BACKGROUND Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately life-threatening.Patients usually experience depression and anxiety,which affect their sleep qualit...BACKGROUND Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately life-threatening.Patients usually experience depression and anxiety,which affect their sleep quality and post-traumatic growth levels.AIM To investigate the effects of sepsis,a one-hour bundle(H1B)management was combined with psychological intervention in patients with sepsis.METHODS This retrospective analysis included 300 patients with sepsis who were admitted to Henan Provincial People’s Hospital between June 2022 and June 2023.According to different intervention methods,the participants were divided into a simple group(SG,n=150)and combined group(CG,n=150).H1B management was used in the SG and H1B management combined with psychological intervention was used in the CG.The changes of negative emotion,sleep quality and post-traumatic growth and prognosis were compared between the two groups before(T0)and after(T1)intervention.RESULTS After intervention(T1),the scores of the Hamilton Anxiety scale and Hamilton Depression scale in the CG were significantly lower than those in the SG(P<0.001).Sleep time,sleep quality,sleep efficiency,daytime dysfunction,sleep disturbance dimension score,and the total score in the CG were significantly lower than those in the SG(P<0.001).The appreciation of life,mental changes,relationship with others,personal strength dimension score,and total score of the CG were significantly higher than those of the SG(P<0.001).The scores for mental health,general health status,physiological function,emotional function,physical pain,social function,energy,and physiological function in the CG were significantly higher than those in the SG(P<0.001).The mechanical ventilation time,intensive care unit stay time,and 28-d mortality of the CG were significantly lower than those of the SG(P<0.05).CONCLUSION H1B management combined with psychological intervention can effectively alleviate the negative emotions of patients with sepsis and increase their quality of sleep and life.展开更多
Artificial nest boxes are placed to attract birds to nest and breed in a specific location,and they are widely used in avian ecology research and in the attraction of insectivorous birds.There is evidence that artific...Artificial nest boxes are placed to attract birds to nest and breed in a specific location,and they are widely used in avian ecology research and in the attraction of insectivorous birds.There is evidence that artificial nest boxes can adversely affect breeding fitness but no great focus has been placed on this issue by researchers.Therefore,we retrieved 321 research papers regarding artificial nest boxes published from 2003 to 2022 and used the'Biblioshiny'program to extract and integrate keywords;we then summarized the adverse effects of artificial nest boxes on avian breeding success.The studies highlighted many drawbacks and misuses in the designing and placement of nest boxes;furthermore,bird attraction was decreased by their inappropriate selection,thus reducing breeding success.Regarding nest box production,there were shortcomings in the construction material,color,smell,and structural design of the boxes used.Nest boxes were also placed at inappropriate densities,locations,orientations,heights,and managed incorrectly.Finally,we propose suggestions for more efficient and safer artificial nest boxes for future use in avian ecology research and bird conservation.展开更多
Utilization of urban underground space has become a vital approach to alleviate the strain on urban land resources,and to optimize the structure and pattem of the city.It is also very important to improve the city env...Utilization of urban underground space has become a vital approach to alleviate the strain on urban land resources,and to optimize the structure and pattem of the city.It is also very important to improve the city environment,build livable city and increase the capacity of the city.Based on the analysis of existing evaluation methods and their problems,a method for evaluating underground space resources based on a negative list of adverse factors affecting underground space development is proposed,to be primarily used in urban planning stages.A list of the adverse factors is established,including limiting factors,constraining factors and influencing factors.Taking Xi'an as an example,using a geographical information system platform,a negative list of adverse factors for the underground space resources in Xi'an City are evaluated,and preventive measures are proposed.Natural resources,exploitable resources,and the potential growth of exploitable underground space resources are evaluated.Underground space assessment in the different development stages of the city,collaborative utilization and safety evaluation for multiple subsurface resources,environmental impact and assessment,as well as evaluation methods based on big data and intelligent optimization algorithms are all discussed with the aim of serving city planning and construction.展开更多
The reformation of equity-split on April 29th, 2005, has promoted market value management and created the necessary conditions for market value management. With the purpose of stabilizing and enhancing corporate marke...The reformation of equity-split on April 29th, 2005, has promoted market value management and created the necessary conditions for market value management. With the purpose of stabilizing and enhancing corporate market value and realizing stockholders' wealth maximization, the market value management becomes especially important for all listed companies. This paper begins with the general introduction of market value management including its definition, contents and performance evaluation systems, appraises the best 10 market value management listed companies during 2007-2008. Then analyzes the benefits of the market value management on the Guizhou Maotai which has gained great achievements on market value management, and finally draw conclusions about market value management's general effects on listed companies.展开更多
This paper selects 11 Chinese listed companies as the sample and compares the effect of premanagement buyouts and post-management buyouts (hereafter MBO). The authors evaluate the effects of MBO according to the cha...This paper selects 11 Chinese listed companies as the sample and compares the effect of premanagement buyouts and post-management buyouts (hereafter MBO). The authors evaluate the effects of MBO according to the change of earnings capacity, management ability, debt paying ability, development ability and capital structure. The result shows that the obvious change does not take place in earnings capacity of the company and management ability, but the development ability of the company improves notably, and most of companies have taken advantage of financial leverage withir two years of post-MBO.展开更多
In this paper, we conduct theoretical research on the listed company financial management mode innovation trend under the registration system background. Cycles of the core macroeconomic environment is each enterprise...In this paper, we conduct theoretical research on the listed company financial management mode innovation trend under the registration system background. Cycles of the core macroeconomic environment is each enterprise that must face the reality of the problem, for the listed companies, the macroeconomic environment is set up financial strategy need to consider problems listed companies must be good at making scientific financial strategy to avoid and reduce the negative influence of the macro-economic changes. Under the condition of the socialist market economy, as the listed company financial management is to maximize the value of the company ultimate goal. Our research combines the registration system background to propose the novel perspective that is meaningful.展开更多
In recent years, the number of the listing corporations in China is increasing, and the promotion of the national economic development is also more obvious. But in the process, because of the short time onto the marke...In recent years, the number of the listing corporations in China is increasing, and the promotion of the national economic development is also more obvious. But in the process, because of the short time onto the market and the lack of the expvrience, some of the listed companies also cannot be compared with the enterprises in the western developed countries in a large extent. Especially in the aspect of the financial management, there are many defects. For example, the control efforts of the financial risks arc inadequate, and the awareness of the management personnel and the employees on the risks is weak, and so on In this case, the listed corporations must strengthen the management of the company's financial risks, develop the more comprehensive financial risk managernent system, and thus ensurc that the companies can have the healthy, stable and sustainable development.展开更多
China (Shanghai) pilot free trade zone (FTZ)formally approved by the state council on August 22, 2013, was officially opened on September 29. It is the important measures to comprehensiw',ly deepen reforms and op...China (Shanghai) pilot free trade zone (FTZ)formally approved by the state council on August 22, 2013, was officially opened on September 29. It is the important measures to comprehensiw',ly deepen reforms and open still wider to the outside world in China. Exploring "pre-establistnnent national treatment" and "negative list" management mode is a feature of the free trade zone of Shanghai, which is adapt to economic globalization, to win the international competition o fthe initiative a qualitative leap.展开更多
This paper overviews earnings management incentive of listed companies and finds the incentives of cost in transactions with stockholders, a comparative performance advantage and a rational response to that market beh...This paper overviews earnings management incentive of listed companies and finds the incentives of cost in transactions with stockholders, a comparative performance advantage and a rational response to that market behavior which is anticipated. This paper tells us that even if there were no agency problems, earnings management should exist all the time.展开更多
Highway engineering requires higher investment and requires a long time of management compared to other construction projects.There are many factors that affect the project cost during the engineering construction sta...Highway engineering requires higher investment and requires a long time of management compared to other construction projects.There are many factors that affect the project cost during the engineering construction stage of a highway.The effective development of cost management in the construction phase of highway engineering under the list pricing model can avoid unnecessary waste and help control the cost of highway engineering.However,there are still some problems in the development of cost management in the construction phase of highway engineering,which will affect the role of the list-based pricing mode in cost management.This paper explores and analyzes the advantages of the list pricing model and the problems existing in the cost management of the highway engineering construction stage under the list pricing model,and proposes effective management strategies to improve cost management of the highway engineering construction stage.展开更多
Rural community is an effective way to simultaneously achieve manage- ment of ecological resources and protection of natural resources, depending on its management mode based on cooperation, motivation, local experien...Rural community is an effective way to simultaneously achieve manage- ment of ecological resources and protection of natural resources, depending on its management mode based on cooperation, motivation, local experiences and extensi- ble boundary. In the research, carbon emission in community is a kind of ecological resources and negative externality is the cause of increase of rural carbon emission. Compared with governmental ruling and marketing approach, community manage- ment mode proves more effective to solve the problem of negative externality of carbon emission in community. Furthermore, rural carbon, emission was analyzed in detail on basis of community management mode and extending mode of carbon emis- sion in rural areas. In addition, some policies and suggestions were proposed to im- prove community management of carbon emission in rural areas, providing an ef- fective way for low-carbon economy in rural areas.展开更多
Corporate mergers and acquisitions(M&As)are subject to skewed logic due to excessive government regulation.China is progressively adopting the Market Access Negative List(MANL)pilot to transfer the power of resour...Corporate mergers and acquisitions(M&As)are subject to skewed logic due to excessive government regulation.China is progressively adopting the Market Access Negative List(MANL)pilot to transfer the power of resource allocation from the government to the market.Using the DID method,we examine the impact of relaxing market access regulation on firms’M&A behavior against China’s institutional background and the M&A events of listed companies from 2012 to 2019.The MANL significantly increases firms’M&A tendency and amount and strengthens the competitive adequacy and fairness of market-oriented M&A decisions.Post-M&A financial performance does not increase,but human capital productivity,innovation effectiveness and total factor productivity do,demonstrating the dynamic balance of profit and efficiency in M&As.展开更多
BACKGROUND Fournier's gangrene(FG)is a serious,aggressive and often deadly polymicrobial infection of the soft tissues of the perineum,the rectum and the external genital organs.It is an anatomical subcategory of ...BACKGROUND Fournier's gangrene(FG)is a serious,aggressive and often deadly polymicrobial infection of the soft tissues of the perineum,the rectum and the external genital organs.It is an anatomical subcategory of necrotizing fasciitis,which has a similar etiology and treatment strategy.CASE SUMMARY A 60-year-old man was admitted to the hospital during severe acute respiratory syndrome coronavirus 2 pandemic with complaints of fever up to 38.9°C,abdominal pain,and edema of the scrotum,the penis,the perineum,and the right gluteal region for 2 d.Computed tomography of the abdomen and the pelvis revealed extensive inflammatory infiltrations of the subcutaneous tissue of the hypogastrium,and the penis;along with liquefaction and presence of gas in the subcutaneous tissues of the scrotum,the perineum,and the right gluteal region.The patient was diagnosed with FG,and was urgently qualified to undergo surgery in the Department of Urology.After performing the necessary examinations,a resection of the necrotic tissues with bilateral orchiectomy and excision of the penile and scrotal skin was performed.After surgery,he was transferred to the intensive care unit for further management.CONCLUSION Early management prevents the resection of the other organs by inhibiting the contiguous spread of infection.展开更多
This review begins with an introduction of groundwater resources in China and their distribution characteristic,followed by an elaboration of the exploitation and utilization of groundwater and the negative environmen...This review begins with an introduction of groundwater resources in China and their distribution characteristic,followed by an elaboration of the exploitation and utilization of groundwater and the negative environmental effects from groundwater overexploitation, and a description of the existing groundwater protection and management measures. At last, the existing problems in groundwater protection and management, with some suggestions, are presented.展开更多
According to the current problems of higher education management informatization,this paper puts forward a development scheme of collaborative platform on education management.The main technology includes three parts...According to the current problems of higher education management informatization,this paper puts forward a development scheme of collaborative platform on education management.The main technology includes three parts.First,integrate the distributed database and use two-tier linked list to realize dynamic data access.Second,the relation graph is used to display the data of each student,so as to realize the visual sharing of data.Third,realize the collaborative information security mechanism from three aspects to ensure the legal sharing of data.Finally,the platform development is completed with Java.It can help to improve the effectiveness of educating students.展开更多
Background: Management of N0 neck in patients with head and neck squamous cell carcinoma (HNSCC) remains a subject of continued debate. Prognostic biomarkers might provide useful information for treatment selection an...Background: Management of N0 neck in patients with head and neck squamous cell carcinoma (HNSCC) remains a subject of continued debate. Prognostic biomarkers might provide useful information for treatment selection and adjustment. Objective: To evaluate the prognostic relevance of VEGF-A and Ki-67 expression to types of neck management. Methods: This prospective study included 140 patients with HNSCC. Tumor expression of VEGF-A and Ki-67 was measured by immunohistochemistry. Based on tumor size and site criteria, 88 patients with N0 neck were categorized as high, intermediate and low risk of subclinical neck diseases and accordingly treated by elective neck dissection (END), irradiation (ENI) and observation. Adjuvant treatment was given to tumor with close or positive margins. A multivariate Cox regression model was used to identify prognostic factors. Impact of biomarker expression, treatment type and risk category on disease-specific survival (DSS) in the setting of N0 neck were evaluated by Kaplan-Meier survival and adjusted hazard ratio (HR). Results: Coexpression of VEGF-A and Ki-67 (HR = 2.351, p = 0.021) and positive node (HR = 2.301, p = 0.009) were independent prognostic factors for HNSCC. In the setting of N0 neck, marker coexpression has an HR of 4.97 (p = 0.004) independent of treatment modalities (p = 0.069) and risk categories (p = 0.971). Alternatively, neither marker expression was predictive of a better treatment outcome for END compared to ENI, as suggested by the odds of patients being survived 15.4 times greater (p = 0.01) and the 5-year DSS rates of 85.1% versus 44.7% (p = 0.008). Conclusion: Coexpression of VEGF-A and Ki-67 is a suggestion of tumor microinvasiveness in addition to risk of lymph node metastasis and may indicate the need of adjuvant treatment despite negative tumor margins. Neither marker expression serves an indicator for the selection of END over ENI in neck management.展开更多
基金Supported by Key R&D and Promotion Special Project(Science and Technology Research)in Henan Province in 2023,No.232102310089.
文摘BACKGROUND Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately life-threatening.Patients usually experience depression and anxiety,which affect their sleep quality and post-traumatic growth levels.AIM To investigate the effects of sepsis,a one-hour bundle(H1B)management was combined with psychological intervention in patients with sepsis.METHODS This retrospective analysis included 300 patients with sepsis who were admitted to Henan Provincial People’s Hospital between June 2022 and June 2023.According to different intervention methods,the participants were divided into a simple group(SG,n=150)and combined group(CG,n=150).H1B management was used in the SG and H1B management combined with psychological intervention was used in the CG.The changes of negative emotion,sleep quality and post-traumatic growth and prognosis were compared between the two groups before(T0)and after(T1)intervention.RESULTS After intervention(T1),the scores of the Hamilton Anxiety scale and Hamilton Depression scale in the CG were significantly lower than those in the SG(P<0.001).Sleep time,sleep quality,sleep efficiency,daytime dysfunction,sleep disturbance dimension score,and the total score in the CG were significantly lower than those in the SG(P<0.001).The appreciation of life,mental changes,relationship with others,personal strength dimension score,and total score of the CG were significantly higher than those of the SG(P<0.001).The scores for mental health,general health status,physiological function,emotional function,physical pain,social function,energy,and physiological function in the CG were significantly higher than those in the SG(P<0.001).The mechanical ventilation time,intensive care unit stay time,and 28-d mortality of the CG were significantly lower than those of the SG(P<0.05).CONCLUSION H1B management combined with psychological intervention can effectively alleviate the negative emotions of patients with sepsis and increase their quality of sleep and life.
基金supported by the National Natural Science Foundation of China(Grant No.32170485,31501867)the Fundamental Research Funds for the Central Universities(Grant No.2572022BE02)。
文摘Artificial nest boxes are placed to attract birds to nest and breed in a specific location,and they are widely used in avian ecology research and in the attraction of insectivorous birds.There is evidence that artificial nest boxes can adversely affect breeding fitness but no great focus has been placed on this issue by researchers.Therefore,we retrieved 321 research papers regarding artificial nest boxes published from 2003 to 2022 and used the'Biblioshiny'program to extract and integrate keywords;we then summarized the adverse effects of artificial nest boxes on avian breeding success.The studies highlighted many drawbacks and misuses in the designing and placement of nest boxes;furthermore,bird attraction was decreased by their inappropriate selection,thus reducing breeding success.Regarding nest box production,there were shortcomings in the construction material,color,smell,and structural design of the boxes used.Nest boxes were also placed at inappropriate densities,locations,orientations,heights,and managed incorrectly.Finally,we propose suggestions for more efficient and safer artificial nest boxes for future use in avian ecology research and bird conservation.
基金This research is supported by National Key Research and Development Project,Ministry of Science and Technology of the People’s Republic of China(2018YFC1504700).
文摘Utilization of urban underground space has become a vital approach to alleviate the strain on urban land resources,and to optimize the structure and pattem of the city.It is also very important to improve the city environment,build livable city and increase the capacity of the city.Based on the analysis of existing evaluation methods and their problems,a method for evaluating underground space resources based on a negative list of adverse factors affecting underground space development is proposed,to be primarily used in urban planning stages.A list of the adverse factors is established,including limiting factors,constraining factors and influencing factors.Taking Xi'an as an example,using a geographical information system platform,a negative list of adverse factors for the underground space resources in Xi'an City are evaluated,and preventive measures are proposed.Natural resources,exploitable resources,and the potential growth of exploitable underground space resources are evaluated.Underground space assessment in the different development stages of the city,collaborative utilization and safety evaluation for multiple subsurface resources,environmental impact and assessment,as well as evaluation methods based on big data and intelligent optimization algorithms are all discussed with the aim of serving city planning and construction.
文摘The reformation of equity-split on April 29th, 2005, has promoted market value management and created the necessary conditions for market value management. With the purpose of stabilizing and enhancing corporate market value and realizing stockholders' wealth maximization, the market value management becomes especially important for all listed companies. This paper begins with the general introduction of market value management including its definition, contents and performance evaluation systems, appraises the best 10 market value management listed companies during 2007-2008. Then analyzes the benefits of the market value management on the Guizhou Maotai which has gained great achievements on market value management, and finally draw conclusions about market value management's general effects on listed companies.
文摘This paper selects 11 Chinese listed companies as the sample and compares the effect of premanagement buyouts and post-management buyouts (hereafter MBO). The authors evaluate the effects of MBO according to the change of earnings capacity, management ability, debt paying ability, development ability and capital structure. The result shows that the obvious change does not take place in earnings capacity of the company and management ability, but the development ability of the company improves notably, and most of companies have taken advantage of financial leverage withir two years of post-MBO.
文摘In this paper, we conduct theoretical research on the listed company financial management mode innovation trend under the registration system background. Cycles of the core macroeconomic environment is each enterprise that must face the reality of the problem, for the listed companies, the macroeconomic environment is set up financial strategy need to consider problems listed companies must be good at making scientific financial strategy to avoid and reduce the negative influence of the macro-economic changes. Under the condition of the socialist market economy, as the listed company financial management is to maximize the value of the company ultimate goal. Our research combines the registration system background to propose the novel perspective that is meaningful.
文摘In recent years, the number of the listing corporations in China is increasing, and the promotion of the national economic development is also more obvious. But in the process, because of the short time onto the market and the lack of the expvrience, some of the listed companies also cannot be compared with the enterprises in the western developed countries in a large extent. Especially in the aspect of the financial management, there are many defects. For example, the control efforts of the financial risks arc inadequate, and the awareness of the management personnel and the employees on the risks is weak, and so on In this case, the listed corporations must strengthen the management of the company's financial risks, develop the more comprehensive financial risk managernent system, and thus ensurc that the companies can have the healthy, stable and sustainable development.
文摘China (Shanghai) pilot free trade zone (FTZ)formally approved by the state council on August 22, 2013, was officially opened on September 29. It is the important measures to comprehensiw',ly deepen reforms and open still wider to the outside world in China. Exploring "pre-establistnnent national treatment" and "negative list" management mode is a feature of the free trade zone of Shanghai, which is adapt to economic globalization, to win the international competition o fthe initiative a qualitative leap.
文摘This paper overviews earnings management incentive of listed companies and finds the incentives of cost in transactions with stockholders, a comparative performance advantage and a rational response to that market behavior which is anticipated. This paper tells us that even if there were no agency problems, earnings management should exist all the time.
文摘Highway engineering requires higher investment and requires a long time of management compared to other construction projects.There are many factors that affect the project cost during the engineering construction stage of a highway.The effective development of cost management in the construction phase of highway engineering under the list pricing model can avoid unnecessary waste and help control the cost of highway engineering.However,there are still some problems in the development of cost management in the construction phase of highway engineering,which will affect the role of the list-based pricing mode in cost management.This paper explores and analyzes the advantages of the list pricing model and the problems existing in the cost management of the highway engineering construction stage under the list pricing model,and proposes effective management strategies to improve cost management of the highway engineering construction stage.
文摘Rural community is an effective way to simultaneously achieve manage- ment of ecological resources and protection of natural resources, depending on its management mode based on cooperation, motivation, local experiences and extensi- ble boundary. In the research, carbon emission in community is a kind of ecological resources and negative externality is the cause of increase of rural carbon emission. Compared with governmental ruling and marketing approach, community manage- ment mode proves more effective to solve the problem of negative externality of carbon emission in community. Furthermore, rural carbon, emission was analyzed in detail on basis of community management mode and extending mode of carbon emis- sion in rural areas. In addition, some policies and suggestions were proposed to im- prove community management of carbon emission in rural areas, providing an ef- fective way for low-carbon economy in rural areas.
基金support obtained from the National Natural Science Foundation of China(Project No.72172156/G0206)for this study.
文摘Corporate mergers and acquisitions(M&As)are subject to skewed logic due to excessive government regulation.China is progressively adopting the Market Access Negative List(MANL)pilot to transfer the power of resource allocation from the government to the market.Using the DID method,we examine the impact of relaxing market access regulation on firms’M&A behavior against China’s institutional background and the M&A events of listed companies from 2012 to 2019.The MANL significantly increases firms’M&A tendency and amount and strengthens the competitive adequacy and fairness of market-oriented M&A decisions.Post-M&A financial performance does not increase,but human capital productivity,innovation effectiveness and total factor productivity do,demonstrating the dynamic balance of profit and efficiency in M&As.
文摘BACKGROUND Fournier's gangrene(FG)is a serious,aggressive and often deadly polymicrobial infection of the soft tissues of the perineum,the rectum and the external genital organs.It is an anatomical subcategory of necrotizing fasciitis,which has a similar etiology and treatment strategy.CASE SUMMARY A 60-year-old man was admitted to the hospital during severe acute respiratory syndrome coronavirus 2 pandemic with complaints of fever up to 38.9°C,abdominal pain,and edema of the scrotum,the penis,the perineum,and the right gluteal region for 2 d.Computed tomography of the abdomen and the pelvis revealed extensive inflammatory infiltrations of the subcutaneous tissue of the hypogastrium,and the penis;along with liquefaction and presence of gas in the subcutaneous tissues of the scrotum,the perineum,and the right gluteal region.The patient was diagnosed with FG,and was urgently qualified to undergo surgery in the Department of Urology.After performing the necessary examinations,a resection of the necrotic tissues with bilateral orchiectomy and excision of the penile and scrotal skin was performed.After surgery,he was transferred to the intensive care unit for further management.CONCLUSION Early management prevents the resection of the other organs by inhibiting the contiguous spread of infection.
基金Major Programs of the Ministry of Rail-ways during the 11th Five-Year Plan Period (No.2005Z007)
文摘This review begins with an introduction of groundwater resources in China and their distribution characteristic,followed by an elaboration of the exploitation and utilization of groundwater and the negative environmental effects from groundwater overexploitation, and a description of the existing groundwater protection and management measures. At last, the existing problems in groundwater protection and management, with some suggestions, are presented.
基金The authors received a specific funding with No.218051360020XN113 for this study。
文摘According to the current problems of higher education management informatization,this paper puts forward a development scheme of collaborative platform on education management.The main technology includes three parts.First,integrate the distributed database and use two-tier linked list to realize dynamic data access.Second,the relation graph is used to display the data of each student,so as to realize the visual sharing of data.Third,realize the collaborative information security mechanism from three aspects to ensure the legal sharing of data.Finally,the platform development is completed with Java.It can help to improve the effectiveness of educating students.
文摘Background: Management of N0 neck in patients with head and neck squamous cell carcinoma (HNSCC) remains a subject of continued debate. Prognostic biomarkers might provide useful information for treatment selection and adjustment. Objective: To evaluate the prognostic relevance of VEGF-A and Ki-67 expression to types of neck management. Methods: This prospective study included 140 patients with HNSCC. Tumor expression of VEGF-A and Ki-67 was measured by immunohistochemistry. Based on tumor size and site criteria, 88 patients with N0 neck were categorized as high, intermediate and low risk of subclinical neck diseases and accordingly treated by elective neck dissection (END), irradiation (ENI) and observation. Adjuvant treatment was given to tumor with close or positive margins. A multivariate Cox regression model was used to identify prognostic factors. Impact of biomarker expression, treatment type and risk category on disease-specific survival (DSS) in the setting of N0 neck were evaluated by Kaplan-Meier survival and adjusted hazard ratio (HR). Results: Coexpression of VEGF-A and Ki-67 (HR = 2.351, p = 0.021) and positive node (HR = 2.301, p = 0.009) were independent prognostic factors for HNSCC. In the setting of N0 neck, marker coexpression has an HR of 4.97 (p = 0.004) independent of treatment modalities (p = 0.069) and risk categories (p = 0.971). Alternatively, neither marker expression was predictive of a better treatment outcome for END compared to ENI, as suggested by the odds of patients being survived 15.4 times greater (p = 0.01) and the 5-year DSS rates of 85.1% versus 44.7% (p = 0.008). Conclusion: Coexpression of VEGF-A and Ki-67 is a suggestion of tumor microinvasiveness in addition to risk of lymph node metastasis and may indicate the need of adjuvant treatment despite negative tumor margins. Neither marker expression serves an indicator for the selection of END over ENI in neck management.