DNA repair factors function through spatiotemporal condensation and dissolution at DNA double-strand breaks(DSBs).Recent advances have indicated that some DSB repair factors undergo liquid-liquid phase separation(LLPS...DNA repair factors function through spatiotemporal condensation and dissolution at DNA double-strand breaks(DSBs).Recent advances have indicated that some DSB repair factors undergo liquid-liquid phase separation(LLPS)and show droplet-like properties,as well as dynamic material exchange.Importantly,LLPS regulates various biological processes,and aberrant LLPS is involved in the pathologic progression of various diseases.展开更多
Mine grouting reinforcement and water plugging projects often require large amounts of grouting materials.To reduce the carbon emission of grouting material production,improve the utilization of solid waste from minin...Mine grouting reinforcement and water plugging projects often require large amounts of grouting materials.To reduce the carbon emission of grouting material production,improve the utilization of solid waste from mining enterprises,and meet the needs of mine reinforcement and seepage control,a double-liquid grouting material containing a high admixture of coal gangue powder/bottom ash geopolymer was studied.The setting time,fluidity,bleeding rate,and mechanical properties of grouting materials were studied through laboratory tests,and SEM analyzed the microstructure of the materials.The results show that the total mixture of calcined gangue does not exceed 60%.And the proportion of bottom ash replacing cement should be within 30%.At the same time,the volume mixture of sodium silicate is 20%.And the water-solid ratio does not exceed 0.6.The stability of the slurry prepared under this ratio is good.The microstructure of the stone body is dense,and its strength can meet the requirements of rock reinforcement and seepage control.Its economic and environmental benefits are more significant than the traditional cement-silicate double-liquid grouting material.展开更多
The geometries of reactant, product and transition state of the title reaction have been optimized by using density functional theory (DFT) at the B3LYP/6-31G(d,p) and B3LYP/6- 311++G(d,p) levels. The variations of th...The geometries of reactant, product and transition state of the title reaction have been optimized by using density functional theory (DFT) at the B3LYP/6-31G(d,p) and B3LYP/6- 311++G(d,p) levels. The variations of the bond parameters in the course of reaction were analyzed. The zero point energy corrections were performed by vibrational analysis. The equilibrium states and the transition state were verified according to the number of virtue frequency of geometry. The intrinsic reaction coordinates (IRC) were calculated from the transition state. The calculated results show that the double bond rearrangement of butene catalyzed by 1-butyl-3-methyl-imidazolium cation is a one-step reaction. The forward energy barrier of isomerization from 1-butene to 2- butene is about 193 kJ·mol-1 and the reverse energy barrier about 209 kJ·mol-1 at the B3LYP/6- 31G(d,p) level, which means that the reaction is easy to proceed at or above room temperature.展开更多
Due to low viscosity of seawater,it is difficult to form a seawater-lubricated film.It is easy to cause the overload and burning phenomenon of seawater-lubrication sliding bearing,and then the operation stability and ...Due to low viscosity of seawater,it is difficult to form a seawater-lubricated film.It is easy to cause the overload and burning phenomenon of seawater-lubrication sliding bearing,and then the operation stability and service life can be shortened seriously.Therefore,the paper introduces an electromagnetic suspension theory into the seawater lubricated sliding bearing.Then a novel magnetic-liquid double suspension bearing can be formed,which can enhance bearing capacity and stiffness greatly.Firstly,the structural characteristics,support-adjustment mechanism of magnetic-liquid double suspension bearing is analyzed.Secondly,based on force balance equation,electromagnetic equation and flow equation,the transfer functions of single DOF bearing system of magnetic-liquid double suspension bearing under constant-flow supply model are deduced.Then bearing capacity,static stiffness and total power loss are selected as static performance indexes.The influence rule of operaton and structural parameters on the static performance of single DOF bearing system will be analyzed.The results show that bearing capacity decreases with the increase of liquid film thickness and width of edge seals,bias current and coil turns decrease.Static stiffness decreases with the increase of liquid film thickness,edge seals width,bias current and coil turns.Total power loss decreases with the increase of liquid film thickness,edge seals width,bias current and coil turns decrease.And static performance indexes can not be affected by liquid viscosity.The proposed research provides some theoretical and experimental basis for the parameter design of magnetic-liquid double suspension bearing.展开更多
基金supported by the National Key R&D Program of China(Grant No.2022YFC2503700)the National Science Fund for Distinguished Young Scholars(Grant No.82225040)+1 种基金the Natural Science Foundation of China(Grant Nos.82103770,82171163,and 82373513)the Guangdong Science and Technology Project(Grant No.2022A1515012363).
文摘DNA repair factors function through spatiotemporal condensation and dissolution at DNA double-strand breaks(DSBs).Recent advances have indicated that some DSB repair factors undergo liquid-liquid phase separation(LLPS)and show droplet-like properties,as well as dynamic material exchange.Importantly,LLPS regulates various biological processes,and aberrant LLPS is involved in the pathologic progression of various diseases.
基金Funding Statement:The research described in this paper was financially supported by the National Natural Science Foundation of China(No.51974172)Innovation and Technology Program of Universities in Shandong Province,China(No.2020KJH001)+1 种基金National Natural Science Foundation of China(No.52274131)State Key Laboratory of Coal Mining and Clean Utilization(No.2021-CMCU-KF017).
文摘Mine grouting reinforcement and water plugging projects often require large amounts of grouting materials.To reduce the carbon emission of grouting material production,improve the utilization of solid waste from mining enterprises,and meet the needs of mine reinforcement and seepage control,a double-liquid grouting material containing a high admixture of coal gangue powder/bottom ash geopolymer was studied.The setting time,fluidity,bleeding rate,and mechanical properties of grouting materials were studied through laboratory tests,and SEM analyzed the microstructure of the materials.The results show that the total mixture of calcined gangue does not exceed 60%.And the proportion of bottom ash replacing cement should be within 30%.At the same time,the volume mixture of sodium silicate is 20%.And the water-solid ratio does not exceed 0.6.The stability of the slurry prepared under this ratio is good.The microstructure of the stone body is dense,and its strength can meet the requirements of rock reinforcement and seepage control.Its economic and environmental benefits are more significant than the traditional cement-silicate double-liquid grouting material.
基金This work was supported by the National Natural Science Key Foundation of China (20490209) and Young Teacher Foundation of Beijing Chemical Technology University (QN0308)
文摘The geometries of reactant, product and transition state of the title reaction have been optimized by using density functional theory (DFT) at the B3LYP/6-31G(d,p) and B3LYP/6- 311++G(d,p) levels. The variations of the bond parameters in the course of reaction were analyzed. The zero point energy corrections were performed by vibrational analysis. The equilibrium states and the transition state were verified according to the number of virtue frequency of geometry. The intrinsic reaction coordinates (IRC) were calculated from the transition state. The calculated results show that the double bond rearrangement of butene catalyzed by 1-butyl-3-methyl-imidazolium cation is a one-step reaction. The forward energy barrier of isomerization from 1-butene to 2- butene is about 193 kJ·mol-1 and the reverse energy barrier about 209 kJ·mol-1 at the B3LYP/6- 31G(d,p) level, which means that the reaction is easy to proceed at or above room temperature.
基金Support by the National Natural Science Foundation of China(No.51705445)the Open Project Funding of Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Controlthe Open Project Funding of Jiangsu Provincial Key Laboratory of Advanced Manufacture and Process for Marine Mechanical Equipment
文摘Due to low viscosity of seawater,it is difficult to form a seawater-lubricated film.It is easy to cause the overload and burning phenomenon of seawater-lubrication sliding bearing,and then the operation stability and service life can be shortened seriously.Therefore,the paper introduces an electromagnetic suspension theory into the seawater lubricated sliding bearing.Then a novel magnetic-liquid double suspension bearing can be formed,which can enhance bearing capacity and stiffness greatly.Firstly,the structural characteristics,support-adjustment mechanism of magnetic-liquid double suspension bearing is analyzed.Secondly,based on force balance equation,electromagnetic equation and flow equation,the transfer functions of single DOF bearing system of magnetic-liquid double suspension bearing under constant-flow supply model are deduced.Then bearing capacity,static stiffness and total power loss are selected as static performance indexes.The influence rule of operaton and structural parameters on the static performance of single DOF bearing system will be analyzed.The results show that bearing capacity decreases with the increase of liquid film thickness and width of edge seals,bias current and coil turns decrease.Static stiffness decreases with the increase of liquid film thickness,edge seals width,bias current and coil turns.Total power loss decreases with the increase of liquid film thickness,edge seals width,bias current and coil turns decrease.And static performance indexes can not be affected by liquid viscosity.The proposed research provides some theoretical and experimental basis for the parameter design of magnetic-liquid double suspension bearing.
