Corporate sustainability reporting has become increasingly important in recent years.However,conventional approaches reach their limits when it comes to quantifying and measuring the actual sustainability performance ...Corporate sustainability reporting has become increasingly important in recent years.However,conventional approaches reach their limits when it comes to quantifying and measuring the actual sustainability performance of a company.This article presents a new approach:Sustainable Performance Accounting(SPA),which is based on an extension of bookkeeping by including ESG bookkeeping.SPA enables companies to systematically measure and manage their sustainability performance.The article provides an overview of the basics of SPA methodology and uses a comprehensive example showing how SPA can be implemented in practice.The article is aimed at interested readers from science and practice as well as decision-makers who are interested in future-oriented sustainability reporting.展开更多
目的探讨Preptin在2型糖尿病性骨质疏松患者骨密度(bone mineral density,BMD)的相关性。方法纳入2型糖尿病患者88例,根据骨密度T值分为3组:骨量正常组(T值>-1.0)(N组)、骨量减少组(-2.5<T值≤-1.0)(R组)和骨质疏松组(T值≤-2.5)...目的探讨Preptin在2型糖尿病性骨质疏松患者骨密度(bone mineral density,BMD)的相关性。方法纳入2型糖尿病患者88例,根据骨密度T值分为3组:骨量正常组(T值>-1.0)(N组)、骨量减少组(-2.5<T值≤-1.0)(R组)和骨质疏松组(T值≤-2.5)(OP组),比较3组患者一般临床资料、临床检验指标、骨密度、血浆Preptin以及结缔组织生长因子(connective tissue growth factor,CTGF)、骨特异性碱性磷酸酶(bone specific alkaline phosphatase,BAP)水平,利用Pearson相关分析研究BMD与一般资料、临床检验资料及骨代谢相关指标间的相关性,并采用SPSS 19.0统计学软件进行Preptin与CTGF、BAP相关曲线的绘制。结果3组患者体重、体质量指数差异有统计学意义(P<0.05)。3组患者骨密度以及骨代谢相关指标均存在显著差异,随着骨密度的降低,3组间Preptin、CTGF、BAP浓度逐渐降低,差异均有统计学意义(P<0.05)。L2~L4 BMD与Preptin、ALP-B、CTGF均呈正相关,Preptin与ALP-B、CTGF均呈正相关(P<0.05)。结论Preptin通过调节CTGF、BAP水平,在2型糖尿病性骨质疏松症的发生发展中发挥重要作用。展开更多
BACKGROUND Large-scale functional connectivity(LSFC)patterns in the brain have unique intrinsic characteristics.Abnormal LSFC patterns have been found in patients with dementia,as well as in those with mild cognitive ...BACKGROUND Large-scale functional connectivity(LSFC)patterns in the brain have unique intrinsic characteristics.Abnormal LSFC patterns have been found in patients with dementia,as well as in those with mild cognitive impairment(MCI),and these patterns predicted their cognitive performance.It has been reported that patients with type 2 diabetes mellitus(T2DM)may develop MCI that could progress to dementia.We investigated whether we could adopt LSFC patterns as discriminative features to predict the cognitive function of patients with T2DM,using connectome-based predictive modeling(CPM)and a support vector machine.AIM To investigate the utility of LSFC for predicting cognitive impairment related to T2DM more accurately and reliably.METHODS Resting-state functional magnetic resonance images were derived from 42 patients with T2DM and 24 healthy controls.Cognitive function was assessed using the Montreal Cognitive Assessment(MoCA).Patients with T2DM were divided into two groups,according to the presence(T2DM-C;n=16)or absence(T2DM-NC;n=26)of MCI.Brain regions were marked using Harvard Oxford(HOA-112),automated anatomical labeling(AAL-116),and 264-region functional(Power-264)atlases.LSFC biomarkers for predicting MoCA scores were identified using a new CPM technique.Subsequently,we used a support vector machine based on LSFC patterns for among-group differentiation.The area under the receiver operating characteristic curve determined the appearance of the classification.RESULTS CPM could predict the MoCA scores in patients with T2DM(Pearson’s correlation coefficient between predicted and actual MoCA scores,r=0.32,P=0.0066[HOA-112 atlas];r=0.32,P=0.0078[AAL-116 atlas];r=0.42,P=0.0038[Power-264 atlas]),indicating that LSFC patterns represent cognition-level measures in these patients.Positive(anti-correlated)LSFC networks based on the Power-264 atlas showed the best predictive performance;moreover,we observed new brain regions of interest associated with T2DM-related cognition.The area under the receiver operating characteristic curve values(T2DM-NC group vs.T2DM-C group)were 0.65-0.70,with LSFC matrices based on HOA-112 and Power-264 atlases having the highest value(0.70).Most discriminative and attractive LSFCs were related to the default mode network,limbic system,and basal ganglia.CONCLUSION LSFC provides neuroimaging-based information that may be useful in detecting MCI early and accurately in patients with T2DM.展开更多
AIM:To Investigate the effects of transforming growth factorβ2(TGF-β2)and connective tissue growth factor(CTGF)on transdifferentiation of human lens epithelial cells(HLECs)cultured in vitro and synthesis of extracel...AIM:To Investigate the effects of transforming growth factorβ2(TGF-β2)and connective tissue growth factor(CTGF)on transdifferentiation of human lens epithelial cells(HLECs)cultured in vitro and synthesis of extracellular matrix(ECM).METHODS:HLECs were treated with TGF-β2(0,0.5,1.0,5,10μg/L)and CTGF(0,15,30,60,100μg/L)for different times(0,24,48,72h)in vitro and the expression ofα-smooth muscle actin(α-SMA),the main component of the extracellular matrix typeⅠcollagen(Col-1)and fibronectin(Fn)were measured by using real-time polymerase chain reaction(PCR)and western-blot.RESULTS:TGF-β2 and CTGF significantly increased expression ofα-SMA mRNA and protein(P【0.05,P【0.001),Fn mRNA and protein(P【0.001),Col-1 mRNA and protein(P【0.001).TGF-β2 could induce HLECs expression of CTGF mRNA and protein in dosedependent manner(P【0.05,P【0.001).TGF-β2 and CTGF could induce HLECs to expressα-SMA,Fn and Col-1 in time-dependent manner.Each time of TGF-β2and CTGF induced HELCs expression ofα-SMA,Fn,Col-1 mRNA and protein was significant increase compared with control(P【0.05,P【0.001).CONCLUSION:TGF-β2 and CTGF could induce HLECs epithelial mesenchymal transition and ECM synthesis.展开更多
By describing the technique of port connection and flow chart ofR/W operation between 24LC01, serial E2PROM, and EM78P447A, features of EM78P447 and its connection with I2C serial bus are introduced. In the end, the p...By describing the technique of port connection and flow chart ofR/W operation between 24LC01, serial E2PROM, and EM78P447A, features of EM78P447 and its connection with I2C serial bus are introduced. In the end, the programe of writing operation is given.展开更多
In this paper, we present one method to attack on the GMR-2 algorithm used in satellite phone under the chosen-plaintexts. First using the relationship of the rows of the two s-boxes and outputs of the F coordinate, w...In this paper, we present one method to attack on the GMR-2 algorithm used in satellite phone under the chosen-plaintexts. First using the relationship of the rows of the two s-boxes and outputs of the F coordinate, we attack on the GMR-2 algorithm. Then we deduce the happening probability of read-collision, and analyze its mathematical expectation. Finally, combining with the read-collision, we present an improved method to attack on the GMR-2 algorithm. The research results show that the complexity of the improved algorithm is about 220, and the session key Kc can be recovered in about 0.3 seconds. Compared with the available method, our method takes less time than the guess-and-decide attack method which is 700 s.展开更多
文摘Corporate sustainability reporting has become increasingly important in recent years.However,conventional approaches reach their limits when it comes to quantifying and measuring the actual sustainability performance of a company.This article presents a new approach:Sustainable Performance Accounting(SPA),which is based on an extension of bookkeeping by including ESG bookkeeping.SPA enables companies to systematically measure and manage their sustainability performance.The article provides an overview of the basics of SPA methodology and uses a comprehensive example showing how SPA can be implemented in practice.The article is aimed at interested readers from science and practice as well as decision-makers who are interested in future-oriented sustainability reporting.
基金Supported by the National Natural Science Foundation of China,No.81771815.
文摘BACKGROUND Large-scale functional connectivity(LSFC)patterns in the brain have unique intrinsic characteristics.Abnormal LSFC patterns have been found in patients with dementia,as well as in those with mild cognitive impairment(MCI),and these patterns predicted their cognitive performance.It has been reported that patients with type 2 diabetes mellitus(T2DM)may develop MCI that could progress to dementia.We investigated whether we could adopt LSFC patterns as discriminative features to predict the cognitive function of patients with T2DM,using connectome-based predictive modeling(CPM)and a support vector machine.AIM To investigate the utility of LSFC for predicting cognitive impairment related to T2DM more accurately and reliably.METHODS Resting-state functional magnetic resonance images were derived from 42 patients with T2DM and 24 healthy controls.Cognitive function was assessed using the Montreal Cognitive Assessment(MoCA).Patients with T2DM were divided into two groups,according to the presence(T2DM-C;n=16)or absence(T2DM-NC;n=26)of MCI.Brain regions were marked using Harvard Oxford(HOA-112),automated anatomical labeling(AAL-116),and 264-region functional(Power-264)atlases.LSFC biomarkers for predicting MoCA scores were identified using a new CPM technique.Subsequently,we used a support vector machine based on LSFC patterns for among-group differentiation.The area under the receiver operating characteristic curve determined the appearance of the classification.RESULTS CPM could predict the MoCA scores in patients with T2DM(Pearson’s correlation coefficient between predicted and actual MoCA scores,r=0.32,P=0.0066[HOA-112 atlas];r=0.32,P=0.0078[AAL-116 atlas];r=0.42,P=0.0038[Power-264 atlas]),indicating that LSFC patterns represent cognition-level measures in these patients.Positive(anti-correlated)LSFC networks based on the Power-264 atlas showed the best predictive performance;moreover,we observed new brain regions of interest associated with T2DM-related cognition.The area under the receiver operating characteristic curve values(T2DM-NC group vs.T2DM-C group)were 0.65-0.70,with LSFC matrices based on HOA-112 and Power-264 atlases having the highest value(0.70).Most discriminative and attractive LSFCs were related to the default mode network,limbic system,and basal ganglia.CONCLUSION LSFC provides neuroimaging-based information that may be useful in detecting MCI early and accurately in patients with T2DM.
基金National Natural Science Foundation of China(No.81070721)Inernational Exchange Program of Shaanxi Province,China(No.2012kw-31)
文摘AIM:To Investigate the effects of transforming growth factorβ2(TGF-β2)and connective tissue growth factor(CTGF)on transdifferentiation of human lens epithelial cells(HLECs)cultured in vitro and synthesis of extracellular matrix(ECM).METHODS:HLECs were treated with TGF-β2(0,0.5,1.0,5,10μg/L)and CTGF(0,15,30,60,100μg/L)for different times(0,24,48,72h)in vitro and the expression ofα-smooth muscle actin(α-SMA),the main component of the extracellular matrix typeⅠcollagen(Col-1)and fibronectin(Fn)were measured by using real-time polymerase chain reaction(PCR)and western-blot.RESULTS:TGF-β2 and CTGF significantly increased expression ofα-SMA mRNA and protein(P【0.05,P【0.001),Fn mRNA and protein(P【0.001),Col-1 mRNA and protein(P【0.001).TGF-β2 could induce HLECs expression of CTGF mRNA and protein in dosedependent manner(P【0.05,P【0.001).TGF-β2 and CTGF could induce HLECs to expressα-SMA,Fn and Col-1 in time-dependent manner.Each time of TGF-β2and CTGF induced HELCs expression ofα-SMA,Fn,Col-1 mRNA and protein was significant increase compared with control(P【0.05,P【0.001).CONCLUSION:TGF-β2 and CTGF could induce HLECs epithelial mesenchymal transition and ECM synthesis.
基金Research on Electromagnetic Scatter Character of very Complicate Object(69571021)
文摘By describing the technique of port connection and flow chart ofR/W operation between 24LC01, serial E2PROM, and EM78P447A, features of EM78P447 and its connection with I2C serial bus are introduced. In the end, the programe of writing operation is given.
基金supported by China Scholarship Council under Grant No.201506965088
文摘In this paper, we present one method to attack on the GMR-2 algorithm used in satellite phone under the chosen-plaintexts. First using the relationship of the rows of the two s-boxes and outputs of the F coordinate, we attack on the GMR-2 algorithm. Then we deduce the happening probability of read-collision, and analyze its mathematical expectation. Finally, combining with the read-collision, we present an improved method to attack on the GMR-2 algorithm. The research results show that the complexity of the improved algorithm is about 220, and the session key Kc can be recovered in about 0.3 seconds. Compared with the available method, our method takes less time than the guess-and-decide attack method which is 700 s.
