The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain damage.Mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent mice.Considering the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge drinking.We demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent mice.Bioinformatic analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling pathways.Taken together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

Association of spiritual well-being with quality of life among undergraduate nursing students

Objective:The study was conducted with the aim of determining the spiritual well-being(SWB)of nursing students and its association with quality of life(QOL).Materials and Methods:A cross-sectional analytical study was conducted with a sample size of 504 nursing students collected from January 2023 to March 2023 in the nursing institutes of Khyber Pakhtunkhwa,Pakistan,using convenient sampling techniques.A Spiritual Health and Life-Orientation Measure(SHALOM)questionnaire for SWB and K-27 QOL(K-27 QOL)instrument were used for data collection that contains three parts.Results:The number of female participants was in the majority(50.4%)compared to male nurses(49.6%).The overall mean score of SWB of the students was 3.79±0.48,while the mean K-27 QOL score was 3.73±0.57.There were significant differences between the groups of gender(P=0.001),while no significant difference within the groups of semester(P=0.061)and college status(0.285).In QOL,there were significant differences within the groups of semester(P=0.000)and college status(P=0.036)while no significant difference in gender category(P=0.480).SHALOM score is positively and moderately correlated with QOL score(r=0.597,P<0.05).Conclusion:Spiritual practices are one of the important factors that are associated positively with QOL,therefore to enhance the QOL,it will require spiritual practices.

A 32-Year Systematic Review:Exploring the State of Christian Spirituality and Mental Health Research

This study reviewed scholarly articles on the relationship between Christian spirituality and mental health published in academic journals from 1980 to 2022.The review analyzed findings from 44 studies that likely used various research methods like surveys,interviews,and experiments.The results reveal a consistent link between Christian beliefs,such as faith,hope,and love,and positive mental health outcomes.Most studies focused on the therapeutic effects of Christian spirituality in alleviating mental disturbances and improving well-being.However,the review also identified gaps in the literature,including a lack of research on the relationship between Christian spirituality and mental illness,small sample sizes,and a lack of cross-cultural and cross-religious investigations.The article emphasizes the importance of addressing these limitations to gain a more comprehensive understanding of the complex relationship between mental health and spirituality.

Exploring the Intersection of Spirituality and Religion:Transcendence,Secularism,and Personal Beliefs in Contemporary Society

This paper explores the intersection of spirituality and religion,focusing on how transcendence,secularism,and personal beliefs shape contemporary spiritual practices.It examines the philosophical foundations of transcendence,the rise of existentialism,and the distinction between spirituality and religion.Secularism's role in fostering personal spirituality and reducing religious authority is discussed,alongside the psychological and societal impacts of spiritual transcendence.The paper also critiques the limitations of spirituality,emphasizing the need for a balanced approach that integrates cognitive development and mental health perspectives.

From Ancient Rituals to Modern Spirituality:The Evolution and Personalization of Religious Experience

This paper explores the evolution of religious experience from ancient nature worship and ancestor reverence to modern individualized spirituality.It examines how early spiritual practices were deeply intertwined with daily life,later becoming institutionalized through formalized religions with complex rituals and doctrines.The rise of mysticism,emphasizing personal connections with the divine,persisted alongside institutional religions.In contemporary society,the shift towards"spiritual but not religious"reflects a return to personalized spiritual paths,driven by individualism and the desire for direct,meaningful spiritual experiences.This trend's implications for both individuals and society are also discussed.

Spiritual Forests—A Nature Conservation Model of Ethnic Minority Communities in Central Viet Nam

This paper aims to analyze and evaluate a model of forest conservation and management of ethnic minority (or indigenous) people in central Vietnam, often referred to as the spiritual forest. These forests, called sacred forest or ghost forests by the ethnic minority people in Thua Thien Hue province, have existed for a long time among forest residents. However, they have recently declined, both in quality and quantity, due to various factors, including changes in society, economy, environment, and perception, among other reasons. Based on research conducted in A Luoi district, Thua Thien Hue province with household interviews, group discussions, and field surveys, we find that spiritual forest retains religious and human significance. They are also often among the last remaining natural forests left due to deforestation by human activities. The research results indicate challenges that conservation of spiritual forest may face, while giving recommendations derived from communities for sustainable forest development and conservation in the region.

Exploring the Multivariate Relationships between Adolescent Depression and Social Support, Religiosity, and Spirituality in a Faith-Based High School

Depression is one of the most common psychological disorders that affect adolescents. In this study, we investigated how depression in adolescents relates to social support, religiosity, and spirituality in multivariate analyses. We also investigated whether age, gender and ethnicity are predictors of depression among adolescents in a faith-based high school. We measured social support using the Child and Adolescent Social Support Scale (CASSS), religiosity with the Duke University Religion Index (DUREL);spirituality with the Spiritual Well-Being Scale (SWBS);and depression with the Center for Epidemiological Studies Depression Scale for Children (CES-DC). Results of the bivariate analyses showed a significant negative association between depression and social support, religiosity, and spirituality (p –0.548, p = 0.00) was negatively related to depression in adolescents. The study found significant gender differences only in religiosity, while significant ethnic differences were only found in social support. Implications to education, practice, research and future directions of study are discussed.

The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67, I^(2) = 0.00%). The combined effect of the interventions was significant(MD = 2.88, 95% CI: 1.53–4.22, P < 0.0001), indicating that the brain-derived neurotrophic factor levels of the children and adolescents in the exercise group were significantly higher than those in the control group. In conclusion, different types of exercise interventions significantly increased brain-derived neurotrophic factor levels in children and adolescents. However, because of the small sample size of this meta-analysis, more high-quality research is needed to verify our conclusions. This metaanalysis was registered at PROSPERO(registration ID: CRD42023439408).

Expression Forms of Spiritual Cultures in Classical Chinese Gardens

By studying close links between classical Chinese gardens and traditional Chinese cultures,it was stressed that spiritual characteristics pursued by classical Chinese gardens were inevitable components of their expression forms,which were also closely related to classical Chinese philosophy,social system and other cultural phenomena.Characteristics of classical Chinese gardens in terms of psychology were analyzed,and it was proposed that they had particular cultural connotations in the spiritual expression and appeal,that is,natural view of "human-nature oneness",etiquette culture of "coordinating with the nature by etiquette",seclusion view of "living in seclusion and pursuing a peaceful life".Concrete expressions of spiritual cultures in classical Chinese gardens were discussed,specifically,the expression of natural views was demonstrated as "respecting the nature,all creatures having its own course(Tao,way of evolution),adopting measures suiting local conditions,skillfully borrowing from other landscapes,simulating natural landscapes";as for the expression of seclusion view,it was demonstrated as the expression of seclusion cultures by inscriptions and steles,the expression of "seclusion" by implicit garden settings;etiquette and hierarchy of classical Chinese gardens were discussed from the perspective of private garden layout and residence construction.On this basis,spiritual world of ancient Chinese were further stu-died,mental patterns of Chinese were believed as the source of classical gardens,and what those hills,water,plants,architecture as well as their combinations expressed were spiritual pursuits of Chinese people.

An Analysis of the Spiritual Salvation of Adela in A Passage to India

This paper mainly analyzes the spiritual salvation of the protagonist Adela in the novel. In the early 20 thcentury, India is under the British colonial rule and Indians suffer a lot from it. India lacks autonomy and there is a wide racial gap between the British and Indians. In this context, Adela has deeply-rooted prejudice against Indians at first, whose discrimination makes her falsely accuse Aziz of attempting to rape her. However, merging into the Indian society gives Adela a chance to see the goodness of Indians, and finally her racial prejudice is eliminated.

The Research of Natural Landscape and Spiritual Development in Enoch Arden

Enoch Arden is a narrative poem by Alfred Tennyson,which turns out to be the record of the process of its hero's spiritual journey and can be interpreted from the perspectives of the description of natural landscape.

Eternal Nature: Spiritual Haven——The Function of Nature in Rip Van Winkle

Rip Van Winkle is one of the most enduring stories of Washington Irving. It is a fantasy tale about a man who somehow "stepped outside of the mainstream of life" (Chang Yao-xin, 1991: 62). Rip Van Winkle lived in a village near the Hudson River north of New York City. He was a simple, good-natured man; he was, moreover, a kind neighbor and an obedient hen-pecked husband. Yet Rip was lazy and this kept him in constant trouble with his wife. His two favorite past-times were sitting in front of the inn, chatting with his friends, and wandering through the mountains with his dog, Wolf. On one of these trips he met a strange dwarf who invited him to join him and other strange-looking dwarfs in a drinking party and a game called nine-pins, in a remote valley. Rip drank too much of beverage and fell asleep. When he woke up, he found that during just one night, twenty years had vanished and strangers were everywhere. His scolding wife had died, and his son, every bit his counterpart in appearance and personality had grown up to replace him. At last he was reunited with a married daughter and began to live a life the same as before.

The Eastern Culture and Salinger——the Revelation of Spiritual Ecology of Buddhism in the Catcher in the Rye

The rapid development of science and technology brought about fundamental doubts about the traditional values and ethics which inevitably led to a spiritual crisis.Salinger had realized that with the deepening of the industrialization and mechanization in the capitalist society,the rationality and the materialistic civilization that highly advocated by westerners have come to an extreme.Salinger turned to the east culture and hoped to seek for a way to save the west from the spiritual crisis.

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

Nonalcoholic fatty liver disease(NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver-which generally follows a benign, non-progressive clinical course-to non-alcoholic steatohepatitis, a subset of NAFLD that may progress to cirrhosis and end-stage liver disease or liver carcinoma. The underlying pathophysiological mechanism of "pediatric" NAFLD remains unclear, although it is strongly associated with obesity and insulin resistance. In this review we provide a general overview on the current understanding of NAFLD in children and adolescents, which underpins practice, enabling early diagnosis and appropriate therapeutic intervention for this life-threatening liver disease.

Psychosocial and spiritual needs of patients with chronic diseases: validation of the Chinese version of the Spiritual Needs Questionnaire

OBJECTIVE： Even in secular societies, a small portion of patients find their spirituality to help cope with illness. But for the majority of patients, psychosocial and spiritual needs are neither addressed nor even considered a relevant factor by health care professionals. To measure such specific needs, the Spiritual Needs Questionnaire （SpNQ） was developed. The aim of this study was to validate the Chinese version of the SpNQ （SpNQ-Ch） and thus to measure psychosocial and spiritual needs of Chinese patients. METHODS： This was a cross-sectional study among 168 patients with chronic diseases who were recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China using standardized questionnaires. We performed reliability and factor analyses, as well as analyses of variance, first order correlations and regression analyses. RESULTS： The 17-item SpNQ-Ch had a similar factorial structure as the original version with two main and three minor factors which accounted for 64% of variance, and internal consistency estimates （Cronbach＇s a） ranging from 0.51 to 0.81. Included were the 4-item scale Inner Peace Needs, the 5-item scale Giving/Generativity （with 2 sub-constructs, Praying and Sources）, and a Needs, the 5-item scale Religious Needs 3-item scale Reflection/Release Needs. In Chinese patients with cancer （63%）, pain affections （10%）, or other chronic conditions （23%）, the needs for Giving/Generativity （which refer to categories of Connectedness and Meaning） and Inner Peace Needs scored highest, while Religious Needs and the Reflection/Release Needs scored lower. CONCLUSION： The SpNQ-Ch is congruent with its primary version, and can be used in future studies with the mostly nonreligious patients from China. First findings indicate specific psychosocial and spiritual needs which should be addressed by health care professionals to support patients in their struggle with chronic illness in terms of psycho-emotional stabilization, finding hope and meaning, and thus achieving peaceful states of mind despite chronic illness.

Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis

AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours.

Efficacy of the structured life review and the short-term life review on the spiritual well-beingof terminally ill cancer patients

GOALS: The aims of this study were to evaluate the treatment efficacy of the structured life review interviews and the Short-Term Life Review on the spiritual well-being of terminally ill cancer patients, in order to improve patients’ quality of life. SUBJECTS and METHODS: Participants were patients in palliative care units in Japan. In the study 1, the structured life review interviews were conducted with 12 patients. They completed the QOL scale of the SELT-M (Skalen zur Erfassung von Lebens qualitat bei Tumor- kranken–Modified Version) questionnaire before and after the interviews. In the study 2, the Short-Term Life Review was conducted with 30 patients. They reviewed their lives in the first session and they confirmed the contents in the album based on the life review in the second session. Duration of the treatment was one week. Measurement instruments included Func- tional Assessment Chronic Illness Therapy- Spiritual (FACIT-Sp). RESULTS: After the structured life review, the mean overall QOL score and Spirituality subscale score of the SELT-M significantly increased, from 2.57 ± 0.61 to 3.58 ± 1.0 (p=0.013) and 2.57 ± 0.61 to 3.14 ± 2.25 (P=0.023), respectively. After the Short-Term Life Review, the mean FACIT-Sp scores significantly increased from 16 ± 8.2 to 24 ± 7.1. CONCLUSION: Both the structured life review and the Short-Term Life Review may be effective in improving the spiritual well-being of terminally ill cancer patients, being higher feasibility for the Short-Term Life Review. We need to use these therapies understanding characteristics of each therapy.

Alexithymia, Psychopathology and Alcohol Misuse in Adolescence: A Population Based Study on 3556 Teenagers

Objectives: To analyze the association between alexithymia and alcohol intake during adolescence, also in relation to psychopathology, in order to identify psychological risk factors for alcohol misuse. Method: 3556 students [mean age (range) 14.5 years (11-18)] were recruited in the Padua area. Each was administered a set of three questionnaires: the Toronto Alexithymia Scale for children (TAS-20) to measure alexithymia, the Questionnaire Adolescent Saturday evening (QAS) to estimate of alcohol intake, and the Youth Self-Report (YSR 11-18) to value psychopathology. Results: Externalizing problems appeared to increase with age and with the amount of alcohol consumed, unlike internalizing problems. The prevalence of alexithymia was 18%, decreasing with age, and it was not associated with alcohol consumption, and used except in younger subjects (≤13), for whom a positive correlation was observed between alexithymia, internalizing problems and alcohol intake. Conclusions: Younger adolescents are more psycho-emotionally vulnerable (internalizing problems and alexithymia) and at a greater risk of alcohol misuse.

Environmental Design and Cultural Spiritual Ecology

Modern people are facing with serious unbalance of spiritual ecology, so modern ecology has gradually taken spiritual ecology into its research scope. The relationship between environmental design and cultural spiritual ecology includes enhancing the artistry of environmental design, therapeutic effect of arts on human cultural spiritual ecology, and achieving the organic integration of human, nature, art and spirits. "Ecological field" of cultural spirit influences values of the masses and promotes the development of history.

Reliability and validity of the Chinese version of spiritual needs questionnaire with 27 items (SpNQ-Ch-27) in cancer patients

Objective: To evaluate the reliability and validity of the Chinese version of the Spiritual Needs Questionnaire with 27 items (SpNQ-Ch-27) for cancer patients.Methods: A total of 457 cancer patients in a tertiary hospital in Xinjiang from March to July in 2017 were investigated by using the SpNQ-Ch-27 and convenient sampling method.They were recruited to validate the discrimination,reliability,and validity of the scale.According to the odd and even questionnaire numbers,data were divided into two groups to do exploratory factor analysis group and confirmatory factor analysis,respectively.Results: SpNQ-Ch-27 included 27 items and six factors,which were extracted by using factor analysis.It could explain 63.08% of the total variance.The total scores of each dimension and the SpNQ-Ch-27 were highly correlated,and the correlation coefficient was from 0.58 to 0.78.For the CFA,the overall fitting ideal was x2/df=2.00,RMSEA =0.07,IFI =0.93,NFI =0.86,CFI =0.92,TLI =0.90;Cronbach's α =0.90;the dimensions of Cronbach's α =0.63-0.95;split-half reliability was 0.82,dimensions were 0.68-0.95.Conclusion: SpNQ-Ch-27 is applicable for Chinese cancer patients with better validity and higher internal consistency,and it can be used as a tool to assess the spiritual needs of cancer patients.