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英汉人体词“hand”和“手”一词多义认知对比研究 被引量:5
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作者 刘志成 《石家庄铁道大学学报(社会科学版)》 2015年第3期44-50,共7页
一词多义是语言中非常普遍的现象,一词多义是认知主体与客观世界互动的情况下对客观世界进一步深化认知的结果。在词义拓展的过程中,隐喻和转喻作为一词多义的认知发展机制被当成一种思维模式和认知方式而引入其中,因此词义拓展过程能... 一词多义是语言中非常普遍的现象,一词多义是认知主体与客观世界互动的情况下对客观世界进一步深化认知的结果。在词义拓展的过程中,隐喻和转喻作为一词多义的认知发展机制被当成一种思维模式和认知方式而引入其中,因此词义拓展过程能在一定程度上展示认知主体的思维发展相似性和差异。英汉人体词是认知世界的"元概念",因此对其一词多义的英汉对比研究对揭示英汉认知主体的思维模式有更深刻的含义。同时,一词多义的对比研究,对于词汇教学、词典编撰、跨文化交际等方面也都具有积极的作用。 展开更多
关键词 人体词 英汉对比 一词多义
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英汉人体词“hand”和“手”一词多义转义范畴认知对比研究 被引量:1
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作者 刘志成 《重庆第二师范学院学报》 2015年第2期96-101,175,共6页
语言中的一词多义是在隐喻和转喻的认知机制共同作用下实现的,它不仅能体现词义演化的过程,而且能在一定程度上揭示认知主体的认知发展过程,此外,语言的基础是词汇,而词汇的核心是词义,因此对一词多义的研究具有重要的语义学意义。同时... 语言中的一词多义是在隐喻和转喻的认知机制共同作用下实现的,它不仅能体现词义演化的过程,而且能在一定程度上揭示认知主体的认知发展过程,此外,语言的基础是词汇,而词汇的核心是词义,因此对一词多义的研究具有重要的语义学意义。同时,范畴化的过程就是范畴建立也即是概念形成的过程,体现了认知主体对认知客体的一种划分标准,因此能体现认知主体重要的思维属性。而人体词是人类认知世界的起点,是认知的"元概念",本文采用定性和定量研究相结合的方法,对比研究了英汉人体词"hand"和"手"一词多义转义范畴认知,从而揭示英汉民族认知思维的差异性和共性。 展开更多
关键词 英汉对比 人体词 一词多义 转义范畴
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A Study of L2 Learner’s Knowledge of Metonymic Sense of“Hand”
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作者 MA Yiting GAO Wencheng 《Sino-US English Teaching》 2020年第9期259-265,共7页
Based on a learner corpus Chinese Learner English Corpus(CLEC)and a native speaker corpus Freiburg Brown Corpus of American English(FROWN),this research investigates the differences between Chinese learners of English... Based on a learner corpus Chinese Learner English Corpus(CLEC)and a native speaker corpus Freiburg Brown Corpus of American English(FROWN),this research investigates the differences between Chinese learners of English and English native speakers in their knowledge of the metonymic senses of human body word“hand”.Two research questions are raised:(1)What are the features that distinguish Chinese English learners from English native speakers?(2)What are the rules in learners’learning of English metonymic senses?In order to answer these two questions,this paper has investigated the frequencies of the identified senses in two corpora of FROWN and CLEC,and the sequence of learning metonymic senses.The results show that Chinese learner’s knowledge of metonymic senses of“hand”is restricted to fixed phrases,especially verb phrases.It is also found that in the process of English learning,learners do have some preferences for basic sense,and then they learn peripheral senses by reciting some fixed phrases. 展开更多
关键词 metonymic sense of“hand” FROWN CLEC type of sense SEQUENCE
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认知隐喻视角下的习语理据读解——以身体词“hand”为例
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作者 刘桃梅 《广东技术师范学院学报》 2013年第4期95-98,共4页
传统语言学认为习语是固定的表达方式,其意义是不可分析的,是没有理据的。认知隐喻学则认为习语的意义是可分析的,包括隐喻、转喻和规约性知识在内的认知机制为我们理解习语的意义提供了理据。通过身体词"hand"习语的系统分析... 传统语言学认为习语是固定的表达方式,其意义是不可分析的,是没有理据的。认知隐喻学则认为习语的意义是可分析的,包括隐喻、转喻和规约性知识在内的认知机制为我们理解习语的意义提供了理据。通过身体词"hand"习语的系统分析,从认知隐喻学角度揭示了习语的理据内在本质,习语的隐喻认知机制有助于我们更好地理解和学习习语。 展开更多
关键词 习语 认知隐喻 认知转喻 hand 认知理据
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“hand”与“手”的认知词义对比分析 被引量:1
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作者 蔡菡丹 《山东农业工程学院学报》 2018年第8期112-114,共3页
本论文基于"手"和"hand"的相关语料,运用原则性多义词分析法,对两个词的认知词义进行对比分析,发现英语和汉语使用者对"手"这一概念的认知普遍性与差异性并存。通过对两个词的原型词义和其扩展义进行细... 本论文基于"手"和"hand"的相关语料,运用原则性多义词分析法,对两个词的认知词义进行对比分析,发现英语和汉语使用者对"手"这一概念的认知普遍性与差异性并存。通过对两个词的原型词义和其扩展义进行细致的描写和分析,本文理清了"手"和"hand"的原义和其拓展义之间的语义结构,同时阐释了中英文化的差异在语言上的细腻体现。 展开更多
关键词 hand 原则性多义词分析法 认知对比分析
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基于HAND的流域洪水淹没快速分析技术 被引量:1
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作者 王述强 吕凯 +3 位作者 刘祥林 师鹏飞 肖家清 郝晓博 《水文》 CSCD 北大核心 2024年第2期57-65,共9页
快速分析计算流域洪水淹没,对于防洪具有重要作用,而基于水动力学模型的经典淹没算法在时效性方面存在不足,制约防洪“四预”功能实现和数字孪生流域建设。针对此,本文建立了基于HAND(Height Above Nearest Drainage)的形态淹没模型,用... 快速分析计算流域洪水淹没,对于防洪具有重要作用,而基于水动力学模型的经典淹没算法在时效性方面存在不足,制约防洪“四预”功能实现和数字孪生流域建设。针对此,本文建立了基于HAND(Height Above Nearest Drainage)的形态淹没模型,用于快速分析流域洪水淹没情况,在乐安河流域上游进行了应用验证。结果表明,模型可在5秒内完成洪水淹没计算,对四场历史洪水和三场设计洪水淹没范围的总体模拟精度平均为0.95,达到水动力学模型的模拟精度;对淹没水深的模拟存在较大误差,平均误差为0.79 m。基于HAND的形态淹没模型可快速绘制全流域洪水淹没范围图,大幅提升影响预报和防洪预演的时效性水平。 展开更多
关键词 hand 形态淹没模型 洪水淹没分析 HEC-RAS模型
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Hand Cooling Enhances the Proprioceptive Drift during Rubber Hand Illusion
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作者 Masanori Sakamoto Yuta Akaike +1 位作者 Kazuya Tatsumi Hirotoshi Ifuku 《Journal of Behavioral and Brain Science》 2024年第7期210-226,共17页
Background: The neural representation of the body is easily altered by integrating multiple sensory signals in the brain. The “Rubber Hand Illusion” (RHI) is one of the most popular experimental paradigms to investi... Background: The neural representation of the body is easily altered by integrating multiple sensory signals in the brain. The “Rubber Hand Illusion” (RHI) is one of the most popular experimental paradigms to investigate this phenomenon. During this illusion, ownership of a rubber hand is temporarily induced. It was shown that external and continuous cooling of the palm enhanced the RHI, suggesting an association between altered the autonomic nervous system regulation and altered the sense of ownership of a specific limb. Purpose: To investigate whether artificially cooling the entire hand for a short period affects the magnitude of the illusion. Methods: Participants immersed their entire hand in cool, cold, or warm water for 1 min before the RHI procedure. Results: We found that cooling the entire hand enhanced the proprioceptive drift during the RHI but not the subjective feeling of ownership. In contrast, warming and intense cooling of the entire hand did not affect the RHI strength. Conclusion: Our results suggest that transient and moderate cooling of the entire hand was sufficient in enhancing the illusory disembodiment of one’s own hand. 展开更多
关键词 hand Temperature COOLING Rubber hand Illusion OWNERSHIP Proprioceptive Drift
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Comparison between Care Strategies for Patients with Osteoarthritis of the Hands Based on the Use of Joint Protection, Assistive Technology and Exercises
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作者 Daniele dos Santos Scarcella Talita Dias da Silva +4 位作者 Victoria Yanara Hernandes da Silva Maria Cândida de Miranda Luzo Selma Lancman Marcia Uchoa de Rezende Carlos Bandeira de Mello Monteiro 《Open Journal of Orthopedics》 2024年第7期295-311,共17页
Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. Purpose: To assess whether a group of people with hand ost... Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. Purpose: To assess whether a group of people with hand osteoarthritis (hOA) who received different types of treatment improved their function after two years of follow-up. Method: The entire sample (n = 97) underwent three follow-up assessments regarding anthropometric parameters of the upper limbs and ability to perform functional activities. Subsequently, the sample was divided into two groups for the intervention periods, called the First Period (n = 73) and the Second Period (n = 24);the First Period kept the same protocol with orientations, and the Second Period went to an intervention with orientation strength exercises and use of orthosis. Findings: In the separate analysis of the three questions of the DASH pain module, no differences were found between the assessment moments for groups of guidelines, treatment, or symptoms. Significant effects were observed for F(2, 162) = 3.5, p = 0.033, η2 = 0.04, and interaction for moments and intervention F(2, 162) = 4.3, p = 0.016, η2 = 0.05. Implications: It can be concluded that only guidance treatment does not benefit patients with hand osteoarthritis. In contrast, guidance, exercise, and orthosis treatment can significantly improve the disease. 展开更多
关键词 hand Osteoarthritis hand Deformities Occupational Therapy
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Observation of Curative Effect of Surgical Nursing in Patients with Grade III Hand-Foot Syndrome
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作者 Liping Zhang Lijuan Zhang +6 位作者 Yun Ding Lili Han Jiamin Kuang Qinghua Luo Xinhua Xie Zeyu Shuang Qiaoling Zhong 《Journal of Cancer Therapy》 2024年第8期280-286,共7页
Objective: To investigate the effect of surgical nursing on grade III Hand-Foot Syndrome (HFS) induced by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery. Method: From January 2019 to Decem... Objective: To investigate the effect of surgical nursing on grade III Hand-Foot Syndrome (HFS) induced by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery. Method: From January 2019 to December 2019, 10 patients with HFS grade III caused by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery in the Breast Department of Cancer Prevention and Treatment Center of Sun Yat-sen University were selected, and surgical nursing methods were used to intervene and observe the therapeutic effects of the patients. Results: One patient was cured within 7 days, the cure rate was 10% in 7 days, 8 patients were cured within 10 days, the cure rate was 80% in 10 days, 10 patients were cured within 15 days, the cure rate was 100% in 15 days. Conclusion: The surgical nursing method is effective for patients with grade III HFS caused by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery, shortening the treatment time of HFS, and is worthy of clinical promotion. 展开更多
关键词 Surgical Nursing Methods Breast Cancer CHEMOTHERAPY Grade III hand-Foot Syndrome
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Epidemiology of Hand Injuries That Presented to the Emergency Department of a Tertiary Care Facility in Suburban Mumbai, India: A Study Including 489 Patients
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作者 Farzin Vajifdar Renaldo Pavrey 《Open Journal of Emergency Medicine》 2024年第2期47-58,共12页
Background: Hand injuries are very common and responsible for a significant number of emergency department (ED) visits, most of which are not to hand specialists [1]. The functionality and outcome of hand injuries can... Background: Hand injuries are very common and responsible for a significant number of emergency department (ED) visits, most of which are not to hand specialists [1]. The functionality and outcome of hand injuries can vary significantly depending on the mechanism and pattern of injuries, which is why it is imperative for emergency physicians to recognize the complexities, and the potential repercussion of missed injuries in such cases. Objective: The aim of this study is to provide epidemiological information on hand injuries and their patterns. The objective is 1) to assess whether most hand injuries are superficial (simple), or involve underlying deeper structures (complex) and 2) to assess whether most hand injuries presented to the emergency department were managed by the emergency physician or plastic/orthopaedic surgeon. Methods: This retrospective single-centre observational study conducted at an emergency department in a tertiary care hospital in Mumbai, India collected data from hand trauma patients using a standardized documentation form. Demographic data, trauma-related data, and disposition plans were analysed. Results: A total of 489 cases sustained hand injuries over a period of one year. The patients were predominantly males in the 20 - 30 year age group and injuries were mainly sustained over the right hand. Most of the injuries were sustained at home (42%). The most common mechanism (34%) was sharp object injury (including needle-stick and other sharps in hospital), followed by blunt injury (30%). Among grievous hand injuries, door jamb was a mechanism noted in 11% of patients, accounting for 50% of all crush injuries. Lacerations were the most common pattern (24.7%) noticed, followed closely by fractures (23.3%). Digits II - IV were injured most commonly (54%), followed by carpals (14%) and the thumb (10%). Nearly 80% of the hand injuries were managed by emergency physicians alone, with 61% of cases involving superficial structures. Though 14% of the cases required plastic surgery intervention, the initial evaluation of all these patients was performed by the emergency physician. Conclusions: Our study highlights the burden of hand injuries on the emergency physician, as well as the odds of missed injuries, directly indicating the necessity of a thorough anatomical knowledge of the structures of the hand, and in turn, a proper physical examination. A dedicated registry for hand trauma would help quantify the mechanism and pattern of injuries, and formulate preventive strategies. 展开更多
关键词 Emergency Department hand Trauma Trauma Registry Emergency Medicine
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Transmission Dynamics and Optimal Control Strategies of a Hand-Foot-Mouth Disease Model with Treatment and Vaccination Interventions
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作者 Jianping Wang Shenghua Zou Zhicai Guo 《Journal of Applied Mathematics and Physics》 2024年第6期2007-2019,共13页
In this article, the transmission dynamics of a Hand-Foot-Mouth disease model with treatment and vaccination interventions are studied. We calculated the basic reproduction number and proved the global stability of di... In this article, the transmission dynamics of a Hand-Foot-Mouth disease model with treatment and vaccination interventions are studied. We calculated the basic reproduction number and proved the global stability of disease-free equilibrium when R0 R0 > 1. Meanwhile, we obtained the optimal control strategies minimizing the cost of intervention and minimizing the infected person. We also give some numerical simulations to verify our theoretical results. 展开更多
关键词 hand-Foot-Mouth Disease Optimal Control Transmission Dynamic Vaccination Interventions
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Design and Implementation of Hand Gesture Detection System Using HM Model for Sign Language Recognition Development
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作者 Sharmin Akter Milu Azmath Fathima +2 位作者 Tanmay Talukder Inzamamul Islam Md. Ismail Siddiqi Emon 《Journal of Data Analysis and Information Processing》 2024年第2期139-150,共12页
Gesture detection is the primary and most significant step for sign language detection and sign language is the communication medium for people with speaking and hearing disabilities. This paper presents a novel metho... Gesture detection is the primary and most significant step for sign language detection and sign language is the communication medium for people with speaking and hearing disabilities. This paper presents a novel method for dynamic hand gesture detection using Hidden Markov Models (HMMs) where we detect different English alphabet letters by tracing hand movements. The process involves skin color-based segmentation for hand isolation in video frames, followed by morphological operations to enhance image trajectories. Our system employs hand tracking and trajectory smoothing techniques, such as the Kalman filter, to monitor hand movements and refine gesture paths. Quantized sequences are then analyzed using the Baum-Welch Re-estimation Algorithm, an HMM-based approach. A maximum likelihood classifier is used to identify the most probable letter from the test sequences. Our method demonstrates significant improvements over traditional recognition techniques in real-time, automatic hand gesture recognition, particularly in its ability to distinguish complex gestures. The experimental results confirm the effectiveness of our approach in enhancing gesture-based sign language detection to alleviate the barrier between the deaf and hard-of-hearing community and general people. 展开更多
关键词 hand Gesture Recognition System
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扶正补土皮内针法联合康复训练治疗脑卒中后肩手综合征Ⅰ期临床观察
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作者 徐臻 李思娜 余金银 《中国中医药现代远程教育》 2025年第1期122-124,共3页
目的研究扶正补土皮内针法联合康复训练对缺血性脑卒中后肩手综合征(SHS)Ⅰ期的影响。方法选取62例卒中后SHSⅠ期患者,随机分为试验组和对照组,每组31例;对照组实施康复训练,试验组则实施扶正补土皮内针治疗联合康复训练。运用简式Fugl-... 目的研究扶正补土皮内针法联合康复训练对缺血性脑卒中后肩手综合征(SHS)Ⅰ期的影响。方法选取62例卒中后SHSⅠ期患者,随机分为试验组和对照组,每组31例;对照组实施康复训练,试验组则实施扶正补土皮内针治疗联合康复训练。运用简式Fugl-Meyer评分、视觉模拟量表(VAS)评分、手部水肿评分评估两组患者的上肢运动功能、疼痛情况及手部水肿程度,并比较临床疗效。结果治疗后,试验组患者简式Fugl-Meyer评分、VAS评分、水肿评分均优于对照组(P<0.05)。试验组治疗总有效率为90.32%(28/31),高于对照组的67.74%(21/31)(P<0.05)。结论扶正补土皮内针法联合康复训练可改善缺血性脑卒中后SHSⅠ期患者的肩部疼痛及水肿程度并促进上肢运动功能的恢复。 展开更多
关键词 痹证 肩手综合征 脑卒中 皮内针 康复训练 扶正补土
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HIT/DLR HandⅡ类人形五指灵巧手机构的研究 被引量:26
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作者 樊绍巍 刘伊威 +4 位作者 金明河 兰天 陈兆芃 刘宏 赵大威 《哈尔滨工程大学学报》 EI CAS CSCD 北大核心 2009年第2期171-177,共7页
为了使灵巧手的外观和结构功能更加类人化,研制了新一代类人形机器人五指灵巧手——HIT/DLR HandⅡ.该灵巧手由一个独立的手掌和5个完全相同的具有4个关节3个自由度的模块化手指构成.机电集成的设计思想保证了所有驱动器,传动系统和电... 为了使灵巧手的外观和结构功能更加类人化,研制了新一代类人形机器人五指灵巧手——HIT/DLR HandⅡ.该灵巧手由一个独立的手掌和5个完全相同的具有4个关节3个自由度的模块化手指构成.机电集成的设计思想保证了所有驱动器,传动系统和电路系统都集成在手指和手掌的内部.钢丝耦合机构的采用,保证了手指末端关节在整个运动范围内都能够保证精确定1:1传动比.包装件同结构功能件融合的设计思想不但进一步缩减的灵巧手的外形尺寸,而且使灵巧手外形更加类人化.所有的创新型设计使灵巧手的手指外形尺寸仅是上一代手指的1/3.此外,为了提高灵巧手的多感知能力,重新设计的力/力拒传感器,位置传感器及温度传感器通巧妙的集成在手指的内部.试验表明,所设计的灵巧手不但达到了设计目标,也表现出了很强的抓握能力. 展开更多
关键词 灵巧手 类人形 模块化 钢丝耦合机构 多感知能力
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五指仿人机器人灵巧手DLR/HIT Hand Ⅱ 被引量:32
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作者 刘伊威 金明河 +2 位作者 樊绍巍 兰天 陈兆芃 《机械工程学报》 EI CAS CSCD 北大核心 2009年第11期10-17,共8页
基于机电一体化设计思想和最新的驱动技术,研制DLR/HIT Ⅱ仿人灵巧手。该灵巧手由5个相同结构的模块化手指和1个独立的手掌构成,每个手指有4个关节、3自由度,所有的驱动器和电路板均集成在手指或手掌内。采用新型的体积小输出力矩大的... 基于机电一体化设计思想和最新的驱动技术,研制DLR/HIT Ⅱ仿人灵巧手。该灵巧手由5个相同结构的模块化手指和1个独立的手掌构成,每个手指有4个关节、3自由度,所有的驱动器和电路板均集成在手指或手掌内。采用新型的体积小输出力矩大的盘式无刷直流驱动电动机、质量轻的谐波减速器、齿形皮带等的驱动传动方案,使手指的体积和质量得到显著减小;采用钢丝耦合传动方案,实现手指末端两个关节的1:1耦合运动;手指具有位置、力/力矩、温度等多种感知功能。层次化的灵巧手硬件结构由手指电气系统、手掌电气系统和PCI总线控制卡等组成,灵巧手具有点对点串行通信、CAN以及网络等多种通信接口。在灵巧手的外观设计中,将外观设计与灵巧手的本体设计融为一体,实现灵巧手与人手相近的体积和外观。5指灵巧手的质量为1.5kg,手指的指尖输出力10N。 展开更多
关键词 DLR/HIT 灵巧手 数字信号处理器 现场可编程门阵列 模块化
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梭梭EF-hand CaBP基因克隆及序列分析 被引量:3
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作者 周晓燕 甘晓燕 +3 位作者 石磊 陈虞超 李苗 宋玉霞 《西北农业学报》 CAS CSCD 北大核心 2012年第6期47-52,57,共7页
采用RT-PCR、RACE等方法从超旱生、耐盐植物梭梭(Haloxylon ammodendron)中扩增出EF-handCaBP(EF-hand calcium-binding protein)基因的cDNA序列(GenBank登录号为JQ023165),其开放阅读框为732bp,推测的氨基酸序列全长为243个氨基酸残基... 采用RT-PCR、RACE等方法从超旱生、耐盐植物梭梭(Haloxylon ammodendron)中扩增出EF-handCaBP(EF-hand calcium-binding protein)基因的cDNA序列(GenBank登录号为JQ023165),其开放阅读框为732bp,推测的氨基酸序列全长为243个氨基酸残基。运用SMART、GOR4、TMPred等生物信息学软件对梭梭EF-hand CaBP功能域、跨膜结构进行分析显示,梭梭EF-hand CaBP含有26个氨基酸的信号肽序列及4个保守的钙结合位点(EF-hand),并且存在2种跨膜模型,推测梭梭EF-hand CaBP基因可能定位于液泡膜或叶绿体膜上。 展开更多
关键词 梭梭 钙结合蛋白 EF-hand手型 序列分析
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秀山金银花(Lonicera macranthoides Hand.-Mazz)的总灰分和酸不溶性灰分的测定 被引量:1
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作者 徐李 关丽英 +1 位作者 曾忠良 罗音久 《西南大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第5期146-150,共5页
目的:检测"秀山金银花"的总灰分和酸不溶性灰分的量,为制定其质量检查标准提供试验数据.方法采用2005年版《中国药典》一部附录IXK的总灰分及酸不溶性灰分的测定方法.结果灰毡毛忍冬总灰分及酸不溶性灰分量分别在8%和3%以下,... 目的:检测"秀山金银花"的总灰分和酸不溶性灰分的量,为制定其质量检查标准提供试验数据.方法采用2005年版《中国药典》一部附录IXK的总灰分及酸不溶性灰分的测定方法.结果灰毡毛忍冬总灰分及酸不溶性灰分量分别在8%和3%以下,渝蕾1号的总灰分和酸不溶性灰分量分别在8%和2%以下.结论:秀山金银花的总灰分和酸不溶性灰分总灰分和酸不溶性灰分量均符合药典灰分不得超过10.0%.酸不溶性灰分,不得超过3.0%要求. 展开更多
关键词 金银花 总灰分 酸不溶性灰分
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EF-hand对钙调磷酸酶B同源蛋白2的生物学功能影响 被引量:1
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作者 张洪菊 李庆华 +3 位作者 王立洪 蔺亚妮 常国强 庞天翔 《中国医药导报》 CAS 2012年第35期28-31,共4页
目的探讨EF-hand结构对钙调磷酸酶B同源蛋白2(CHP2)的生物学功能的影响。方法通过PCR扩增CHP2 cDNA片段,构建带GFP标签的野生型及EF-hand突变型CHP2表达质粒;与钠氢离子交换蛋白1(NHE1)共转染PS120细胞;采用激光共聚焦显微镜、膜滤过法... 目的探讨EF-hand结构对钙调磷酸酶B同源蛋白2(CHP2)的生物学功能的影响。方法通过PCR扩增CHP2 cDNA片段,构建带GFP标签的野生型及EF-hand突变型CHP2表达质粒;与钠氢离子交换蛋白1(NHE1)共转染PS120细胞;采用激光共聚焦显微镜、膜滤过法、免疫共沉淀等手段,明确CHP2结合Ca2+的数量、部位,以及对CHP2与NHE1结合的影响;在血清饥饿条件下,观察表达EF-hand突变的CHP2(NHE1/CHP2-EF3m/4m)对细胞生存的影响。结果分别突变EF-hand结构EF3或EF4,CHP2结合Ca2+减少;同时突变EF3和EF4,CHP2不能结合Ca2+;免疫共沉淀实验结果显示乙二胺四乙酸(EDTA)剥夺CHP2携带的Ca2+之后,CHP2与NHE1结合的数量明显减少;不携带Ca2+的CHP2在细胞内与NHE1结合的数量也明显减少;在血清饥饿条件下,表达不携带Ca2+的CHP2的细胞存活数量减少。结论 CHP2能结合2个Ca2+,结合部位在EF3和EF4;携带Ca2+能增强CHP2与NHE1的结合能力;在血清饥饿条件下,携带Ca2+的CHP2能提升细胞抵抗死亡的能力。 展开更多
关键词 钙调磷酸酶B同源蛋白2 钠氢交换蛋白1 EF-hand CA2+
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低频脉冲电刺激结合上肢运动训练对脑卒中后肩手综合征患者上肢功能的影响
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作者 孙玲 张青 +1 位作者 郭艮春 张文慧 《中国实用神经疾病杂志》 2025年第1期58-62,共5页
目的分析低频脉冲电刺激结合上肢运动训练对脑卒中后肩手综合征患者上肢功能的影响。方法选取2021-01—2023-01南通大学第六附属医院收治的100例脑卒中肩手综合征患者,按随机数字表分为观察组50例与对照组50例。对照组患者予以常规康复... 目的分析低频脉冲电刺激结合上肢运动训练对脑卒中后肩手综合征患者上肢功能的影响。方法选取2021-01—2023-01南通大学第六附属医院收治的100例脑卒中肩手综合征患者,按随机数字表分为观察组50例与对照组50例。对照组患者予以常规康复治疗,观察组患者在对照组基础上采取低频脉冲电刺激结合上肢运动训练,2组患者康复治疗均为8周,比较2组患者的临床疗效、上肢肌肉的表面肌电信号(s EMG)、肩手功能与关节活动度状况及并发症发生情况。结果观察组患者的总有效率94.00%,高于对照组患者的80.00%(P<0.05)。观察组患者治疗后肱二头肌、肱三头肌、腕伸肌、三角肌等上肢肌肉s EMG的RMS、MF水平均高于对照组(P<0.05),SHSS评分[(3.87±0.95)分]低于对照组[(5.32±1.04)分](P<0.05),肩、腕ROM评分[分别为(2.21±0.47)分、(2.26±0.49)分]均高于对照组[分别为(1.78±0.55)分、(1.82±0.50)分](P<0.05)。观察组患者并发症发生率8.00%,低于对照组患者的24.00%,差异有统计学意义(P<0.05)。结论低频脉冲电刺激结合上肢运动训练能够显著改善脑卒中肩手综合征患者的上肢功能和肩腕活动度,促进上肢肌肉sEMG指标恢复,临床疗效显著,并发症发生率低。 展开更多
关键词 脑卒中 肩手综合征 低频脉冲电刺激 上肢运动训练 上肢功能
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累及Hand knob区的分水岭梗死致“垂腕”1例及文献复习 被引量:2
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作者 王继蕊 林梅青 +1 位作者 徐家欢 商秀丽 《中国实用神经疾病杂志》 2020年第16期1462-1465,共4页
目的探讨以“垂腕”为主要临床表现的分水岭梗死的临床特点及影像学特点。方法收集1例以“垂腕”为主要临床表现的分水岭梗死患者的临床资料并复习相关文献。结果Hand knob区受累的分水岭梗死也可使患者出现单纯“垂腕”症状。结论“垂... 目的探讨以“垂腕”为主要临床表现的分水岭梗死的临床特点及影像学特点。方法收集1例以“垂腕”为主要临床表现的分水岭梗死患者的临床资料并复习相关文献。结果Hand knob区受累的分水岭梗死也可使患者出现单纯“垂腕”症状。结论“垂腕”不仅是周围神经系统受累的标志,也可由于Hand knob区受累的分水岭梗死所致。 展开更多
关键词 分水岭梗死 垂腕 hand knob区 临床特点 影像学特点
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