Multimodal monitoring(MMM)in the intensive care unit(ICU)has become increasingly sophisticated with the integration of neurophysical principles.However,the challenge remains to select and interpret the most appropriat...Multimodal monitoring(MMM)in the intensive care unit(ICU)has become increasingly sophisticated with the integration of neurophysical principles.However,the challenge remains to select and interpret the most appropriate combination of neuromonitoring modalities to optimize patient outcomes.This manuscript reviewed current neuromonitoring tools,focusing on intracranial pressure,cerebral electrical activity,metabolism,and invasive and noninvasive autoregulation moni-toring.In addition,the integration of advanced machine learning and data science tools within the ICU were discussed.Invasive monitoring includes analysis of intracranial pressure waveforms,jugular venous oximetry,monitoring of brain tissue oxygenation,thermal diffusion flowmetry,electrocorticography,depth electroencephalography,and cerebral microdialysis.Noninvasive measures include transcranial Doppler,tympanic membrane displacement,near-infrared spectroscopy,optic nerve sheath diameter,positron emission tomography,and systemic hemodynamic monitoring including heart rate variability analysis.The neurophysical basis and clinical relevance of each method within the ICU setting were examined.Machine learning algorithms have shown promise by helping to analyze and interpret data in real time from continuous MMM tools,helping clinicians make more accurate and timely decisions.These algorithms can integrate diverse data streams to generate predictive models for patient outcomes and optimize treatment strategies.MMM,grounded in neurophysics,offers a more nuanced understanding of cerebral physiology and disease in the ICU.Although each modality has its strengths and limitations,its integrated use,especially in combination with machine learning algorithms,can offer invaluable information for individualized patient care.展开更多
In accounts of the development and progression of psychophysical disorders such as Hereditary Spastic Paraplegia (HSP) and Facioscapulohumeral Muscular Dystrophy (FSHD), the role of beliefs, perceptions, and behaviora...In accounts of the development and progression of psychophysical disorders such as Hereditary Spastic Paraplegia (HSP) and Facioscapulohumeral Muscular Dystrophy (FSHD), the role of beliefs, perceptions, and behavioral patterns has often been overlooked in favor of a genetically determinist paradigm. This paper explores the impact of NeuroPhysics Treatment (NPT) on patients with HSP and FSHD. Through a series of clinical case reports, I demonstrate how intensive four-day NPT sessions can lead to rapid restoration of lost functions, challenging the conventional view of these disorders. I hypothesize that, by modulating the patient’s perceptual and behavioral frameworks, NPT facilitates the emergence of healthier patterns, suggesting that environmental and psychological factors significantly influence the manifestation and management of these conditions. These findings indicate that the role of genetic inheritance may be overstated and that beliefs and perceptions could play a crucial role in the evolution of psychophysical disorders. The implications of this research extend beyond the traditional treatment paradigms, advocating for a more holistic approach that integrates the psychophysical dimensions of health and challenges the deterministic perspective of genetic inheritance.展开更多
This paper offers a critical examination of“neurophysicalism”,namely the thesis that phenomenal consciousness is nothing over and above neural states(processes)in the brain,in light of empirical researches on some“...This paper offers a critical examination of“neurophysicalism”,namely the thesis that phenomenal consciousness is nothing over and above neural states(processes)in the brain,in light of empirical researches on some“altered states of consciousness”(lucid dreaming and mystical experiences).By probing the implication of“neurophysicalism”in the empirical world,it is argued that“neurophysicalism”is committed to the principle of“psycho-neural isomorphism”to the effect that the structural features of any state(process)of phenomenal consciousness are isomorphic to the physical structural features of the corresponding“neural correlate”of that state(process)of consciousness.However,in the case of lucid dreaming and mystical experiences,the principle of“psycho-neural isomorphism”does not hold true,which implies that there is a structural mismatch between the phenomenal structure and the physical structure of the corresponding“neural correlates”.The phenomenal structure of lucid dreaming is characterized by features that are unconstant,bizarre,and uncertain,whereas the“neural correlates”of lucid dreaming possess physical structure that is deterministic(with low entropy).In the case of mystical experiences,although the phenomenal structure is characterized by strong realness and constancy,the physical structure of the corresponding“neural correlates”is chaotic and disordered(with high entropy).The phenomenon of structural mismatch challenges“neurophysicalism”in the empirical world.Some possible objections from“neurophysicalists”are examined,including“neural misrepresentation”,“errors of introspective reports”,and“neural correlates not being detected”,none of which withstands scrutiny.The author concludes by proposing an alternative metaphysics for consciousness that takes the brain to be a“valve”“filtering”and constraining unbound consciousness.展开更多
文摘Multimodal monitoring(MMM)in the intensive care unit(ICU)has become increasingly sophisticated with the integration of neurophysical principles.However,the challenge remains to select and interpret the most appropriate combination of neuromonitoring modalities to optimize patient outcomes.This manuscript reviewed current neuromonitoring tools,focusing on intracranial pressure,cerebral electrical activity,metabolism,and invasive and noninvasive autoregulation moni-toring.In addition,the integration of advanced machine learning and data science tools within the ICU were discussed.Invasive monitoring includes analysis of intracranial pressure waveforms,jugular venous oximetry,monitoring of brain tissue oxygenation,thermal diffusion flowmetry,electrocorticography,depth electroencephalography,and cerebral microdialysis.Noninvasive measures include transcranial Doppler,tympanic membrane displacement,near-infrared spectroscopy,optic nerve sheath diameter,positron emission tomography,and systemic hemodynamic monitoring including heart rate variability analysis.The neurophysical basis and clinical relevance of each method within the ICU setting were examined.Machine learning algorithms have shown promise by helping to analyze and interpret data in real time from continuous MMM tools,helping clinicians make more accurate and timely decisions.These algorithms can integrate diverse data streams to generate predictive models for patient outcomes and optimize treatment strategies.MMM,grounded in neurophysics,offers a more nuanced understanding of cerebral physiology and disease in the ICU.Although each modality has its strengths and limitations,its integrated use,especially in combination with machine learning algorithms,can offer invaluable information for individualized patient care.
文摘In accounts of the development and progression of psychophysical disorders such as Hereditary Spastic Paraplegia (HSP) and Facioscapulohumeral Muscular Dystrophy (FSHD), the role of beliefs, perceptions, and behavioral patterns has often been overlooked in favor of a genetically determinist paradigm. This paper explores the impact of NeuroPhysics Treatment (NPT) on patients with HSP and FSHD. Through a series of clinical case reports, I demonstrate how intensive four-day NPT sessions can lead to rapid restoration of lost functions, challenging the conventional view of these disorders. I hypothesize that, by modulating the patient’s perceptual and behavioral frameworks, NPT facilitates the emergence of healthier patterns, suggesting that environmental and psychological factors significantly influence the manifestation and management of these conditions. These findings indicate that the role of genetic inheritance may be overstated and that beliefs and perceptions could play a crucial role in the evolution of psychophysical disorders. The implications of this research extend beyond the traditional treatment paradigms, advocating for a more holistic approach that integrates the psychophysical dimensions of health and challenges the deterministic perspective of genetic inheritance.
文摘This paper offers a critical examination of“neurophysicalism”,namely the thesis that phenomenal consciousness is nothing over and above neural states(processes)in the brain,in light of empirical researches on some“altered states of consciousness”(lucid dreaming and mystical experiences).By probing the implication of“neurophysicalism”in the empirical world,it is argued that“neurophysicalism”is committed to the principle of“psycho-neural isomorphism”to the effect that the structural features of any state(process)of phenomenal consciousness are isomorphic to the physical structural features of the corresponding“neural correlate”of that state(process)of consciousness.However,in the case of lucid dreaming and mystical experiences,the principle of“psycho-neural isomorphism”does not hold true,which implies that there is a structural mismatch between the phenomenal structure and the physical structure of the corresponding“neural correlates”.The phenomenal structure of lucid dreaming is characterized by features that are unconstant,bizarre,and uncertain,whereas the“neural correlates”of lucid dreaming possess physical structure that is deterministic(with low entropy).In the case of mystical experiences,although the phenomenal structure is characterized by strong realness and constancy,the physical structure of the corresponding“neural correlates”is chaotic and disordered(with high entropy).The phenomenon of structural mismatch challenges“neurophysicalism”in the empirical world.Some possible objections from“neurophysicalists”are examined,including“neural misrepresentation”,“errors of introspective reports”,and“neural correlates not being detected”,none of which withstands scrutiny.The author concludes by proposing an alternative metaphysics for consciousness that takes the brain to be a“valve”“filtering”and constraining unbound consciousness.
