This paper is to analyze the novel in the following aspects: The Chinese-American cultural conflicts, the mother and daughter relations and sisters’ relations, the psychological critics, and the postcolonial identit...This paper is to analyze the novel in the following aspects: The Chinese-American cultural conflicts, the mother and daughter relations and sisters’ relations, the psychological critics, and the postcolonial identity. The novel is about multiple explanations of the aspects mentioned above. The writer confuses the Chinese culture, the relationship of the two sisters. Under the superficial description, the writer shows the psychological status of the main character and the practically existence of postcolonial identity and embodiment in the novel.展开更多
The recent advances in remote sensing and computer techniques give birth to the explosive growth of remote sensing images.The emergence of cloud storage has brought new opportunities for storage and management of mass...The recent advances in remote sensing and computer techniques give birth to the explosive growth of remote sensing images.The emergence of cloud storage has brought new opportunities for storage and management of massive remote sensing images with its large storage space,cost savings.However,the openness of cloud brings challenges for image data security.In this paper,we propose a weighted image sharing scheme to ensure the security of remote sensing in cloud environment,which takes the weights of participants(i.e.,cloud service providers)into consideration.An extended Mignotte sequence is constructed according to the weights of participants,and we can generate image shadow shares based on the hash value which can be obtained from gray value of remote sensing images.Then we store the shadows in every cloud service provider,respectively.At last,we restore the remote sensing image based on the Chinese Remainder Theorem.Experimental results show the proposed scheme can effectively realize the secure storage of remote sensing images in the cloud.The experiment also shows that no matter weight values,each service providers only needs to save one share,which simplifies the management and usage,it also reduces the transmission of secret information,strengthens the security and practicality of this scheme.展开更多
Background: We aimed to evaluate the short-term metabolic effects of a GLP-1a, (liraglutide) versus a DPP-4i, (vildagliptin) in a group of sub-Saharan type 2 diabetes patients. Methods: We conducted a randomized contr...Background: We aimed to evaluate the short-term metabolic effects of a GLP-1a, (liraglutide) versus a DPP-4i, (vildagliptin) in a group of sub-Saharan type 2 diabetes patients. Methods: We conducted a randomized controlled single blinded clinical trial in 14 uncontrolled type 2 diabetes patients (HbA1c ≥ 53 mmol/mol) with mean duration of diabetes of 8 [1 - 12] years and median age of 57 [49 - 61] years. Baseline treatment consisted of metformin in monotherapy or metformin plus sulfonylureas. Participants were randomly allocated to 2 groups of add-on 1.2 mg/day subcutaneous liraglutide in group 1 or 100 mg/day of oral vildagliptin in group 2 for 2 weeks. In all participants, insulin secretion in response to mixed meal tolerance test, insulin sensitivity by 80 mU/m<sup>2</sup>/min hyperinsulinemic-euglycemic clamp, body composition, and lipid profile were measured before and after intervention. Results: At the end of intervention, insulin sensitivity remained unchanged both with liraglutide from 6.6 [4.2 - 7.9] to 6.9 [4.3 - 10.8] mg/kg/min;p = 0.61 and vildagliptin from 7.1 [5.3 - 9.0] to 6.5 [5.6 - 9.4] mg/kg/min (p = 0.86). The area under the C-peptide curve varied from 5.5 [1.0 - 10.9] to 14.9 [10.8 - 17.2] nmol/L/120min, p = 0.09 in group 1 and from 1.1 [0.5 - 14.1] to 13.0 [9.6 - 16.9] nmol/L/120min (p = 0.17) in group 2. LDL Cholesterol levels decreased significantly with liraglutide from 0.85 g/L [0.51 - 1.02] to 0.54 g/L [0.50 - 0.73] (p = 0.04) but not with Vildagliptin. Body weight tended to decrease in group 1 (−0.6 kg) versus modest increase in group 2 (+1.1 kg). Conclusion: Short-term metabolic effects of Liraglutide and Vildagliptin add-on therapy are comparable in sub-Saharan type 2 diabetes patients with a more favorable trend for Liraglutide on body weight, lipid profile, and insulin secretion.展开更多
Background: Lack of first phase insulin secretion during oral glucose tolerance test [OGTT] in Type 2 Diabetes Mellitus (DM) is attributed to glucose toxicity. Alternatively, the role of insulin resistance in impaired...Background: Lack of first phase insulin secretion during oral glucose tolerance test [OGTT] in Type 2 Diabetes Mellitus (DM) is attributed to glucose toxicity. Alternatively, the role of insulin resistance in impaired insulin release secondary to lack of glucose entry into β cells may be responsible, but is not examined. Aim: The role of insulin sensitivity in 1st phase insulin secretion was assessed. Material and Methods: Plasma glucose (G) and insulin (I) concentrations were determined after an overnight fast (F) and upto 60 minutes during OGTT with glucose 75g in 12 normal (N), 14 with impaired glucose tolerance (IGT) and 41 subjects with Type 2 DM. First phase insulin secretion (Δ Insulin) was determined as a percentage rise from baseline 100x (Peak-Basal)/Basal. Insulin sensitivity was determined as FI x FG (mUxmM/L). Results: FG were normal (7.0 mM/L in Type 2 DM. FI x FG and ? insulin were 35 ± 4 and 389 ± 89% in N;77 ± 5 and 254 ± 65% in IGT;and 235 ± 19 and 95 ± 15% in Type 2 DM. Significant negative correlations were noted between ? insulin one hand and FI x FG on the other amongst all subjects [p < 0.0001 for all correlations]. Conclusion: Decline of 1st phase insulin secretion in IGT and Type 2 DM may be attributed to inhibited release of depleted insulin stores in the β Cells induced by impaired glucose entry due to insulin resistance, and is unlikely to be caused by glucose toxicity in IGT in presence of fasting euglycemia.展开更多
Food quality is of primary concern in the food industry and to the consumer. Systems that mimic human senses have been developed and applied to the characterization of food quality. The five primary senses are: visio...Food quality is of primary concern in the food industry and to the consumer. Systems that mimic human senses have been developed and applied to the characterization of food quality. The five primary senses are: vision, hearing, smell, taste and touch. In the characterization of food quality, people assess the samples sensorially and differentiate “good”from “bad”on a continuum. However, the human sensory system is subjective, with mental and physical inconsistencies, and needs time to work. Artificial senses such as machine vision, the electronic ear, electronic nose, electronic tongue, artificial mouth and even artificial the head have been developed that mimic the human senses. These artificial senses are coordinated individually or collectively by a pat- tern recognition technique, typically artificial neural networks, which have been developed based on studies of the mechanism of the human brain. Such a structure has been used to formulate methods for rapid characterization of food quality. This research presents and discusses individual artificial sensing systems. With the concept of multi-sensor data fusion these sensor systems can work collectively in some way. Two such fused systems, artificial mouth and artificial head, are described and discussed. It indicates that each of the individual systems has their own artificially sensing ability to differentiate food samples. It further indicates that with a more complete mimic of human intelligence the fused systems are more powerful than the individual sys- tems in differentiation of food samples.展开更多
Negative-sense RNA viruses comprise several zoonotic pathogens that mutate rapidly and frequently emerge in people including Influenza, Ebola, Rabies, Hendra and Nipah viruses. Acute respiratory distress syndrome, enc...Negative-sense RNA viruses comprise several zoonotic pathogens that mutate rapidly and frequently emerge in people including Influenza, Ebola, Rabies, Hendra and Nipah viruses. Acute respiratory distress syndrome, encephalitis and vasculitis are common disease outcomes in people as a result of pathogenic viral infection, and are also associated with high case fatality rates. Viral spread from exposure sites to systemic tissues and organs is mediated by virulence factors, including viral attachment glycoproteins and accessory proteins, and their contribution to infection and disease have been delineated by reverse genetics; a molecular approach that enables researchers to experimentally produce recombinant and reassortant viruses from cloned cD NA. Through reverse genetics we have developed a deeper understanding of virulence factors key to disease causation thereby enabling development of targeted antiviral therapies and well-defined live attenuated vaccines. Despite the value of reverse genetics for virulence factor discovery, classical reverse genetic approaches may not provide sufficient resolution for characterization of heterogeneous viral populations, because current techniques recover clonal virus, representing a consensus sequence. In this review the contribution of reverse genetics to virulence factor characterization is outlined, while the limitation of the technique is discussed withreference to new technologies that may be utilized to improve reverse genetic approaches.展开更多
In this paper, we carry out QoE (Quality of Experience) assessment to investigate influences of olfactory and auditory senses on fairness for a networked virtual 3D object identification game with haptics. In the game...In this paper, we carry out QoE (Quality of Experience) assessment to investigate influences of olfactory and auditory senses on fairness for a networked virtual 3D object identification game with haptics. In the game, two players try to identify objects which are placed in a shared 3D virtual space. In the assessment, we carry out the game in four cases. Smells and sounds are presented in the first case, only sounds are done in the second case, and only smells are done in the third case. In the last case, we present neither smell nor sound. As a result, we demonstrate that the fairness deteriorates more largely as the difference in conditions between two users becomes larger.展开更多
The intelligent textile sensors based on fiber(1D)and fabric(2D)are the ideal candidates for wearable devices.Their flexible weaving and unique structure endow them with flexibility,lightweight,good air permeability,a...The intelligent textile sensors based on fiber(1D)and fabric(2D)are the ideal candidates for wearable devices.Their flexible weaving and unique structure endow them with flexibility,lightweight,good air permeability,and feasible integration with garments.In view of the spring-up of novel textile-based strain sensors,the novel materials and fabrication approaches were elaborated from spatial perspectives,i.e.,1D fibers/yarn and 2D fabric.The intrinsic sensing mechanism is the primary fac-tor affecting sensor sensitivity,and the variation trend of the sensing signal is closely related to it.Although existing studies have involved various sensing mechanisms,there is still lacking systematic classification and discussion.Hence,the sensing mechanisms of textile-based sensors were elaborated from spatial perspectives.Considering that strain sensors were mostly based on resistance variation,the sensing mechanisms of resistive textile-based strain sensors were mainly focused,mainly including fiber deformation,tunneling effect,crack propagation,fabric deformation,electrical contact and bridge connec-tion.Meanwhile,the corresponding resistance prediction models,usually used as important data fitting methodology,were also comprehensively discussed,which can reproduce the resistance trend and provide guidance for the sensor performance.Finally,the multifunctionality of textile-based strain sensors was summarized,namely multi-mode signal detection,visual interaction,energy collection,thermal management and medical treatment were discussed.It was expected to provide research insights into the multifunctional integration of textile sensors.展开更多
Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since...Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited.Herein,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)holograms.The LC holograms are used as spatially separated shares to carry secret images.The polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and capacity.Besides,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information security.In implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC hologram.With the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.展开更多
In this paper, we carry out QoE (Quality of Experience) assessment of fairness between players in a networked balloon bursting game with olfactory and haptic senses. We also make a comparison of the fairness among dif...In this paper, we carry out QoE (Quality of Experience) assessment of fairness between players in a networked balloon bursting game with olfactory and haptic senses. We also make a comparison of the fairness among different types of networked games with olfactory and haptic senses in the assessment. Then, we clarify the differences owing to usage of olfactory and haptic senses among the games. As a result, we illustrate that the fairness is largely affected by the delay difference, and we also demonstrate that the allowable range depends on the type of games, type of senses which are employed in the games, and the play methods.展开更多
Stretchable thermoelectric-based self-powered sensors have attracted widespread attention for wearable electronic devices.However,the development of thermoelectric materials with wearable comfort,green,and multimodal ...Stretchable thermoelectric-based self-powered sensors have attracted widespread attention for wearable electronic devices.However,the development of thermoelectric materials with wearable comfort,green,and multimodal synergy remains chal-lenging.In this paper,we prepared a poly(3,4-ethylenedioxythiophene)/multi-walled carbon nanotube(PEDOT/MWCNT)-based thermoelectric fabric for self-powered strain-temperature dual-parameter sensing via spraying and in situ bio-polymer-ization.Compared with ferric chloride(FeCl_(3)),used in chemical polymerization,the PEDOT thermoelectric fabric prepared by enzymatic polymerization is not doped with metal ions,making the thermoelectric performance of flexible wearable fabrics more stable.In addition,the energy-filtration effect of PEDOT and MWCNT efficiently enhanced the thermoelectric performance of the fabric.The fabric has over 320%elongation potential and excellent breathability while exhibiting excel-lent wearability.Moreover,the fabric-based sensor had a wide strain range(1-100%)and temperature detection limit(1℃).In addition,fabric-based sensors were tested by sewing them directly onto clothing or attachment accessories,and showed a rapid response to changes in human joint bending and microenvironmental temperature differences.Moreover,the sensor could be integrated into an intelligent firefighting suit,to continuously and synergistically monitor health abnormalities in firefighter's body movement and temperature thresholds in the micro-environmental temperature of the suit.The developed self-powered dual-parameter wearable sensor shows fascinating potential for applications in human health monitoring,human-computer interaction devices,and intelligent robotics.展开更多
A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manu...A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manuscript.An erbi-um-doped fiber amplifier(EDFA)was employed to amplify the output optical power so that the signal level was further enhanced.The optical path length(OPL)and the ratio of optical path length to volume(RLV)of the MPC is 37.7 m and 13.8 cm^(-2),respectively.A commercial QTF and a self-designed trapezoidal-tip QTF with low frequency of 9461.83 Hz were used as the detectors of the sensor,respectively.The target gas selected to test the performance of the system was acetylene(C2H2).When the optical power was constant at 1000 mW,the minimum detection limit(MDL)of the C2H2-LITES sensor can be achieved 48.3 ppb when using the commercial QTF and 24.6 ppb when using the trapezoid-al-tip QTF.An improvement of the detection performance by a factor of 1.96 was achieved after replacing the commer-cial QTF with the trapezoidal-tip QTF.展开更多
An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and demonstrated.The system incorporates integrated-path differential absorption l...An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and demonstrated.The system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber laser.By combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric pollution.Extensive static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 km.Flight experiments is conducted with the helicopter.Scanning of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 s.The test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.展开更多
The narrow sense and applicable limit of Practical Salinity Scale 1978 (PSS78) and volumetric titration using silver nitrate to measure the salinity of non conservative oceanwater are discussed.The salinity obtained ...The narrow sense and applicable limit of Practical Salinity Scale 1978 (PSS78) and volumetric titration using silver nitrate to measure the salinity of non conservative oceanwater are discussed.The salinity obtained by electrical conductivity method and chlorinity salinity method obviously deviates from the absolute salinity( S A). The Density Salinity Scale(DSS98)proposed by the writers can be extensively used in conservative and non conservative water samples. The merits of the density salinity scale are as follows. (1)The Density Salinity Scale is only related to seawater mass and its buoyant effect, and is not influenced by the variation in seawater composition, and therefore,has high reliability,and repeatability for salinity determination. (2)The salinity values measured by the DSS98 have a conservative property.For oceanwater samples the salinity values are the same as those determined by the PSS78; for non conservative water samples(e g. samples from industrial sources),the salinity values are close to the absolute salinity values in comparison with those measured by the PSS78 and the Knudsen method. (3)For a solution with given solute mass,the solution concentration can be converted into the corresponding salinity by the Density Salinity Scale using the expansion coefficient of the solution and the calibration coefficient of the partial molar volume of the solute.展开更多
Remote sensing data plays an important role in natural disaster management.However,with the increase of the variety and quantity of remote sensors,the problem of“knowledge barriers”arises when data users in disaster...Remote sensing data plays an important role in natural disaster management.However,with the increase of the variety and quantity of remote sensors,the problem of“knowledge barriers”arises when data users in disaster field retrieve remote sensing data.To improve this problem,this paper proposes an ontology and rule based retrieval(ORR)method to retrieve disaster remote sensing data,and this method introduces ontology technology to express earthquake disaster and remote sensing knowledge,on this basis,and realizes the task suitability reasoning of earthquake disaster remote sensing data,mining the semantic relationship between remote sensing metadata and disasters.The prototype system is built according to the ORR method,which is compared with the traditional method,using the ORR method to retrieve disaster remote sensing data can reduce the knowledge requirements of data users in the retrieval process and improve data retrieval efficiency.展开更多
The rapid development of the Internet of Things and artificial intelligence technologies has increased the need for wearable,portable,and self-powered flexible sensing devices.Triboelectric nanogenerators(TENGs)based ...The rapid development of the Internet of Things and artificial intelligence technologies has increased the need for wearable,portable,and self-powered flexible sensing devices.Triboelectric nanogenerators(TENGs)based on gel materials(with excellent conductivity,mechanical tunability,environmental adaptability,and biocompatibility)are considered an advanced approach for developing a new generation of flexible sensors.This review comprehensively summarizes the recent advances in gel-based TENGs for flexible sensors,covering their principles,properties,and applications.Based on the development requirements for flexible sensors,the working mechanism of gel-based TENGs and the characteristic advantages of gels are introduced.Design strategies for the performance optimization of hydrogel-,organogel-,and aerogel-based TENGs are systematically summarized.In addition,the applications of gel-based TENGs in human motion sensing,tactile sensing,health monitoring,environmental monitoring,human-machine interaction,and other related fields are summarized.Finally,the challenges of gel-based TENGs for flexible sensing are discussed,and feasible strategies are proposed to guide future research.展开更多
Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin a...Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin action and secretion (using the surrogate indexes) suggesting their use in large studies in populations of pancreas/ islets transplanted patients.展开更多
Glaciers in the Pamir region are experiencing rapid melting and receding due to climate change,which has a significant implication for the Amu Darya river basin.Predominantly,surging glaciers,which undergo unpredictab...Glaciers in the Pamir region are experiencing rapid melting and receding due to climate change,which has a significant implication for the Amu Darya river basin.Predominantly,surging glaciers,which undergo unpredictable advances,are potentially leading to the obstruction of high-altitude river channels and also glacial lake outburst floods.decrease of-703.5±30.0 m.There is a substantial increase in the number(from 19 to 75)and area(from 4889.7±0.6 m2 to 15345.5±0.6 m2)of RGS lakes along with supra-glacier ponds based on a comparison of ArcGIS base map in 2011 and high-resolution UAV data in 2023.For M glacier,number of lakes increased from 4 to 22 but the lake area declined from 10715.2±0.6 to 365.6±0.6 m2.It was noted that the largest lake in 2011 with an area of 10406.4±0.6 m2 at the southeastern portion of the glacier was not observed in 2023 due to outburst.Both the glaciers have substantially impacted the river flow(Abdukahor river)by obstructing a significant proportion of river channel in recent years and might cause outburst floods.These findings enhance the understanding of glacier dynamics and their impacts on the surrounding areas,emphasizing the urgent need for continued monitoring and appropriate management strategies,with a specific focus on surging glaciers and the associated risks.展开更多
Reasonably constructing an atomic interface is pronouncedly essential for surface-related gas-sensing reaction.Herein,we present an ingen-ious feedback-regulation system by changing the interactional mode between sing...Reasonably constructing an atomic interface is pronouncedly essential for surface-related gas-sensing reaction.Herein,we present an ingen-ious feedback-regulation system by changing the interactional mode between single Pt atoms and adjacent S species for high-efficiency SO_(2)sensing.We found that the single Pt sites on the MoS_(2)surface can induce easier volatiliza-tion of adjacent S species to activate the whole inert S plane.Reversely,the activated S species can provide a feedback role in tailoring the antibonding-orbital electronic occupancy state of Pt atoms,thus creating a combined system involving S vacancy-assisted single Pt sites(Pt-Vs)to synergistically improve the adsorption ability of SO_(2)gas molecules.Further-more,in situ Raman,ex situ X-ray photoelectron spectroscopy testing and density functional theory analysis demonstrate the intact feedback-regulation system can expand the electron transfer path from single Pt sites to whole Pt-MoS_(2)supports in SO_(2)gas atmosphere.Equipped with wireless-sensing modules,the final Pt1-MoS_(2)-def sensors array can further realize real-time monitoring of SO_(2)levels and cloud-data storage for plant growth.Such a fundamental understanding of the intrinsic link between atomic interface and sensing mechanism is thus expected to broaden the rational design of highly effective gas sensors.展开更多
文摘This paper is to analyze the novel in the following aspects: The Chinese-American cultural conflicts, the mother and daughter relations and sisters’ relations, the psychological critics, and the postcolonial identity. The novel is about multiple explanations of the aspects mentioned above. The writer confuses the Chinese culture, the relationship of the two sisters. Under the superficial description, the writer shows the psychological status of the main character and the practically existence of postcolonial identity and embodiment in the novel.
基金This research was partly supported by(National Natural Science Foundation of China under 41671431,61572421and Shanghai Science and Technology Commission Project 15590501900.
文摘The recent advances in remote sensing and computer techniques give birth to the explosive growth of remote sensing images.The emergence of cloud storage has brought new opportunities for storage and management of massive remote sensing images with its large storage space,cost savings.However,the openness of cloud brings challenges for image data security.In this paper,we propose a weighted image sharing scheme to ensure the security of remote sensing in cloud environment,which takes the weights of participants(i.e.,cloud service providers)into consideration.An extended Mignotte sequence is constructed according to the weights of participants,and we can generate image shadow shares based on the hash value which can be obtained from gray value of remote sensing images.Then we store the shadows in every cloud service provider,respectively.At last,we restore the remote sensing image based on the Chinese Remainder Theorem.Experimental results show the proposed scheme can effectively realize the secure storage of remote sensing images in the cloud.The experiment also shows that no matter weight values,each service providers only needs to save one share,which simplifies the management and usage,it also reduces the transmission of secret information,strengthens the security and practicality of this scheme.
文摘Background: We aimed to evaluate the short-term metabolic effects of a GLP-1a, (liraglutide) versus a DPP-4i, (vildagliptin) in a group of sub-Saharan type 2 diabetes patients. Methods: We conducted a randomized controlled single blinded clinical trial in 14 uncontrolled type 2 diabetes patients (HbA1c ≥ 53 mmol/mol) with mean duration of diabetes of 8 [1 - 12] years and median age of 57 [49 - 61] years. Baseline treatment consisted of metformin in monotherapy or metformin plus sulfonylureas. Participants were randomly allocated to 2 groups of add-on 1.2 mg/day subcutaneous liraglutide in group 1 or 100 mg/day of oral vildagliptin in group 2 for 2 weeks. In all participants, insulin secretion in response to mixed meal tolerance test, insulin sensitivity by 80 mU/m<sup>2</sup>/min hyperinsulinemic-euglycemic clamp, body composition, and lipid profile were measured before and after intervention. Results: At the end of intervention, insulin sensitivity remained unchanged both with liraglutide from 6.6 [4.2 - 7.9] to 6.9 [4.3 - 10.8] mg/kg/min;p = 0.61 and vildagliptin from 7.1 [5.3 - 9.0] to 6.5 [5.6 - 9.4] mg/kg/min (p = 0.86). The area under the C-peptide curve varied from 5.5 [1.0 - 10.9] to 14.9 [10.8 - 17.2] nmol/L/120min, p = 0.09 in group 1 and from 1.1 [0.5 - 14.1] to 13.0 [9.6 - 16.9] nmol/L/120min (p = 0.17) in group 2. LDL Cholesterol levels decreased significantly with liraglutide from 0.85 g/L [0.51 - 1.02] to 0.54 g/L [0.50 - 0.73] (p = 0.04) but not with Vildagliptin. Body weight tended to decrease in group 1 (−0.6 kg) versus modest increase in group 2 (+1.1 kg). Conclusion: Short-term metabolic effects of Liraglutide and Vildagliptin add-on therapy are comparable in sub-Saharan type 2 diabetes patients with a more favorable trend for Liraglutide on body weight, lipid profile, and insulin secretion.
文摘Background: Lack of first phase insulin secretion during oral glucose tolerance test [OGTT] in Type 2 Diabetes Mellitus (DM) is attributed to glucose toxicity. Alternatively, the role of insulin resistance in impaired insulin release secondary to lack of glucose entry into β cells may be responsible, but is not examined. Aim: The role of insulin sensitivity in 1st phase insulin secretion was assessed. Material and Methods: Plasma glucose (G) and insulin (I) concentrations were determined after an overnight fast (F) and upto 60 minutes during OGTT with glucose 75g in 12 normal (N), 14 with impaired glucose tolerance (IGT) and 41 subjects with Type 2 DM. First phase insulin secretion (Δ Insulin) was determined as a percentage rise from baseline 100x (Peak-Basal)/Basal. Insulin sensitivity was determined as FI x FG (mUxmM/L). Results: FG were normal (7.0 mM/L in Type 2 DM. FI x FG and ? insulin were 35 ± 4 and 389 ± 89% in N;77 ± 5 and 254 ± 65% in IGT;and 235 ± 19 and 95 ± 15% in Type 2 DM. Significant negative correlations were noted between ? insulin one hand and FI x FG on the other amongst all subjects [p < 0.0001 for all correlations]. Conclusion: Decline of 1st phase insulin secretion in IGT and Type 2 DM may be attributed to inhibited release of depleted insulin stores in the β Cells induced by impaired glucose entry due to insulin resistance, and is unlikely to be caused by glucose toxicity in IGT in presence of fasting euglycemia.
文摘Food quality is of primary concern in the food industry and to the consumer. Systems that mimic human senses have been developed and applied to the characterization of food quality. The five primary senses are: vision, hearing, smell, taste and touch. In the characterization of food quality, people assess the samples sensorially and differentiate “good”from “bad”on a continuum. However, the human sensory system is subjective, with mental and physical inconsistencies, and needs time to work. Artificial senses such as machine vision, the electronic ear, electronic nose, electronic tongue, artificial mouth and even artificial the head have been developed that mimic the human senses. These artificial senses are coordinated individually or collectively by a pat- tern recognition technique, typically artificial neural networks, which have been developed based on studies of the mechanism of the human brain. Such a structure has been used to formulate methods for rapid characterization of food quality. This research presents and discusses individual artificial sensing systems. With the concept of multi-sensor data fusion these sensor systems can work collectively in some way. Two such fused systems, artificial mouth and artificial head, are described and discussed. It indicates that each of the individual systems has their own artificially sensing ability to differentiate food samples. It further indicates that with a more complete mimic of human intelligence the fused systems are more powerful than the individual sys- tems in differentiation of food samples.
文摘Negative-sense RNA viruses comprise several zoonotic pathogens that mutate rapidly and frequently emerge in people including Influenza, Ebola, Rabies, Hendra and Nipah viruses. Acute respiratory distress syndrome, encephalitis and vasculitis are common disease outcomes in people as a result of pathogenic viral infection, and are also associated with high case fatality rates. Viral spread from exposure sites to systemic tissues and organs is mediated by virulence factors, including viral attachment glycoproteins and accessory proteins, and their contribution to infection and disease have been delineated by reverse genetics; a molecular approach that enables researchers to experimentally produce recombinant and reassortant viruses from cloned cD NA. Through reverse genetics we have developed a deeper understanding of virulence factors key to disease causation thereby enabling development of targeted antiviral therapies and well-defined live attenuated vaccines. Despite the value of reverse genetics for virulence factor discovery, classical reverse genetic approaches may not provide sufficient resolution for characterization of heterogeneous viral populations, because current techniques recover clonal virus, representing a consensus sequence. In this review the contribution of reverse genetics to virulence factor characterization is outlined, while the limitation of the technique is discussed withreference to new technologies that may be utilized to improve reverse genetic approaches.
文摘In this paper, we carry out QoE (Quality of Experience) assessment to investigate influences of olfactory and auditory senses on fairness for a networked virtual 3D object identification game with haptics. In the game, two players try to identify objects which are placed in a shared 3D virtual space. In the assessment, we carry out the game in four cases. Smells and sounds are presented in the first case, only sounds are done in the second case, and only smells are done in the third case. In the last case, we present neither smell nor sound. As a result, we demonstrate that the fairness deteriorates more largely as the difference in conditions between two users becomes larger.
基金supported by the major project of the National Natural Science Foundation of China(52090033/52090030).
文摘The intelligent textile sensors based on fiber(1D)and fabric(2D)are the ideal candidates for wearable devices.Their flexible weaving and unique structure endow them with flexibility,lightweight,good air permeability,and feasible integration with garments.In view of the spring-up of novel textile-based strain sensors,the novel materials and fabrication approaches were elaborated from spatial perspectives,i.e.,1D fibers/yarn and 2D fabric.The intrinsic sensing mechanism is the primary fac-tor affecting sensor sensitivity,and the variation trend of the sensing signal is closely related to it.Although existing studies have involved various sensing mechanisms,there is still lacking systematic classification and discussion.Hence,the sensing mechanisms of textile-based sensors were elaborated from spatial perspectives.Considering that strain sensors were mostly based on resistance variation,the sensing mechanisms of resistive textile-based strain sensors were mainly focused,mainly including fiber deformation,tunneling effect,crack propagation,fabric deformation,electrical contact and bridge connec-tion.Meanwhile,the corresponding resistance prediction models,usually used as important data fitting methodology,were also comprehensively discussed,which can reproduce the resistance trend and provide guidance for the sensor performance.Finally,the multifunctionality of textile-based strain sensors was summarized,namely multi-mode signal detection,visual interaction,energy collection,thermal management and medical treatment were discussed.It was expected to provide research insights into the multifunctional integration of textile sensors.
基金support from the National Natural Science Foundation of China (No.62005164,62222507,62175101,and 62005166)the Shanghai Natural Science Foundation (23ZR1443700)+3 种基金Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (23SG41)the Young Elite Scientist Sponsorship Program by CAST (No.20220042)Science and Technology Commission of Shanghai Municipality (Grant No.21DZ1100500)the Shanghai Municipal Science and Technology Major Project,and the Shanghai Frontiers Science Center Program (2021-2025 No.20).
文摘Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited.Herein,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)holograms.The LC holograms are used as spatially separated shares to carry secret images.The polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and capacity.Besides,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information security.In implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC hologram.With the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.
文摘In this paper, we carry out QoE (Quality of Experience) assessment of fairness between players in a networked balloon bursting game with olfactory and haptic senses. We also make a comparison of the fairness among different types of networked games with olfactory and haptic senses in the assessment. Then, we clarify the differences owing to usage of olfactory and haptic senses among the games. As a result, we illustrate that the fairness is largely affected by the delay difference, and we also demonstrate that the allowable range depends on the type of games, type of senses which are employed in the games, and the play methods.
基金supported by the National Key R&D Program of China(2021YFC2104000)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_2349)+1 种基金National Natural Science Foundation of China(22109054)China Postdoctoral Science Foundation(2021M691264).
文摘Stretchable thermoelectric-based self-powered sensors have attracted widespread attention for wearable electronic devices.However,the development of thermoelectric materials with wearable comfort,green,and multimodal synergy remains chal-lenging.In this paper,we prepared a poly(3,4-ethylenedioxythiophene)/multi-walled carbon nanotube(PEDOT/MWCNT)-based thermoelectric fabric for self-powered strain-temperature dual-parameter sensing via spraying and in situ bio-polymer-ization.Compared with ferric chloride(FeCl_(3)),used in chemical polymerization,the PEDOT thermoelectric fabric prepared by enzymatic polymerization is not doped with metal ions,making the thermoelectric performance of flexible wearable fabrics more stable.In addition,the energy-filtration effect of PEDOT and MWCNT efficiently enhanced the thermoelectric performance of the fabric.The fabric has over 320%elongation potential and excellent breathability while exhibiting excel-lent wearability.Moreover,the fabric-based sensor had a wide strain range(1-100%)and temperature detection limit(1℃).In addition,fabric-based sensors were tested by sewing them directly onto clothing or attachment accessories,and showed a rapid response to changes in human joint bending and microenvironmental temperature differences.Moreover,the sensor could be integrated into an intelligent firefighting suit,to continuously and synergistically monitor health abnormalities in firefighter's body movement and temperature thresholds in the micro-environmental temperature of the suit.The developed self-powered dual-parameter wearable sensor shows fascinating potential for applications in human health monitoring,human-computer interaction devices,and intelligent robotics.
基金National Natural Science Foundation of China(Grant Nos.62335006,62022032,62275065,and 61875047)Key Laboratory of Opto-Electronic Information Acquisition and Manipulation(Anhui University),Ministry of Education(Grant No.OEIAM202202)Fundamental Research Funds for the Central Universities(Grant No.HIT.OCEF.2023011).
文摘A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manuscript.An erbi-um-doped fiber amplifier(EDFA)was employed to amplify the output optical power so that the signal level was further enhanced.The optical path length(OPL)and the ratio of optical path length to volume(RLV)of the MPC is 37.7 m and 13.8 cm^(-2),respectively.A commercial QTF and a self-designed trapezoidal-tip QTF with low frequency of 9461.83 Hz were used as the detectors of the sensor,respectively.The target gas selected to test the performance of the system was acetylene(C2H2).When the optical power was constant at 1000 mW,the minimum detection limit(MDL)of the C2H2-LITES sensor can be achieved 48.3 ppb when using the commercial QTF and 24.6 ppb when using the trapezoid-al-tip QTF.An improvement of the detection performance by a factor of 1.96 was achieved after replacing the commer-cial QTF with the trapezoidal-tip QTF.
文摘An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and demonstrated.The system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber laser.By combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric pollution.Extensive static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 km.Flight experiments is conducted with the helicopter.Scanning of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 s.The test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.
文摘The narrow sense and applicable limit of Practical Salinity Scale 1978 (PSS78) and volumetric titration using silver nitrate to measure the salinity of non conservative oceanwater are discussed.The salinity obtained by electrical conductivity method and chlorinity salinity method obviously deviates from the absolute salinity( S A). The Density Salinity Scale(DSS98)proposed by the writers can be extensively used in conservative and non conservative water samples. The merits of the density salinity scale are as follows. (1)The Density Salinity Scale is only related to seawater mass and its buoyant effect, and is not influenced by the variation in seawater composition, and therefore,has high reliability,and repeatability for salinity determination. (2)The salinity values measured by the DSS98 have a conservative property.For oceanwater samples the salinity values are the same as those determined by the PSS78; for non conservative water samples(e g. samples from industrial sources),the salinity values are close to the absolute salinity values in comparison with those measured by the PSS78 and the Knudsen method. (3)For a solution with given solute mass,the solution concentration can be converted into the corresponding salinity by the Density Salinity Scale using the expansion coefficient of the solution and the calibration coefficient of the partial molar volume of the solute.
基金supported by the National Key Research and Development Program of China(2020YFC1512304).
文摘Remote sensing data plays an important role in natural disaster management.However,with the increase of the variety and quantity of remote sensors,the problem of“knowledge barriers”arises when data users in disaster field retrieve remote sensing data.To improve this problem,this paper proposes an ontology and rule based retrieval(ORR)method to retrieve disaster remote sensing data,and this method introduces ontology technology to express earthquake disaster and remote sensing knowledge,on this basis,and realizes the task suitability reasoning of earthquake disaster remote sensing data,mining the semantic relationship between remote sensing metadata and disasters.The prototype system is built according to the ORR method,which is compared with the traditional method,using the ORR method to retrieve disaster remote sensing data can reduce the knowledge requirements of data users in the retrieval process and improve data retrieval efficiency.
基金supported by the National Natural Science Foundation of China(22068005,22278091)the Training Program for 1000 Backbone Teachers in Guangxi(2022).
文摘The rapid development of the Internet of Things and artificial intelligence technologies has increased the need for wearable,portable,and self-powered flexible sensing devices.Triboelectric nanogenerators(TENGs)based on gel materials(with excellent conductivity,mechanical tunability,environmental adaptability,and biocompatibility)are considered an advanced approach for developing a new generation of flexible sensors.This review comprehensively summarizes the recent advances in gel-based TENGs for flexible sensors,covering their principles,properties,and applications.Based on the development requirements for flexible sensors,the working mechanism of gel-based TENGs and the characteristic advantages of gels are introduced.Design strategies for the performance optimization of hydrogel-,organogel-,and aerogel-based TENGs are systematically summarized.In addition,the applications of gel-based TENGs in human motion sensing,tactile sensing,health monitoring,environmental monitoring,human-machine interaction,and other related fields are summarized.Finally,the challenges of gel-based TENGs for flexible sensing are discussed,and feasible strategies are proposed to guide future research.
文摘Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin action and secretion (using the surrogate indexes) suggesting their use in large studies in populations of pancreas/ islets transplanted patients.
基金funded by the Gansu Provincial Science and Technology Program(22ZD6FA005)Gansu Postdoctoral Science Foundation(Grant number-E339880204)。
文摘Glaciers in the Pamir region are experiencing rapid melting and receding due to climate change,which has a significant implication for the Amu Darya river basin.Predominantly,surging glaciers,which undergo unpredictable advances,are potentially leading to the obstruction of high-altitude river channels and also glacial lake outburst floods.decrease of-703.5±30.0 m.There is a substantial increase in the number(from 19 to 75)and area(from 4889.7±0.6 m2 to 15345.5±0.6 m2)of RGS lakes along with supra-glacier ponds based on a comparison of ArcGIS base map in 2011 and high-resolution UAV data in 2023.For M glacier,number of lakes increased from 4 to 22 but the lake area declined from 10715.2±0.6 to 365.6±0.6 m2.It was noted that the largest lake in 2011 with an area of 10406.4±0.6 m2 at the southeastern portion of the glacier was not observed in 2023 due to outburst.Both the glaciers have substantially impacted the river flow(Abdukahor river)by obstructing a significant proportion of river channel in recent years and might cause outburst floods.These findings enhance the understanding of glacier dynamics and their impacts on the surrounding areas,emphasizing the urgent need for continued monitoring and appropriate management strategies,with a specific focus on surging glaciers and the associated risks.
基金This work was supported by the National Natural Science Foundation of China(62271299)Shanghai Sailing Program(22YF1413400).Shanghai Engineering Research Center for We thank the Integrated Circuits and Advanced Display Materials.
文摘Reasonably constructing an atomic interface is pronouncedly essential for surface-related gas-sensing reaction.Herein,we present an ingen-ious feedback-regulation system by changing the interactional mode between single Pt atoms and adjacent S species for high-efficiency SO_(2)sensing.We found that the single Pt sites on the MoS_(2)surface can induce easier volatiliza-tion of adjacent S species to activate the whole inert S plane.Reversely,the activated S species can provide a feedback role in tailoring the antibonding-orbital electronic occupancy state of Pt atoms,thus creating a combined system involving S vacancy-assisted single Pt sites(Pt-Vs)to synergistically improve the adsorption ability of SO_(2)gas molecules.Further-more,in situ Raman,ex situ X-ray photoelectron spectroscopy testing and density functional theory analysis demonstrate the intact feedback-regulation system can expand the electron transfer path from single Pt sites to whole Pt-MoS_(2)supports in SO_(2)gas atmosphere.Equipped with wireless-sensing modules,the final Pt1-MoS_(2)-def sensors array can further realize real-time monitoring of SO_(2)levels and cloud-data storage for plant growth.Such a fundamental understanding of the intrinsic link between atomic interface and sensing mechanism is thus expected to broaden the rational design of highly effective gas sensors.