I CAN HELP!

"You worked hard.You're almost done,"says Philip as he looks around.He's at his friend Brett's house。"Almost.Packing all these boxes was a lot of work.I'm excited to move into my new apartment,"Brett says.

Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia

AIM:To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional treatment.METHODS:Twenty-one children with functional amblyopia,aged 5.7±2.1y(range:4-10y),underwent comprehensive ophthalmic and refractive evaluations.Spectral domain-optical coherence tomography(SD-OCT)and multifocal electroretinography(mfERG)were conducted to analyze the macular retinal thickness and the first-order response P1 ring of the mfERG in the amblyopic eye(AE)compared to the fellow good eye(GE).RESULTS:Initially,visual acuity in the AE ranged from 20/800 to 20/40,while the GE exhibited a range of 20/25 to 20/20(P<0.01).After 6mo of treatment,17 patients demonstrated improved visual acuity in the AE to 20/50 or better,while 4 children showed no improvement.SD-OCT revealed comparable macular and optic disc structures between the AE and GE.Prior to treatment,the mfERG P1 ring amplitude was significantly reduced in the AE compared to GE(P<0.05).The AE/GE ratio of P1 ring amplitude showed significant improvement post-treatment.However,a smaller AE/GE ratio before treatment was associated with poorer improvement post-treatment.CONCLUSION:In the management of functional amblyopia,a thorough assessment of amblyopic eye examinations is crucial.Approximately 20%of amblyopic eyes may not achieve significant improvement in visual acuity,despite the absence of detectable organic retinal abnormalities.mfERG may reveal underlying abnormalities.Integrating mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.

Causes and Countermeasures of Helping Poor Students to Learn English

In English teaching, there is a common phenomenon: at the beginning of English learning, students are enthusiastic and full of interest; then polarization appears after a period of study. Some of the students become discouraged and lose confidence in learning English, and gradually become the so-called poor learners. Therefore, teachers should make careful analysis, find out the causes and regulate countermeasures to improve teaching methods, so that every student can get a comprehensive and healthy development.

Diagnosis of poorly differentiated adenocarcinoma of the stomach by confocal laser endomicroscopy:A case report

BACKGROUND In recent years,confocal laser endomicroscopy(CLE)has become a new endoscopic imaging technology at the microscopic level,which is extensively performed for real-time in vivo histological examination.CLE can be performed to distinguish benign from malignant lesions.In this study,we diagnosed using CLE an asymptomatic patient with poorly differentiated gastric adenocarcinoma.CASE SUMMARY A 63-year-old woman was diagnosed with gastric mucosal lesions,which may be gastric cancer,in the small curvature of the stomach by gastroscopy.She consented to undergo CLE for morphological observation of the gastric mucosa.Through the combination of CLE diagnosis and postoperative pathology,the intraoperative CLE diagnosis was considered to be reliable.According to our experience,CLE can be performed as the first choice for the diagnosis of gastric cancer.CONCLUSION CLE has several advantages over pathological diagnosis.We believe that CLE has great potential in the diagnosis of benign and malignant gastric lesions.

基于HELP模式的集束化干预策略在老年髋部骨折术后谵妄护理中的应用

目的探讨基于医院老年生活计划(the hospital elder life program,HELP)模式的集束化干预策略对老年髋部骨折患者术后谵妄的预防及护理效果。方法选取2019年9月至2022年6月住院并手术的老年髋部骨折患者167例,用数字表法随机分为对照组87例和观察组80例,分别收住A病区和B病区。其中对照组患者给予骨折围手术期常规护理,观察组在常规护理基础上,增加基于HELP模式的集束化干预方案进行谵妄的预防及护理。结果观察组患者谵妄发生率(8.75%)低于对照组(20.69%),谵妄持续时间(3.36±0.56)d短于对照组(4.25±1.03)d,差异均有统计学意义(P<0.05);观察组患者术后3 d内疼痛评分、术后40项恢复质量评分、住院费用、出院时患者满意度调查评分均优于对照组,差异有统计学意义(P<0.05),但两组患者术后重度疼痛发生情况比较,差异无统计学意义(P>0.05)。结论基于HELP模式的集束化干预策略应用于老年髋部骨折术后谵妄护理,能有效地降低了患者术后谵妄的发生率,最大程度提高患者术后恢复质量,提高患者满意度。

“The Source of Flowing Water”:How Targeted Poverty Alleviation Helps China’s Rural Poor Access Credit

Based on the China Household Finance Survey(CHFS)data of 2011-2017,this paper investigated the effects of China’s targeted poverty alleviation policy on rural credit access and amount using the“difference-in-differences”methodology.This study found that the targeted poverty alleviation policy increased the availability and amount of formal credit to poor households and reduced the proportion and amount of their borrowing through informal channels,and that the effects increased amid the policy’s implementation over time.This paper further found that the policy effects were more significant for China’s western regions,reflecting a positive role of targeted poverty alleviation in coordinating pro-poor finance across regions.Compared with poor counties,poor households from non-poor counties experienced a greater increase in their probability and amount of formal credit access,reflecting China’s approach of reducing regional poverty before targeting more precisely at individual poor households.This paper also uncovered that no significant“elite capture”effect had existed in the allocation of formal agricultural credit under targeted poverty alleviation,but extremely poor households experienced no significant change in their access to formal credit.While the targeted poverty alleviation policy has helped create a sound rural credit market,it should further improve access to formal finance for extremely poor households.

Associated Factors to Poor Blood Pressure Control in Hypertensives Followed Up at the Campus University Hospital of Lome (Togo)

Introduction: Hypertension is a real public health issue and its control is very difficult. We aim to determine the frequency of uncontrolled hypertension in hypertensive patients followed up as an outpatient at the campus university hospital of Lome (Togo) and to search for the associated factors. Methodology: The study was cross-sectional, descriptive and analytical, carried out from February (2022) to August 2022 in 260 hypertensive patients aged 22 years old, followed up (on an) as an outpatient for at least 3 months at the Lome University Hospital campus. A univariate then multivariate analysis were conducted in order to highlight the most common factors significantly linked to uncontrolled. Results: The mean age of hypertensives was 56.4 ± 12.7 years, the sex ratio (M/F) was 0.59. Prevalence of uncontrolled blood pressure was 42%. Associated Factors to poor blood pressure control in our study were age > 60 years (OR = 1.6 CI [1.17 - 2.50]), low socio-economic level (OR = 2.2 CI [1.96 - 4.33]), high cardiovascular risk level (OR = 3.1 CI [2.18 - 4.52]), non-adherence to regular blood pressure monitoring (OR = 3.3 CI [2.21 - 5.55]), low compliance to treatment (OR = 4.1 CI [2.33 - 6.76]) and a chronic renal failure (OR = 2.1 CI [1.21 - 3.10]). Conclusion: Nearly half of the hypertensives in our study had poorly controlled blood pressure by antihypertensive treatment medication. The factors of this poor control were age > 60 years, low socio-economic level, high or very high level of cardiovascular risk, low compliance to treatment, and renal failure.

The Rich Help the Poor

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Gallbladder carcinosarcoma with a poor prognosis: A case report

BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis.To date,only approximately 100 patients have been reported in the English literature.The prognosis of this tumor type is poor,the preoperative diagnosis is difficult,and there is a possibility of a misdiagnosis.We present an unsuccessful case of carcinosarcoma of the gallbladder with a preoperative misdiagnosis and rapid early postoperative recurrence.Therefore,we have a deeper understanding of the poor prognosis of gallbladder carcinosarcoma(GBC)patients.CASE SUMMARY The patient is a 65-year-old male.He was admitted to the hospital because of right upper abdomen distending pain and discomfort for half a month.Abdominal magnetic resonance imaging revealed a polycystic mass in the right lobe of the liver and the fossa of the gallbladder.After admission,the patient was diagnosed with a liver abscess,which was treated by abscess puncture drainage.Obviously,this treatment was unsuccessful.Hepatectomy and cholecystectomy were performed one month after the puncture.Postoperative pathologic examination revealed carcinosarcoma of the gallbladder,and the resected specimen contained two tumor components.One month after surgery,the patient's tumor recurred in situ and started to compress the duodenum,resulting in duodenal obstruction and bleeding.The treatment was not effective.The patient died of gastrointestinal hemorrhage and hypovolemic shock.CONCLUSION Carcinosarcoma of the gallbladder is a rare malignant tumor that is easily misdiagnosed preoperatively and has a poor prognosis.

Autosomal Dominant Polycystic Kidney Disease: Epidemiological, Clinical Aspects and Predictive Factors of Poor Renal Prognosis (About 300 Cases)

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a common, multisystemic, and progressive hereditary disease. It accounts for 6 to 8% of incident cases of end-stage chronic renal disease (ESRD) in developed countries. The aim of this study is to describe the predictive factors for the development of end-stage chronic kidney disease (CKD) in the course of this disease. Material and Methods: This is a retrospective, descriptive, and analytical study including 300 cases of ADPKD collected at the Nephrology Department of Ibn-Sina Hospital in Rabat over a period of 30 years (1993 to 2023). Included in the study are all patients with ADPKD meeting the ultrasound diagnostic criteria. The analysis focused on demographic, clinical, paraclinical, evolutionary data, as well as prognostic factors associated with renal function deterioration. Results: The mean age of patients at diagnosis is 51.53 +/− 17 years [16 - 93] with a male predominance. The median serum creatinine at diagnosis is 15.5 mg/l [10 - 34]. 21% of patients had ESRD (eGFR 300 mg/24h (21%). The most common cystic complication is hemorrhage (12.3%). 21.3% of patients had hepatorenal polycystic disease. In adjusted analysis, the predictive risk factors for the occurrence of ESRD were smoking (p = 0.019), anemia (p Conclusion: ADPKD can progress insidiously to ESRD. Identification and early treatment of predictive factors for poor renal prognosis could contribute to a better outcome for this disease.

HELP护理模式在老年骨折患者术后护理中的应用价值

目的:探究住院老年人生活项目(HELP)护理模式在提高老年骨科患者术后早期离床活动依从性及自护能力中的价值。方法:选取2020年1月—2022年12月我院收治的75例老年骨科手术患者为研究对象。按随机数字表法将其分为观察组(n=38)和对照组(n=37)。对照组采用常规护理,观察组采用HELP护理模式,比较2组患者术后早期离床活动依从性、自护能力、术后并发症。结果:相比于对照组,观察组患者术后离床时间更短、每次活动持续时间更长,组间差异有统计学意义(P<0.05);干预后,2组自护能力评分均较干预前升高,且观察组高于对照组,差异有统计学意义(P<0.05);相比于对照组,观察组术后便秘、泌尿感染、压疮、下肢血栓并发症总发生率更低,组间差异有统计学意义(P<0.05)。结论:相比于常规护理方式,采用HELP护理模式对于老年骨科手术患者而言,更有利于增强术后早期离床活动依从性,更能提升自护能力,减少术后并发症。

Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs,the outcomes often exhibit suboptimal particle size distribution and large particle sizes,limiting their effectiveness.In this study,we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs,enabling the fabrication of nanoparticles with fine and uniform particle size distribution.Regorafenib(1 g),as a model drug,copovidone(5 g),and sodium dodecyl sulfate(0.1 g)were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray dryer.The electrostatic spray-dried nanoparticles(ESDN)showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles(CSDN).ESDN demonstrated significantly enhanced solubility and rapid release in water.In vitro studies revealed that ESDN induced apoptosis in HCT-116 cells to a greater extent,exhibiting superior cytotoxicity compared to CSDN.Furthermore,ESDN substantially improved oral bioavailability and antitumor efficacy compared to CSDN.These findings suggest that ESD shows potential in developing enhanced drug delivery systems for poorly water-soluble drugs,effectively addressing the limitations associated with CSD methods.

Turning Dreams Into Reality China is committed to helping African countries to build their space capability

An important feature of China developing its aerospace industry is its insistence on self-reliance and independent innovation,because China firmly believes that aerospace is a hi-tech industry and high core technologies cannot be bought.Only by mastering core technologies can China firmly grasp the initiative in development.

Discussion on the Ideological and Political Education for Poor College Students

At present,ideological and political education is significant for poor college students.The focus of funding for poor students has gradually transformed from providing economic support for them to ideological and spiritual help,which puts forward higher requirements on how to carry out ideological and political work.It also requires us to advance the work of ideological and moral education and put it in the most important position in the ideological and educational work for poor college students.Combined with the reality of poor college students,we will adhere to the idea of being student-oriented and endeavor to enhance the effectiveness,pertinence,and relevance of the work of ideological and political education.This paper analyzes the significance and problems of ideological and political education for poor college students and puts forward effective ways to solve the problems from the levels of ideology,cognition,and teaching staff.

基于HELP理念在预防高龄髋部骨折患者术后谵妄护理的应用

构建基于HELP理念的多学科干预方案,并探讨其在预防高龄患者髋部骨折术后谵妄的应用效果。方法 在证据检索总结下形成相关预防护理管理方案。选取收治于上海市同仁医院骨科的高龄髋部骨折患者,将其中2021年07月-2022年06月的纳入对照组,进行常规护理;降2022年07月-2023年6月的纳入实验组,进行上述护理管理方案的落实。最后对比两组的护理效果。结果 实验组的POD发生率远低于对照组(P<0.05),但两组在POD持续时间和睡眠时间方面的对比,差异不存在统计学意义(P>0.05)。结论 为高龄髋部骨折患者提供基于HELP理念的多学科干预方案,可以预防术后谵妄的发生,效果比较突出,值得临床推广应用。

宽带故障全天候实时智能化管控机器人研究及应用

为提升网络质量,研发了宽带故障全天候实时智能化管控机器人,该机器人通过有线宽带链路通道质量智能检测技术和宽带故障全生命实时智能化管控系统预判网络故障并做出智能响应。利用随机森林算法训练模型预测故障,整合宽带网络实时数据,通过数据匹配和AI算法生成故障信息,并由钉钉机器人进行智能调度,实现故障层级、方案和人员的全覆盖,自动生成响应方案。实验表明,该机器人能有效预测高风险链路,故障处理高效,用户满意率大幅度提升。

HELP法在中草药分析中的应用研究──冬虫夏草的化学成分测定

基于直观推导式演进特征投影（ＨＥＬＰ）法，对冬虫夏草子座和虫体分别进行了多组分同时定性定量测定．结果表明，ＨＥＬＰ法能减少样本提取分离的步骤，降低色谱分离条件的要求，提高检测准确度．

GC-MS与HELP法分析玫瑰精油化学成分

气相色谱-质谱法(GC-MS)分析江西大马士革玫瑰精油的化学成分。各色谱峰对应的质谱于NIST标准质谱库中进行相似度检索,共匹配鉴定64个组分,占总峰面积的92.8%;分别提取6个色谱峰的色谱-质谱二维数据,直观推导式演进特征投影分析法(HELP)解析获得新的色谱和质谱。结果结合NIST质谱库检索,与纯品色谱对照,共鉴定出7个组分,总相对含量为49.77%。解析所得组分中,β-苯乙醇、橙花醇、L-香茅醇和香叶醇的相对含量接近ISO 9842:2003《玫瑰油》保加利亚同类油的要求。

炎症因子联合检测在妊娠期糖尿病患者中的应用价值

目的 分析炎症因子联合检测在妊娠期糖尿病(GDM)患者中的应用价值。方法 选取2022年1月至2024年4月在厦门大学附属第一医院进行治疗的98例GDM患者作为观察组,另选取同期在厦门大学附属第一医院进行产检的40例健康孕妇作为对照组。检测白细胞计数(WBC)、降钙素原(PCT)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)水平,根据糖耐量筛查结果对GDM严重程度进行分级,并根据是否发生不良妊娠结局,将GDM患者分为妊娠结局不良组和妊娠结局良好组。绘制受试者工作特征(ROC)曲线分析血清炎症因子对GDM患者发生不良妊娠结局的预测价值。结果 观察组WBC、PCT、IL-6、CRP水平高于对照组,差异均有统计学意义(P<0.05)。轻度、中度、重度GDM患者分别有58、25、15例。不同严重程度GDM患者WBC、PCT、IL-6、CRP水平比较,轻度患者<中度患者<重度患者,任意两两比较,差异均有统计学意义(P<0.05)。观察组不良妊娠结局总发生率高于对照组,差异有统计学意义(P<0.05)。妊娠结局良好组有46例患者,妊娠结局不良组有52例患者。妊娠结局不良组WBC、PCT、IL-6、CRP水平高于妊娠结局良好组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,WBC、PCT、IL-6、CRP单独预测GDM患者发生不良妊娠结局的曲线下面积(AUC)分别为0.690、0.805、0.820、0.753,4项指标联合检测的AUC为0.947。结论 GDM患者WBC、PCT、IL-6、CRP水平升高,且这些指标可作为GDM患者不良妊娠结局的预测因子,可能与GDM的诊断、发展及预后密切相关。