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Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori 被引量:1
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作者 Miao-Miao Lin Shan-Shan Yang +6 位作者 Qiu-Yue Huang Guang-Hui Cui Xiao-Fen Jia Yao Yang Zong-Ming Shi Hui Ye Xue-Zhi Zhang 《World Journal of Gastroenterology》 SCIE CAS 2024年第24期3086-3105,共20页
BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric cancer.HP infection affects ove... BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric cancer.HP infection affects over 4.4 billion people globally,with a worldwide infection rate of up to 50%.The multidrug resistance of HP poses a serious challenge to eradication.It has been monstrated that compared to bismuth quadruple therapy,Qingre Huashi decoction(QHD)combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions;in addition,QHD directly inhibit and kill HP in vitro.METHODS In this study,12 HP strains were isolated in vitro after biopsy during gastroscopy of HP-infected patients.In vitro,the minimum inhibitory concentration(MIC)values for clinical HP strains and biofilm quantification were determined through the E-test method and crystal violet staining,respectively.The most robust biofilm-forming strain of HP was selected,and QHD was evaluated for its inhibitory and bactericidal effects on the strain with strong biofilm formation.This assessment was performed using agar dilution,E-test,killing dynamics,and transmission electron microscopy(TEM).The study also explored the impact of QHD on antibiotic resistance in these HP strains with strong biofilm formation.Crystalline violet method,scanning electron microscopy,laser confocal scanning microscopy,and(p)ppGpp chromatographic identification were employed to evaluate the effect of QHD on biofilm in strong biofilm-forming HP strains.The effect of QHD on biofilm and efflux pump-related gene expression was evaluated by quantitative polymerase chain reaction.Non-targeted metabolomics with UHPLC-MS/MS was used to identify potential metabolic pathways and biomarkers which were different between the NC and QHD groups.RESULTS HP could form biofilms of different degrees in vitro,and the intensity of formation was associated with the drug resistance of the strain.QHD had strong bacteriostatic and bactericidal effects on HP,with MICs of 32-64 mg/mL.QHD could inhibit the biofilm formation of the strong biofilm-forming HP strains,disrupt the biofilm structure,lower the accumulation of(p)ppGpp,decrease the expression of biofilm-related genes including LuxS,Spot,glup(HP1174),NapA,and CagE,and reduce the expression of efflux pump-related genes such as HP0605,HP0971,HP1327,and HP1489.Based on metabolomic analysis,QHD induced oxidative stress in HP,enhanced metabolism,and potentially inhibited relevant signaling pathways by upregulating adenosine monophosphate(AMP),thereby affecting HP growth,metabolism,and protein synthesis.CONCLUSION QHD exerts bacteriostatic and bactericidal effects on HP,and reduces HP drug resistance by inhibiting HP biofilm formation,destroying its biofilm structure,inhibiting the expression of biofilm-related genes and efflux pump-related genes,enhancing HP metabolism,and activating AMP in HP. 展开更多
关键词 qingre Huashi decoction Helicobacter pylori Drug resistance BIOFILM Metabolomics
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Effect of Qingre Huayu Decoction on Autophagy and Apoptosis of Neurons in Rats with Ischemic Brain Injury by Regulating Ca^(2+)/CaMKKβ-AMPK-mTOR Pathway
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作者 Qun TONG Xuelan KUANG +2 位作者 Jinfeng ZHOU Jinhua YUAN Xianjing ZENG 《Medicinal Plant》 2024年第5期39-43,共5页
[Objectives]To explore the neuroprotective mechanism of Qingre Huayu Decoction on rats with acute cerebral ischemia injury.[Methods]SD rats were divided into sham operation group,ischemia model group,low,medium and hi... [Objectives]To explore the neuroprotective mechanism of Qingre Huayu Decoction on rats with acute cerebral ischemia injury.[Methods]SD rats were divided into sham operation group,ischemia model group,low,medium and high dose groups of Qingre Huayu De-coction,with 10 rats in each group.Referring to the MCAO operation model,both the sham operation group and the model group were given normal saline by gavage,and the Qingre Huayu Decoction group was given different doses of Qingre Huayu Decoction by gavage.After the op-eration,the rats were scored for neurological deficit,neurons were stained with HE,apoptotic cells were detected with TUNEL,and the levels of autophagy and apoptotic proteins in the Ca^(2+)/CaMKKβ-AMPK-mTORpathway in brain tissue were detected with Western-blot.[Results]Compared with the model group,the neurological function score of Qingre Huayu Decoction Group decreased significantly(P<0.05),the pathological damage of neurons in Qingre Huavu Decoction Group decreased.the proportion of apoptosis-positive cells detected by TUNEL de-creased(P<0.05),and the expression of CaMKKβand AMPK increased,expression of mTOR decreased,expression of Beclin-1 and LC3 increased,and expression of Caspase-3decreased in Qingre Huayu Decoction Group(P<0.05).[Conclusions]Qingre Huayu Decoction may play a neuroprotective role by activating Ca^(2+)/CaMKKβ-AMPK-mTOR pathway and regulating the level of apoptosis and autophagy. 展开更多
关键词 qingre Huayu decoction Ischemic brain injury Apoptosis Autophagy
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Effect of Qingre Buyi Decoction (清热补益汤) on Nitric Oxide and Histomorphology of Intestinal Mucosa in Rats with Radiation Enteritis
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作者 丁小凡 李德杏 赵林 《Chinese Journal of Integrated Traditional and Western Medicine》 2003年第2期120-123,共4页
Objective: To explore the mechanism of Qingre Buyi Decoction (清热补益汤,QBD) in prevention and treatment of radiation enteritis in rats. Methods: Forty-eight Wistar rats were randomly divided into four groups, the TC... Objective: To explore the mechanism of Qingre Buyi Decoction (清热补益汤,QBD) in prevention and treatment of radiation enteritis in rats. Methods: Forty-eight Wistar rats were randomly divided into four groups, the TCM group, the WM group, the model group and the control group, 12 in each group. Rats in the former three groups were given orally with QBD, norfloxacin and normal saline once a day for 7 successive days, after being irradiated with X-ray at single dose of 10 Gy for modeling of radiation enteritis, while rats in the control group were untreated. Animals were sacrificed at the end of the medication. NO concentration, mean height and number of villi per centimeter in their small intestinal mu-cosa were measured. Results: The intestinal NO concentration was significantly lower in the TCM and WM groups than that in the model group(P<0.05), while the number of villi was significantly more and the height higher in the former two groups than those in the model group (P<0.01 for both), but no significant difference was shown between the TCM group and the WM group. Conclusion: QBD could inhibit the production of NO, increase the number and height of intestinal villi in rats with radiation enteritis, suggesting that it could reduce the inflammatory reaction of intestinal mucosa to irradiation, protect muco-sa from radiation damage, and promote the regeneration of mucosa. 展开更多
关键词 qingre Buyi decoction radiation enteritis nitric oxide HISTOMORPHOLOGY RATS
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A study of ultrasonography for the treatment of Qingre Liangxue decoction on blood-heat psoriasis
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作者 Jia-Yan Li Li-Li Ma Yi-Miao Fang 《Clinical Research Communications》 2022年第4期1-5,共5页
Objective:The clinical effectiveness of blood-heat psoriasis treated by Qingre Liangxue decoction and ultrasound imaging changes of lesions was observed.Methods:Patients with blood-heat psoriasis were selected and ran... Objective:The clinical effectiveness of blood-heat psoriasis treated by Qingre Liangxue decoction and ultrasound imaging changes of lesions was observed.Methods:Patients with blood-heat psoriasis were selected and randomly grouped into two groups:the treatment group taking the Qingre Liangxue decoction orally,the control group taking the Compound Glycyrrhizin Tablets orally,both groups applying topical emollient lotion for a 12-week treatment period.Ultrasound images of target lesions and healthy skin were collected at different treatment times.Results:The epidermal thickness thought,the dermal density incremented as well as the subepidermal low-echogenic band(SLEB)width narrowed in both groups during the treatment.Conclusion:Qingre Liangxue decoction has signified efficiency in the treatment of blood-heat psoriasis,and high-frequency ultrasound has the advantages of non-invasive,timely and objective in the evolution. 展开更多
关键词 qingre Liangxue decoction high-frequency ultrasonography epidermal thickness dermal density subepidermal low-echogenic band
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Clinical Evaluation of Yangyin Qingre Shengji Decoction(养阴清热生肌汤)in Preventing and Treating Acute Radiation Esophagitis
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作者 LIU Li-hua YANG Hai-yan 《World Journal of Integrated Traditional and Western Medicine》 2022年第3期23-27,共5页
Objective:To explore the prevention and treatment effect of Yangyin Qingre Shengji Decoction(养阴清热生肌汤)on acute radiation esophagitis.Methods:From May 2020 to February 2021,60 patients with malignant tumor who un... Objective:To explore the prevention and treatment effect of Yangyin Qingre Shengji Decoction(养阴清热生肌汤)on acute radiation esophagitis.Methods:From May 2020 to February 2021,60 patients with malignant tumor who underwent radiotherapy were selected as the research objects.They were divided into two groups by odd and even number drawing,30 cases in the control group and 30 cases in the observation group.The control group took mixed solution orally,while the observation group took Yangyin Qingre Shengji Decoction.The clinical effects,occurrence time,duration,grading of acute radiation esophagitis and TCM syndrome scores of dry mouth and constipation were compared between the two groups.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05);Compared with the control group,the time of acute radiation esophagitis was prolonged and the duration of symptoms was shortened in the observation group(P<0.05);The incidence of above gradeⅡin the observation group was significantly lower than that in the control group,and the incidence of below gradeⅠwas significantly higher than that in the control group(P<0.05);There was no significant difference in the scores of dry mouth and constipation between the two groups before treatment(P>0.05),the scores of the two groups were decreased after treatment,and the observation group was lower than the control group(P<0.05).Conclusion:Yangyin Qingre Shengji Decoction(养阴清热生肌汤)has a positive effect on prevention and treatment of acute radiation esophagitis in patients with malignant tumor undergoing radiotherapy,which can be popularized. 展开更多
关键词 Acute radiation esophagitis Yangyin qingre Shengji decoction(养阴清热生肌汤) Clinical curative effect
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A One-year Evaluation of Radiographic Progression in Patients with Rheumatoid Arthritis Treated by Qingre Huoxue Decoction(清热活血方) 被引量:12
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作者 姜泉 周新尧 +4 位作者 王雷 余卫 汪平 曹炜 唐晓颇 《Chinese Journal of Integrative Medicine》 SCIE CAS 2012年第4期256-261,共6页
Objective: TO investigate the effects of Qingre Huoxue Decoction (清热活血方, clearing heat and promoting blood flow; QRHXD), on the radiographic progression in patients with rheumatoid arthritis (RA) by X-ray im... Objective: TO investigate the effects of Qingre Huoxue Decoction (清热活血方, clearing heat and promoting blood flow; QRHXD), on the radiographic progression in patients with rheumatoid arthritis (RA) by X-ray imaging. Methods: Eighty-six patients with active RA diagnosed as damp-heat and blood stasis syndrome were randomized into a QRHXD group and a QRHXD plus methotrexate (MTX) group, with 43 cases in each group. After one-year of treatment, 21 cases in each group (42 in total) were evaluated. Radiographs of hands were obtained at the baseline and after 12 months of treatment. Images were evaluated by investigators blinded to chronology and clinical data, and assessed according to the SharpNan der Heijde methods. Results: High intrareader agreements were reached (mean intraobserver intraclass coefficients: 0.95). No significant change in any imaging parameters of joint destruction was observed at 12 months in either group; and the differences between the two groups were not significant (P〉0.05). The mean of the changing score in the QRHXD group was 3.5 ± 4.1, and 2.4 ± 3.5 in the QRHXD+MTX group, while the baseline radiographic score of patients in the QRHXD group was relatively higher (18.9± 19.1 vs. 14.0± 14.0). The mean rates of the changing scores of the two groups were similar (0.24 ± 0.28 vs. 0.25± 0.44, P=0.40). The severity of progression in the two groups was also similar (P=0.46), 7 cases without radiographic progression in the QRHXD group and 8 in the QRHXD+MTX group, 3 cases with obvious radiographic progression in the QRHXD group and 1 in the QRHXD+MTX group. Conclusion: Radiographic progression of RA patients in both groups is similar, indicating that the QRHXD Decoction has a potential role in preventing bone destruction. 展开更多
关键词 rheumatoid arthritis qingre Huoxue decoction Chinese medicine HERB RADIOLOGY bone destruction
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Study of Qingre Liyan Decoction(清热利咽汤)in Treating and Preventing Acute Radioactive Oral Mucositis 被引量:6
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作者 吴敏慧 袁彬 +1 位作者 刘秋芳 王倩 《Chinese Journal of Integrative Medicine》 SCIE CAS 2007年第4期280-284,共5页
Objective: To study the effect of Qingre Liyan Decoction (清热利咽汤 QRLYD) in the prevention and treatment of acute radiative oral mucositis (AROM), and to explore the mechanism of QRLYD by detecting epidermal g... Objective: To study the effect of Qingre Liyan Decoction (清热利咽汤 QRLYD) in the prevention and treatment of acute radiative oral mucositis (AROM), and to explore the mechanism of QRLYD by detecting epidermal growth factor (EGF) and T lymphocytes (CD3, CD4, and CD8). Methods: Sixty patients conforming with the standard were randomly assigned to two groups, 30 patients in each group. Patients in the trial group were treated with QRLYD, and those in the control group were treated with Dobell's solution, both groups receiving conventional radiation treatment. The treatment course for both groups was 6 weeks on average. Blood routine test, CD3, CD4, and CD8 in the peripheral blood and EGF in the saliva were detected one day before and on the 14th and 28th day of radio-therapy. Results: Patients in the trial group were in good condition with normal spirits and intake of food and drinks. The incidence of AROM is lower and the effect in preventing AROM is higher in the trial group than those in the control group (P〈0.05). The EGF in saliva, and CD4 and CD8 in the blood of patients in the trial group were higher than those in the control group (P〈0.05). Conclusion: QRLYD can cure and prevent AROM. The mechanism may be related with its effects in enhancing body immunity and promoting salivary EGF. 展开更多
关键词 qingre Liyan decoction acute radiative oral mucositis epidermal growth factor T lymphocytes
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Efficacy of Qingre Huashi decoction(清热化湿方) on infection of Helicobacter pylori:inhibiting adhesion,antioxidant,and anti-inflammation 被引量:5
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作者 HUANG Qiuyue YE Hui +5 位作者 SHI Zongming JIA Xiaofen LIN Miaomiao CHU Yingming YU Jing ZHANG Xuezhi 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2022年第6期915-921,共7页
OBJECTIVE: To investigate the phytochemical profile of Qingre Huashi decoction( 清 热 化 湿 方, QHD) and evaluate the mechanisms rationalizing the use of QHD against Helicobacter pylori(H. pylori)-associated gastritis... OBJECTIVE: To investigate the phytochemical profile of Qingre Huashi decoction( 清 热 化 湿 方, QHD) and evaluate the mechanisms rationalizing the use of QHD against Helicobacter pylori(H. pylori)-associated gastritis. METHODS: QHD is composed of 11 herbs, which was prepared by a fixed Pharmacy and concentrated into clear paste. High-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(HPLC-QTOF/MS) was used to detect the phytochemical profile of QHD. The toxicity of QHD against H. pylori and human gastric epithelial cells was evaluated by the toxicology test and cell counting kit-8 assay. The adhesion model was constructed by incubating H. pylori and gastric mucosal epithelial cells for 2 h. The urease assay was used to examine the antiadhesion effects of QHD, and gene expression of adhesins was evaluated by quantitative polymerase chain reaction. The antioxidant activity was assessed by DCFHDA labeling. To evaluate the anti-inflammatory effect, the levels of pro-inflammatory cytokines in the culture supernatant were detected by enzyme-linked immunosorbent assay. RESULTS: HPLC-QTOF/MS profiling indicated the presence of primary compounds 1-20 in QHD. Drug concentration was determined as 1, 2, and 5 mg/m L by the toxic concentration of QHD against H. pylori and human gastric epithelial cells. QHD prevented H. pylori adhesion to the human gastric epithelial cells and reduced levels of reactive oxygen species. QHD also reduced the level of interleukin-8 and other proinflammatory cytokines that were upregulated by H. pylori infection. CONCLUSION: QHD could inhibit H. pylori adhesion, and exert antioxidant and anti-inflammatory effects in vitro. 展开更多
关键词 Helicobacter pylori bacterial adhesion oxidative stress inflammation qingre Huashi decoction
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Safety and Efficacy of Qingre Buyi Decoction(清热补益煎剂)in the Treatment of Acute Radiation Proctitis:A Prospective,Randomized and Controlled Trial 被引量:3
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作者 王烈 张再重 +3 位作者 涂小煌 邹忠东 刘建华 王瑜 《Chinese Journal of Integrative Medicine》 SCIE CAS 2009年第4期272-278,共7页
Objective:To investigate the efficiency,safety,and possible mechanisms of Qingre Buyi Decoction(清热补益煎剂,QBD)in the treatment of acute radiation proctitis(ARP).Methods:This study was a single center,prospective,si... Objective:To investigate the efficiency,safety,and possible mechanisms of Qingre Buyi Decoction(清热补益煎剂,QBD)in the treatment of acute radiation proctitis(ARP).Methods:This study was a single center,prospective,single blind,randomized,and placebo-controlled clinical trial.A total of 60 patients with ARP was equally and randomly distributed into the control group(conventional treatment)and the combination group(conventional treatment plus QBD).The changes of main Chinese medicine clinical symptoms and signs,in... 展开更多
关键词 qingre Buyi decoction acute radiation proctitis Chinese herbal medicine
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Effectiveness of Qingre Lishi Yishen decoction on the glomerular fibrosis of immunoglobulin A nephropathy in a rat’s model 被引量:2
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作者 Dang Wanyu Hou Linyi +3 位作者 Yan Huimin Wu Xiaoming Zhen Xiaofang Hao Jing 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2019年第4期516-523,共8页
OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s m... OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s model was established by combine with intragastric administration of bovine serum albumin(BSA) + intravenous injection of lipopolysaccharide(LPS) by + subcutaneous injection of carbon tetrachloride(CCL4). Then the animals were randomly divided into four groups: control group, IgAN model group, IgAN model with Valsartan(Val) treatment group and IgAN model with QRLS treatment group. To observe the indexes of 24-h urine protein, renal function, deposition of immune complexes, expression of activation factor, fibrosis marker and inflammatory cytokines in four different groups.RESULTS: The Val or QRLS treatment group:(a) it reduced the immune complexes deposition of IgA in glomerular mesangial and inhibited mesangial cell proliferation;(b) it decreased the expression of smooth muscle actin(α-SMA), fibronectin(FN) and tumor necrosis factor alpha(TNF-α).CONCLUSION: The study suggested that QRLS ameliorate renal structure and function in IgAN rat’s model. Furthermore, we also observed that QRLS alleviated mesangial cells activation and matrix accumulation partly by decreasing the α-SMA,then to downregulated the expression of FN and TNF-α. 展开更多
关键词 Glomerulonephritis IGA MESANGIAL cells FIBRONECTINS Tumor NECROSIS FACTOR-ALPHA qingre Lishi Yishen decoction
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Clinical Observation of Bronchial AsthmaTreeted with Qingre Dingchuan Decoction(清热定喘汤)
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作者 Chu Dong-ning (褚东宁 )(People’s Hospital of Shangcheng District , Hangzhou 310001 )Lu Hang(陆航) Yu Xi-lin (俞锡林) and Wang Xu (王旭)(Institute of Pediatrics, Zhejiang Medical University) 《Chinese Journal of Integrative Medicine》 SCIE CAS 1995年第4期281-282,共2页
Seventy patients of bronchial asthma ( 40 were adult and 30 child) were treated by QingreDingchuan decoction (QRDCD) , the erythrocytic superoxide dismutase (SOD) and blood lipid peroxide(LPO) levels were observed bef... Seventy patients of bronchial asthma ( 40 were adult and 30 child) were treated by QingreDingchuan decoction (QRDCD) , the erythrocytic superoxide dismutase (SOD) and blood lipid peroxide(LPO) levels were observed before and after treatment. Results showed that the patients , SOD was de-creased while their LPO increased signiticantly than that ot normal control. After treatment the LPO reducedsignificantly while the SOD elevated, the total effective rate ot adult group was 77. 5% and that of child groupwas 96 . 7 % . 展开更多
关键词 bronchial asthma qingre Dingchuan decoction
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Effect of Bushen Qingre Yuyin Decoction on Salivary Secretion, Spleen Index, Submandibular Gland Index, Submandibular Gland Histomorphology, and aqp5 Expression in the Nonobese Diabetic Mouse Model
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作者 Wan-Ru Wang Huan-Yu Liu +5 位作者 Zhi-Xiong Ren Lu Chen Sai Liu Lian-Cun Shi Xiao-Ping Yan Feng Mi 《World Journal of Traditional Chinese Medicine》 2020年第4期508-514,共7页
Objective:The objective of this study was to observe the effect of Bushen Qingre Yuyin Decoction on the spleen index,submandibular gland index,salivary secretion,submandibular gland morphology,and aquaporin 5(AQP5)exp... Objective:The objective of this study was to observe the effect of Bushen Qingre Yuyin Decoction on the spleen index,submandibular gland index,salivary secretion,submandibular gland morphology,and aquaporin 5(AQP5)expression levels in the submandibular gland.Materials and Methods:Fifty 8-week-old nonobese diabetic(NOD)female mice were randomly divided into the following five groups:model;hydroxychloroquine;and high-,medium-,and low-dose Bushen Qingre Yuyin Decoction prescription.The blank group consisted of ten 8-week-old Balb/C rats.Bushen Yuyin Qingre Decoction was administered by gavage at 20,40,and 80 g/kg in the low-,medium-,and high-dose groups,respectively.The hydroxychloroquine group was administered hydroxychloroquine at a dose of 80 mg/kg by gavage.The normal and model groups were administered the same amount of saline.After the different administrations,the amount of salivary secretion in the mice was regularly observed.After 12 weeks,the mice were sacrificed,and their submandibular gland tissues were excised,stained with hematoxylin-eosin,and pathologically scored.AQP5 expression levels in the tissues were detected using real-time polymerase chain reaction.Results:The spleen index of mice in the high-dose group was higher than that in the model group(P<0.05),and the submandibular gland index of the hydroxychloroquine group and all the Bushen Qingre Yuyin Decoction prescription groups was higher than that in the model group(P<0.05).After 6 weeks,the salivary volume of the hydroxychloroquine group and all the Bushen Qingre Yuyin Decoction prescription groups was significantly higher than that of the model group(P<0.05);the amount of lymphocyte infiltration in mice among each administration group was significantly reduced(P<0.05);and the AQP5 expression levels in the submandibular glands of mice had significantly increased in the hydroxychloroquine and high-dose groups(P<0.05),with the high-dose group showing the best effect.Conclusion:Bushen Qingre Yuyin Decoction can effectively increase the spleen and submandibular gland indexes of NOD mice,increase the amount of salivary secretion,reduce lymphocyte infiltration in submandibular gland tissue,and significantly increase AQP5 expression levels,which may be positively correlated with the administered dose. 展开更多
关键词 Aquaporin 5 Bushen qingre Yuyin decoction nonobese diabetic mouse Sjogren’s syndrome Submandibular gland histomorphology
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针刺迎香穴联合清热通窍汤加减治疗过敏性鼻炎临床研究 被引量:1
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作者 窦晓清 尚红坤 宋照营 《新中医》 CAS 2024年第3期132-138,共7页
目的:观察针刺迎香穴联合清热通窍汤加减治疗过敏性鼻炎的临床疗效。方法:选择98例过敏性鼻炎患者,按随机数字表法分为参照组与研究组各49例。参照组给予西医基础治疗,研究组在参照组基础上给予针刺迎香穴联合清热通窍汤加减治疗。比较... 目的:观察针刺迎香穴联合清热通窍汤加减治疗过敏性鼻炎的临床疗效。方法:选择98例过敏性鼻炎患者,按随机数字表法分为参照组与研究组各49例。参照组给予西医基础治疗,研究组在参照组基础上给予针刺迎香穴联合清热通窍汤加减治疗。比较2组治疗前后转化生长因子-β (TGF-β)、白细胞介素-4 (IL-4)、白细胞介素-5 (IL-5)、肿瘤坏死因子-α (TNF-α)、可溶性血管细胞黏附分子-1 (sVCAM-1)、白细胞介素-33 (IL-33)、特异性免疫球蛋白E (IgE)、集落刺激因子(CSF)、嗜酸粒细胞(EOS)、微小R-487b (miR-487b)、水通道蛋白1 (AQP1)、鼻阻力(NR)、鼻黏膜纤毛输送率(MTR)、鼻黏膜纤毛传输时间(MTT)、鼻黏膜纤毛清除速率(MCV)、峰值呼气流速(PEF)、PEF昼夜变异率、第1秒用力呼气容积(FEV1)水平及症状评分、鼻结膜炎生存质量量表(RQLQ)评分,并比较2组临床疗效及不良反应。结果:研究组治疗总有效率95.92%,高于参照组83.67%(P<0.05)。治疗后,2组sVCAM-1、IL-5水平降低(P<0.05),且研究组低于参照组(P<0.05),2组TGF-β、IL-10水平升高(P<0.05),且研究组高于参照组(P<0.05)。治疗后,2组TNF-α、IL-33、AQP1水平降低(P<0.05),且研究组低于参照组(P<0.05),2组miR-487b水平升高(P<0.05),且研究组高于参照组(P<0.05)。治疗后,2组CSF、特应性IgE、EOS水平均降低(P<0.05),且研究组低于参照组(P<0.05)。治疗后,2组MCV、MTR水平升高(P<0.05),且研究组高于参照组(P<0.05),2组NR、MTT水平降低(P<0.05),且研究组低于参照组(P<0.05)。治疗后,2组PEF昼夜变异率降低(P<0.05),且研究组低于参照组(P<0.05),2组FEV1、PEF水平升高(P<0.05),且研究组高于参照组(P<0.05)。治疗后,2组症状、RQLQ评分降低(P<0.05),且研究组低于参照组(P<0.05)。研究组不良反应总发生率低于参照组(P<0.05)。结论:针刺迎香穴联合清热通窍汤加减治疗过敏性鼻炎,可改善患者免疫应答,抑制机体炎症,提升通气及鼻黏膜纤毛功能,缓解患者致敏症状,提升患者临床疗效及生活质量,降低不良反应发生率。 展开更多
关键词 过敏性鼻炎 迎香穴 针刺 清热通窍汤 免疫应答 炎症因子 鼻黏膜纤毛功能
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滋肾通淋排石汤辅助治疗在肾结石术后患者中的应用及机制 被引量:1
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作者 钟晔 刘建 张伟涛 《辽宁中医杂志》 CAS 北大核心 2024年第3期86-89,共4页
目的探讨滋肾通淋排石汤辅助治疗在肾结石术后患者中的应用及机制。方法选取该院2021年2月—2022年2月收治的肾结石术后患者202例,按照随机数字表法分为对照组和观察组各101例。两组患者均给予常规的输尿管软镜碎石术进行治疗,术后给予... 目的探讨滋肾通淋排石汤辅助治疗在肾结石术后患者中的应用及机制。方法选取该院2021年2月—2022年2月收治的肾结石术后患者202例,按照随机数字表法分为对照组和观察组各101例。两组患者均给予常规的输尿管软镜碎石术进行治疗,术后给予对照组患者常规体位排石治疗,观察组患者在对照组基础上给予滋肾通淋排石汤联合进行治疗,两组均治疗2周。比较两组治疗后的临床疗效,治疗前后的中医证候积分、肾功能、炎性应激指标水平,不同时点的视觉模拟评分(visual analog scale,VAS)。结果治疗后观察组临床总有效率高于对照组;与治疗前比较,治疗后两组尿频、腰痛、少腹急满、血尿、淋漓不爽评分及血清β2微球蛋白(β2 microglobulin,β2-MG)、肌酐(serum creatinine,Scr)、中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、尿素氮(blood urea nitrogen,BUN)、白细胞介素-10(interleukin-10,IL-10)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、高迁移率族蛋白-1(high mobility group box-1 protein,HMGB1)、单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平均降低,观察组低于对照组;与治疗前比较,治疗3 d~2周后两组VAS评分呈逐渐降低趋势,观察组低于对照组,差异均有统计学意义(均P<0.05)。结论滋肾通淋排石汤应用于肾结石术后患者,可以减轻疼痛,改善肾功能,抑制炎症反应和应激反应,提升临床治疗效果。 展开更多
关键词 肾结石 滋肾通淋排石汤 中医证候 肾功能 炎症反应 应激反应
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清热凉血汤联合围刺治疗银屑病的临床疗效及安全性研究
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作者 王洁 刘兴静 +3 位作者 曹前 李悦 夏琴 徐蓉 《上海医药》 CAS 2024年第17期45-48,共4页
目的:研究分析采用清热凉血汤与围刺联合治疗银屑病患者的临床效果。方法:将银屑病患者86例随机分为对照组和观察组,各43例。对照组采用单一清热凉血汤治疗,而观察组在此基础上,加以围刺联合治疗,比较两组各项指标。结果:治疗后,观察组... 目的:研究分析采用清热凉血汤与围刺联合治疗银屑病患者的临床效果。方法:将银屑病患者86例随机分为对照组和观察组,各43例。对照组采用单一清热凉血汤治疗,而观察组在此基础上,加以围刺联合治疗,比较两组各项指标。结果:治疗后,观察组的治疗有效率高于对照组;四项目瘙痒量表、皮肤病生活质量指数、银屑病面积与严重性指数以及中医证候评分,转化生长因子β、肿瘤坏死因子α、白介素-23以及白介素-17水平和不良反应发生率均低于对照组(P<0.05)。结论:临床上运用围刺和清热凉血汤对银屑病患者进行联合治疗,可以减轻机体炎症反应,改善症状,提高治疗效果,并且安全性高,不良反应发生率低。 展开更多
关键词 银屑病 围刺 清热凉血汤 炎症因子
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清热祛浊方联合二甲双胍治疗2型糖尿病疗效分析
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作者 赵红敏 李兰 +7 位作者 孔五宝 牛跃龙 陈伟 王晓蕴 代亚芳 王子龙 冯娜娜 李华君 《长春中医药大学学报》 2024年第7期751-755,共5页
目的探究清热祛浊方联合二甲双胍治疗痰湿瘀热型2型糖尿病及对炎性因子的影响。方法选取2020年1月—2021年1月北省沧州中西医结合医院收治的130例痰湿瘀热型2型糖尿病患者,随机分为试验组和对照组,各65例。对照组予以常盐酸二甲双胍治疗... 目的探究清热祛浊方联合二甲双胍治疗痰湿瘀热型2型糖尿病及对炎性因子的影响。方法选取2020年1月—2021年1月北省沧州中西医结合医院收治的130例痰湿瘀热型2型糖尿病患者,随机分为试验组和对照组,各65例。对照组予以常盐酸二甲双胍治疗,试验组在西药治疗基础上加用自拟清热祛浊方。2组均治疗3个月。比较2组临床疗效、中医证候积分、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbAlc)及超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、胰岛素抵抗(IR)。结果治疗后,试验组总有效率为93.85%,对照组总有效率为81.54%,试验组高于对照组(P<0.05);2组中医证候积分、FPG、2 hPG、HbAlc、hs-CRP、IL-6、TNF-α、IR均降低(P<0.05),试验组均低于对照组(P<0.05)。结论清热祛浊方联合二甲双胍治疗痰湿瘀热型2型糖尿病可提高临床疗效,降低血糖和炎症反应,值得推广。 展开更多
关键词 2型糖尿病 清热祛浊方 炎性反应 胰岛素抵抗
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清热利湿方联合美沙拉嗪治疗湿热内蕴证糖尿病肠病临床疗效观察
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作者 李明哲 柳越冬 +2 位作者 陈萌 张威 石岩 《中华中医药学刊》 CAS 北大核心 2024年第8期50-53,共4页
目的探讨清热利湿方治疗糖尿病肠病疗效及对患者生活质量的影响。方法将48例湿热内蕴证糖尿病肠病患者按随机数字表法分观察组和对照组,每组24例;两组均口服美沙拉嗪肠溶片,观察组加予清热利湿方日2次口服治疗,统计肠炎疾病量表(inflamm... 目的探讨清热利湿方治疗糖尿病肠病疗效及对患者生活质量的影响。方法将48例湿热内蕴证糖尿病肠病患者按随机数字表法分观察组和对照组,每组24例;两组均口服美沙拉嗪肠溶片,观察组加予清热利湿方日2次口服治疗,统计肠炎疾病量表(inflammatory bowel disease questionnaire,IBDQ)评分及相关症状体征。结果观察组与对照组IBDQ评分各分项得分治疗后均高于治疗前,但观察组分数增加较为明显,且观察组在全身症状、肠道症状、情感功能、社会功能、总分等方面得分增加均高于对照组,在全身症状改善方面尤为显著。两组在生活质量量表(the MOS item short from health survey,SF-36)量表中生理机能(physical functioning,PF)、生理职能(role physical,RP)、活力(vitality,VT)、精神健康(mental health,MH)、整体健康(general health,GH)等方面治疗前与治疗后差异有统计学意义(均P<0.05)。观察组总有效率91.67%(22/24),两组间疗效比较差异有统计学意义(P<0.05)。两组病例均耐受良好,未见明显不良反应,1年内复发率观察组低于对照组(均P<0.05)。结论清热利湿方可以有效清热利湿,改善患者病情,是针对糖尿病肠病的一种有效治疗方案,可以提高湿热内蕴证糖尿病肠病患者的治疗有效率,明显提高患者的生活质量,值得临床进一步研究及推广。 展开更多
关键词 糖尿病肠病 清热利湿方 湿热内蕴 生活质量 中西医结合
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自拟清热润目汤联合朱氏风池三针法配合眼周取穴对老年睑板腺功能障碍致干眼的治疗效果
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作者 朱艳霞 李新 应佳 《中国药物与临床》 CAS 2024年第13期817-821,共5页
目的探究自拟清热润目汤联合朱氏风池三针法配合眼周取穴对老年睑板腺功能障碍致干眼的治疗效果。方法将2021年8月至2023年8月浙江省丽水市中心医院眼科收治的109例老年睑板腺功能障碍致干眼患者作为研究对象。根据患者接受的不同治疗... 目的探究自拟清热润目汤联合朱氏风池三针法配合眼周取穴对老年睑板腺功能障碍致干眼的治疗效果。方法将2021年8月至2023年8月浙江省丽水市中心医院眼科收治的109例老年睑板腺功能障碍致干眼患者作为研究对象。根据患者接受的不同治疗方式进行分组,将接受常规西药治疗的患者纳入A组(53例),将接受西药治疗和自拟清热润目汤联合朱氏风池三针法配合眼周取穴治疗的患者纳入B组(56例),2组均治疗3个月。对比2组患者的治疗有效性、干眼程度[国际标准眼表疾病指数(OSDI)]、睑板腺功能(睑脂排出能力、眼睑分泌物性状)、角膜染色情况、非入侵泪膜破裂时间和并发症发生率(角膜溃疡、角膜穿孔、继发细菌感染)。结果B组的治疗有效率(95%)高于A组(81%)(P<0.05);B组患者的干眼程度[正常(63%)、轻度干眼(32%)、中度干眼(5%)、重度干眼(0)]低于A组[正常(41%)、轻度干眼(47%)、中度干眼(8%)、重度干眼(4%)](P<0.05);B组患者的睑脂排出能力正常率(73%)高于A组(51%),眼睑分泌物性状正常率(68%)高于A组(47%)(P<0.05);B组患者的角膜染色评分(4.6±0.7)分低于A组(6.5±0.8)分,非入侵泪膜破裂时间(11.0±1.3)s长于A组(10.3±1.1)s(P<0.05);B组并发症发生率(13%)与A组(8%)差异无统计学意义(P>0.05)。结论自拟清热润目汤联合朱氏风池三针法配合眼周取穴对老年睑板腺功能障碍致干眼的疗效显著,可有效缓解干眼症状、恢复眼睑功能、增强泪膜稳定性。 展开更多
关键词 自拟清热润目汤 朱氏风池三针法 老年人 睑板腺功能障碍 干眼病
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基于网络药理学与分子对接技术探讨滋肾养血活血汤治疗胚胎反复种植失败作用机制
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作者 宋红艳 何东杰 +2 位作者 石少琦 崔天薇 卫爱武 《新中医》 CAS 2024年第8期180-188,共9页
目的:通过网络药理学和分子对接技术探讨滋肾养血活血汤治疗胚胎反复种植失败(RIF)的作用机制。方法:利用中药系统药理数据库和分析平台(TCMSP)查找滋肾养血活血汤组成药物的化学成分,并筛选出有效活性成分及有效活性成分的作用靶点,通... 目的:通过网络药理学和分子对接技术探讨滋肾养血活血汤治疗胚胎反复种植失败(RIF)的作用机制。方法:利用中药系统药理数据库和分析平台(TCMSP)查找滋肾养血活血汤组成药物的化学成分,并筛选出有效活性成分及有效活性成分的作用靶点,通过GeneCards和人类在线孟德尔遗传(OMIM)数据库筛选RIF疾病靶点,将药物有效活性成分作用靶点与RIF疾病靶点取交集,借助String平台制作蛋白质-蛋白质互作(PPI)网络,然后利用Cytoscape3.9.1软件进行网络结构的拓扑分析筛选核心靶点,并构建中药-活性成分-靶点可视化网络图,利用DAVID在线数据库对核心靶点进行富集分析,采用AutoDock Vina软件对筛选出的主要药物有效活性成分和疾病关键靶点进行分子对接验证。结果:共获得122个药物有效活性成分和256个药物作用靶点,疾病相关靶点2215个,药物-疾病核心靶点36个。经筛选获得5个主要药物有效活性成分与9个疾病关键靶点。京都基因与基因组百科全书(KEGG)富集分析结果显示,滋肾养血活血汤治疗RIF可能主要通过调控缺氧诱导因子-1(HIF-1)、肿瘤坏死因子(TNF)、丝裂原活化蛋白激酶(MAPK)等多种信号通路发挥治疗作用。分子对接结果表明,β-谷甾醇与蛋白激酶B1(AKT1)、丹参酮ⅡA与HIF-1A、丹参酮ⅡA与TNF、槲皮素与HIF-1A对接活性较好。结论:滋肾养血活血汤可能通过槲皮素、山柰酚、木犀草素、β-谷甾醇、丹参酮ⅡA等与靶蛋白相互结合,调控多种信号通路发挥治疗RIF的作用。 展开更多
关键词 胚胎反复种植失败 滋肾养血活血汤 网络药理学 分子对接 作用机制
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清热活血排石汤结合体外冲击波碎石术对输尿管结石患者中医证候积分的影响
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作者 郑铎 田彦 《世界复合医学》 2024年第5期59-63,共5页
目的 探究清热活血排石汤结合体外冲击波碎石术对输尿管结石患者中医证候积分的影响。方法 回顾性选取2021年1月—2023年12月松原市中心医院收治的98例输尿管结石患者的临床资料,以不同治疗方法分为对照组、研究组,各49例,两组均应用体... 目的 探究清热活血排石汤结合体外冲击波碎石术对输尿管结石患者中医证候积分的影响。方法 回顾性选取2021年1月—2023年12月松原市中心医院收治的98例输尿管结石患者的临床资料,以不同治疗方法分为对照组、研究组,各49例,两组均应用体外冲击波碎石术治疗,在此基础上,术后对照组应用常规药物治疗,研究组在对照组基础上应用清热活血排石汤,比较两组治疗效果、中医证候积分、肾功能指标(血肌酐、尿素氮)、排石情况(开始排石时间、排石周期)及不良反应发生率。结果 研究组治疗总有效率为97.96%(48/49),高于对照组的83.67%(41/49),差异有统计学意义(χ^(2)=4.404,P<0.05)。治疗前两组中医证候积分、血肌酐、尿素氮比较,差异无统计学意义(P均>0.05);治疗后,研究组中医证候积分、血肌酐、尿素氮均低于对照组,差异有统计学意义(P均<0.05)。研究组开始排石时间、排石周期均短于对照组,差异有统计学意义(P均<0.05)。研究组结石清除率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 在输尿管结石患者体外冲击波碎石术及常规药物治疗基础上,联合应用清热活血排石汤,可提升治疗效果,降低中医证候积分,减轻肾功能损伤,提升结石清除率,且安全性良好。 展开更多
关键词 输尿管结石 体外冲击波碎石 清热活血排石汤
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