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Homer1b/c通过内质网功能调节由谷氨酸兴奋性毒性损伤诱发的小鼠海马神经元HT22细胞自噬
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作者 张敏敏 朱宣 +4 位作者 沈红健 吕楠 吴雄枫 徐小龙 吴涛 《海军军医大学学报》 CAS CSCD 北大核心 2024年第3期277-283,共7页
目的研究Homer1b/c蛋白在谷氨酸兴奋性毒性损伤诱发的细胞自噬中的作用及机制。方法选用小鼠海马神经元HT22细胞,通过500μmol/L L-谷氨酸处理建立细胞损伤模型。用siRNA慢病毒转染方式下调Homer1b/c表达,用10μmol/L钙离子螯合剂BAPTA... 目的研究Homer1b/c蛋白在谷氨酸兴奋性毒性损伤诱发的细胞自噬中的作用及机制。方法选用小鼠海马神经元HT22细胞,通过500μmol/L L-谷氨酸处理建立细胞损伤模型。用siRNA慢病毒转染方式下调Homer1b/c表达,用10μmol/L钙离子螯合剂BAPTA-AM、10 mmol/L内质网应激抑制剂4-PBA分别抑制细胞内钙离子释放和内质网应激后,使用蛋白质印迹法检测细胞中Homer1b/c蛋白,自噬效应蛋白[beclin-1、微管相关蛋白1轻链3(LC3)]及内质网应激标志蛋白[C/EBP同源蛋白(CHOP)、葡萄糖调节蛋白78(GRP 78)]的表达水平。结果L-谷氨酸处理HT22细胞12 h后,细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值均较对照组升高(均P<0.05);与转染对照组相比,下调Homer1b/c表达可降低细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值(均P<0.05);抑制细胞内钙离子释放和内质网应激均能降低细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值(均P<0.05);下调Homer1b/c表达后,抑制细胞内钙离子释放和内质网应激未能进一步降低细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值。结论Homer1b/c能够调节谷氨酸兴奋性毒性损伤诱发的细胞自噬,其调节作用可能与内质网功能有关。 展开更多
关键词 海马神经元 自噬 homer 钙稳态 内质网应激 兴奋性损伤 谷氨酸
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基于HOMER Pro的孤岛微电网优化设计与研究
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作者 田拥军 刘阳京 《科技与创新》 2024年第14期39-42,共4页
多能互补的孤岛微电网通常用来解决偏僻地区的用电问题,以南海某海岛的微电网系统优化设计为例,采用HOMER Pro电力系统仿真软件为辅助设计平台,根据当地的太阳能、风能资源丰富的特点选择风、光、油、储多能互补方式为微电网提供电力,... 多能互补的孤岛微电网通常用来解决偏僻地区的用电问题,以南海某海岛的微电网系统优化设计为例,采用HOMER Pro电力系统仿真软件为辅助设计平台,根据当地的太阳能、风能资源丰富的特点选择风、光、油、储多能互补方式为微电网提供电力,给出了HOMER Pro的仿真结果,仿真显示所设计的系统具有较好的经济效益、环保效益及供电稳定性。 展开更多
关键词 孤岛微电网 优化 homer Pro 多能互补
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Homer1b/c“支架”在CTNND2-/-自闭症模型鼠中的作用研究
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作者 张翰鸿 王岩 +4 位作者 吕明其 聂应 蔡锦雯 王楚萱 李英博 《重庆医科大学学报》 CAS CSCD 北大核心 2024年第4期409-414,共6页
目的:观察CTNND2-/-自闭症模型鼠前额叶皮层中支架蛋白荷马1b/c(homer protein homolog 1b and 1c,Homer1b/c)与三磷酸肌醇受体(inositol 1,4,5-trisphosphate receptor,IP3R)、代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mG... 目的:观察CTNND2-/-自闭症模型鼠前额叶皮层中支架蛋白荷马1b/c(homer protein homolog 1b and 1c,Homer1b/c)与三磷酸肌醇受体(inositol 1,4,5-trisphosphate receptor,IP3R)、代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mGluR5)和香克3蛋白(sh3 and multiple ankyrin repeat domains 3,Shank3)蛋白相关复合体的变化;前额叶皮层中常见氨基酸的变化,发现自闭症模型鼠中可能参与疾病发生的关键靶点。方法:蛋白免疫印迹法(Western blot,WB)法检测CTNND2-/-自闭症模型鼠前额叶皮层中支架蛋白Homer1b/c、突触后密度蛋白-95(postsynaptic density protein 95,PSD-95)、突触素蛋白(synaptophysin,SYP)、囊泡谷氨酸转运体1(vesicular glutamate transporter 1,vGluT1)的表达的变化;通过免疫荧光(immunofluorescence,IF)观察Homer1b/c与IP3R、mGluR5和Shank3蛋白的表达与共定位;免疫共沉淀(co-immunoprecipitation,CO-IP)技术分别观察Homer1b/c与IP3R、mGluR5或Shank3结合的变化;使用液相色谱(liquid chromatography,LC)观察前额叶皮层中常见氨基酸的变化。结果:与对照组相比,CTNND2-/-模型鼠前额叶皮层中Homer1b/c(P=0.003)、PSD-95(P=0.003)以及SYP蛋白(P=0.046)的表达均明显降低;同时,Homer1b/c与IP3R、mGluR5、Shank3蛋白相互之间结合减少;前额叶皮层中常见的兴奋性神经递质谷氨酸(glutamate,Glu)和抑制性神经递质γ-氨基丁酸(γ-aminobutyric acid,GABA)的表达无明显变化(P=0.366,P=0.355),组氨酸(histidine,His)(P=0.036),酪氨酸(tyrosine,Tyr)(P=0.030)表达则明显增高。结论:CTNND2-/-自闭症模型鼠中Homer1b/c蛋白低表达,同时Homer1b/c与IP3R、Shank3、mGluR5蛋白复合物的形成减少,并推测低表达的Homer1b/c可能是导致自闭症神经元突触异常发育的关键靶点。 展开更多
关键词 homer1b/c 自闭症谱系障碍 CTNND2基因敲除鼠
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Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury 被引量:1
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作者 Yanan Dou Xiaowei Fei +7 位作者 Xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao Lyu Zhou Fei Xia Li Fei Fei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1608-1617,共10页
Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in ... Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in neuroinflammation in the cerebrum.However,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown.In our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion injury.For in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller cells.We found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion injury.Furthermore,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte rleukin-18.The opposite results we re observed with Homerla ove rexpression.Finally,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion injury.Taken together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury. 展开更多
关键词 CASPASE-8 homer1a INTERLEUKIN-18 INTERLEUKIN-1Β intraocular pressure ischemia/reperfusion injury JSH-23 Müller cells NLRP3 nuclear factor-kB p65 RETINA
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基于HOMER的多场景离网型微电网优化设计
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作者 张一凡 颜世烨 +3 位作者 李斌 柳丹 叶季蕾 刘丽丽 《太阳能学报》 EI CAS CSCD 北大核心 2024年第8期123-134,共12页
基于HOMER软件对武汉某商业园区开展离网型光-柴-储微电网系统优化设计研究。首先,构建多运行策略下离网型光-柴-储微电网系统容量优化配置模型;在此基础上,分析不同运行策略下系统容量配置、光伏渗透比例和电池储能运行状态,并得出离... 基于HOMER软件对武汉某商业园区开展离网型光-柴-储微电网系统优化设计研究。首先,构建多运行策略下离网型光-柴-储微电网系统容量优化配置模型;在此基础上,分析不同运行策略下系统容量配置、光伏渗透比例和电池储能运行状态,并得出离网型光-柴-储微电网系统最优运行策略;然后,基于最优运行策略开展多场景下离网型光-柴-储微电网容量优化配置,对多场景离网型光-柴-储微电网的平准化度电成本本(LCOE)、系统净现值(NPC)和总排放等性能进行比较分析;最后,结合具体案例开展敏感性因素分析。结果表明,所提容量配置模型可实现系统经济性与清洁性的最佳权衡,并降低系统对于储能电池的依赖;通过敏感性分析得出不同机组参数、负荷参数对系统最优配置的影响。 展开更多
关键词 微电网 可再生能源 储能 homer仿真 多场景 容量配置
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Special Issue:Questions&Data for Better Science and Innovation Call for submissions
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《Journal of Data and Information Science》 CSCD 2024年第3期I0002-I0002,共1页
Editors Yang Wang,Xi'an Jiaotong University Dongbo Shi,Shanghai Jiaotong University Ye Sun,University College London Zhesi Shen,National Science Library,CAS Topic of the Special Issue What are the top questions to... Editors Yang Wang,Xi'an Jiaotong University Dongbo Shi,Shanghai Jiaotong University Ye Sun,University College London Zhesi Shen,National Science Library,CAS Topic of the Special Issue What are the top questions towards better science and innovation and the required data to answer these questions? 展开更多
关键词 COLLEGE questionS ISSUE
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MKEAH:Multimodal knowledge extraction and accumulation based on hyperplane embedding for knowledge-based visual question answering
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作者 Heng ZHANG Zhihua WEI +6 位作者 Guanming LIU Rui WANG Ruibin MU Chuanbao LIU Aiquan YUAN Guodong CAO Ning HU 《虚拟现实与智能硬件(中英文)》 EI 2024年第4期280-291,共12页
Background External knowledge representations play an essential role in knowledge-based visual question and answering to better understand complex scenarios in the open world.Recent entity-relationship embedding appro... Background External knowledge representations play an essential role in knowledge-based visual question and answering to better understand complex scenarios in the open world.Recent entity-relationship embedding approaches are deficient in representing some complex relations,resulting in a lack of topic-related knowledge and redundancy in topic-irrelevant information.Methods To this end,we propose MKEAH:Multimodal Knowledge Extraction and Accumulation on Hyperplanes.To ensure that the lengths of the feature vectors projected onto the hyperplane compare equally and to filter out sufficient topic-irrelevant information,two losses are proposed to learn the triplet representations from the complementary views:range loss and orthogonal loss.To interpret the capability of extracting topic-related knowledge,we present the Topic Similarity(TS)between topic and entity-relations.Results Experimental results demonstrate the effectiveness of hyperplane embedding for knowledge representation in knowledge-based visual question answering.Our model outperformed state-of-the-art methods by 2.12%and 3.24%on two challenging knowledge-request datasets:OK-VQA and KRVQA,respectively.Conclusions The obvious advantages of our model in TS show that using hyperplane embedding to represent multimodal knowledge can improve its ability to extract topic-related knowledge. 展开更多
关键词 Knowledge-based visual question answering HYPERPLANE Topic-related
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PAL-BERT:An Improved Question Answering Model
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作者 Wenfeng Zheng Siyu Lu +3 位作者 Zhuohang Cai Ruiyang Wang Lei Wang Lirong Yin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期2729-2745,共17页
In the field of natural language processing(NLP),there have been various pre-training language models in recent years,with question answering systems gaining significant attention.However,as algorithms,data,and comput... In the field of natural language processing(NLP),there have been various pre-training language models in recent years,with question answering systems gaining significant attention.However,as algorithms,data,and computing power advance,the issue of increasingly larger models and a growing number of parameters has surfaced.Consequently,model training has become more costly and less efficient.To enhance the efficiency and accuracy of the training process while reducing themodel volume,this paper proposes a first-order pruningmodel PAL-BERT based on the ALBERT model according to the characteristics of question-answering(QA)system and language model.Firstly,a first-order network pruning method based on the ALBERT model is designed,and the PAL-BERT model is formed.Then,the parameter optimization strategy of the PAL-BERT model is formulated,and the Mish function was used as an activation function instead of ReLU to improve the performance.Finally,after comparison experiments with traditional deep learning models TextCNN and BiLSTM,it is confirmed that PALBERT is a pruning model compression method that can significantly reduce training time and optimize training efficiency.Compared with traditional models,PAL-BERT significantly improves the NLP task’s performance. 展开更多
关键词 PAL-BERT question answering model pretraining language models ALBERT pruning model network pruning TextCNN BiLSTM
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Operational requirements analysis method based on question answering of WEKG
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作者 ZHANG Zhiwei DOU Yajie +3 位作者 XU Xiangqian MA Yufeng JIANG Jiang TAN Yuejin 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第2期386-395,共10页
The weapon and equipment operational requirement analysis(WEORA) is a necessary condition to win a future war,among which the acquisition of knowledge about weapons and equipment is a great challenge. The main challen... The weapon and equipment operational requirement analysis(WEORA) is a necessary condition to win a future war,among which the acquisition of knowledge about weapons and equipment is a great challenge. The main challenge is that the existing weapons and equipment data fails to carry out structured knowledge representation, and knowledge navigation based on natural language cannot efficiently support the WEORA. To solve above problem, this research proposes a method based on question answering(QA) of weapons and equipment knowledge graph(WEKG) to construct and navigate the knowledge related to weapons and equipment in the WEORA. This method firstly constructs the WEKG, and builds a neutral network-based QA system over the WEKG by means of semantic parsing for knowledge navigation. Finally, the method is evaluated and a chatbot on the QA system is developed for the WEORA. Our proposed method has good performance in the accuracy and efficiency of searching target knowledge, and can well assist the WEORA. 展开更多
关键词 operational requirement analysis weapons and equipment knowledge graph(WEKG) question answering(QA) neutral network
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基于Homer Pro的离网型光储系统容量配置分析
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作者 肖伟超 杨韩 +1 位作者 江期枫 卢淇民 《能源研究与管理》 2024年第3期98-103,111,共7页
为探索离网型光储柴混合发电系统中光储容量配置与月最低光照有效时间和年平均光照有效时间的关系,基于Homer Pro微电网软件对光储柴混合发电系统进行模拟,在用电特性相同的情况下,分析了中国某地、苏里南某地和秘鲁某地3个光照强度不... 为探索离网型光储柴混合发电系统中光储容量配置与月最低光照有效时间和年平均光照有效时间的关系,基于Homer Pro微电网软件对光储柴混合发电系统进行模拟,在用电特性相同的情况下,分析了中国某地、苏里南某地和秘鲁某地3个光照强度不同地区理论计算的光储容量配置和Homer Pro微电网软件衍生优化的净现值最低光储容量配置的关系。结果表明:3个不同光照强度地区采用月最低光照有效时间理论计算的储能容量与Homer Pro微电网软件衍生优化的储能容量比值为1.134、1.052和1.019,光伏容量比值为0.97、1.34和1.30;采用年均光照有效时间理论计算的储能容量与Homer Pro微电网软件衍生优化的储能容量比值为1.134、1.052和1.019,光伏容量比值为1.46、1.48和1.50;采用年均光照时间理论计算的光储容量配置与Homer Pro微电网软件衍生优化的光储容量配置比值较为稳定,所以采用月平均光照时间理论计算的储能容量乘以1.07、光伏容量乘以1.48可以得到趋近于Homer Pro微电网软件衍生优化的净现值最低的光储容量,这对于研究离网型光储柴混合发电系统的光储容量配置具有重要参考意义。 展开更多
关键词 微电网 储能 光伏 homer Pro微电网软件 优化配置 敏感性分析
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DPAL-BERT:A Faster and Lighter Question Answering Model
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作者 Lirong Yin Lei Wang +8 位作者 Zhuohang Cai Siyu Lu Ruiyang Wang Ahmed AlSanad Salman A.AlQahtani Xiaobing Chen Zhengtong Yin Xiaolu Li Wenfeng Zheng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第10期771-786,共16页
Recent advancements in natural language processing have given rise to numerous pre-training language models in question-answering systems.However,with the constant evolution of algorithms,data,and computing power,the ... Recent advancements in natural language processing have given rise to numerous pre-training language models in question-answering systems.However,with the constant evolution of algorithms,data,and computing power,the increasing size and complexity of these models have led to increased training costs and reduced efficiency.This study aims to minimize the inference time of such models while maintaining computational performance.It also proposes a novel Distillation model for PAL-BERT(DPAL-BERT),specifically,employs knowledge distillation,using the PAL-BERT model as the teacher model to train two student models:DPAL-BERT-Bi and DPAL-BERTC.This research enhances the dataset through techniques such as masking,replacement,and n-gram sampling to optimize knowledge transfer.The experimental results showed that the distilled models greatly outperform models trained from scratch.In addition,although the distilled models exhibit a slight decrease in performance compared to PAL-BERT,they significantly reduce inference time to just 0.25%of the original.This demonstrates the effectiveness of the proposed approach in balancing model performance and efficiency. 展开更多
关键词 DPAL-BERT question answering systems knowledge distillation model compression BERT Bi-directional long short-term memory(BiLSTM) knowledge information transfer PAL-BERT training efficiency natural language processing
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基于HOMER的海岛型微电网系统容量配置方法研究
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作者 马超 赵严树 孔丹 《电力设备管理》 2024年第12期90-92,共3页
由于海岛孤悬于海洋之中,至今众多岛屿供电依托于柴油发电机,造成了海岛环境污染,且发电经济性较低;为解决海岛用电困难,保护环境,建设离网型微电网系统保证用电可靠性,提高海岛居民的生活质量迫在眉睫,建设离网型微电网系统成为解决海... 由于海岛孤悬于海洋之中,至今众多岛屿供电依托于柴油发电机,造成了海岛环境污染,且发电经济性较低;为解决海岛用电困难,保护环境,建设离网型微电网系统保证用电可靠性,提高海岛居民的生活质量迫在眉睫,建设离网型微电网系统成为解决海岛居民用电难题的有效途径,而微电网系统各微源合理的容量配置,成为控制系统经济性关键性指标。 展开更多
关键词 分布式电源 homer 海岛微电网 容量配置
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基于HOMER仿真的风光储互补发电系统容量优化配置研究 被引量:6
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作者 左冲 贾彦 +4 位作者 孟克其劳 刘雪强 邢志泰 包道日娜 赵明智 《内蒙古电力技术》 2023年第1期21-25,共5页
以系统总成本最小为目标函数,基于可再生能源发电混合系统优化仿真软件(Hybrid Optimization Model for Electric Renewables,HOMER),针对某工业园区的风光资源数据和负荷情况,进行了设备成本和参数设定。在获得的配置方案中,对比分析... 以系统总成本最小为目标函数,基于可再生能源发电混合系统优化仿真软件(Hybrid Optimization Model for Electric Renewables,HOMER),针对某工业园区的风光资源数据和负荷情况,进行了设备成本和参数设定。在获得的配置方案中,对比分析了并网型风光储、风光互补以及风储、光储发电系统的优化配置方案,分析其弃电率和经济性,验证了风光储系统的优越性,最终得到并网型风光储互补发电系统总净现成本最小的配置,并对其各设备的年发电量、系统可靠性及经济性进行了分析,可为可再生能源多能互补微电网风光储系统容量优化配置的研究提供参考。 展开更多
关键词 风光储互补发电系统 homer仿真 容量优化 多能互补
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Analysis of community question-answering issues via machine learning and deep learning:State-of-the-art review 被引量:3
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作者 Pradeep Kumar Roy Sunil Saumya +2 位作者 Jyoti Prakash Singh Snehasish Banerjee Adnan Gutub 《CAAI Transactions on Intelligence Technology》 SCIE EI 2023年第1期95-117,共23页
Over the last couple of decades,community question-answering sites(CQAs)have been a topic of much academic interest.Scholars have often leveraged traditional machine learning(ML)and deep learning(DL)to explore the eve... Over the last couple of decades,community question-answering sites(CQAs)have been a topic of much academic interest.Scholars have often leveraged traditional machine learning(ML)and deep learning(DL)to explore the ever-growing volume of content that CQAs engender.To clarify the current state of the CQA literature that has used ML and DL,this paper reports a systematic literature review.The goal is to summarise and synthesise the major themes of CQA research related to(i)questions,(ii)answers and(iii)users.The final review included 133 articles.Dominant research themes include question quality,answer quality,and expert identification.In terms of dataset,some of the most widely studied platforms include Yahoo!Answers,Stack Exchange and Stack Overflow.The scope of most articles was confined to just one platform with few cross-platform investigations.Articles with ML outnumber those with DL.Nonetheless,the use of DL in CQA research is on an upward trajectory.A number of research directions are proposed. 展开更多
关键词 answer quality community question answering deep learning expert user machine learning question quality
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冠心病病人血清Homer1及LKB1水平与冠状动脉病变严重程度的相关性
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作者 邱洪 叶加宝 殷莺 《中西医结合心脑血管病杂志》 2023年第21期3988-3991,共4页
目的:探讨冠心病病人血清中Homer1及肝激酶B1(LKB1)水平与冠状动脉病变严重程度的相关性。方法:选取2021年1月—2021年12月在苏州市立医院确诊为冠心病并行冠状动脉造影检查的94例病人为病例组,并选取同期就诊的不明原因胸痛非冠心病病... 目的:探讨冠心病病人血清中Homer1及肝激酶B1(LKB1)水平与冠状动脉病变严重程度的相关性。方法:选取2021年1月—2021年12月在苏州市立医院确诊为冠心病并行冠状动脉造影检查的94例病人为病例组,并选取同期就诊的不明原因胸痛非冠心病病人42例为对照组。收集病人入院后的一般资料,并对血清Homer1及LKB1水平进行检测。根据Gensini积分分为3组,<20分为轻度组,20~55分为中度组,>55分为重度组。结果:病例组94例冠心病根据冠状动脉狭窄程度分为轻度组32例,中度组26例,重度组36例。轻度组、中度组与重度组血清Homer1水平均高于对照组,血清LKB1水平均低于对照组,重度组血清Homer1水平高于中度组、轻度组,血清LKB1水平低于中度组、轻度组,中度组血清Homer1水平高于轻度组,血清LKB1水平低于轻度组,差异均有统计学意义(P<0.05)。相关性分析结果显示,冠心病病人血清Homer1水平与Gensini积分呈正相关(r=0.603,P<0.05);冠心病病人血清LKB1水平与Gensini积分呈负相关(r=-0.659,P<0.05)。受试者工作特征(ROC)曲线分析结果显示,血清Homer1诊断冠心病的截断值为0.39 ng/mL,曲线下面积(AUC)为0.857,敏感度为79.79%,特异度为83.33%。血清LKB1诊断冠心病的截断值为3.81μg/L,AUC为0.694,敏感度为70.21%,特异度为73.80%。结论:冠心病病人血清Homer1水平高于不明原因胸痛非冠心病病人,且随冠状动脉病变程度加重而升高,LKB1水平低于不明原因胸痛非冠心病病人,且随冠状动脉病变程度加重而下降,血清Homer1及LKB1均对冠心病有预测价值。 展开更多
关键词 冠心病 homer1 肝激酶B1 冠状动脉病变 相关性
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ALBERT with Knowledge Graph Encoder Utilizing Semantic Similarity for Commonsense Question Answering 被引量:1
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作者 Byeongmin Choi YongHyun Lee +1 位作者 Yeunwoong Kyung Eunchan Kim 《Intelligent Automation & Soft Computing》 SCIE 2023年第4期71-82,共12页
Recently,pre-trained language representation models such as bidirec-tional encoder representations from transformers(BERT)have been performing well in commonsense question answering(CSQA).However,there is a problem th... Recently,pre-trained language representation models such as bidirec-tional encoder representations from transformers(BERT)have been performing well in commonsense question answering(CSQA).However,there is a problem that the models do not directly use explicit information of knowledge sources existing outside.To augment this,additional methods such as knowledge-aware graph network(KagNet)and multi-hop graph relation network(MHGRN)have been proposed.In this study,we propose to use the latest pre-trained language model a lite bidirectional encoder representations from transformers(ALBERT)with knowledge graph information extraction technique.We also propose to applying the novel method,schema graph expansion to recent language models.Then,we analyze the effect of applying knowledge graph-based knowledge extraction techniques to recent pre-trained language models and confirm that schema graph expansion is effective in some extent.Furthermore,we show that our proposed model can achieve better performance than existing KagNet and MHGRN models in CommonsenseQA dataset. 展开更多
关键词 Commonsense reasoning question answering knowledge graph language representation model
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Expert Recommendation in Community Question Answering via Heterogeneous Content Network Embedding 被引量:1
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作者 Hong Li Jianjun Li +2 位作者 Guohui Li Rong Gao Lingyu Yan 《Computers, Materials & Continua》 SCIE EI 2023年第4期1687-1709,共23页
ExpertRecommendation(ER)aims to identify domain experts with high expertise and willingness to provide answers to questions in Community Question Answering(CQA)web services.How to model questions and users in the hete... ExpertRecommendation(ER)aims to identify domain experts with high expertise and willingness to provide answers to questions in Community Question Answering(CQA)web services.How to model questions and users in the heterogeneous content network is critical to this task.Most traditional methods focus on modeling questions and users based on the textual content left in the community while ignoring the structural properties of heterogeneous CQA networks and always suffering from textual data sparsity issues.Recent approaches take advantage of structural proximities between nodes and attempt to fuse the textual content of nodes for modeling.However,they often fail to distinguish the nodes’personalized preferences and only consider the textual content of a part of the nodes in network embedding learning,while ignoring the semantic relevance of nodes.In this paper,we propose a novel framework that jointly considers the structural proximity relations and textual semantic relevance to model users and questions more comprehensively.Specifically,we learn topology-based embeddings through a hierarchical attentive network learning strategy,in which the proximity information and the personalized preference of nodes are encoded and preserved.Meanwhile,we utilize the node’s textual content and the text correlation between adjacent nodes to build the content-based embedding through a meta-context-aware skip-gram model.In addition,the user’s relative answer quality is incorporated to promote the ranking performance.Experimental results show that our proposed framework consistently and significantly outperforms the state-of-the-art baselines on three real-world datasets by taking the deep semantic understanding and structural feature learning together.The performance of the proposed work is analyzed in terms of MRR,P@K,and MAP and is proven to be more advanced than the existing methodologies. 展开更多
关键词 Heterogeneous network learning expert recommendation semantic representation community question answering
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东莨菪碱调节SIN3A表达对水杨酸诱导耳鸣大鼠mGluR5/Homer1信号通路的影响
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作者 颜微微 邓可斌 《河北医药》 CAS 2023年第19期2933-2936,共4页
目的探究东莨菪碱(SPL)调节SIN3A表达对水杨酸诱导的耳鸣大鼠mGluR5/Homer1信号通路的影响。方法将50只大鼠分为对照组、模型组、阳性组、SPL低、高剂量组,每组10只。分别对5组大鼠进行惊跳反射前脉冲抑制(PPI)检测和听性脑干反应(ABR)... 目的探究东莨菪碱(SPL)调节SIN3A表达对水杨酸诱导的耳鸣大鼠mGluR5/Homer1信号通路的影响。方法将50只大鼠分为对照组、模型组、阳性组、SPL低、高剂量组,每组10只。分别对5组大鼠进行惊跳反射前脉冲抑制(PPI)检测和听性脑干反应(ABR)检测;RT-qPCR检测大鼠听皮层组织中SIN3A的mRNA水平;Western blot检测大鼠听皮层组织中SIN3A、mGluR5、Homer1蛋白的表达。结果与对照组相比,模型组大鼠的前脉冲抑制率、ABR阈值、mGluR5和Homer1的蛋白表达均显著升高(P<0.05),SIN3A mRNA水平和蛋白表达降低(P<0.05);与模型组相比,阳性组和SPL处理组大鼠的前脉冲抑制率、ABR阈值、mGluR5和Homer1的蛋白表达均显著降低(P<0.05),SIN3A mRNA水平和蛋白表达升高(P<0.05)。结论SPL可以通过促进SIN3A的表达,来抑制水杨酸诱导的耳鸣大鼠mGluR5/Homer1信号通路。 展开更多
关键词 东莨菪碱 SIN3A mGluR5/homer1信号通路 耳鸣大鼠
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Overview and Comparison to Words of Antiquity Through Homeric Epics
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作者 Sema SANDALCI Berna CACAN 《Journal of Literature and Art Studies》 2017年第12期1567-1573,共7页
This study aims to examine the relations between languages of antiquity and some words in Homer's epics, Iliad and Odyssey, that are considered the first written texts and important in terms of the richness of Greek ... This study aims to examine the relations between languages of antiquity and some words in Homer's epics, Iliad and Odyssey, that are considered the first written texts and important in terms of the richness of Greek vocabulary. Although the words in Homeric epics carry a value for ancient Anatolia, there are no studies in this field in our eotmtry. For this purpose, with the help of words we have, we will focus on: (a) bond of these words with Hittite, partially (b) some archaic qualities for some Latin words, developed later and also continued of some ground and phrases in the everyday life in the same region for centuries on the language of the people depending on the oral transmission. At the end of the study, we will discuss the changes of the words in philological level as well as in terms of the letter, sounds and meaning by used words in Homer's epics as will be explained in this study. 展开更多
关键词 homer WORDS linguistic bonds archaic marks today marks
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A Solar Energy System Design for Green Hydrogen Production in South-Western Nigeria, Lagos State, Using HOMER & ASPEN
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作者 Wilson Fidelis Ekpotu Joseph Taiwo Akintola +1 位作者 Martins Chineme Obialor Philemon Chukwuebuka Udom 《Open Journal of Optimization》 2023年第2期72-97,共26页
Solar system design for green hydrogen production has become the most prominent renewable energy research area, and this has also actively fueled the desire to achieve net-zero emissions. Hydrogen is a promising energ... Solar system design for green hydrogen production has become the most prominent renewable energy research area, and this has also actively fueled the desire to achieve net-zero emissions. Hydrogen is a promising energy carrier because it possesses more energy capacity than fossil fuels and the abundant nature of renewable energy systems can be utilized for green hydrogen production. However, the design of an optimized electrical energy system required for hydrogen production is crucial. Solar energy is indeed beneficial for green hydrogen production and this research designed, discussed, and provided high-level research on HOMER design for green hydrogen production and deployed the energy requirement with ASPEN Plus to optimize the energy system, while also incorporating fuzzy logic and PID control approaches. In addition, a promising technology with a high potential for renewable hydrogen energy is the proton exchange membrane (PEM) electrolyzer. Since its cathode (hydrogen electrode) may be operated over a wide range of pressure, a control process must be added to the system in order for it to work dynamically efficiently. This system can be characterized as an analogous circuit that consists of a resistor, capacitor, and reversible voltage. As a result, this research work also explores the Fuzzy-PID control of the PEM electrolysis system. Both the PID and Fuzzy Logic control systems were simulated using the control simulation program Matlab R2018a, which makes use of Matlab script files and the Simulink environment. Based on the circuit diagram, a transfer function that represents the mathematical model of the plant was created, and the PEM electrolysis control system is determined to be highly significant and applicable to the two control systems. The PI controller, however, has a 30.8% overshoot deficit, but when the fuzzy control system is compared to the PID controller, it is found that the fuzzy control system achieves stability more quickly, demonstrating its benefit over PID. 展开更多
关键词 homer Solar Design Solar Energy Renewable Energy Green Hydrogen Production Fuzzy Logic homer
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