DRAGON/DONJON程序在CARR物理计算中的适用性研究

反中子阱型研究堆独特的堆芯和反射层结构对传统上适用于动力堆的确定论堆芯物理计算方法提出了挑战。使用确定论程序DRAGON/DONJON对反中子阱型设计的中国先进研究堆(China Advanced Research Reactor,CARR)进行了堆芯物理计算与适用性分析。采用了多组件方法改善CARR堆芯组件均匀化计算的环境影响;使用OPTEX反射层优化方法对反射层均匀化群常数进行修正。将蒙特卡罗方法的计算结果作为参考解,使用DRAGON程序挂载几种常用的多群截面库进行组件计算,选择偏差最小的SHEM-295作为CARR堆芯物理计算截面库。将DRAGON/DONJON的计算结果与传统“三步法”和参考解进行对比表明:临界工况附近的有效增殖系数keff、堆芯活性区和重水箱中间位置的热中子注量率分布以及标准燃料组件的功率分布等核特性参数偏差较小。对于堆芯与重水箱交界、水池外真空边界、跟随体组件等处计算结果出现较大偏差的原因进行了分析。证明了使用DRAGON/DONJON程序进行CARR物理计算具备可行性且相较于传统“三步法”计算精度有了明显改善,能够满足CARR堆上实验方案设计、运行参数快速计算分析等需求。

Journal Club教学法用于临床药学专业硕士研究生理论教学实践

目的探讨Journal Club教学法在临床药学专业硕士研究生理论教学中的应用效果。方法选取重庆医科大学2022年的2020级(4名)、2021级(6名)临床药学专业硕士研究生为研究对象。课前,2个年级的学生分别以小组为单位,围绕与“临床药物治疗学前沿”授课内容相关的2个临床用药问题,通过设定关键词、检索文献、分析评价、证据分级,制订最优用药方案;课中以幻灯片形式分享经典文献,并对最优用药方案进行循证药学证据分析。采用匿名问卷调查法统计对该教学法8个条目完全赞同、基本同意及否定的人数,并计算占比;授课教师对学生撰写的综述进行评分(90~100分、80~89分、70~79分、60~69分分别为优、良、中、及格);统计学生通过本轮教学的论文发表情况。结果2020级、2021级分别发放调查问卷4份、6份,均全部回收,有效回收率均为100.00%;对所有调查项目均完全赞同或基本同意的分别有29人次、47人次。期末考试成绩为优、良、中的,2020级分别有2名(50.00%)、1名(25.00%)、1名(25.00%),优良率为75.00%;2021级分别有2名(33.33%)、3名(50.00%)、1名(16.67%),优良率为83.33%。2021级学生有1篇综述发表在科学引文索引(SCI)期刊上。结论Journal Club教学法有助于提高学生的文献查阅能力和英文阅读能力,可调动自主学习的积极性,增强独立思考能力和科研创新意识。

Tracing the pace of an approaching‘seismic dragon king’:Additional evidence for the Noto earthquake swarm and the 2024 M_(W) 7.5 Noto earthquake

‘Dragon king’theory of extreme events has been systematically proposed and discussed since 2012,the last‘year of dragon’in the Chinese lunar calendar(Sornette and Ouillon,2012;Yukalov and Sornette,2012;Sachs et al.,2012),and has been under discussion till present(e.g.,Eliazar,2017;Lin et al.,2018;Glette-Iversen and Aven,2021;Premraj et al.,2021;Lei et al.,2023).In this theoretical framework based on the physics of complexity,a‘dragon king’is defined as an event so extreme that it lies outside a power-law distribution.What is of special interest is that,according to its theory,a‘dragon king’event should pose significant predictability(Sornette and Ouillon,2012).As the next‘year of dragon’approaches soon,it is worth revisiting this concept.

A Preliminary Study on Guangdong Shangyuan Fire Dragon Dance Culture

Dragon is a traditional totem of the Chinese nation and is worshiped by the Chinese people all over the world,representing auspiciousness,strength and wisdom.China has a vast territory.As for the rich and diverse intangible cultural heritage,there are many cultural treasures directly related to"dragon",and fire dragon dance is one of them.

Zhongshan:Rising Dragon of Guangdong

My journey to Zhongshan City in Guangdong Province alongside experts,foreign correspondents,and local Chinese journalists proved to be an enlightening exploration of the intricacies of China’s development,especially within its smaller cities.While a brief five-day sojourn wasn’t sufficient for intimacy with the city’s entirety,the immersion into Zhongshan’s cultural,historical,and modern facets,including Zhongshan Museum,urban planning zones,business hubs,an industrial park,ancient villages,Dr.Sun Yat-sen Museum,and a monumental bridge project,left me with the impression that the city is awakening like a dragon ascending from the heart of Guangdong.

A meta-analysis on the clinical efficacy of fire dragon cupping in the treatment of lumbar disc herniation

Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse effects.Prolonged use can severely impair the liver and kidney functions of patients.Hence,the role of safe and effective traditional Chinese medicine techniques becomes pivotal.Among various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing LDH.Nonetheless,there is a scarcity of systematic and standardised evidence from evidence-based medicine studies.Therefore,conducting a meta-analysis is imperative.Methods:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and CINAHL.The search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December 2023.Two researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising RevMan 5.3 software for meta-analysis.Results:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),P<0.00001),less pain(standardized mean difference=–1.33,95%CI(–1.49,–1.16),P<0.00001),and some improvement in lumbar function(Japanese Orthopaedic Association scores:mean difference=3.37,95%CI(2.31,4.43),P<0.00001.Conclusion:The fire dragon cupping therapy significantly alleviates LDH,warranting its extensive application.However,considering the limitations in the number and quality of studies included,the aforementioned conclusion necessitates further validation through more high-quality research.

Welcoming The Year Of Dragon

People across China have begun decorating their houses,pasting poetic couplets and auspicious words on the doors,buying new clothes,and getting ready to make dumplings.You guessed right-it’s time to celebrate the Spring Festival,and ring in the Chinese New Year-the Year of the Dragon.

The Coiling Dragon Cliff Skywalk

If you're a sort of human who gets woozy on a step stool,then this story probably isn't for you.On the other hand,if you have a strong stomach and like taking extreme selfies,then the Coiling Dragon Cliff Skywalk in Hunan Province,China may be the place you want to go.Attached more than 1,400 meters straight up the side of Tianmen Mountain in China's Zhangjiajie City,the Coiling Dragon Cliff Skywalk is almost inconceivable.

A Warm Reception for the Year of the Dragon

A dragon year,so I read somewhere,is one in which,individually and collectively,we are filled with energy and confidence.It’s supposed to be a year of transformation,good fortune and prosperity;all of which,it seems to me,is just what the world needs as it continues to shake off the effects of the COVID-19 pandemic.

The Impact of Student Club Development on the Scientific Literacy of Vocational College Students

This paper explores the impact of student club development on the scientific literacy of vocational college students.As society increasingly values innovation and scientific literacy,vocational colleges bear a significant responsibility in cultivating students’overall quality.Taking the Modeling and Simulation student club as a case study,the research team conducted a 12-week study.The results indicate that various club activities aimed at enhancing scientific literacy have positively influenced the development of students’scientific competencies.Students’practical skills and innovative thinking have been effectively improved.Our research demonstrates the positive role of student clubs in enhancing the scientific literacy of vocational college students,providing valuable experience and references for the development of similar clubs in the future.

Club Med北戴河黄金海岸度假村设计思考

Club Med北戴河黄金海岸度假村项目的设计理念源于基地本身,将Club Med简单、快乐、阳光的品牌文化和多元文化的特别度假理念融入设计中,倡导人与自然和谐共处的生活方式,体现京津冀独特的人文情怀,同时采用与环境相协调的建筑材料,融入环境的色彩,打造有特色、高品质、全新的度假产品,酒店的开业将引领秦皇岛黄金海岸进入全球高端度假人群之视野。

DRAGON评分对颅内大血管闭塞致急性缺血性卒中静脉溶栓桥接机械取栓临床结局的预测作用

目的评估前循环颅内大血管闭塞致急性缺血性卒中患者入院时DRAGON[dense cerebral artery,mRS(改良Rankin量表),age,glucose level,onset to treatment time,NIHSS(美国国立卫生研究院卒中量表)]评分对静脉溶栓桥接机械取栓术后患者临床结局的预测作用。方法回顾性连续纳入2015年1—12月急性缺血性卒中血管内治疗试验(EAST)中接受机械取栓及静脉溶栓桥接机械取栓治疗的急性缺血性卒中患者149例,为发病至治疗时间≤6 h,于术前经CT血管成像和(或)MR血管成像和(或)DSA证实。根据治疗后90 d mRS评分,将149例患者分为预后良好(mRS评分0~2分)组和预后不良(mRS评分3~6分)组。收集并比较两组患者的人口学资料、脑血管病危险因素(高血压病、糖尿病、心房颤动等)、入院时NIHSS评分、发病时间、卒中前mRS评分、影像学特征、实验室检查、DRAGON评分、治疗方式的差异。对静脉溶栓桥接机械取栓不同预后者上述指标进行比较,并采用受试者工作特征(ROC)曲线确定DRAGON预测静脉溶栓桥接机械取栓患者预后的最佳截断值。结果(1)预后良好组患者基线NIHSS评分低于预后不良组[14(11,18)分比18(14,21)分],男性比例高于预后不良组[71.1%(59/83)比50.0%(33/66)],组间差异均有统计学意义(均P<0.01);两组年龄、高血压病、糖尿病、心房颤动、高脂血症、卒中史、高密度征、早期脑梗死征象的差异均无统计学意义(均P>0.05)。(2)预后良好组血糖水平及基线DARGON评分均低于预后不良组,组间差异均有统计学意义[(6.5±1.5)mmol/L比(8.2±3.3)mmol/L,(4.4±1.3)分比(5.2±1.4)分;均P<0.01];两组发病至治疗时间、发病至再通时间、血肌酐、白细胞计数、卒中前mRS 0~1分比例及静脉溶栓桥接机械取栓比例的差异均无统计学意义(均P>0.05)。(3)静脉溶栓桥接机械取栓术后预后良好者基线NIHSS评分、发病至治疗时间、发病至成功再通时间、血糖水平、基线DARGON评分均低于预后不良者,二者差异均有统计学意义[14(10,16)分比19(16,24)分,168(126,134)min比239(210,295)min,199(183,285)min比275(260,345)min,(6.4±1.2)mmol/L比(9.0±2.4)mmol/L,(4.3±1.5)分比(6.1±1.2)分;均P<0.05];二者间其余基线和临床资料的差异均无统计学意义(均P>0.05)。(4)基线DRAGON评分预测静脉溶栓桥接机械取栓术后90 d预后的ROC曲线下面积为0.830,最佳截断值为6分,其敏感度为63.6%,特异度为91.7%。结论入院时DRAGON评分可能对前循环大血管闭塞致急性缺血性卒中患者接受静脉溶栓桥接机械取栓后的预后具有一定的预测作用。

Dragon评分对急性缺血性卒中静脉溶栓近期疗效的预测价值

目的：探究急性缺血性卒中患者静脉溶栓前基于Dragon评分对患者14 d结局的预测作用。方法回顾性分析60例接受静脉溶栓[阿替普酶（ r-tPA）]的急性脑梗死患者，依据溶栓前的Dragon评分将患者分为3组：A组（评分小于等于3分）、B组（评分等于4分）和C组（评分大于等于5分），比较3组患者的近期（14 d）预后。依据14 d的临床疗效分为优效组和非优效组，采用Logistic回归模型分析Dragon评分对患者14 d结局的预测作用。结果 A组优效率为65．2％、B组为优效率66．7％、C组优效率27．3％，经χ2检验，A、B之间差异无统计学意义（P＞0．05），A、C组和B、C组之间差异有统计学意义（P＜0．05），且C组的治愈和显效病例评分为5分、6分和7分的例均无好的结局。溶栓后14 d 3组颅内出血转化之间差异无统计学意义（P＝1．000）。二元Logistic回归分析显示Dragon评分与缺血性卒中溶栓患者的优效率有相关性（OR＝0．566，95％Cl 0．356～0．900，P＝0．016）。结论溶栓前Dragon评分小于5分的急性缺血性卒中患者，具有更加良好的近期（14 d）预后。

基于DRAGON程序的多种中子输运计算方法对比分析

为了对比分析多种三维全堆芯pin-by-pin中子输运计算方法的计算能力,尤其是研究评估特征线法(MOC)求解强非均匀性大规模问题的能力,基于DRAGON4.07程序,以C5G7组件、堆芯基准题为算例,比较分析了MOC方法(步特征线法MOC-SC和菱形差分特征线法MOC-DD)、碰撞概率法(CP)、界面流法(IC)的计算效率、计算精度、计算存贮及计算规模。分析结果表明:对于C5G7-UO2组件问题,MOC-SC的计算精度与CP方法相当,优于MOC-DD和IC方法,计算时间约为CP方法的2倍,内存占用量远小于CP方法;对于二维C5G7堆芯问题,MOC方法的计算精度、计算效率及内存占用量均优于CP和IC方法;而用MOC方法实现大规模三维问题的pin-by-pin计算时,还依赖于并行加速手段,尤其是计算存贮问题的突破。

RGMb/DRAGON与BMP信号转导

RGMb/DRAGON为RGM家族成员之一,在许多组织和器官中存在并表达.最初它作为粘附分子在神经系统中调节轴突排斥被发现.近来研究发现,它还是BMP的辅助受体,与BMP配体和受体结合,通过调控BMP信号通路在繁殖、肾脏机能的维持以及免疫疾病等生理和病理条件下发挥重要作用.本文评述了RGMb的基因及蛋白结构特征、表达定位及其在神经系统中的作用,并重点介绍了其在BMP信号通路中的作用机制和生物学研究进展.

Journal club:有效的循证医学教学方法

Journal club在欧美医学生毕业后教育中有着悠久的历史,其主要目的有三:阅读最新的医学文献;指导临床实践;批判性地阅读,实例学习文章的设计、医学统计和流行病学处理等知识。在我院神经外科专业研究生教学中初步应用这种教学方法,认为这是一种培养临床专业研究生循证医学思维方式实用和有效的方法。

Dragon程序在金属燃料铅铋快堆堆芯计算中的应用与偏差分析

铅铋合金或铅冷却快堆(LFR)是具有良好应用前景的第四代先进核能系统之一。针对环形芯体金属燃料(UZr,UPuZr)LFR的燃料组件与堆芯,利用Dragon/Donjon程序开展中子学计算,获得了基于ENDF/B 8.0库的172群和295群多群中子数据库、输运方法(SP3)和扩散方法(MCFD)的结果及其与蒙卡程序RMC的偏差。采用SP3算法针对UZr燃料得到的k;偏差小于550×10;对于UPuZr燃料采用MCFD算法得到的k;偏差小于-700×10;。控制棒组件价值的偏差小于7.6%;172群和295群库的结果基本无差异。应用SP3算法的燃料组件功率偏差小于±6.0%;SP3算法的偏差小于MCFD的。结果证明,Dragon/Donjon程序在金属燃料铅铋快堆物理分析中具有可行性。

《针灸学研究进展》的“Journal Club模式”探索

在开展《针灸学研究进展》课程教学过程中,在教学方法方面引入"Journal Club模式",提高研究生的课堂参与度,促使研究生主动学习,同时培养其语言表达及分析问题的能力。文章从Journal Club简介、本课程JC设计、小结3个方面进行了论述,以期对本门课程的教学有所启示,提高教学效果,为针灸学研究生的培养提供借鉴。

Dragon软件用于黄酮类化合物抗氧化活性的预测

以Dragon软件计算的Burden特征值作为变量,采用多元回归的方法对18个黄酮化合物的抗氧化活性建立定量结构-活性相关模型,所建模型的相关系数为0.950,用该模型对黄酮的抗氧化物活性进行预测,估算值和文献值接近。通过Jackknife法和交互检验证明该模型具有总体稳健性和良好的预测能力。

改良MRI-DRAGON评分在急性缺血性卒中血管内治疗后预后预测中的价值

目的探讨改良MRI-DRAGON评分在急性缺血性卒中血管内治疗后预后中的预测价值。材料与方法回顾性分析2020年1月至2021年12月在两家医院接受血管内治疗的急性缺血性卒中患者的临床和影像学资料,根据临床及影像变量对患者进行MRI-DRAGON评分和改良MRI-DRAGON评分并进行比较。在治疗后3个月采用改良Rankin量表评估患者预后(0~2分为预后良好;3~6分为预后不良)。Logistic回归分析计算MRI-DRAGON评分和改良MRI-DRAGON评分对卒中不良预后预测的C-统计值。应用受试者工作特征(receiver operating characteristic,ROC)曲线分别分析两种评分对患者预后的预测价值,采用DeLong检验比较两者的差异。结果共纳入95例患者,预后良好组49例,预后不良组46例。两组间MRI-DRAGON评分(Z=5.046,P=0.023)与改良MRI-DRAGON评分(Z=-4.429,P<0.001)均存在显著差异。Logistic回归分析显示改良MRI-DRAGON评分预测卒中不良预后的C-统计值明显高于MRI-DRAGON评分[0.87(95%CI:0.78~0.90)vs.0.77(95%CI:0.65~0.81)]。ROC曲线显示改良MRI-DRAGON评分预测卒中预后的曲线下面积明显高于MRI-DRAGON评分(0.889 vs.0.757;Z=-2.294,P=0.022),其敏感度和特异度分别达91.3%和87.3%。结论改良MRI-DRAGON评分较传统MRI-DRAGON评分可更有效地预测急性缺血性卒中患者血管内治疗后3个月的预后。