Over the past few years,China’s higher education institutions have experienced remarkable growth in online teaching.However,it remains uncertain whether and how the sense of presence perceived by students affects the...Over the past few years,China’s higher education institutions have experienced remarkable growth in online teaching.However,it remains uncertain whether and how the sense of presence perceived by students affects their online learning outcomes when teachers use online teaching media for communication.This sense specifically pertains to the extent to which students perceive themselves as“real persons”and establish connections with others.Therefore,this study constructs a conceptual model elucidating the impact of presence on students’online learning outcomes and empirically examines the mechanism through which three types of presence influence students’online learning.The test results of the structural equation modeling(SEM)indicate that:(a)teaching presence,social presence,and cognitive presence all exhibit significantly positive outcomes on students’online learning outcomes;(b)these three types of presence can also indirectly and positively influence students’online learning outcomes through the mediating effect of flow experience and learning satisfaction;and(c)flow experience and learning satisfaction play a sequential mediating role in the process by which presence impacts students’online learning outcomes.We hope that the relevant research findings may contribute to unveiling the“black box”of the impact of presence on students’online learning outcomes and offer valuable insights for college educators to overcome online teaching constraints and enhance online teaching quality.展开更多
Enhancing the sense of presence of participants is an important issue in terms of security awareness for remote collaboration in extended reality.However,conventional methods are insufficient to be aware of remote sit...Enhancing the sense of presence of participants is an important issue in terms of security awareness for remote collaboration in extended reality.However,conventional methods are insufficient to be aware of remote situations and to search for and control remote workspaces.This study pro-poses a spatial multi-presence system that simultaneously provides multiple spaces while rapidly exploring these spaces as users perform collaborative work in an extended reality environment.The proposed system provides methods for arranging and manipulating remote and personal spaces by creating an annular screen that is invisible to the user.The user can freely arrange remote participants and their workspaces on the annular screen.Because users can simultaneously view various spaces arranged on the annular screen,they can perform collaborative work while simultaneously feeling the presence of multiple spaces and can be fully immersed in a specific space.In addition,the personal spaces where users work can also be arranged through the annular screen.According to the results of the performance evaluations,users participating in remote collaborative works can visualize the spaces of multiple users simultaneously and feel their presence,thereby increasing their understanding of the spaces.Moreover,the proposed system reduces the time to perform tasks and gain awareness of the emergency in remote workspaces.展开更多
With the rapid development of immersive multimedia technologies,360-degree video services have quickly gained popularity and how to ensure sufficient spatial presence of end users when viewing 360-degree videos become...With the rapid development of immersive multimedia technologies,360-degree video services have quickly gained popularity and how to ensure sufficient spatial presence of end users when viewing 360-degree videos becomes a new challenge.In this regard,accurately acquiring users’sense of spatial presence is of fundamental importance for video service providers to improve their service quality.Unfortunately,there is no efficient evaluation model so far for measuring the sense of spatial presence for 360-degree videos.In this paper,we first design an assessment framework to clarify the influencing factors of spatial presence.Related parameters of 360-degree videos and headmounted display devices are both considered in this framework.Well-designed subjective experiments are then conducted to investigate the impact of various influencing factors on the sense of presence.Based on the subjective ratings,we propose a spatial presence assessment model that can be easily deployed in 360-degree video applications.To the best of our knowledge,this is the first attempt in literature to establish a quantitative spatial presence assessment model by using technical parameters that are easily extracted.Experimental results demonstrate that the proposed model can reliably predict the sense of spatial presence.展开更多
Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interfe...Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome activation.Despite this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive.Consequently,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in CRC.Our findings showed a reduced AIM2 expression in most CRC cell lines.Elevation of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell apoptosis.Further research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and proliferation.Altogether,our achievements distinctly underscored AIM2’s antitumor role in CRC.AIM2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC.展开更多
The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sal...The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.展开更多
Progress is described regarding the development of a new electrotactile feedback glove designed for application to dexterous robot. The sensitivity of operator's finger against electrical stimulus pulse is conside...Progress is described regarding the development of a new electrotactile feedback glove designed for application to dexterous robot. The sensitivity of operator's finger against electrical stimulus pulse is considered. It is found that frequency, duty ratio, and voltage amplitude of electrical stimulus pulse determine the sensitivity of finger. The effects of materials, sizes, arrangements and shapes of electrodes on sensitivity of finger are analyzed. Finally, the tactile tele presence system is designed to experimentally confirm that the robot with electrotactile feedback glove can manipulate dexterous robotic multi fingered hand and identify and classify three sorts of objects.展开更多
We extend Bespalov-Talanov (B-T) theory on small-scale self-focusing (SSSF) to include vector effect of a very narrow intense laser beam with application of the vector self-focusing model. The gain spectrum for pertur...We extend Bespalov-Talanov (B-T) theory on small-scale self-focusing (SSSF) to include vector effect of a very narrow intense laser beam with application of the vector self-focusing model. The gain spectrum for perturbations is obtained by using the standard linear instability analysis. It is shown that the influence on SSSF of vector effect is closely related to the beam width. For a very narrow beam, the role played by vector effect becomes significant, it reduces the fastest growing frequency and the maximum growth rate, and shortens the frequency range for perturbation growing, and thus deviates the gain spectrum from that of B-T theory.展开更多
Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some...Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some of which are common in the working environment. The biological significance of the presence of such autoantibodies is presently unclear. In the present study, we used immunoblotting to investigate the presence of antibodies against the different stress proteins, Hsp27, Hsp60, Hsp71, Hse (heat shock cognate ) 73 and Hsp89a and D in groups of workers exposed to high temperature or carbon monoxide. These data were related to a detailed clinical evaluation and to various laboratory measurements including electrocardiogram (ECG), B echogram, white blood cell counts and typing, the activity of alanine aminotransferase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) and lymphocyte DNA damage. Antibodies to Hsp27 and Hsp71 were found more frequently in the high temperature and carbon monoxide-exposed groups than in controls (P (0.05 ). The carbon monoxide-exposed group showed the highest incidence of anti-Hsp antibodies. Anti-Hsp60 antibodies were only detected in workers exposed to high temperature or carbon monoxide. The percentage of workers with abnormal ECG, B echogram changes and displaying hepatitis B antigen (HBsAg ) was higher in the carbon monoxide group than in the control group (P<0.05 ).There was a significant inerease in the activity of ALT in the high temperature and carbon monoxide groups and in the activities of ACP and ALP in the carbon monoxide group (P<0.05 ). The extent of DNA damage measured in lymphoeytes was higher in workers from the high temperature and carbon monoxide-cxposed groups. We suggest that the increased frequeney of antibodies to Hsps is the result of these damages, of the release of denatured Hsps and of a decrease in the phagocytic ability of macrophages in these workers. The data gathered in the present study show a statistical relation between the occurrence of antibodies against Hsps and the frequency of health problems in workers and suggest a potential role for the antibodies as useful biomarkers to assess whether workers are experieneing environmental stress展开更多
This study aimed at comparing the level of social presence generated in a voice-based chat room and a text-based forum when learners tried to build personal relationships and form an online community for learning on a...This study aimed at comparing the level of social presence generated in a voice-based chat room and a text-based forum when learners tried to build personal relationships and form an online community for learning on an online language course in China. A mixed-method approach was taken for the study, drawing on data from questionnaires to find out about student perception of social presence, and postings of text messages and audio messages in the communication of the student learning process to search for students’ projected social presence in terms of affective, interactive and cohesive features. Interviews were also conducted to supplement additional information with the hope of forming a complete picture of social presence in the reality of an online learning environment. The text-based forum and the voice-based chat room were found to have a different impact on student social presence. In terms of student perception, most of them were more likely to get to know peers in the text-based forum and thus developed a sense of community in their learning process of the online course. Yet they believed that the voice-based chat room had the advantage of helping them with course learning. In the actual interaction, the voice-based chat room was more interactive although the text-based forum was more affective and cohesive. But in terms of the affective category, the problem with the existing framework in literature was that there were no prosodic features included. Therefore, in future more research is needed to probe for the relationship between prosodic sound features and social presence, and the present theoretic framework must be extended. In interviews, students explained that in the voice-based chat room prosodic features led to higher peer awareness, which further reinforced this need.展开更多
With the rapid global proliferation of the Internet and telecommunication networks, online education, one form of distance education is currently becoming the fastest growing trend of domestic and international educat...With the rapid global proliferation of the Internet and telecommunication networks, online education, one form of distance education is currently becoming the fastest growing trend of domestic and international education. A major challenge to designing online learning is the development of appropriate means to facilitate the social environment that is critical for higher order learning in many disciplines. In many online learning designs, the majority of resources are channeled to web interface design and technology, while little or no resources are devoted to facilitating the teaching and learning process, the negotiation of meaning and the validation of knowledge among peers and instructors that depends on a conducive socio-cultural environment and adequate learner support.展开更多
基金the project“Research on the Evaluation Mechanism of College Ideological and Political Education:A Perspective on Teacher-Student Development,”funded by Zhejiang Provincial College Ideological and Political Education Research Project.
文摘Over the past few years,China’s higher education institutions have experienced remarkable growth in online teaching.However,it remains uncertain whether and how the sense of presence perceived by students affects their online learning outcomes when teachers use online teaching media for communication.This sense specifically pertains to the extent to which students perceive themselves as“real persons”and establish connections with others.Therefore,this study constructs a conceptual model elucidating the impact of presence on students’online learning outcomes and empirically examines the mechanism through which three types of presence influence students’online learning.The test results of the structural equation modeling(SEM)indicate that:(a)teaching presence,social presence,and cognitive presence all exhibit significantly positive outcomes on students’online learning outcomes;(b)these three types of presence can also indirectly and positively influence students’online learning outcomes through the mediating effect of flow experience and learning satisfaction;and(c)flow experience and learning satisfaction play a sequential mediating role in the process by which presence impacts students’online learning outcomes.We hope that the relevant research findings may contribute to unveiling the“black box”of the impact of presence on students’online learning outcomes and offer valuable insights for college educators to overcome online teaching constraints and enhance online teaching quality.
基金supported by“Regional Innovation Strategy(RIS)”through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(MOE)(2021RIS-004).
文摘Enhancing the sense of presence of participants is an important issue in terms of security awareness for remote collaboration in extended reality.However,conventional methods are insufficient to be aware of remote situations and to search for and control remote workspaces.This study pro-poses a spatial multi-presence system that simultaneously provides multiple spaces while rapidly exploring these spaces as users perform collaborative work in an extended reality environment.The proposed system provides methods for arranging and manipulating remote and personal spaces by creating an annular screen that is invisible to the user.The user can freely arrange remote participants and their workspaces on the annular screen.Because users can simultaneously view various spaces arranged on the annular screen,they can perform collaborative work while simultaneously feeling the presence of multiple spaces and can be fully immersed in a specific space.In addition,the personal spaces where users work can also be arranged through the annular screen.According to the results of the performance evaluations,users participating in remote collaborative works can visualize the spaces of multiple users simultaneously and feel their presence,thereby increasing their understanding of the spaces.Moreover,the proposed system reduces the time to perform tasks and gain awareness of the emergency in remote workspaces.
基金supported in part by ZTE Industry⁃University⁃Institute Coop⁃eration Funds.
文摘With the rapid development of immersive multimedia technologies,360-degree video services have quickly gained popularity and how to ensure sufficient spatial presence of end users when viewing 360-degree videos becomes a new challenge.In this regard,accurately acquiring users’sense of spatial presence is of fundamental importance for video service providers to improve their service quality.Unfortunately,there is no efficient evaluation model so far for measuring the sense of spatial presence for 360-degree videos.In this paper,we first design an assessment framework to clarify the influencing factors of spatial presence.Related parameters of 360-degree videos and headmounted display devices are both considered in this framework.Well-designed subjective experiments are then conducted to investigate the impact of various influencing factors on the sense of presence.Based on the subjective ratings,we propose a spatial presence assessment model that can be easily deployed in 360-degree video applications.To the best of our knowledge,this is the first attempt in literature to establish a quantitative spatial presence assessment model by using technical parameters that are easily extracted.Experimental results demonstrate that the proposed model can reliably predict the sense of spatial presence.
基金supported by the Gusu Medical Key Talent Project of Suzhou City of China(GSWS2020005)the New Pharmaceutics and Medical Apparatuses Project of Suzhou City of China(SLJ2021007)+3 种基金the Suzhou City Key Clinical Disease Diagnosis and Treatment Technology Special Project,China(LCZX202129)Wujiang Science and Educational Health Revitalization Fund Project,Suzhou,China(WWK202015)the Scientific Research Project of Suzhou Ninth People’s Hospital,Suzhou,China(YK202008)and Suzhou“Science and Education”Youth Science and Technology Project,Suzhou,China(KJXW2020075).
文摘Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome activation.Despite this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive.Consequently,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in CRC.Our findings showed a reduced AIM2 expression in most CRC cell lines.Elevation of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell apoptosis.Further research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and proliferation.Altogether,our achievements distinctly underscored AIM2’s antitumor role in CRC.AIM2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC.
文摘The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.
文摘Progress is described regarding the development of a new electrotactile feedback glove designed for application to dexterous robot. The sensitivity of operator's finger against electrical stimulus pulse is considered. It is found that frequency, duty ratio, and voltage amplitude of electrical stimulus pulse determine the sensitivity of finger. The effects of materials, sizes, arrangements and shapes of electrodes on sensitivity of finger are analyzed. Finally, the tactile tele presence system is designed to experimentally confirm that the robot with electrotactile feedback glove can manipulate dexterous robotic multi fingered hand and identify and classify three sorts of objects.
基金Supported by the High Technology Research and Development Program of China(Grant No.863-416-5).
文摘We extend Bespalov-Talanov (B-T) theory on small-scale self-focusing (SSSF) to include vector effect of a very narrow intense laser beam with application of the vector self-focusing model. The gain spectrum for perturbations is obtained by using the standard linear instability analysis. It is shown that the influence on SSSF of vector effect is closely related to the beam width. For a very narrow beam, the role played by vector effect becomes significant, it reduces the fastest growing frequency and the maximum growth rate, and shortens the frequency range for perturbation growing, and thus deviates the gain spectrum from that of B-T theory.
文摘Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some of which are common in the working environment. The biological significance of the presence of such autoantibodies is presently unclear. In the present study, we used immunoblotting to investigate the presence of antibodies against the different stress proteins, Hsp27, Hsp60, Hsp71, Hse (heat shock cognate ) 73 and Hsp89a and D in groups of workers exposed to high temperature or carbon monoxide. These data were related to a detailed clinical evaluation and to various laboratory measurements including electrocardiogram (ECG), B echogram, white blood cell counts and typing, the activity of alanine aminotransferase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) and lymphocyte DNA damage. Antibodies to Hsp27 and Hsp71 were found more frequently in the high temperature and carbon monoxide-exposed groups than in controls (P (0.05 ). The carbon monoxide-exposed group showed the highest incidence of anti-Hsp antibodies. Anti-Hsp60 antibodies were only detected in workers exposed to high temperature or carbon monoxide. The percentage of workers with abnormal ECG, B echogram changes and displaying hepatitis B antigen (HBsAg ) was higher in the carbon monoxide group than in the control group (P<0.05 ).There was a significant inerease in the activity of ALT in the high temperature and carbon monoxide groups and in the activities of ACP and ALP in the carbon monoxide group (P<0.05 ). The extent of DNA damage measured in lymphoeytes was higher in workers from the high temperature and carbon monoxide-cxposed groups. We suggest that the increased frequeney of antibodies to Hsps is the result of these damages, of the release of denatured Hsps and of a decrease in the phagocytic ability of macrophages in these workers. The data gathered in the present study show a statistical relation between the occurrence of antibodies against Hsps and the frequency of health problems in workers and suggest a potential role for the antibodies as useful biomarkers to assess whether workers are experieneing environmental stress
文摘This study aimed at comparing the level of social presence generated in a voice-based chat room and a text-based forum when learners tried to build personal relationships and form an online community for learning on an online language course in China. A mixed-method approach was taken for the study, drawing on data from questionnaires to find out about student perception of social presence, and postings of text messages and audio messages in the communication of the student learning process to search for students’ projected social presence in terms of affective, interactive and cohesive features. Interviews were also conducted to supplement additional information with the hope of forming a complete picture of social presence in the reality of an online learning environment. The text-based forum and the voice-based chat room were found to have a different impact on student social presence. In terms of student perception, most of them were more likely to get to know peers in the text-based forum and thus developed a sense of community in their learning process of the online course. Yet they believed that the voice-based chat room had the advantage of helping them with course learning. In the actual interaction, the voice-based chat room was more interactive although the text-based forum was more affective and cohesive. But in terms of the affective category, the problem with the existing framework in literature was that there were no prosodic features included. Therefore, in future more research is needed to probe for the relationship between prosodic sound features and social presence, and the present theoretic framework must be extended. In interviews, students explained that in the voice-based chat room prosodic features led to higher peer awareness, which further reinforced this need.
文摘With the rapid global proliferation of the Internet and telecommunication networks, online education, one form of distance education is currently becoming the fastest growing trend of domestic and international education. A major challenge to designing online learning is the development of appropriate means to facilitate the social environment that is critical for higher order learning in many disciplines. In many online learning designs, the majority of resources are channeled to web interface design and technology, while little or no resources are devoted to facilitating the teaching and learning process, the negotiation of meaning and the validation of knowledge among peers and instructors that depends on a conducive socio-cultural environment and adequate learner support.