Yu Xiangzhi:Presenting Working People's Enthusiasm and Dedication in the New Era via Paintings

In recent years,artist Yu Xiangzhi has focused on the new outlook of the working people in the new era and created a series of portraits called "Paean to Heroes",presenting working people's enthusiasm and dedication in the new era with paintings.He hopes that this series of works can resonate with the public,who will pay more attention to the life and working conditions of grassroots workers.Recently,this magazine has interviewed Yu Xiangzhi and talked about the story behind the creation of his "Paean to Heroes"series of oil paintings.

Preventive Effect of Xiangsha Yangwei Pills on the Novel Coronavirus Pneumonia from"Genuine Qi Exists,Illness Never"

The preventive effect of traditional Chinese medicine on the novel coronavirus(COVID-19)pneumonia is embodied in the"prevention before disease onset"of"treatment of disease"theory of thought,and it is considered that the key to the success or failure of prevention is whether the healthy qi is abundant or not.This article discusses and understands the"genuine qi"from the The Medical Classic of the Yellow Emperor,and describes its meaning comprehensively and systematically,combining with the expansion and supplement of many doctors in later generations.The"genuine qi"includes healthy qi,pulse qi,congenital qi,personal qi,Jing qi primordial qi and food energy,all of which are closely related to spleen-stomach.The function of spleen-stomach is normal,water and grain are transported properly,and the rise and fall of qi is appropriate,then the human body's qi is abundant,the anti-evil force is strong,and people are not easy to cause disease;even if the disease,the prognosis is better.This the novel coronavirus pneumonia comprehensive analysis,belongs to the traditional Chinese medicine science"damp-toxin epidemic",therefore the prevention should pay more attention to strengthen spleen and stomach,eliminate dampness,and Xiangsha Yangwei Pills is the appropriate choice.

Unstable periodic orbits analysis in the Qi system

We use the variational method to extract the short periodic orbits of the Qi system within a certain topological length.The chaotic dynamical behaviors of the Qi system with five equilibria are analyzed by the means of phase portraits,Lyapunov exponents,and Poincarémaps.Based on several periodic orbits with different sizes and shapes,they are encoded systematically with two letters or four letters for two different sets of parameters.The periodic orbits outside the attractor with complex topology are discovered by accident.In addition,the bifurcations of cycles and the bifurcations of equilibria in the Qi system are explored by different methods respectively.In this process,the rule of orbital period changing with parameters is also investigated.The calculation and classification method of periodic orbits in this study can be widely used in other similar low-dimensional dissipative systems.

Effect of Sijunzi Decoction on the Myonuclear Domain of Rat Soleus in Spleen Qi Deficiency

Objective: To study the mechanism of Sijunzi decoction treating limb weakness in spleen Qi deficiency (SQD) based on the myonuclear domain (MND) theory. Methods: 40 male Sprague-Dawley rats were randomly divided into the normal group, SQD model group (model group), SQD+ still water group (SW group) and SQD+ Sijunzi decoction group (CM group), 10 rats each group;Grip-Strength Meter was used to measure limb grip strength;transmission electron microscope was employed to observe the ultrastructural changes of the myofibers, Image Pro 6.0 was used to measure the myonuclear numbers, cross-section area (CSA) and then their ratios (the MND sizes) were calculated, immunofluorescence assay was chosen to test the expressions of paired box gene 7 (Pax7) and myogenic differentiation antigen (MyoD). Results: Compared with those in the normal group, limb grip strength was decreased, sarcomeres were abnormal, and all the myonuclear numbers, CSA and MND sizes were reduced, but the Pax7+ cell numbers were increased, significantly, in the model and SW groups;Compared with those in the model and SW groups, limb grip strength was increased, sarcomeres were basically normal, the myonuclear number and CSA were both greater, and the Pax7+ and MyoD+ cell numbers were both increased, significantly, in the CM group. Conclusion: Sijunzi decoction might increase the myonuclear number by activating the MSCs to treat limb weakness in SQD.

Nashville Qi?Chinese Medicine in an American Heartland

This article shares preliminary results from current research on Chinese medicine in Nashville,Tennessee,a city in the American South known both as“Music City,USA”and“The Buckle of the Bible Belt.”The author has interviewed dozens of patients and practitioners in Nashville to understand how Chinese medicine came to the city,what styles of practice are present,and whether or not new understandings of Chinese medicine’s fundamental concept of qi might emerge from the unique cultural setting of the American South.While Chinese medicine is flourishing in the city,because of complexities at the intersection of religion,science,and the experience of healing,the clinical encounter between patients and practitioners is not typically characterized by a mutual embrace of a language of qi.

The First Documented Experience of Qi and an Account of Healing Failure:4th-Century BCE

This essay will review the earliest case that documents a patient’s experience of qi,one found on a bamboo text buried with the patient who died in the 318 BCE.Details of the healing encounter and of concepts of illness show how non-transmitted documents hidden from later editors in tombs preserve an older layer of medical understanding than that in transmitted canons,such as the Huang Di Nei Jing(Inner Canon of the Yellow Emperor).The 4th-century BCE case record described below is the longest early medical record concerning the treatment of a specific individual.It is also an account of failure formally recorded for the sake of the survivors and buried with the dead to be transmitted to the world of the spirits.The essay begins with a reevaluation of ancient concept of qi and then moves on to the individual case record.

WTA ‘Xianghu Dialogue' 2022 Opens in Hangzhou

From February 24 to 25,World Tourism Alliance(WTA)"Xianghu Dialogue"2022 was held in Hangzhou,Zhejiang Province,under the theme of"Harmonious Symbiosis:A New Paradigm for a New Tourism"to build consensus and promote cooperation.

Clinical effects of a traditional Chinese medicine nursing programme to intervene in gastric pain of the spleen and stomach with Qi deficiency

BACKGROUND Gastroparesis is a common digestive disorder characterized by delayed gastric emptying,which can lead to symptoms such as nausea,vomiting,abdominal pain,and poor appetite.Traditional Chinese medicine(TCM)has been used for centuries to treat gastrointestinal disorders,including gastroparesis.TCM theory suggests that spleen and stomach qi deficiency syndrome is one of the main pathogenic factors in gastroparesis.Nursing care plays an important role in the treatment of gastroparesis,and TCM nursing interventions have shown promising results in improving patient outcomes.However,there is limited research on the clinical effectiveness of TCM nursing interventions for gastroparesis with spleen stomach deficiency syndrome.This study aimed to evaluate the clinical effect of TCM nursing intervention in the treatment of gastroparesis with spleen stomach deficiency syndrome and to compare it with routine nursing interventions.AIM To analyze the clinical effect of traditional Chinese medicine nursing intervention in the treatment of gastric paraplegia with spleen stomach deficiency syndrome.METHODS From January 2020 to July 2021,80 patients with gastroparesis of spleen stomach qi deficiency type diagnosed in our hospital were selected for the study.The 80 patients were randomly divided into a control group and an experimental group,with 40 cases in each group.During the treatment period,the control group received routine nursing interventions,while the experimental group received traditional Chinese medicine nursing procedures.Compare the nursing effects of the two groups and observe the changes in traditional Chinese medicine symptom scores,pain levels,and sleep quality before and after treatment.RESULTS After treatment,comparing the treatment effects of the two groups,the total effective rate of the experimental group was significantly higher than that of the control group,with statistical significance(P<0.05).There was no statistically significant difference in the TCM symptom score,visual analogue scale(VAS)score,and Pittsburgh sleep quality index(PSQI)score between the two groups before treatment(P>0.05).However,after treatment,the TCM syndrome scores,VAS scores,and PSQI scores of the experimental group were significantly lower than those of the control group,with a statistically significant difference(P<0.05).CONCLUSION In the clinical nursing intervention of patients with mild gastroparesis due to spleen and stomach qi deficiency,the traditional Chinese medicine nursing plan has good clinical application value and nursing effect,and has a good effect on improving patients’pain and sleep quality.

《沧浪诗话》诗歌体制论的误读与辩正

“体制”是严羽诗论的核心概念,但因习焉不察的割裂与混淆,其确切内涵与本来面目未能完整呈现,也妨碍了对严羽诗论体系及诗学思想的整体理解。藉由文本精析与逻辑归纳相结合,可知《沧浪诗话》中“体制”概念指向诗歌作品完整而具体的本体存在,这一基本内涵不因其《诗体》中辨体角度不同而互异。诗之“体制”不仅包含“词理意兴”等基本要素,且以“格力”“兴趣”“气象”“音节”等为之“用”,以更充分表现诗体的内在品质和艺术力量。其中“格力”以诗意为本,是诗中整体思想情感所表现的精神力量;“兴趣”以诗情为本,是诗体所表达的自然感发、含蓄蕴藉的情致和意趣;“气象”以诗象为本,是诗体所呈现的自然雄浑的整体艺术形象;“音节”以诗语为本,是诗体中充分韵律化、表意化的艺术语言。着眼于贯通式诗歌体制观,可对《沧浪诗话》的概念关系和整体结构获得更切近实际、更切合语境的理解。

基于5QI精确调度空口资源测试研究

移动通信网络传输等有线资源较为充足,容易受限的是无线空口资源。当5G用户数较多,此时空口资源不足,需要根据用户等级精准调度空口资源,做到空口资源正比公平分配。本案例研究通过差异化设置5QI做到精准分配无线资源,合理化分配空口资源,提升用户满意度。

Doctor Song Fuyin's Experience in Treating Hashimoto's Thyroiditis Based on Qi,Blood Essence and Spirit Syndrome Differentiation Stage Classification

The paper systematically summarizes the experience of Director Song Fuyin in treating Hashimoto's thyroiditis which is a typical emotional disease that causes obvious changes in organ morphology and endocrine and body fluid metabolism.It belongs to the category of psychosomatic diseases,and is the embodiment of a series of pathogenesis processes of qi disease,blood disease,essence disease and deformation in TCM theory.The whole course of the disease is dominated by the dialectical relationship of mutual influence,mutual control,mutual root and mutual use among the deity disease,qi disease,blood disease,essence and spiritual disease.Therefore,the treatment emphasizes the dialectical relationship based on qi,blood,essence and spirit.At the beginning,the treatment focuses on regulating qi and clearing heat and eliminating phlegm;at the middle stage,the treatment focuses on replenishing essence and promoting yang and eliminating wind and calming the deity;at the late stage,the treatment focuses on replenishing qi and eliminating phlegm and promoting collages.Flexible use of calming the spirits,regulating qi,dispersing essence,eliminating phlegm,promoting blood and other methods of stage classification treatment,can be targeted,improve the cure rate of the disease.This article aims to clarify the experience of Director Song Fuyin in treating Hashimoto's thyroiditis based on syndrome differentiation of qi,blood essence and spirit.

基于《黄帝内经》气虚理论对动脉粥样硬化论治探微

动脉粥样硬化是心血管疾病的病理基础。本虚标实为动脉粥样硬化的基本病机。从《黄帝内经》气虚理论出发,以五脏及营卫之气的虚损作为切入点,探讨其影响津液血液运行从而产生“痰瘀毒”等病理产物的作用机制,探讨动脉粥样硬化的病因病机。治疗上应以补益为主,佐以活血化瘀之法。

疏调气机法联合桂枝茯苓胶囊治疗子宫肌瘤的疗效及其对血清TGF-β_(1)、TSGF的影响

目的:探究疏调气机法联合桂枝茯苓胶囊治疗子宫肌瘤的疗效及其对血清转化生长因子β_(1)(transforming growth factor-β_(1),TGF-β_(1))、肿瘤特异性生长因子(tumor specific growth factor,TSGF)的影响。方法:将135例子宫肌瘤患者采用随机数字表法分为对照A组、对照B组和联合组,每组45例。3组均给予常规西药治疗,在此基础上,对照A组采用疏调气机法治疗,对照B组采用桂枝茯苓胶囊治疗,联合组采用疏调气机法联合桂枝茯苓胶囊治疗。比较3组疗效、不良反应发生率及治疗前后子宫肌瘤体积、子宫体积、子宫内膜厚度、中医证候积分、血清雌激素指标[雌二醇(estradiol,E_(2))、黄体生成素(luteinizing hormone,LH)、催乳素(prolactin,PRL)]、氧化应激指标[晚期氧化蛋白产物(advanced oxidation protein products,AOPP)、丙二醛(malonaldehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)]、TGF-β_(1)、TSGF水平。结果:联合组总有效率为97.78%(44/45),高于对照A组的84.44%(38/45)、对照B组的80.00%(36/45)(P<0.05);治疗后3组患者子宫肌瘤体积、子宫体积均小于治疗前,联合组小于对照A组、对照B组;子宫内膜厚度大于治疗前,联合组大于对照A组、对照B组(P<0.05);与本组治疗前比较,治疗后3组患者月经异常、下腹胀痛、面色晦暗积分均降低,联合组低于对照A组、对照B组(P<0.05);治疗后3组患者血清PRL、LH、E_(2)水平均低于治疗前,联合组低于对照A组、对照B组(P<0.05);治疗后3组患者血清SOD水平均高于治疗前,且联合组高于对照A组、对照B组,血清AOPP、MDA水平均低于治疗前,联合组低于对照A组、对照B组(P<0.05);与本组治疗前比较,治疗后3组患者血清TGF-β_(1)、TSGF水平均降低,联合组低于对照A组、对照B组(P<0.05);联合组不良反应发生率为13.33%(6/45),与对照A组的6.67%(3/45)、对照B组的8.89%(4/45)比较,差异无统计学意义(P>0.05)。结论:疏调气机法联合桂枝茯苓胶囊能提高子宫肌瘤临床疗效,下调血清TGF-β_(1)、TSGF水平,且具有一定安全性。

基于正邪理论探讨Th17/Treg细胞在慢性心衰中的作用

慢性心力衰竭是多种心血管疾病的终末期阶段,心肌损伤后,免疫介导的Th17、Treg细胞在心衰的发病机制具有关键作用,通过分泌炎症因子,导致心肌纤维化、心室重塑。中医正邪理论内涵丰富,对于认识Th17/Treg细胞与心衰的发展及相互作用具有指导意义,隶属于正邪理论范畴,即Th17/Treg细胞平衡,有利于维持机体的免疫平衡,属于“正气”范畴;Th17/Treg细胞失衡可能破坏机体内环境的稳定,导致免疫异常,促进疾病的发生,属于“邪气”范畴。基于此,作者以正邪理论为切入点,从宏观、微观角度来阐述Th17/Treg细胞在慢性心力衰竭发展中的作用,提出心衰早期,正虚为主,邪实为辅;心衰中期,正虚邪实;心衰晚期,邪实为主,正虚为辅;心衰终末期,正虚为主。临床通过扶正祛邪,调整机体正邪平衡,恢复机体Th17/Treg细胞的动态平衡,以期为中医理论阐述Th17/Treg在心衰的发展作用的现代研究奠定基础,为心衰的诊治提供新的理论依据。

基于糖代谢和胰岛素抵抗评估益气养阴法治疗气阴两虚型2型糖尿病的疗效

目的分析益气养阴法治疗气阴两虚型2型糖尿病对患者糖代谢和胰岛素抵抗评估的影响。方法南京中医药大学附属南京市中西医结合医院2019年6月—2022年3月收治的90例气阴两虚型2型糖尿病患者随机分为胰岛素泵治疗组(45例)和益气养阴治疗组(45例)。益气养阴治疗组采用胰岛素泵强化治疗联合益气养阴法进行治疗,胰岛素泵治疗组单独进行胰岛素泵强化治疗,两组均治疗2周。统计两组治疗2周后的临床疗效及治疗期间不良反应发生情况,比较两组治疗前和治疗2周后中医证候积分、糖代谢情况、胰岛素抵抗情况。结果治疗2周后,益气养阴治疗组总有效率为91.11%(41/45),高于胰岛素泵治疗组[73.33%(33/45),P<0.05]。治疗2周后与治疗前比较,两组口燥咽干、倦怠乏力、失眠、自汗盗汗、五心烦热、气短懒言评分及血清空腹血糖(fasting blood glucose,FPG)、餐后2 h血糖(postprandial 2-hour blood glucose,2 h PG)、糖化血红蛋白(glycated hemoglobin,HbA1c)、空腹胰岛素(fasting insulin,FINS)水平、胰岛素抵抗指数(Homa-IR)降低,益气养阴治疗组低于胰岛素泵治疗组(P<0.05),两组胰岛素敏感指数(insulin sensitivity index,ISI)、胰岛功能指数(Homa-islet)升高,益气养阴治疗组高于胰岛素泵治疗组(P<0.05)。治疗期间,益气养阴治疗组总不良反应发生率与胰岛素泵治疗组比较,差异无统计学意义(P>0.05)。结论气阴两虚型2型糖尿病患者采用益气养阴法进行治疗,可有效改善患者中医证候、糖代谢,降低患者机体胰岛素抵抗程度,具有较好的治疗效果。

明目药“法象”新解

法象思维用药是中药法象药理学研究的基础,对传统中医药的发展起着重要作用。本文通过应用法象思维取明目中药形态之象、天时之象、升降之象、色泽之象、经脉之象和习性之象,进而“取象比类”分析《中华人民共和国药典》收录的29味明目中药的法象机制,如青箱子,其形类眼球,乌黑发亮;珍珠,其色泽宝光闪烁,与目之光泽相类;菊花,得秋金之气,金克木而明目等,以期进一步丰富眼科用药理论,启发中医眼科临床用药思路,回归中医药原创思维,更好地指导临床用药。

基于营卫理论探讨桂枝-赤芍配伍重塑肿瘤血管微环境的网络药理学机制

目的:采用网络药理学方法预测桂枝-赤芍配伍影响肿瘤血管生成的潜在靶点和通路,从分子网络药理学水平探索该配伍重塑肿瘤血管微环境的网络药理学机制。方法:采用中药系统药理学数据库与分析平台(TCMSP)检索桂枝、赤芍的化学成分和潜在靶点,选择口服生物利用度≥30%和类药性≥0.18作为化学成分筛选条件;在GeneCards数据库中检索血管生成的靶点;利用Cytoscape 3.6.0软件绘制桂枝-赤芍配伍-化合物-靶点-血管生成网络;使用STRING 11.0在线软件构建蛋白质-蛋白质相互作用(PPI)网络并挖掘核心靶点;采用David Bioinformatics Resources数据库对该复方活性成分潜在的靶点网络中的蛋白进行基因本体(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析。结果:桂枝-赤芍配伍的33种有效成分作用于血管生成过程的77个靶点,PPI网络的核心靶点包括蛋白激酶B(Akt)1、JUN、白细胞介素6、基质金属蛋白酶、血管内皮生长因子A、一氧化氮合酶2和缺氧诱导因子-1α等多个蛋白。GO功能富集分析提示,该配伍的关键蛋白主要参与了DNA结合转录激活剂活性、血红素结合、抗氧化活性、核受体活性和转录因子活性等生物过程。KEGG通路富集分析显示,该配伍参与了缺氧诱导因子-1(HIF-1)信号通路、肿瘤蛋白53信号通路、细胞凋亡信号通路、表皮生长因子受体酪氨酸激酶抑制剂耐药信号通路、血管内皮生长因子(VEGF)信号通路和磷脂酰肌醇3激酶-Akt信号通路等,提示桂枝-赤芍配伍与肿瘤血管生成的关系最为密切。结论:桂枝-赤芍配伍中的黄芩素、谷甾醇和鞣花酸等成分可能通过HIF-1信号通路、VEGF信号通路影响肿瘤血管生成,干预肿瘤的生物学行为。

基于“营卫亢害调平”理论探析胰岛素抵抗

胰岛素抵抗是多种代谢性疾病的共同致病基础,可引起糖类、脂类、蛋白质等物质聚于体内,为祖国医学痰湿、瘀血、浊毒之害。经过对《黄帝内经》亢害承制理论的发扬,将“营卫亢害调平”理论纳入该病的病程分析中,其发展阶段可概括为卫亢成痰、营壅致瘀、浊毒伤正三个阶段。治当以祛痰降脂平卫亢、散瘀通络除营亢、化浊解毒安脏腑为分期治疗大法,以求营卫调平。

基于“阳化气,阴成形”理论辨治痿证

津气两伤是痿证的病变基础,亦是“阳化气,阴成形”失衡的结果。阳化气不足,阴成形失衡,而致脏腑功能失调,水饮痰瘀内生,四肢九窍失养,发为痿证。本文基于“阳化气,阴成形”理论,探讨高颖教授采用助阳化气法治疗阳化气不足的重症肌无力,益肾调形法治疗阴成形失衡的多发性硬化,阴阳双补法治疗阴阳俱损的运动神经元病。治疗痿证,需审证求因,明辨阴阳,调整偏颇,在疾病早期给予中医药治疗,以延缓疾病演变进程、改善预后。

气机升降理论内涵及不寐病辨证分型探讨

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