Objective:To observe the efficacy of Yiqi Huoxue Decoction in the treatment of patients with diabetic nephropathy(DN)stageⅢwith qi and yin deficiency and stasis and its effects on vascular endothelial growth factor(V...Objective:To observe the efficacy of Yiqi Huoxue Decoction in the treatment of patients with diabetic nephropathy(DN)stageⅢwith qi and yin deficiency and stasis and its effects on vascular endothelial growth factor(VEGF)and transforming growth factor-β(TGF-β1).Methods:Sixty patients with stage DN of Qi-yin deficiency and stasis type DN who were treated in the Endocrinology Department of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from September 2018 to December 2019 were selected as the research subjects.The remainder method was used to divide them into 30 cases in the observation group and 30 cases in the control group.Patients in both groups were referred to the guidelines and expert consensus for general treatment of DN(hypogl-ycemic,antihypertensive,lipid-lowering,etc.).The control group was given pancreatic kallikrein enteric-coated tablets orally once,120U,3 times a day,and the observation group was given The traditional Chinese medicine Yiqi Huoxue Decoction was taken orally,one dose daily,twice a day in the morning and evening;the two groups intervened continuously for 8 weeks.Detect blood FPG,PBG,HbA1c,β2-MG,BUN,SCr,VEGF,TGF-β1,and urine mALB and UACR levels before and after treatment,and calculate eGFR before and after treatment in both groups;observe changes in TCM syndrome scores in the two groups,Compare its clinical efficacy.Results:After 8 weeks of treatment,the total clinical effective rate of patients in the observation group was 93.3%,which was significantly different from the control group of 76.6%(P<0.05);the TCM syndrome scores in the observation group were significantly lower than those before treatment and in the control group(P<0.05);The levels of FPG,HbA1c,PPG,mALB,β2-MG,UACR,VEGF,and TGF-β1 in the observation group were significantly lower than those in the control group,with significant differences(P<0.05).The levels of SCr and BUN in the observation group were significantly lower.Compared with before treatment,eGFR increased,but there was no signi-ficant difference(P>0.05).Conclusion:Yiqi Huoxue Decoction for the treatment of patients with DN typeⅢqi-yin deficiency and stasis type,not only helps to lower blood sugar levels,improve TCM syndromes,but also can reduce early renal damage,reduce urine albumin,and delay kidney function It may be further worsened and has better safety.The mechanism may be related to reducing the levels of VEGF and TGF-β1,thereby delaying the fibrosis of tubulointerstitial scar and inhibi-ting glomerular capillary sclerosis.展开更多
目的探讨益气甘露方治疗2型糖尿病气阴两虚证的临床疗效及其对血清代谢产物的影响。方法将80例2型糖尿病气阴两虚证患者随机分为对照组、试验组,每组40例,同时选取了40名与糖尿病患者年龄、性别相匹配的健康人作为健康对照组。西药对照...目的探讨益气甘露方治疗2型糖尿病气阴两虚证的临床疗效及其对血清代谢产物的影响。方法将80例2型糖尿病气阴两虚证患者随机分为对照组、试验组,每组40例,同时选取了40名与糖尿病患者年龄、性别相匹配的健康人作为健康对照组。西药对照组予二甲双胍治疗,中药试验组予益气甘露方治疗,对比治疗前后两组的临床疗效、生化指标、炎症因子、中医症状积分及血清代谢产物的变化。结果治疗前,两组患者的血糖及血脂指标比较差异无统计学意义(P>0.05);治疗后,两组患者的FPG、2 h PG、HbAlc、INS、INS120′、TC、TG、LDL-C、TNF-α、IL-6、hs-CRP水平与治疗前比较差异均具有统计学意义(P<0.05),且中药试验组疗效不低于西药对照组。2型糖尿病气阴两虚证与健康人的差异性代谢物主要有溶血磷脂酸、磷脂酰乙醇胺、心磷脂、二氢生物蝶呤等,所参与的代谢途径主要涉及脂类代谢和氨基酸代谢。结论益气甘露方可以降低血糖、血脂及炎症水平,调节脂质与氨基酸代谢,改善临床症状。展开更多
基金Chinese Medicine Research Project of Jiangxi Provincial Health and Family Planning Commission(No.2018A004)
文摘Objective:To observe the efficacy of Yiqi Huoxue Decoction in the treatment of patients with diabetic nephropathy(DN)stageⅢwith qi and yin deficiency and stasis and its effects on vascular endothelial growth factor(VEGF)and transforming growth factor-β(TGF-β1).Methods:Sixty patients with stage DN of Qi-yin deficiency and stasis type DN who were treated in the Endocrinology Department of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from September 2018 to December 2019 were selected as the research subjects.The remainder method was used to divide them into 30 cases in the observation group and 30 cases in the control group.Patients in both groups were referred to the guidelines and expert consensus for general treatment of DN(hypogl-ycemic,antihypertensive,lipid-lowering,etc.).The control group was given pancreatic kallikrein enteric-coated tablets orally once,120U,3 times a day,and the observation group was given The traditional Chinese medicine Yiqi Huoxue Decoction was taken orally,one dose daily,twice a day in the morning and evening;the two groups intervened continuously for 8 weeks.Detect blood FPG,PBG,HbA1c,β2-MG,BUN,SCr,VEGF,TGF-β1,and urine mALB and UACR levels before and after treatment,and calculate eGFR before and after treatment in both groups;observe changes in TCM syndrome scores in the two groups,Compare its clinical efficacy.Results:After 8 weeks of treatment,the total clinical effective rate of patients in the observation group was 93.3%,which was significantly different from the control group of 76.6%(P<0.05);the TCM syndrome scores in the observation group were significantly lower than those before treatment and in the control group(P<0.05);The levels of FPG,HbA1c,PPG,mALB,β2-MG,UACR,VEGF,and TGF-β1 in the observation group were significantly lower than those in the control group,with significant differences(P<0.05).The levels of SCr and BUN in the observation group were significantly lower.Compared with before treatment,eGFR increased,but there was no signi-ficant difference(P>0.05).Conclusion:Yiqi Huoxue Decoction for the treatment of patients with DN typeⅢqi-yin deficiency and stasis type,not only helps to lower blood sugar levels,improve TCM syndromes,but also can reduce early renal damage,reduce urine albumin,and delay kidney function It may be further worsened and has better safety.The mechanism may be related to reducing the levels of VEGF and TGF-β1,thereby delaying the fibrosis of tubulointerstitial scar and inhibi-ting glomerular capillary sclerosis.
文摘目的探讨益气甘露方治疗2型糖尿病气阴两虚证的临床疗效及其对血清代谢产物的影响。方法将80例2型糖尿病气阴两虚证患者随机分为对照组、试验组,每组40例,同时选取了40名与糖尿病患者年龄、性别相匹配的健康人作为健康对照组。西药对照组予二甲双胍治疗,中药试验组予益气甘露方治疗,对比治疗前后两组的临床疗效、生化指标、炎症因子、中医症状积分及血清代谢产物的变化。结果治疗前,两组患者的血糖及血脂指标比较差异无统计学意义(P>0.05);治疗后,两组患者的FPG、2 h PG、HbAlc、INS、INS120′、TC、TG、LDL-C、TNF-α、IL-6、hs-CRP水平与治疗前比较差异均具有统计学意义(P<0.05),且中药试验组疗效不低于西药对照组。2型糖尿病气阴两虚证与健康人的差异性代谢物主要有溶血磷脂酸、磷脂酰乙醇胺、心磷脂、二氢生物蝶呤等,所参与的代谢途径主要涉及脂类代谢和氨基酸代谢。结论益气甘露方可以降低血糖、血脂及炎症水平,调节脂质与氨基酸代谢,改善临床症状。
