆全量还田,以秸秆不还田(R0)为对照,测定土壤还原性物质总量、Eh、亚铁离子、锰离子和铵态氮含量,分析水稻分蘖、根系干质量、根系活力和水稻产量等指标。[结果]秸秆还田后生育前期土壤Eh显著降低,还原性物质数量增加,S2的还原性物质高于砂壤土。与对照相比,2021年在移栽后56d之前秸秆还田处理还原性物质总量、铁和锰离子含量分别提高了8.36%~199.64%、1.43%~160.03%和8.43%~57.68%。2022年在移栽后45 d前对应增加了2.95%~163.61%、0.77%~19.74%和3.28%~64.96%。随着秸秆还田量增加,还原性物质总量、铁和锰含量有增加趋势。在移栽后56 d前(2021年)和35 d前(2022年)秸秆还田显著增加了土壤铵态氮含量11.28%~50.67%和10.79%~351.53%。秸秆还田使水稻分蘖期和拔节期的根系干质量降低15.06%~45.80%,秸秆还田显著降低了砂壤土上水稻分蘖期和拔节期的根系活力,在S2土壤上RL和RM增加了拔节期根系活力,RH降低了根系活力。秸秆还田后水稻分蘖数在水稻生育期降低了7.23%~48.44%,干物质积累量降低了3.59%~43.57%。RL和RM处理第二年水稻产量降低不明显,RH处理2年均显著减产。砂壤土中氧化还原电位高于S2,S2还原性物质总量、锰离子含量、铵态氮含量、根系干质量、根系活力、分蘖数、干物质积累量和产量均高于砂壤土。[结论]在本研究条件下,秸秆还田显著增加还原性物质总量,抑制水稻早期生长。黏重土壤上秸秆全量还田引起减产,砂壤土上中低产量下秸秆全量还田不会造成穗数显著降低,因促进大穗形成不会造成显著减产。采取有效措施减少秸秆还田下还原性物质危害是秸秆还田技术优化的重点。

Modulation of the late summer Northeast China cold vortex by previous-winter ENSO

本文利用再分析资料,研究了前冬ENSO对夏末东北冷涡(NCCV)的调制作用.结果表明,前冬ENSO与夏末NCCV强度之间存在显著的相关性,El Nino(La Ni?a)对应于弱(强)的NCCV.印度洋海盆模态(IOBM)在前冬ENSO对夏末东北亚地区大气环流的影响中起着至关重要的作用.作为东部型El Nino的被动响应,IOBM可以从前冬一直持续至夏末,并在夏末激发“中国中部上空气旋—东北亚地区上空反气旋”的经向遥相关模态,从而不利于NCCV增强.反之亦然.此外,印度洋的信号在中部型El Nino和中性年份相对较弱,使得它们对于NCCV的影响不显著.

基于元学习个性化推荐研究综述

推荐系统作为缓解“信息过载”的工具,为用户过滤冗余信息并提供个性化服务,近年来得到了广泛应用。然而,实际推荐场景中,通常存在冷启动与不同推荐算法难以根据实际环境自适应选择等问题。元学习因其具有基于少量训练样本快速学会新知识和技能的优点,被越来越多地应用于推荐系统相关研究中。对现有基于元学习技术缓解推荐系统冷启动问题以及自适应推荐问题的主要研究进行探讨。首先,分析了基于元学习推荐在上述2个方面已取得的相关研究进展;然后,指出了现有元学习推荐研究存在难以适应复杂任务分布、计算代价高和容易陷入局部最优等问题;最后,对元学习在推荐系统领域的一些最新研究方向进行了展望。

不同覆盖措施对寒地苹果园土壤物理特性和树体生长的影响

为探索适合东北寒地雨养苹果园幼树生长的土壤覆盖技术,以当地主栽苹果品种龙丰为试材,连续2年采用稻草、玉米秸秆、食用菌菌渣和园艺地布覆盖,以清耕为对照,研究不同覆盖处理对苹果园土壤温度、含水量、容重、孔隙度以及树体生长的影响。结果表明:覆盖可显著影响表层土壤温度,与清耕对照相比,覆盖稻草显著降低了土壤温度,覆盖玉米秸秆和覆盖食用菌菌渣能够稳定土壤温度;覆盖处理显著提高了土壤含水量,以覆盖食用菌菌渣最佳,5—10月平均土壤含水量较对照提高40.5%;覆盖有机材料可降低土壤容重,增加土壤孔隙度,在成熟期与对照差异显著,以覆盖玉米秸秆最佳。覆盖促进了龙丰幼树生长,春梢长度和新梢长度、粗度增加,干径增加,促进了叶片生长。综合比较,覆盖园艺地布促进树体生长效果最佳,覆盖玉米秸秆和覆盖食用菌菌渣对改善土壤环境效果最好,同时也能够促进树体生长。

激光复合冷喷涂技术研究进展

冷喷涂是一种基于材料高速撞击产生剧烈塑性变形实现结合的沉积方法,具备加工温度低、沉积效率高、热影响小等优势,已在增材制造、工业关键零部件的修复再制造等领域展现出巨大潜力。冷喷涂复合制造技术是一种新兴技术,其中激光复合冷喷涂是一个重要的方向,近年来得到了越来越多的关注。对激光复合冷喷涂技术研究进展进行回顾和总结,对激光预处理、激光同步复合和激光后处理3种复合方式进行重点阐释。针对每种复合方式,分别从复合原理、复合优势及复合效果3个方面进行总结,对比激光复合冷喷涂技术与单一技术在沉积层微观组织以及性能等方面的差异。通过对激光复合冷喷涂技术最新进展的全面总结和归纳,将为进一步推动激光复合冷喷涂技术的研究和应用提供指导和参考。

Analysis of Cold Air and Precipitation in Central and Eastern China, 2-5 October, 2022

This paper used potential height field data published by the China National Climate Center and the US NCEP reanalysis data. A study was conducted on a strong cold wave weather process in central and eastern China from October 2 to 5, 2022. The results show that this weather process is a cold air weather process of “horizontal trough to vertical” type from the east of Novaya Zemlya Island. Cold air passes through Russia and Mongolia south, controlling northern China. The precipitation process is caused by the combination of high-altitude trough, ground front, warm and humid air flow, and precipitation weather formed by the influence of warm and humid air due to the 700 hPa shear line. The northern Sichuan Basin and the middle and lower reaches of the Yellow River in China can precipitate almost 50 mm. Water vapor is transported from the South China Sea to central and eastern China by the southwest warm and humid air flow along the west side of the West Pacific Subtropical High. Water vapor is concentrated over the precipitation area through horizontal convergence and is the most important source of water vapor causing precipitation.

夏热冬冷气候下太阳能住宅装配式设计实践

为推动我国村镇领域技术创新,建设绿色宜居村镇环境,针对夏热冬冷地区住宅的太阳能利用,从材料到构造,到建筑设计层面,完成与其配合的一体化技术设计策略研究及节能策略的应用探索。借助国际太阳能竞赛的契机,从前期设计的策略选取到后期项目的完成结果,总结实践经验,对比预期和实践的差距及原因。结果表明,前期平面、结构、材料、构造等都满足了对于太阳能利用技术的一体化设计,同时考虑了自然采光、隔热、遮阳等策略的应用,以减少能量损耗,取得了相应的效果,并对未达到预期效果的原因作出评判。

嵌套加强的LQ550高强冷弯薄壁C型钢连续檩条受力性能研究

为提高LQ550级高强冷弯薄壁C型钢连续檩条的承载能力,采用在支座处嵌套的方法来加强连续檩条。对未加强和采用两种嵌套方式加强的檩条共7组试件进行三点受弯试验,得到了试件的承载性能和破坏形态,试验结果表明加强后的试件出现跨中局部屈曲和嵌套端部局部屈曲两种破坏形态。采用ABAQUS软件建立了非线性有限元模型对嵌套加强的檩条进行数值模拟,有限元分析得到的承载力和破坏形态与试验结果吻合良好,验证了有限元模型的准确性。基于验证的有限元模型,分析了两种嵌套方式和不同嵌套长度对檩条承载力的提升,且表明嵌套檩条的长度宜取为连续檩条跨度的1/5~1/4。

中国县域数字乡村发展的空间格局及驱动因素研究

基于北京大学新农村发展研究院公布的2018年中国1880个县域数字乡村指数数据,采用探索性空间数据分析、冷热点分析和地理探测器等方法,考察中国县域数字乡村发展的空间格局及其驱动因素。结果表明:1)中国县域数字乡村发展水平呈现明显的“梯度化”特征,数字乡村发展水平由东部向西部逐渐递减,数字乡村在长三角地区呈“片状分布”,而在西部地区和东北地区呈“点状分布”。2)中国县域数字乡村发展呈现明显的空间集聚特征,在经济发展水平较高、网络基础设施较为完善的长三角地区形成“高-高”集聚。数字乡村发展呈现次热点区和热点区围绕高热点区集聚的“中心-外围”结构形态。在热点区与冷点区之间形成“T”字形狭长地带,将热点区与冷点区分隔开。3)中国县域数字乡村发展的总体基尼系数为0.0359,其中数字乡村的区域间差距是数字乡村发展总体差异的主要来源。4)产业经济、人口教育、财政金融和基础设施的空间分异特征对数字乡村空间分布具有较强的影响。

钛合金薄壁构件快速加热冷模热冲压成形技术进展

为了解决钛合金薄壁构件热成形效率低、成本高、组织性能控制难度大等问题,近年来钛合金冷模热冲压成形技术受到关注。在该新技术中利用室温模具对加热后的钛合金板材进行快速冲压成形和模内快速冷却,由于取消了模具加热,可以变革性地提高钛合金薄壁构件成形效率、降低成本。然而,与传统等温成形不同,在冷模热冲压成形过程中,钛合金板材温度不断下降,这对钛合金成形极限、回弹及组织性能等的控制提出了全新的挑战。分析了钛合金薄壁构件冷模热冲压成形技术特点及存在的问题,归纳了快速加热对钛合金组织性能的影响规律,综述了钛合金薄壁构件快速加热冷模热冲压成形工艺进展,最后对该技术未来的发展方向进行了展望。

基于甘肃寒旱区域划分视角的寒旱农业概念和发展问题研究

甘肃是全国寒旱特征最明显、寒旱区域最为集中的省份,也是寒旱农业活动最集中、最典型的省份。本文结合农业地理学、生态保护与可持续性发展理论来分析和研究寒旱农业概念等寒旱农业基础理论问题,重点以“寒”“旱”气候特征详细划分了甘肃寒旱农业的区域范围,以此分析不同气候类型、地形条件下寒旱农业的特殊性,进而较为全面和系统地提出和诠释了寒旱农业的定义、内涵和特征。在此基础上,探讨了甘肃独特的寒旱区域和寒旱气候的变化对农业生产的多重性影响,以趋利避害,因势利导,探索具有“寒旱”内在特质的新时期甘肃特色优势农业发展道路。

Optimal Design of Grid-Connected Microgrid System for Cold Chain Logistics Centre in China

The growing interest in energy conservation has inspired companies to seek alternatives to highly polluting fuel electricity generation. This study designed an optimised solar wind power generation system to fulfil the energy requirement of a cold chain logistics centre. This study first conducted a thorough analysis of the clarity indicators and daily temperature positions of the cold chain logistics centre, determined the average daily electricity demand, and proposed an effective design scheme. The energy simulation software, RETScreen 8.0, was used to determine the scale of solar photovoltaic and wind power projects that meet the expected energy needs of the cold chain logistics centre. The results indicated that the estimated annual total energy demand was 833689.2 kWh. The annual power generation of 6 kW from solar photovoltaic projects and 150 kW from wind power projects was found to be enough to meet the expected electricity demand. Solar photovoltaic power generation and wind power generation account for 2.44% and 97.56%, respectively. The hybrid energy system achieved a 96.6% reduction in carbon emissions and provides a reasonable payback period of 6.1 years and an electricity generation of 904368.674 kWh per year. The feasibility of the project and the calculated period of investment return are very reasonable. Therefore, this hybrid renewable energy system provides reliable power by combining energy sources.

Analysis of a Large Scale Cold Air Weather Process in China during January 2021

This study uses data provided by the National Meteorological Information Center of China, Japan Meteorological Agency (JMA) and National Oceanic Atmospheric Administration (NOAA) Physical Sciences Laboratory of the USA to analyze a cold air weather process at the beginning of January 2021. Synoptic analysis is mainly used to summarize synoptic laws or patterns based on observational data, and describe and infer weather processes. The main conclusions are as follows: The cold air travels south along the northwest path, affecting most of China. During the cold wave process, the first cold air is weak, which has a certain cooling effect on northern China. The second cold air was guided by the low vortex, the accumulation in the transverse groove of Mongolia was strengthened, and the cooling effect was significant. The southwest jet showed an increasing trend, and the water vapor transport conditions were good. However, due to the relatively gentle southern branch system, the warm and humid air flow was weak and the precipitation level was small. The purpose of this study is to better understand a large-scale cold air weather process in January 2021 in China.

冷泉碳酸盐工厂的提出及古气候意义

【意义】碳酸盐工厂的提出及其分类研究对于推动碳酸盐岩沉积学发展具有重要意义,但现行分类方案不足以囊括所有碳酸盐沉积类型,因此亟须从机理和过程层面对碳酸盐工厂类型予以梳理、扩充。【进展】传统碳酸盐工厂的碳源主要为大气—海洋中的无机碳库,而一些特殊海相和陆相碳酸盐工厂的碳则主要源于外源碳库,因而两者具有本质上的区别。后者往往对于追溯深时水体环境和气候事件具有重大意义。【结论与展望】以冷泉碳酸盐岩为例,正式提出“冷泉碳酸盐工厂”概念,综述了其沉积特征、生物组成及生物地球化学过程,并举例阐述其古气候意义。基于外源碳库的碳酸盐工厂类型理应得到重视。