POEMS(polyneuropathy,organomegaly,endocrinopathy,M-protein and skin changes)综合征是一种单克隆浆细胞异常增殖的副肿瘤综合征,患病率约为0.3/10万[1]。该病累积神经、内分泌、骨骼、免疫及造血等系统,临床上诊断需要2个基本要素...POEMS(polyneuropathy,organomegaly,endocrinopathy,M-protein and skin changes)综合征是一种单克隆浆细胞异常增殖的副肿瘤综合征,患病率约为0.3/10万[1]。该病累积神经、内分泌、骨骼、免疫及造血等系统,临床上诊断需要2个基本要素:多发性周围神经病和单克隆浆细胞病[2]。周围神经病变是超过60%的POEMS综合征患者的首发症状,不少患者早期就诊于神经内科并被误诊为慢性炎性脱髓鞘性多发性神经根神经病(chronic inflammatory demyelinating polyneuropathy,CIDP)等原发性神经系统疾病[3]。由于神经病变进展缓慢、致残率高,多数患者就诊时症状严重且已造成神经不可逆性损伤,给患者生活带来极大不便,因此早识别、早诊断、及时治疗至关重要。本文报告1例采用达雷妥尤单抗(Daratumumab,Dara)联合方案治疗伴有严重周围神经病变的POEMS综合征,分析了神经病变的发病机制,并强调了POEMS综合征诊断的复杂性以及Daratumumab作为新一代药物在治疗中的潜在优势。展开更多
Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“r...Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance.展开更多
视差不连续区域和重复纹理区域的误匹配率高一直是影响双目立体匹配测量精度的主要问题,为此,本文提出一种基于多特征融合的立体匹配算法。首先,在代价计算阶段,通过高斯加权法赋予邻域像素点的权值,从而优化绝对差之和(Sum of Absolute...视差不连续区域和重复纹理区域的误匹配率高一直是影响双目立体匹配测量精度的主要问题,为此,本文提出一种基于多特征融合的立体匹配算法。首先,在代价计算阶段,通过高斯加权法赋予邻域像素点的权值,从而优化绝对差之和(Sum of Absolute Differences,SAD)算法的计算精度。接着,基于Census变换改进二进制链码方式,将邻域内像素的平均灰度值与梯度图像的灰度均值相融合,进而建立左右图像对应点的判断依据并优化其编码长度。然后,构建基于十字交叉法与改进的引导滤波器相融合的聚合方法,从而实现视差值再分配,以降低误匹配率。最后,通过赢家通吃(Winner Take All,WTA)算法获取初始视差,并采用左右一致性检测方法及亚像素法提高匹配精度,从而获取最终的视差结果。实验结果表明,在Middlebury数据集的测试中,所提SAD-Census算法的平均非遮挡区域和全部区域的误匹配率为分别为2.67%和5.69%,测量200~900 mm距离的平均误差小于2%;而实际三维测量的最大误差为1.5%。实验结果检验了所提算法的有效性和可靠性。展开更多
文摘Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance.
文摘视差不连续区域和重复纹理区域的误匹配率高一直是影响双目立体匹配测量精度的主要问题,为此,本文提出一种基于多特征融合的立体匹配算法。首先,在代价计算阶段,通过高斯加权法赋予邻域像素点的权值,从而优化绝对差之和(Sum of Absolute Differences,SAD)算法的计算精度。接着,基于Census变换改进二进制链码方式,将邻域内像素的平均灰度值与梯度图像的灰度均值相融合,进而建立左右图像对应点的判断依据并优化其编码长度。然后,构建基于十字交叉法与改进的引导滤波器相融合的聚合方法,从而实现视差值再分配,以降低误匹配率。最后,通过赢家通吃(Winner Take All,WTA)算法获取初始视差,并采用左右一致性检测方法及亚像素法提高匹配精度,从而获取最终的视差结果。实验结果表明,在Middlebury数据集的测试中,所提SAD-Census算法的平均非遮挡区域和全部区域的误匹配率为分别为2.67%和5.69%,测量200~900 mm距离的平均误差小于2%;而实际三维测量的最大误差为1.5%。实验结果检验了所提算法的有效性和可靠性。
