Attention mechanism has been a successful method for multimodal affective analysis in recent years. Despite the advances, several significant challenges remain in fusing language and its nonverbal context information....Attention mechanism has been a successful method for multimodal affective analysis in recent years. Despite the advances, several significant challenges remain in fusing language and its nonverbal context information. One is to generate sparse attention coefficients associated with acoustic and visual modalities, which helps locate critical emotional se-mantics. The other is fusing complementary cross‐modal representation to construct optimal salient feature combinations of multiple modalities. A Conditional Transformer Fusion Network is proposed to handle these problems. Firstly, the authors equip the transformer module with CNN layers to enhance the detection of subtle signal patterns in nonverbal sequences. Secondly, sentiment words are utilised as context conditions to guide the computation of cross‐modal attention. As a result, the located nonverbal fea-tures are not only salient but also complementary to sentiment words directly. Experi-mental results show that the authors’ method achieves state‐of‐the‐art performance on several multimodal affective analysis datasets.展开更多
BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully elucidated.It is hypothesized that demographic,somatic,lifestyle...BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully elucidated.It is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in AD.AIM To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and leukocytes.METHODS This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory markers,somatic variables,psychological questionnaires,and lifestyle parameters.Hierarchical regression analyses were used to predict inflammatory markers from demographic,somatic,lifestyle,and personality variables.RESULTS Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(e.g.anti-diabetics),age and education,and age of affective disorder diagnosis.For leukocytes,20.1%of the variance was explained by smoking,diet,metabolic syndrome(MetS),and anti-inflammatory medication(e.g.non-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach significance.CONCLUSION Metabolic components seem important,with mounting evidence for a metabolic affective disorder subtype.Lifestyle modifications and psychoeducation should be employed to prevent or treat MetS in AD.展开更多
In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical performances.By controlling reasonable elemental composition and processing parameters,the medium entro...In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical performances.By controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower costs.In this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen reduction.The phases and magnetic properties of FeCoNi medium entropy alloy were investigated.Results showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal reduction.The alloy prepared by hydrogen reduction was uniform and showed a relatively high purity.Moreover,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.展开更多
Affective factors and cognitive factors are two important parts of English learning, However, English teaching in recent years have taken into special consideration the necessity of knowledge and intelligence and comp...Affective factors and cognitive factors are two important parts of English learning, However, English teaching in recent years have taken into special consideration the necessity of knowledge and intelligence and comparatively ignored the development of affection. It may greatly reduce students' English learning capacity and limit the whole development of students. This paper will discuss the definition and the importance of affection and some main affective factors, and illustrate some implications of how to implement practical affective activities.展开更多
This paper focuses on the vocational college students' experiences in English learning, classroom activities, attitudes to their English learning and achievements. It aims to find out how to make use of their posi...This paper focuses on the vocational college students' experiences in English learning, classroom activities, attitudes to their English learning and achievements. It aims to find out how to make use of their positive personal factors to improve their English achievement so that both vocational college teachers and students may gain some enlightenment from the study.展开更多
Autonomous study emphasizes the learner's initiative,enthusiasm and creativity.In all fields of education,there is growing emphasis on "learner-centered" teaching methods and the ability of learner auton...Autonomous study emphasizes the learner's initiative,enthusiasm and creativity.In all fields of education,there is growing emphasis on "learner-centered" teaching methods and the ability of learner autonomy.Many experts and scholars have found that learning strategies plays an important role in English language learning,but the importance of affective strategy use in English learning is often ignored by people.Therefore,this paper focuses on the frequencies of affective strategies use in English learning and their relationships so as to enable college students to use positive affective strategies effectively to improve their autonomous learning ability.展开更多
The new curriculum standard points out that affection is one of the most important goals of fundamental education. The non-target language environment is easier to cause the affective change of middle school students ...The new curriculum standard points out that affection is one of the most important goals of fundamental education. The non-target language environment is easier to cause the affective change of middle school students who are changeable in their affective state. Based on the affective filter hypothesis, this paper deals with the adjustment to affective factors in English learning by using Internet English Curriculum Resource, such as attitude and motivation, anxiety and inhibition, self-esteem and self-confidence. At last, some suggestions are offered to judge Internet English Curriculum Resource.展开更多
Foreign language teaching has shifted from teacher-centered teaching method to student-centered in recent years.Affective factors should be paid enough attention in teacher-learner interaction in.This paper aims to ma...Foreign language teaching has shifted from teacher-centered teaching method to student-centered in recent years.Affective factors should be paid enough attention in teacher-learner interaction in.This paper aims to make an exploration into the effects of affective factors in college learners'classroom.展开更多
Traditional English teaching lacks the consciousness of the importance of learner's affective factors and has trouble in training the qualified English speakers that the society needs.This paper talks about the im...Traditional English teaching lacks the consciousness of the importance of learner's affective factors and has trouble in training the qualified English speakers that the society needs.This paper talks about the importance of learner's motivation,attitude and personality.It is proposed that teachers should adopt the eclectic method accompanying with student-centered class.Teachers are asked to pay more attention to their different roles and the ways to create a positive climate for learning in class.展开更多
Admittedly cognitive variables such as intelligence and aptitude exert great impact on English learning. Affective variables, however, are of intense importance in determining English learning as well, because affect ...Admittedly cognitive variables such as intelligence and aptitude exert great impact on English learning. Affective variables, however, are of intense importance in determining English learning as well, because affect is a starting machine that sets the learning mechanism in motion and learning will run into difficulty if affect does not work properly. Besides, there is mounting interest in exploring the affective domain. Therefore, this paper focuses upon the analyses of four affective variables(attitude, motivation, self-esteem and anxiety) that have bearings on English learning and sets forth Implications for English teaching.展开更多
Nowadays,the development of economy as well as the progress of society requires better English competence of college students.As a result,a large number of college students are obsessedby affective barriers in their E...Nowadays,the development of economy as well as the progress of society requires better English competence of college students.As a result,a large number of college students are obsessedby affective barriers in their English learning,especially when they have to cope with CET 4 or CET 6,which is more and more difficult.This paper focuses on how to help college students overcome their affective barriers more effectively to improve their English learning.展开更多
The paper mainly discusses the importance of affective factors in college English listening teaching and gives some sug gestions on how to cultivate students'positive affective factors.
Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the ...Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders.展开更多
"The Input Hypothesis"and"The Affective Filter Hypothesis"are the most important branches of the"Monitor The ory"declared by the famous American linguist Krashen in 1980s.This thesis is b..."The Input Hypothesis"and"The Affective Filter Hypothesis"are the most important branches of the"Monitor The ory"declared by the famous American linguist Krashen in 1980s.This thesis is based on Krashen's Input Hypothesis and Affec tive Filter Hypothesis,aiming to provide an applicable guide for foreign language teachers and learners in China.展开更多
This research is framed within the affective computing, which explains the importance of emotions in human cognition (decision making, perception, interaction and human intelligence). Applying this approach to a pedag...This research is framed within the affective computing, which explains the importance of emotions in human cognition (decision making, perception, interaction and human intelligence). Applying this approach to a pedagogical agent is an essential part to enhance the effectiveness of the teaching-learning process of an intelligent learning system. This work focuses on the design of the inference engine that will give life to the interface, where the latter is represented by a pedagogical agent. The inference engine is based on an affective-motivational model. This model is implemented by using artificial intelligence technique called fuzzy cognitive maps.展开更多
Artificial intelligence technology has revolutionized every industry and trade in recent years. However, its own development is encountering bottlenecks that it is unable to implement empathy with human emotions. So a...Artificial intelligence technology has revolutionized every industry and trade in recent years. However, its own development is encountering bottlenecks that it is unable to implement empathy with human emotions. So affective computing is getting more attention from researchers. In this paper, we propose an amygdala-inspired affective computing framework to realize the recognition of all kinds of human personalized emotions. Similar to the amygdala, the instantaneous emergency emotion is first computed more quickly in a low-redundancy convolutional neural network compressed by pruning and weight sharing with hashing trick. Then, the real-time process emotion is identified more accurately by the memory level neural networks, which is good at handling time-related signals. Finally, the intracranial emotion is recognized in personalized hidden Markov models. We demonstrate on Facial Expression of Emotion Dataset and the recognition accuracy of external emotions(including the emergency emotion and the process emotion) reached 85.72%. And the experimental results proved that the personalized affective model can generate desired intracranial emotions as expected.展开更多
Background: To explore the therapeutic effect of Tongxinluo capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. Methods: Fifty-six patients with Syndrome X and Affective Disorder were randomly div...Background: To explore the therapeutic effect of Tongxinluo capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. Methods: Fifty-six patients with Syndrome X and Affective Disorder were randomly divided into a Tongxinluo capsule group and a placebo control group. The duration of treatment was 12 weeks. A 6-minute walking test, exercise load electrocardiogram and clinical symptom assessment were performed before and after treatment. After 12 weeks of treatment, the scores of the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were repeated. The levels of serum endothelin-1 (ET-1) and nitric oxide (NO) were measured before and after treatment. Results: Compared with the placebo control group, the Tongxinluo group SAS and SDS scores were lower than those before treatment (all P < 0.01), and the 6-minute walking distance increased significantly (P < 0.01). Clinical symptoms were significantly improved. The exercise test results suggested that, while improved, there was no significant difference (P > 0.05) when compared to before treatment. In the Tongxinluo treatment group, the levels of plasma endothelin-1 decreased significantly (P < 0.01) and nitric oxide levels were significantly increased (P < 0.01), with a significant difference when compared to the control group (P Conclusions: The Tongxinluo capsule can improve the Affective Disorder of Syndrome X, reduce the degree of anxiety and depression, increase exercise tolerance, reduce clinical symptoms, and improve vascular endothelial function.展开更多
Daily separation of rat pups from their mothers while the preweaning period has an impact on behavior and stress response of pups. We hypothesized that maternal separation may create a depression-like state in mother ...Daily separation of rat pups from their mothers while the preweaning period has an impact on behavior and stress response of pups. We hypothesized that maternal separation may create a depression-like state in mother rats from which we separate the rat pups and decrease their reproductive function and fertility. Also, we aimed to evaluate the transmission degree of depression and anxiety across generations. Females aged 3 months were divided in two groups of 10 rats each. After a first mating and a first parturition, we conducted maternal separation 3 h during 22 days for the experienced group while the control group mothers kept their pups. At 4 months of age, females underwent behavioral tests and a second mating. Second generation’s pups were also subjected to behavioral tests. Behavioral tests showed that mothers which experienced separation were more depressive and anxious than control ones, also they had a lower litter size. Rats pups of the second generation whose mothers experienced maternal separation also revealed behavior changes akin to depression and anxiety. Thus, maternal separation causes depressive and anxious-likestates on mother rats which experienced separation and has an impact on their litter size. Also, consequences of maternal separation seem to last throughout generations.展开更多
Background:Resistance exercise has numerous,well-documented benefits on the health and functional performance of older adults.However,little information exists on the affective responses to resistance exercise in this...Background:Resistance exercise has numerous,well-documented benefits on the health and functional performance of older adults.However,little information exists on the affective responses to resistance exercise in this population.As affective responses can predict continued exercise behavior,examining if and how they differ between resistance exercise intensities and frequencies in older adults may provide important data to improve resistance exercise prescription.Methods:We monitored the affective responses of older adults when performing high-velocity,low-load(HVLL)or low-velocity,high-load(LVHL)resistance exercise once or twice weekly.A total of 40 moderately to highly active,but resistance-exercise naïve,older adults(60-79 years)completed 1 of 4 randomly assigned progressive resistance exercise conditions:HVLL once weekly(HVLL1:n=10),HVLL twice weekly(HVLL2:n=10),LVHL once weekly(LVHL1:n=10),or LVHL twice weekly(LVHL2:n=10).The Physical Activity Affect Scale,Felt Arousal Scale,Feeling Scale,rating of perceived exertion,Visual Analog Scale,and the Physical Activity Enjoyment Scale were used to assess enjoyment and affective responses.Results:The results from Physical Activity Enjoyment Scale(out of 35)suggest that all exercise conditions were largely and similarly enjoyable to older adults(HVLL1:30.9±2.4;LVHL1:31.9±3.6;HVLL2:30.9±3.5;LVHL2:30.2±3.7)despite greater fatigue(p=0.033;ηp^2p=0.22)and perceived workload(p=0.042;ηp^2=0.20)in LVHL(results from Visual Analog Scale).Conclusion:Moderately to highly physically active older adults may tolerate higher intensities of resistance exercise performed once or twice weekly without experiencing a negative impact on enjoyment.However,the role that supervision and social interaction played in shaping the participants’responses is unclear.展开更多
基金National Key Research and Development Plan of China, Grant/Award Number: 2021YFB3600503National Natural Science Foundation of China, Grant/Award Numbers: 62276065, U21A20472。
文摘Attention mechanism has been a successful method for multimodal affective analysis in recent years. Despite the advances, several significant challenges remain in fusing language and its nonverbal context information. One is to generate sparse attention coefficients associated with acoustic and visual modalities, which helps locate critical emotional se-mantics. The other is fusing complementary cross‐modal representation to construct optimal salient feature combinations of multiple modalities. A Conditional Transformer Fusion Network is proposed to handle these problems. Firstly, the authors equip the transformer module with CNN layers to enhance the detection of subtle signal patterns in nonverbal sequences. Secondly, sentiment words are utilised as context conditions to guide the computation of cross‐modal attention. As a result, the located nonverbal fea-tures are not only salient but also complementary to sentiment words directly. Experi-mental results show that the authors’ method achieves state‐of‐the‐art performance on several multimodal affective analysis datasets.
文摘BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully elucidated.It is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in AD.AIM To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and leukocytes.METHODS This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory markers,somatic variables,psychological questionnaires,and lifestyle parameters.Hierarchical regression analyses were used to predict inflammatory markers from demographic,somatic,lifestyle,and personality variables.RESULTS Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(e.g.anti-diabetics),age and education,and age of affective disorder diagnosis.For leukocytes,20.1%of the variance was explained by smoking,diet,metabolic syndrome(MetS),and anti-inflammatory medication(e.g.non-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach significance.CONCLUSION Metabolic components seem important,with mounting evidence for a metabolic affective disorder subtype.Lifestyle modifications and psychoeducation should be employed to prevent or treat MetS in AD.
基金financially supported by the National Natural Science Foundation of China(Nos.52074078 and 52374327)the Applied Fundamental Research Program of Liaoning Province,China(No.2023JH2/101600002)+3 种基金the Liaoning Provincial Natural Science Foundation,China(No.2022-YQ-09)the Shenyang Young Middle-Aged Scientific and Technological Innovation Talent Support Program,China(No.RC220491)the Liaoning Province Steel Industry-University-Research Innovation Alliance Cooperation Project of Bensteel Group,China(No.KJBLM202202)the Fundamental Research Funds for the Central Universities,China(Nos.N2201023 and N2325009)。
文摘In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical performances.By controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower costs.In this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen reduction.The phases and magnetic properties of FeCoNi medium entropy alloy were investigated.Results showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal reduction.The alloy prepared by hydrogen reduction was uniform and showed a relatively high purity.Moreover,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.
文摘Affective factors and cognitive factors are two important parts of English learning, However, English teaching in recent years have taken into special consideration the necessity of knowledge and intelligence and comparatively ignored the development of affection. It may greatly reduce students' English learning capacity and limit the whole development of students. This paper will discuss the definition and the importance of affection and some main affective factors, and illustrate some implications of how to implement practical affective activities.
文摘This paper focuses on the vocational college students' experiences in English learning, classroom activities, attitudes to their English learning and achievements. It aims to find out how to make use of their positive personal factors to improve their English achievement so that both vocational college teachers and students may gain some enlightenment from the study.
文摘Autonomous study emphasizes the learner's initiative,enthusiasm and creativity.In all fields of education,there is growing emphasis on "learner-centered" teaching methods and the ability of learner autonomy.Many experts and scholars have found that learning strategies plays an important role in English language learning,but the importance of affective strategy use in English learning is often ignored by people.Therefore,this paper focuses on the frequencies of affective strategies use in English learning and their relationships so as to enable college students to use positive affective strategies effectively to improve their autonomous learning ability.
文摘The new curriculum standard points out that affection is one of the most important goals of fundamental education. The non-target language environment is easier to cause the affective change of middle school students who are changeable in their affective state. Based on the affective filter hypothesis, this paper deals with the adjustment to affective factors in English learning by using Internet English Curriculum Resource, such as attitude and motivation, anxiety and inhibition, self-esteem and self-confidence. At last, some suggestions are offered to judge Internet English Curriculum Resource.
文摘Foreign language teaching has shifted from teacher-centered teaching method to student-centered in recent years.Affective factors should be paid enough attention in teacher-learner interaction in.This paper aims to make an exploration into the effects of affective factors in college learners'classroom.
文摘Traditional English teaching lacks the consciousness of the importance of learner's affective factors and has trouble in training the qualified English speakers that the society needs.This paper talks about the importance of learner's motivation,attitude and personality.It is proposed that teachers should adopt the eclectic method accompanying with student-centered class.Teachers are asked to pay more attention to their different roles and the ways to create a positive climate for learning in class.
文摘Admittedly cognitive variables such as intelligence and aptitude exert great impact on English learning. Affective variables, however, are of intense importance in determining English learning as well, because affect is a starting machine that sets the learning mechanism in motion and learning will run into difficulty if affect does not work properly. Besides, there is mounting interest in exploring the affective domain. Therefore, this paper focuses upon the analyses of four affective variables(attitude, motivation, self-esteem and anxiety) that have bearings on English learning and sets forth Implications for English teaching.
文摘Nowadays,the development of economy as well as the progress of society requires better English competence of college students.As a result,a large number of college students are obsessedby affective barriers in their English learning,especially when they have to cope with CET 4 or CET 6,which is more and more difficult.This paper focuses on how to help college students overcome their affective barriers more effectively to improve their English learning.
文摘The paper mainly discusses the importance of affective factors in college English listening teaching and gives some sug gestions on how to cultivate students'positive affective factors.
文摘Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders.
文摘"The Input Hypothesis"and"The Affective Filter Hypothesis"are the most important branches of the"Monitor The ory"declared by the famous American linguist Krashen in 1980s.This thesis is based on Krashen's Input Hypothesis and Affec tive Filter Hypothesis,aiming to provide an applicable guide for foreign language teachers and learners in China.
文摘This research is framed within the affective computing, which explains the importance of emotions in human cognition (decision making, perception, interaction and human intelligence). Applying this approach to a pedagogical agent is an essential part to enhance the effectiveness of the teaching-learning process of an intelligent learning system. This work focuses on the design of the inference engine that will give life to the interface, where the latter is represented by a pedagogical agent. The inference engine is based on an affective-motivational model. This model is implemented by using artificial intelligence technique called fuzzy cognitive maps.
基金supported by National Key R&D Program of China, No. 2018YFB1003905Natural Science Foundation of China, No.61873026the Fundamental Research Funds for the Central Universities, No.FRFTP-18-008A3
文摘Artificial intelligence technology has revolutionized every industry and trade in recent years. However, its own development is encountering bottlenecks that it is unable to implement empathy with human emotions. So affective computing is getting more attention from researchers. In this paper, we propose an amygdala-inspired affective computing framework to realize the recognition of all kinds of human personalized emotions. Similar to the amygdala, the instantaneous emergency emotion is first computed more quickly in a low-redundancy convolutional neural network compressed by pruning and weight sharing with hashing trick. Then, the real-time process emotion is identified more accurately by the memory level neural networks, which is good at handling time-related signals. Finally, the intracranial emotion is recognized in personalized hidden Markov models. We demonstrate on Facial Expression of Emotion Dataset and the recognition accuracy of external emotions(including the emergency emotion and the process emotion) reached 85.72%. And the experimental results proved that the personalized affective model can generate desired intracranial emotions as expected.
文摘Background: To explore the therapeutic effect of Tongxinluo capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. Methods: Fifty-six patients with Syndrome X and Affective Disorder were randomly divided into a Tongxinluo capsule group and a placebo control group. The duration of treatment was 12 weeks. A 6-minute walking test, exercise load electrocardiogram and clinical symptom assessment were performed before and after treatment. After 12 weeks of treatment, the scores of the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were repeated. The levels of serum endothelin-1 (ET-1) and nitric oxide (NO) were measured before and after treatment. Results: Compared with the placebo control group, the Tongxinluo group SAS and SDS scores were lower than those before treatment (all P < 0.01), and the 6-minute walking distance increased significantly (P < 0.01). Clinical symptoms were significantly improved. The exercise test results suggested that, while improved, there was no significant difference (P > 0.05) when compared to before treatment. In the Tongxinluo treatment group, the levels of plasma endothelin-1 decreased significantly (P < 0.01) and nitric oxide levels were significantly increased (P < 0.01), with a significant difference when compared to the control group (P Conclusions: The Tongxinluo capsule can improve the Affective Disorder of Syndrome X, reduce the degree of anxiety and depression, increase exercise tolerance, reduce clinical symptoms, and improve vascular endothelial function.
文摘Daily separation of rat pups from their mothers while the preweaning period has an impact on behavior and stress response of pups. We hypothesized that maternal separation may create a depression-like state in mother rats from which we separate the rat pups and decrease their reproductive function and fertility. Also, we aimed to evaluate the transmission degree of depression and anxiety across generations. Females aged 3 months were divided in two groups of 10 rats each. After a first mating and a first parturition, we conducted maternal separation 3 h during 22 days for the experienced group while the control group mothers kept their pups. At 4 months of age, females underwent behavioral tests and a second mating. Second generation’s pups were also subjected to behavioral tests. Behavioral tests showed that mothers which experienced separation were more depressive and anxious than control ones, also they had a lower litter size. Rats pups of the second generation whose mothers experienced maternal separation also revealed behavior changes akin to depression and anxiety. Thus, maternal separation causes depressive and anxious-likestates on mother rats which experienced separation and has an impact on their litter size. Also, consequences of maternal separation seem to last throughout generations.
基金This study was funded by Cybex International as part of a funded PhD.
文摘Background:Resistance exercise has numerous,well-documented benefits on the health and functional performance of older adults.However,little information exists on the affective responses to resistance exercise in this population.As affective responses can predict continued exercise behavior,examining if and how they differ between resistance exercise intensities and frequencies in older adults may provide important data to improve resistance exercise prescription.Methods:We monitored the affective responses of older adults when performing high-velocity,low-load(HVLL)or low-velocity,high-load(LVHL)resistance exercise once or twice weekly.A total of 40 moderately to highly active,but resistance-exercise naïve,older adults(60-79 years)completed 1 of 4 randomly assigned progressive resistance exercise conditions:HVLL once weekly(HVLL1:n=10),HVLL twice weekly(HVLL2:n=10),LVHL once weekly(LVHL1:n=10),or LVHL twice weekly(LVHL2:n=10).The Physical Activity Affect Scale,Felt Arousal Scale,Feeling Scale,rating of perceived exertion,Visual Analog Scale,and the Physical Activity Enjoyment Scale were used to assess enjoyment and affective responses.Results:The results from Physical Activity Enjoyment Scale(out of 35)suggest that all exercise conditions were largely and similarly enjoyable to older adults(HVLL1:30.9±2.4;LVHL1:31.9±3.6;HVLL2:30.9±3.5;LVHL2:30.2±3.7)despite greater fatigue(p=0.033;ηp^2p=0.22)and perceived workload(p=0.042;ηp^2=0.20)in LVHL(results from Visual Analog Scale).Conclusion:Moderately to highly physically active older adults may tolerate higher intensities of resistance exercise performed once or twice weekly without experiencing a negative impact on enjoyment.However,the role that supervision and social interaction played in shaping the participants’responses is unclear.