Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics

BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.

基于人机联系接口的On-CALL系统的设计与应用

水电厂的On-CALL系统保证水电站的正常运行的主要信息系统之一。针对当前常用On-CALL系统接口缺乏、功能单一和交互界面呆板的问题,猴子岩水电站基于电站运行的实际场景,重新设计了整个On-CALL系统的底层数据通讯方式和人机界面,实现了对人员、信息、权限的精细管理,在实际应用中获得了良好的应用效果。

Simultaneous Interpreting Output Assessment of Earnings Conference Call: Case Analysis of Tencent 2022 Q3 Result Announcement

Quality in simultaneous interpreting is a frequently discussed concept. In the enterprise setting, earnings conference call remains a rarely explored field. This thesis offers a descriptive study on assessing interpreting quality from perspectives of fidelity, fluency, and appropriacy. As the corpus, Tencent 2022 Third Quarter Result Announcement provides an ideal transcript to the author to conduct its analysis. Interpreting is frequently done without bearing in mind the multitude of factors that can affect the quality of interpreting. Drawing a conclusion that the interpreter does make a lot of omissions, pauses and hesitations posing a negative effect on the fidelity, fluency and accuracy of the interpreting, the present author suggests that more preparation should be done for improving performance, such as terminologies, company background information, a reasonable speech rate, good image and acoustic quality, and so on.

Calling与使命:中西文化中的心理学界定与发展

Calling成为近年来西方职业心理学关注的新焦点。Calling概念起源于新教改革,经历了从宗教性到世俗性的转变过程。对calling的中文翻译为"使命",使命在中国的概念演化过程与calling相似,内涵相近,但也存在中西文化差异。使命为职业心理学提供了新的切入点,它有助于个体的职业生涯发展、生活满意度和人生意义感等方面,具有很大的理论和应用价值。国内相关研究可从概念界定方面入手,进一步综合运用多种方法考察使命感的作用,并可将职业使命感与一般使命感分别进行研究。

The mediating role of organizational commitment between calling and work engagement of nurses: A cross-sectional study

Objective: Nurse shortage is a critical problem for global healthcare services.It impacts the quality of clinical care.Work engagement is the core competence of hospitals,which indicates employee's positive attitude toward organization and work.This study aimed to explore the relationships among calling,organizational commitment,and work engagement.Methods: A cross-sectional study was designed,and 320 nurses from tertiary hospitals in China completed the questionnaires that included demographic information,calling scale,employee engagement scale,and organizational commitment scale.Pearson correlation was performed to test the correlations among calling,organizational commitment,and work engagement.Stepwise regression analyses were performed to explore the mediating role of organizational commitment.The bootstrap method was employed to confirm the mediating effect.Results: Nurses' work engagement score was at the medium degree,whereas calling and organizational commitment were in the medium to high level.The results revealed that calling,organizational commitment,work engagement,and each dimension were positively correlated with one another (r=0.145-0.922,P < 0.01).The organizational commitment plays a partially mediating effect between calling and work engagement (β =0.603 to 0.333,P < 0.01).Conclusions: The mediation effect of organizational commitment was verified,which provided a comprehensive understanding of how calling impacted work engagement.Moreover,administrators should not only promote interventions to increase work engagement but also pay attention to calling and organizational commitment so as to improve their work engagement.Taken together,increased level of work engagement is required in the current nursing field.

Circadian Rhythm of Calling Behavior in the Emei Music Frog(Babina daunchina) is Associated with Habitat Temperature and Relative Humidity

Generally, the function of vocalizations made by male anurans are to attract females or defend resources. Typically, males vocalize in choruses during one or more periods in a twenty-four-hour cycle, which varies, however, among species. Nevertheless, the causal factors influencing circadian variations of calling patterns in anuran species are not clear. In this study, male chorus vocalizations were monitored in the Emei music frog(Babina daunchina) for 17 consecutive days during the breeding season, while its habitat air temperature and relative humidity in the course of experiments were measured as well. The results revealed that the circadian calling patterns were characterized by two periods of peak vocalization, which were observed from 0500 h to 0700 h and from 1300 h to 2000 h, while the lowest activity period was found from 2100 h to 2200 h. Both calls/h and notes/h were positively correlated with air temperature and negatively with relative humidity. Overall, our data indicate that the Emei music frogs(B. daunchina) could regulate their vocal activities based on the changes of physical micro-environment(e. g., temperature or humidity) to maximize reproductive success.

Responding Depth of Photocatalytic Activity of TiO_2 Self-assembled Films

The electrostatically self-assembly method is getting strategically important to prepare multilayer thin films. With careful choice of component materials, this method should allow for the preparation of multilayer thin films with a variety of excellent technological properties. Ti02/PSS multilayer thin films with ordered structure were prepared by electrostatic self-assembly method. UV-Vis-NIR spectrophotometer, X-ray photoelectron spectroscopy (XPS), and atom force microscopy (AFM) were used to characterize the structure and performance of the multilayer films. Because electrostatically self-assembly method allows molecular-level control over the film composition and thickness, this paper studied the responding depth of photocatalytic activity of Ti02 self-assembled films in detail.

Responding to fire in an intensive care unit: Management and lessons learned

Healthcare institutions are vulnerable to disruptionfrom events such as earthquakes, fires, and floods, andthe damage incurred can endanger the lives of patientsin the hospital.[1] In this type of scenario hospital staffhave primary responsibility for the hospitalized patients＇safety, since patients are neither fit to respond to sucha disaster, nor do they know how to respond.[2,3] Thesituation becomes more difficult and challenging if thedisaster occurs in critical care areas such as intensivecare units （ICUs） and operating rooms.

Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet

BACKGROUND After receiving entecavir or combined with FuzhengHuayu tablet(FZHY)treatment,some sufferers with hepatitis B virus(HBV)-related liver fibrosis could achieve a histological improvement while the others may fail to improve even worsen.Serum metabolomics at baseline in these patients who were effective in treatment remain unclear.AIM To explore baseline serum metabolites characteristics in responders.METHODS A total of 132 patients with HBV-related liver fibrosis and 18 volunteers as healthy controls were recruited.First,all subjects were divided into training set and validation set.Second,the included patients were subdivided into entecavir responders(E-R),entecavir no-responders(E-N),FZHY+entecavir responders(FR),and FZHY+entecavir no-responders(F-N)following the pathological histological changes after 48 wk’treatments.Then,Serum samples of all subjects before treatment were tested by high performance liquid chromatographytandem mass spectrometry(LC-MS)high-performance LC-MS.Data processing was conducted using multivariate principal component analysis and orthogonal partial least squares discriminant analysis.Diagnostic tests of selected differential metabolites were used for Boruta analyses and logistic regression.RESULTS As for the intersection about differential metabolic pathways between the groups E-R vs E-N and F-R vs F-N,results showed that 4 pathways including linoleic acid metabolism,aminoacyl-tRNA biosynthesis,cyanoamino acid metabolism,alanine,aspartate and glutamate metabolism were screened out.As for the differential metabolites,these 7 intersected metabolites including hydroxypropionic acid,tyrosine,citric acid,taurochenodeoxycholic acid,benzoic acid,2-Furoic acid,and propionic acid were selected.CONCLUSION Our findings showed that 4 metabolic pathways and 7 differential metabolites had potential usefulness in clinical prediction of the response of entecavir or combined with FZHY on HBV fibrotic liver.

Terminal-to-Terminal Calling for GEO Broadband Mobile Satellite Communication

Satellite and terrestrial components of IMT-Advanced need to be integrated so that the traditional strengths of each component can be fully exploited. LTE/LTE-A is now a recognized foundation of terrestrial 4G networks, and mobile satellite networks should be based on it. Long transmission delay is one of the main disadvantages of satellite communication, especially in a GEO system, and terminal-to-terminal （TtT） design reduces this delay. In this paper, we propose a protocol architecture based on LTE/LTE-A for GEO mobile satellite communication. We propose a detailed call procedure and four TtT modes for this architecture. We describe the division of tasks between the satellite gateway （SAT-GW） and satellite as well as TtT processing in the physical layer of the satellite in order to reduce delay and ensure compatibility with a terrestrial LTE/LTE-A system.

基于运营商公共开放Wi-Fi网络的Wi-Fi Calling业务集成方法

针对移动运营商如何利用其公共Wi-Fi网络引入Wi-Fi Calling业务并提升当前Wi-Fi网络流量不足、用户体验差等问题,分析了公共开放Wi-Fi的网络特性,提出了基于公共Wi-Fi网络进行业务集成和控制的通用思路,进一步设计了基于公共Wi-Fi网络进行Wi-Fi Calling业务集成的方法,从而实现了Wi-Fi Calling用户自动接入Wi-Fi网络,并改进当前Wi-Fi Calling存在的一些缺陷。通过基于公共Wi-Fi现网环境验证,用户体验较好,Wi-Fi Calling增强能力得以体现,通过Wi-Fi Calling业务开展可以激活运营商公共Wi-Fi网络使用。

Spring Voices in Korean Rice Fields:The Effect of Abiotic Variables and Syntopic Calls on the Calling Activity of the Treefrog Dryophytes suweonensis

The calling activity of anurans is influenced by environmental variables and calls produced by syntopic amphibians,among other variables.Some variables have a strong influence,such as temperature and predation dilution,while others may have a periodical influence such as the moon cycle.Here,we hypothesised that the calling activity of the Suweon treefrog,Dryophytes suweonensis,is restricted by specific environmental variables but reinforced by the calling activity of specific syntopic anurans.Within the criteria set by the experimental design,D.suweonensis calling activity was significantly influenced by moon phase,temperature,date,time to sunset and the calling activity of Pelophylax nigromaculatus and D.japonicus.These variables are expected to be related to chorus size,predation,breeding phenology and competition,suggesting a broad plasticity in the calling activity of the species.

Be Called and Be Healthier:How Does Calling Influence Employees’Anxiety and Depression in the Workplace?

Despite limited studies have found the negative relationships between calling and mental health symptoms,its underlying mechanism is still unknown.Drawing on the conservation of resources theory(COR),this study developed the resources model that explains the relationships between career calling,anxiety and depression,and the underlying mechanism.With a sample of 628 employees from the two-wave survey,the theorized model was tested.The results showed that career calling was able to decrease the levels of employees’anxiety and depression,and two important resources(i.e.,personal growth,and meaningful work)provided explanatory mechanisms for the relationships.The findings highlight the importance of spirituality in the workplace.Theoretical and practical implications are discussed.

Emplacement Depths and Exhumation of Mesozoic Granitoids Responding to Lithospheric Destruction in the Jiaodong Peninsula, North China Craton

1 Introduction The North China Craton(NCC)has experienced lithospheric destruction in Mesozoic accompanied with crustal exhumation.Fission track or(U-Th)/He dating of zircon and apatite for the Mesozoic granitoids in the

JOURNAL OF SALT LAKE RESEARCH CALLING FOR PAPERS

Brief sJournal of Salt Lake Research is a scientific periodical of natural science which is approved by the National Science Committee,sponsored by Qinghai Institute of Salt Lakes and published by Science press.Our tasks are to cover and exchange the research reports,scientific papers and accomplishments on the developments of science and technology of salt lakes,underground water,gas water and other natural resources,

JOURNAL OF SALT LAKE RESEARCH CALLING FOR PAPERS Briefs

Journal of Salt Lake Research is a scientific periodical of natural science which is approved by the National Science Committee,sponsored by Qinghai Institute of Salt Lakes and

China's Agriculture Calling for Foreign Investment

At the recently-convened meetings of the National People’sCongress and the Chinese People’s Political ConsultativeCoference, agriculture has once again become a hot topicattracting attentions of deputies. Speeding up the opening up ofagricultural sector and properly resolving the thorny financial andtechnological problems confronting it become a highlighted issuein the State’s plan to utilize foreign investment in the coming fewyears.

JOURNAL OF SALT LAKE RESEARCH CALLING FOR PAPERS Briefs

Journal of Salt Lake Research is a scientific periodical of natural science which is approved by the National Science Com-mittee,sponsored by Qinghai Institute of Salt Lakes and published by Science press.Our tasks are to cover and exchange the research reports,scientific papers and accomplishments on the developments of sci-ence and technology of salt lakes。

JOURNAL OF SALT LAKE RESEARCH CALLING FOR PAPERS Briefs

Journal of Salt Lake Research is a scientific periodical of natural science which is approved by the National Science Com-mittee,sponsored by Qinghai Institute of Salt Lakes and published by Science press.Our tasks are to