Objective:To investigate the effects of Compound Fufangteng Mixture(CFM)on the expression levels of CD11b^(+)monocytes surface activation molecules CD2,CD69 and depleted molecules PD-1 and CD95 in spleen and periphera...Objective:To investigate the effects of Compound Fufangteng Mixture(CFM)on the expression levels of CD11b^(+)monocytes surface activation molecules CD2,CD69 and depleted molecules PD-1 and CD95 in spleen and peripheral blood of immunosuppressed mice.Methods:30 healthy SPF Balb/c male mice were randomly divided into Control,immunosuppressive model group(CTX group),high,medium and low dose intervention group(CTX+CFM-H group,CTX+CFM-M group,CTX+CFM-L group),Astragalus particles(AP)intervention group(CTX+AP group).The mice in each intervention group were injected intraperitoneally with cyclophosphamide(CTX)70 mg/kg for 3 consecutive days,and then administered for 10 d according to the group regimen,and the materials were taken 24 h after the last dose.Flow cytometry detected the expression of CD11b^(+)monocytes surface activation molecules(CD2,CD69)and depleting molecules(PD-1,CD95)in mouse peripheral blood.Results:Compared with the control group,the expression levels of CD11b^(+)and CD69+in the spleen of CTX+CFM-H,CTX+CFM-M and CTX+CFM-L groups showed an improvement trend,and decreased with the dose gradient of CFM.Conclusion:CFM could regulate the immune function of splenic CD11b+ CD69 cells in immunosuppressed mice.展开更多
It was shown by TEM and X-ray analysis that there are four types of grains of the main Ni3Al phase in the structure of the intermetallic obtained by the self-propagation high temperature method (SHS). Every type of gr...It was shown by TEM and X-ray analysis that there are four types of grains of the main Ni3Al phase in the structure of the intermetallic obtained by the self-propagation high temperature method (SHS). Every type of grains has its own domain and dislocation structure. There are mono- and polydomains with and without dislocations. The grains of the main phase of monoand polydomains without dislocations and polydomains with dislocations were formed by diffusion in the solid phase. In these conditions NiAl3 phase is located on the grain boundary of the main phase. The Ni2Al3 phase is located at the triple joints of the main phase.展开更多
The Ni_3B phase was formed when boron (0.5 at. pct B) was added to the intermetallic of sto- ichiometric and off-stoichiometric (Ni-24 at. pct Al) compounds. In the alloy of stoichiometric composition the particles o...The Ni_3B phase was formed when boron (0.5 at. pct B) was added to the intermetallic of sto- ichiometric and off-stoichiometric (Ni-24 at. pct Al) compounds. In the alloy of stoichiometric composition the particles of Ni_3B phase has the size around 0.1μm and is located on the grain boundary of the main phase. The decreasing of concentrations of Al in the ofF-stoichiometric alloy leads to increase in the degree of the long-range order parameter, increasing the concen- trations of boron in the solid solution and decreasing its localization on the grain boundary. Microalloying of boron leads to increasing in the fraction of grain monodomains with disloca- tions up to 0.7 in the alloy of the off-stoichiometric composition and up to 1 in the alloy of the stoichiometric composition. It was established the correlation between the degree of the concentration inhomogeneity, average density of the dislocations and the average long range-order parameter.展开更多
A set of compressed natural gas (CNG) multi-point direct injection system of spark-ignited engines and the corresponding measurement and data acquisition systems were developed in this paper. Based on different inject...A set of compressed natural gas (CNG) multi-point direct injection system of spark-ignited engines and the corresponding measurement and data acquisition systems were developed in this paper. Based on different injection modes, the mixture formation and combustion of CNG low-pressure direct injection (LPDI) engines were studied under varying factors such as air/ fuel ratio, injection timing. Meanwhile, three-dimensional simulations were adopted to explain the mixture formation mechanisms of CNG low-pressure compound direct injection (LPCDI) mode. On the basis of test results and simulation of the mixture homogeneous degree, the conception of injection window was proposed, and the LPCDI mode was proved to be more beneficial to the mixture concentration stratification formation in cylinder under lean-burning conditions, which resulted in effective combustion and stability.展开更多
BACKGROUND Iron deficiency anemia(IDA)is a prevalent nutritional disorder during pregnancy.Clinical studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating IDA in pregnancy can ...BACKGROUND Iron deficiency anemia(IDA)is a prevalent nutritional disorder during pregnancy.Clinical studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating IDA in pregnancy can reduce adverse effects and improve clinical outcomes.Nonetheless,the comparative efficacy of different CPMs remains unclear.AIM To assess the safety and effectiveness of different CPMs for treating IDA during pregnancy using network meta-analysis.METHODS We conducted a search for randomized controlled trials(RCTs)that combined CPM and OI for IDA treatment in pregnancy,spanning from 2013 to the present.Data analysis was performed using Rev Man 5.3 and Stata 14.0 on literature that satisfied the quality criteria.RESULTS The analysis included 45 RCTs,encompassing 4422 pregnant patients with IDA.Six CPMs were examined,including Shengxuebao Mixture,Shengxuening Tablets(SXN),Yiqi Weixue CPMs(YQWX),Jianpi Shengxue CPMs(JPSX),Yiqi Buxue Tablets,and Compound Hongyi Buxue Oral Liquid(FFHY).Findings indicated that FFHY+OI significantly improved the clinical effective rate.SXN+OI was most effective in boosting red blood cells counts and hemoglobin levels.YQWX+OI showed superior results in improving serum ferritin,and SXN+OI was most effective in increasing serum iron levels.JPSX+OI was optimal in reducing adverse pregnancy outcomes,while YQBX+OI effectively minimized adverse events.A cluster analysis suggested that SXN+OI could be the potentially optimal therapeutic regimen for IDA in pregnancy.CONCLUSION This study demonstrates that the combination of OI with CPMs offers better outcomes than OI alone.Based on clinical efficacy and other measured outcomes,SXN+OI emerges as the most effective treatment modality for improving the health of pregnant patients with IDA.展开更多
基金National Natural Science Foundation Project(No.81860780)Guangxi Natural Science Foundation General Project(No.2020GXNSFAA297162)。
文摘Objective:To investigate the effects of Compound Fufangteng Mixture(CFM)on the expression levels of CD11b^(+)monocytes surface activation molecules CD2,CD69 and depleted molecules PD-1 and CD95 in spleen and peripheral blood of immunosuppressed mice.Methods:30 healthy SPF Balb/c male mice were randomly divided into Control,immunosuppressive model group(CTX group),high,medium and low dose intervention group(CTX+CFM-H group,CTX+CFM-M group,CTX+CFM-L group),Astragalus particles(AP)intervention group(CTX+AP group).The mice in each intervention group were injected intraperitoneally with cyclophosphamide(CTX)70 mg/kg for 3 consecutive days,and then administered for 10 d according to the group regimen,and the materials were taken 24 h after the last dose.Flow cytometry detected the expression of CD11b^(+)monocytes surface activation molecules(CD2,CD69)and depleting molecules(PD-1,CD95)in mouse peripheral blood.Results:Compared with the control group,the expression levels of CD11b^(+)and CD69+in the spleen of CTX+CFM-H,CTX+CFM-M and CTX+CFM-L groups showed an improvement trend,and decreased with the dose gradient of CFM.Conclusion:CFM could regulate the immune function of splenic CD11b+ CD69 cells in immunosuppressed mice.
文摘It was shown by TEM and X-ray analysis that there are four types of grains of the main Ni3Al phase in the structure of the intermetallic obtained by the self-propagation high temperature method (SHS). Every type of grains has its own domain and dislocation structure. There are mono- and polydomains with and without dislocations. The grains of the main phase of monoand polydomains without dislocations and polydomains with dislocations were formed by diffusion in the solid phase. In these conditions NiAl3 phase is located on the grain boundary of the main phase. The Ni2Al3 phase is located at the triple joints of the main phase.
文摘The Ni_3B phase was formed when boron (0.5 at. pct B) was added to the intermetallic of sto- ichiometric and off-stoichiometric (Ni-24 at. pct Al) compounds. In the alloy of stoichiometric composition the particles of Ni_3B phase has the size around 0.1μm and is located on the grain boundary of the main phase. The decreasing of concentrations of Al in the ofF-stoichiometric alloy leads to increase in the degree of the long-range order parameter, increasing the concen- trations of boron in the solid solution and decreasing its localization on the grain boundary. Microalloying of boron leads to increasing in the fraction of grain monodomains with disloca- tions up to 0.7 in the alloy of the off-stoichiometric composition and up to 1 in the alloy of the stoichiometric composition. It was established the correlation between the degree of the concentration inhomogeneity, average density of the dislocations and the average long range-order parameter.
基金Supported by National High Technology Research and Development Program ("863" Program) of China (No.2008AA11A114)
文摘A set of compressed natural gas (CNG) multi-point direct injection system of spark-ignited engines and the corresponding measurement and data acquisition systems were developed in this paper. Based on different injection modes, the mixture formation and combustion of CNG low-pressure direct injection (LPDI) engines were studied under varying factors such as air/ fuel ratio, injection timing. Meanwhile, three-dimensional simulations were adopted to explain the mixture formation mechanisms of CNG low-pressure compound direct injection (LPCDI) mode. On the basis of test results and simulation of the mixture homogeneous degree, the conception of injection window was proposed, and the LPCDI mode was proved to be more beneficial to the mixture concentration stratification formation in cylinder under lean-burning conditions, which resulted in effective combustion and stability.
基金Supported by Shandong Province Traditional Chinese Medicine Science and Technology Project,No.Q-2022126Weifang Municipal Health Commission Traditional Chinese Medicine Scientific Research Project,No.014,2022(Category 3).
文摘BACKGROUND Iron deficiency anemia(IDA)is a prevalent nutritional disorder during pregnancy.Clinical studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating IDA in pregnancy can reduce adverse effects and improve clinical outcomes.Nonetheless,the comparative efficacy of different CPMs remains unclear.AIM To assess the safety and effectiveness of different CPMs for treating IDA during pregnancy using network meta-analysis.METHODS We conducted a search for randomized controlled trials(RCTs)that combined CPM and OI for IDA treatment in pregnancy,spanning from 2013 to the present.Data analysis was performed using Rev Man 5.3 and Stata 14.0 on literature that satisfied the quality criteria.RESULTS The analysis included 45 RCTs,encompassing 4422 pregnant patients with IDA.Six CPMs were examined,including Shengxuebao Mixture,Shengxuening Tablets(SXN),Yiqi Weixue CPMs(YQWX),Jianpi Shengxue CPMs(JPSX),Yiqi Buxue Tablets,and Compound Hongyi Buxue Oral Liquid(FFHY).Findings indicated that FFHY+OI significantly improved the clinical effective rate.SXN+OI was most effective in boosting red blood cells counts and hemoglobin levels.YQWX+OI showed superior results in improving serum ferritin,and SXN+OI was most effective in increasing serum iron levels.JPSX+OI was optimal in reducing adverse pregnancy outcomes,while YQBX+OI effectively minimized adverse events.A cluster analysis suggested that SXN+OI could be the potentially optimal therapeutic regimen for IDA in pregnancy.CONCLUSION This study demonstrates that the combination of OI with CPMs offers better outcomes than OI alone.Based on clinical efficacy and other measured outcomes,SXN+OI emerges as the most effective treatment modality for improving the health of pregnant patients with IDA.
