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多主体协同开发社区教育课程的PERSONAL模式探索——基于“我爱我家”的个案研究
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作者 陈莉 《继续教育研究》 2024年第3期40-47,共8页
通过对“我爱我家”这一社区自发课程的跟踪调查,发现社区自发课程开发实质上是一个组织学习过程,经过个体直觉、知识解释、知识整合等环节实现组织的制度化学习,在推动学习型无边界组织生成的同时,生成社区教育课程。在这一过程中,政策... 通过对“我爱我家”这一社区自发课程的跟踪调查,发现社区自发课程开发实质上是一个组织学习过程,经过个体直觉、知识解释、知识整合等环节实现组织的制度化学习,在推动学习型无边界组织生成的同时,生成社区教育课程。在这一过程中,政策(policies)支持、专家(expert)指导、区域需求和区域特征(regional)、社区系统(system)、组织化(organization)等多要素叠加发挥作用,通过不断拓展新鲜(new)领域的积极行动(action)整合所有资源,并推动跨越边界的学习(learning)贯穿始终。因此,多主体协同的社区自发课程可以不完全地概括为PERSONAL模式。要以PERSONAL模式发展社区自发课程,需要以学习者为中心,注重发展人际互动,营造有利于跨组织交互学习的教育生态系统。 展开更多
关键词 社区自发课程 组织学习 多主体协同 personAL模式
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Intermittent disturbance mechanical behavior and fractional deterioration mechanical model of rock under complex true triaxial stress paths 被引量:1
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作者 Zhi Zheng Hongyu Xu +3 位作者 Kai Zhang Guangliang Feng Qiang Zhang Yufei Zhao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第1期117-136,共20页
Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensiona... Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing disasters.Therefore,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is proposed.True triaxial static compression and intermittent disturbance tests are carried out on monzogabbro.The effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture mechanism.Rapid increases in microseismic parameters during rock loading can be precursors for intermittent rock disturbance.Based on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental results.The sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are predicted.This study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads. 展开更多
关键词 true triaxial static and disturbance test Mechanical properties Failure mechanism and precursor Intermittent disturbance effect Fractional mechanical model
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Personalized Perioperative Care for a Patient with a 10-Year-Old Postpartum Old Thrombus after Neoadjuvant Therapy for Breast Cancer
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作者 Xia Zhang 《Advances in Breast Cancer Research》 CAS 2024年第3期27-35,共9页
Breast cancer is one of the most common malignant tumors in women, and has become the main cause threatening women’s health. A case of breast cancer with neoadjuvant chemotherapy was discharged after active treatment... Breast cancer is one of the most common malignant tumors in women, and has become the main cause threatening women’s health. A case of breast cancer with neoadjuvant chemotherapy was discharged after active treatment and nursing. 展开更多
关键词 Breast Cancer Neoadjuvant Chemotherapy personalized Care
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Correlation of personality with individual reproductive success in shrub-nesting birds depends on their life history style
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作者 Jianchuan Li Wen Zhang +5 位作者 Ningning Sun Yujie Wang Lifang Gao Ran Feng Liqing Fan Bo Du 《Avian Research》 SCIE CSCD 2024年第1期42-49,共8页
Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain ... Two questions in the research of animal personality—whether there is a correlation between a personality trait and individual reproductive success,and what is the genetic basis underlying a personality trait—remain unresolved.We addressed these two questions in three shrub-nesting birds,the Azure-winged Magpie(Cyanopica cyanus,AM),White-collared Blackbird(Turdus albocinctus,WB),and Brown-cheeked Laughingthrush(Trochalopteron henrici,BL).The personality type of an individual was first identified according to its response to a territorial intruder.Then,we compared the fleeing distance,breeding parameters,and differential expressed genes(DEGs) in the brain transcriptome between bold and shy breeders.In the three species,bold breeders exhibited more aggressiveness towards an intruder of their territory than did shy breeders.The reproductive success of bold breeders was significantly higher than that of shy breeders in AM but not in WB and BL.The three species shared one DEG,crabp1,which was up-regulated in bold relative to in shy individuals.By regulating the expression of corticotropin-releasing hormone,higher crabp1 gene expression can decrease cellular response to retinoic acid.Therefore,bold individuals are insensitive to external stresses and able to exhibit more aggressiveness to intruders than their shier counterparts.Aggressiveness is beneficial to bold individuals in AM but not in WB and BL because the former could evoke neighbors to make the same response of defending against intruders but the latter could not.Although a personality trait may have the same genetic basis across species,its correlation with reproductive success depends largely on the life history style of a species. 展开更多
关键词 BOLDNESS Life history style personALITY Reproductive success Transcriptome analysis
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Self-supervised recalibration network for person re-identification
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作者 Shaoqi Hou Zhiming Wang +4 位作者 Zhihua Dong Ye Li Zhiguo Wang Guangqiang Yin Xinzhong Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期163-178,共16页
The attention mechanism can extract salient features in images,which has been proved to be effective in improving the performance of person re-identification(Re-ID).However,most of the existing attention modules have ... The attention mechanism can extract salient features in images,which has been proved to be effective in improving the performance of person re-identification(Re-ID).However,most of the existing attention modules have the following two shortcomings:On the one hand,they mostly use global average pooling to generate context descriptors,without highlighting the guiding role of salient information on descriptor generation,resulting in insufficient ability of the final generated attention mask representation;On the other hand,the design of most attention modules is complicated,which greatly increases the computational cost of the model.To solve these problems,this paper proposes an attention module called self-supervised recalibration(SR)block,which introduces both global and local information through adaptive weighted fusion to generate a more refined attention mask.In particular,a special"Squeeze-Excitation"(SE)unit is designed in the SR block to further process the generated intermediate masks,both for nonlinearizations of the features and for constraint of the resulting computation by controlling the number of channels.Furthermore,we combine the most commonly used Res Net-50 to construct the instantiation model of the SR block,and verify its effectiveness on multiple Re-ID datasets,especially the mean Average Precision(m AP)on the Occluded-Duke dataset exceeds the state-of-the-art(SOTA)algorithm by 4.49%. 展开更多
关键词 person re-identification Attention mechanism Global information Local information Adaptive weighted fusion
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Personal Thermal Management by Radiative Cooling and Heating
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作者 Shidong Xue Guanghan Huang +3 位作者 Qing Chen Xungai Wang Jintu Fan Dahua Shou 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第8期225-267,共43页
Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building hea... Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building heating,ventilation,and air-conditioning systems.In recent years,there has been a surge in advancements in personal thermal management(PTM),aiming to regulate heat and moisture transfer within our immediate surroundings,clothing,and skin.The advent of PTM is driven by the rapid development in nano/micro-materials and energy science and engineering.An emerging research area in PTM is personal radiative thermal management(PRTM),which demonstrates immense potential with its high radiative heat transfer efficiency and ease of regulation.However,it is less taken into account in traditional textiles,and there currently lies a gap in our knowledge and understanding of PRTM.In this review,we aim to present a thorough analysis of advanced textile materials and technologies for PRTM.Specifically,we will introduce and discuss the underlying radiation heat transfer mechanisms,fabrication methods of textiles,and various indoor/outdoor applications in light of their different regulation functionalities,including radiative cooling,radiative heating,and dual-mode thermoregulation.Furthermore,we will shine a light on the current hurdles,propose potential strategies,and delve into future technology trends for PRTM with an emphasis on functionalities and applications. 展开更多
关键词 personal thermal management Radiative cooling and heating Thermal comfort Dynamic thermoregulation
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Dynamic Hand Gesture-Based Person Identification Using Leap Motion and Machine Learning Approaches
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作者 Jungpil Shin Md.AlMehedi Hasan +2 位作者 Md.Maniruzzaman Taiki Watanabe Issei Jozume 《Computers, Materials & Continua》 SCIE EI 2024年第4期1205-1222,共18页
Person identification is one of the most vital tasks for network security. People are more concerned about theirsecurity due to traditional passwords becoming weaker or leaking in various attacks. In recent decades, f... Person identification is one of the most vital tasks for network security. People are more concerned about theirsecurity due to traditional passwords becoming weaker or leaking in various attacks. In recent decades, fingerprintsand faces have been widely used for person identification, which has the risk of information leakage as a resultof reproducing fingers or faces by taking a snapshot. Recently, people have focused on creating an identifiablepattern, which will not be reproducible falsely by capturing psychological and behavioral information of a personusing vision and sensor-based techniques. In existing studies, most of the researchers used very complex patternsin this direction, which need special training and attention to remember the patterns and failed to capturethe psychological and behavioral information of a person properly. To overcome these problems, this researchdevised a novel dynamic hand gesture-based person identification system using a Leap Motion sensor. Thisstudy developed two hand gesture-based pattern datasets for performing the experiments, which contained morethan 500 samples, collected from 25 subjects. Various static and dynamic features were extracted from the handgeometry. Randomforest was used to measure feature importance using the Gini Index. Finally, the support vectormachinewas implemented for person identification and evaluate its performance using identification accuracy. Theexperimental results showed that the proposed system produced an identification accuracy of 99.8% for arbitraryhand gesture-based patterns and 99.6% for the same dynamic hand gesture-based patterns. This result indicatedthat the proposed system can be used for person identification in the field of security. 展开更多
关键词 person identification leap motion hand gesture random forest support vector machine
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Microdynamic mechanical properties and fracture evolution mechanism of monzogabbro with a true triaxial multilevel disturbance method
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作者 Zhi Zheng Bin Deng +3 位作者 Hong Liu Wei Wang Shuling Huang Shaojun Li 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期385-411,共27页
The far-field microdynamic disturbance caused by the excavation of deep mineral resources and underground engineering can induce surrounding rock damage in high-stress conditions and even lead to disasters.However,the... The far-field microdynamic disturbance caused by the excavation of deep mineral resources and underground engineering can induce surrounding rock damage in high-stress conditions and even lead to disasters.However,the mechanical properties and damage/fracture evolution mechanisms of deep rock induced by microdynamic disturbance under three-dimensional stress states are unclear.Therefore,a true triaxial multilevel disturbance test method is proposed,which can completely simulate natural geostress,excavation stress redistribution(such as stress unloading,concentration and rotation),and subsequently the microdynamic disturbance triggering damaged rock failure.Based on a dynamic true triaxial test platform,true triaxial microdynamic disturbance tests under different frequency and amplitudes were carried out on monzogabbro.The results show that increasing amplitude or decreasing frequency diminishes the failure strength of monzogabbro.Deformation modulus gradually decreases during disturbance failure.As frequency and amplitude increase,the degradation rate of deformation modulus decreases slightly,disturbance dissipated energy increases significantly,and disturbance deformation anisotropy strengthens obviously.A damage model has been proposed to quantitatively characterize the disturbance-induced damage evolution at different frequency and amplitude under true triaxial stress.Before disturbance failure,the micro-tensile crack mechanism is dominant,and the micro-shear crack mechanism increases significantly at failure.With the increase of amplitude and frequency,the micro-shear crack mechanism increases.When approaching disturbance failure,the acoustic emission fractal dimension changes from a stable value to local large oscillation,and finally increases sharply to a high value at failure.Finally,the disturbance-induced failure mechanism of surrounding rock in deep engineering is clearly elucidated. 展开更多
关键词 true triaxial disturbance test Mechanical properties Fracture evolution mechanism Disturbance-induced damage evolution Failure mechanism and precursor
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Personalized treatment of perihilar cholangiocarcinoma based on tumor genetic and molecular characteristics
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作者 He-Nan Tang Ming-Wei Wang +1 位作者 Xue-Song Liu Yan Jiao 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第9期2769-2773,共5页
This editorial discusses the article written by Tchilikidi et al that was published in the latest edition of the World Journal of Gastrointestinal Surgery.Genetic and molecular profiling of perihilar cholangiocarcinom... This editorial discusses the article written by Tchilikidi et al that was published in the latest edition of the World Journal of Gastrointestinal Surgery.Genetic and molecular profiling of perihilar cholangiocarcinoma(pCCA)has identified a number of key abnormalities that drive tumor growth and spread,including pyruvate kinase M2,proline rich 11,and transcription factor 7,etc.pCCA has specific genetic and molecular features that can be used to develop personalized treatment plans.Personalized treatment approaches offer new opportunities for effectively targeting the underlying drivers of tumor growth and progression.The findings based on tumor genetic and molecular characteristics highlight the importance of developing personalized treatment strategies. 展开更多
关键词 Perihilar cholangiocarcinoma Molecular characteristics Tumor genetic personALIZED TREATMENT
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BGP in Nigeria--25 Years of Staying True to Our Original Aspirations Through Thick and Thin
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作者 Yang Tao 《China Oil & Gas》 CAS 2024年第1期52-56,共5页
Aspan of twenty-five years,for a company,constitutes a engthy and eventful journey.Twenty-five years ago,a group of oil professionals from the Bureau of Geophysical Prospecting INC (hereinafter referred to as BGP),set... Aspan of twenty-five years,for a company,constitutes a engthy and eventful journey.Twenty-five years ago,a group of oil professionals from the Bureau of Geophysical Prospecting INC (hereinafter referred to as BGP),set foot on the land of Nigeria and embarked on a legendary journey.This is a narrative of resilience,commitment,and heartfelt passion,an inspiring saga that touches the soul. 展开更多
关键词 CONSTITUTE true GEOPHYSICAL
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Personality Trait Detection via Transfer Learning
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作者 Bashar Alshouha Jesus Serrano-Guerrero +2 位作者 Francisco Chiclana Francisco P.Romero Jose A.Olivas 《Computers, Materials & Continua》 SCIE EI 2024年第2期1933-1956,共24页
Personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human resources.Tra-... Personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human resources.Tra-ditional machine learning techniques have been broadly employed for personality trait identification;nevertheless,the development of new technologies based on deep learning has led to new opportunities to improve their performance.This study focuses on the capabilities of pre-trained language models such as BERT,RoBERTa,ALBERT,ELECTRA,ERNIE,or XLNet,to deal with the task of personality recognition.These models are able to capture structural features from textual content and comprehend a multitude of language facets and complex features such as hierarchical relationships or long-term dependencies.This makes them suitable to classify multi-label personality traits from reviews while mitigating computational costs.The focus of this approach centers on developing an architecture based on different layers able to capture the semantic context and structural features from texts.Moreover,it is able to fine-tune the previous models using the MyPersonality dataset,which comprises 9,917 status updates contributed by 250 Facebook users.These status updates are categorized according to the well-known Big Five personality model,setting the stage for a comprehensive exploration of personality traits.To test the proposal,a set of experiments have been performed using different metrics such as the exact match ratio,hamming loss,zero-one-loss,precision,recall,F1-score,and weighted averages.The results reveal ERNIE is the top-performing model,achieving an exact match ratio of 72.32%,an accuracy rate of 87.17%,and 84.41%of F1-score.The findings demonstrate that the tested models substantially outperform other state-of-the-art studies,enhancing the accuracy by at least 3%and confirming them as powerful tools for personality recognition.These findings represent substantial advancements in personality recognition,making them appropriate for the development of user-centric applications. 展开更多
关键词 personality trait detection pre-trained language model big five model transfer learning
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Personalized Lower Limb Gait Reconstruction Modeling Based on RFA-ProMP
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作者 Chunhong Zeng Kang Lu +1 位作者 Zhiqin He Qinmu Wu 《Computers, Materials & Continua》 SCIE EI 2024年第7期1441-1456,共16页
Personalized gait curves are generated to enhance patient adaptability to gait trajectories used for passive training in the early stage of rehabilitation for hemiplegic patients.The article utilizes the random forest... Personalized gait curves are generated to enhance patient adaptability to gait trajectories used for passive training in the early stage of rehabilitation for hemiplegic patients.The article utilizes the random forest algorithm to construct a gait parameter model,which maps the relationship between parameters such as height,weight,age,gender,and gait speed,achieving prediction of key points on the gait curve.To enhance prediction accuracy,an attention mechanism is introduced into the algorithm to focus more on the main features.Meanwhile,to ensure high similarity between the reconstructed gait curve and the normal one,probabilistic motion primitives(ProMP)are used to learn the probability distribution of normal gait data and construct a gait trajectorymodel.Finally,using the specified step speed as input,select a reference gait trajectory from the learned trajectory,and reconstruct the curve of the reference trajectoryusing the gait keypoints predictedby the parametermodel toobtain the final curve.Simulation results demonstrate that the method proposed in this paper achieves 98%and 96%curve correlations when generating personalized lower limb gait curves for different patients,respectively,indicating its suitability for such tasks. 展开更多
关键词 personalized lower limb gait prediction random forest probabilistic movement primitives
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All Voices Should Be Heard and Heeded in a True Democracy
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作者 ZHANG HUI 《China Today》 2024年第5期46-49,共4页
For all its different forms,democracy is expected to promote people’s well-being,instead of being weaponized to justify hegemony,as democracy is also a principle of global governance.
关键词 true VOICE SHOULD
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Experimental and numerical study on dynamic mechanical behaviors of shale under true triaxial compression at high strain rate
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作者 Xiaoping Zhou Linyuan Han +1 位作者 Jing Bi Yundong Shou 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第2期149-165,共17页
High-energy gas fracturing of shale is a novel,high efficacy and eco-friendly mining technique,which is a typical dynamic perturbing behavior.To effectively extract shale gas,it is important to understand the dynamic ... High-energy gas fracturing of shale is a novel,high efficacy and eco-friendly mining technique,which is a typical dynamic perturbing behavior.To effectively extract shale gas,it is important to understand the dynamic mechanical properties of shale.Dynamic experiments on shale subjected to true triaxial compression at different strain rates are first conducted in this research.The dynamic stress-strain curves,peak strain,peak stress and failure modes of shale are investigated.The results of the study indicate that the intermediate principal stress and the minor principal stress have the significant influence on the dynamic mechanical behaviors,although this effect decreases as the strain rate increases.The characteristics of compression-shear failure primarily occur in shale subjected to triaxial compression at high strain rates,which distinguishes it from the fragmentation characteristics observed in shale under dynamic uniaxial compression.Additionally,a numerical three-dimensional Split Hopkinson Pressure Bar(3D-SHPB),which is established by coupling PFC3D and FLAC3D methods,is validated to replicate the laboratory characteristics of shale.The dynamic mechanical characteristics of shale subjected to different confining stresses are systematically investigated by the coupling PFC3D and FLAC3D method.The numerical results are in good agreement with the experimental data. 展开更多
关键词 Dynamic behaviors true triaxial compression High strain rates Dynamic failure mechanism PFC3D-FLAC3D coupled method
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The Impact of Big Five Personality Traits on Older Europeans’ Physical Health
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作者 Eleni Serafetinidou Christina Parpoula 《Journal of Biomedical Science and Engineering》 2024年第2期41-56,共16页
Investigating the role of Big Five personality traits in relation to various health outcomes has been extensively studied. The impact of “Big Five” on physical health is here explored for older Europeans with a focu... Investigating the role of Big Five personality traits in relation to various health outcomes has been extensively studied. The impact of “Big Five” on physical health is here explored for older Europeans with a focus on examining age groups differences. The study sample included 378,500 respondents derived from the seventh data wave of Survey of Health, Aging and Retirement in Europe (SHARE). The physical health status of older Europeans was estimated by constructing an index considering the combined effect of well-established health indicators such as the number of chronic diseases, mobility limitations, limitations with basic and instrumental activities of daily living, and self-perceived health. This index was used for an overall physical health assessment, for which the higher the score for an individual, the worst health level. Then, through a dichotomization process applied to the retrieved Principal Component Analysis scores, a two-group discrimination (good or bad health status) of SHARE participants was obtained as regards their physical health condition, allowing for further con-structing logistic regression models to assess the predictive significance of “Big Five” and their protective role for physical health. Results showed that neuroti-cism was the most significant predictor of physical health for all age groups un-der consideration, while extraversion, agreeableness and openness were not found to significantly affect the self-reported physical health levels of midlife adults aged 50 up to 64. Older adults aged 65 up to 79 were more prone to open-ness, whereas the oldest old individuals aged 80 up to 105 were mainly affected by openness and conscientiousness. . 展开更多
关键词 Big Five personality Traits Physical Health Older Europeans SHARE Principal Component Analysis
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Anisotropic strength,deformation and failure of gneiss granite under high stress and temperature coupled true triaxial compression
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作者 Hongyuan Zhou Zaobao Liu +2 位作者 Fengjiao Liu Jianfu Shao Guoliang Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期860-876,共17页
The anisotropic mechanical behavior of rocks under high-stress and high-temperature coupled conditions is crucial for analyzing the stability of surrounding rocks in deep underground engineering.This paper is devoted ... The anisotropic mechanical behavior of rocks under high-stress and high-temperature coupled conditions is crucial for analyzing the stability of surrounding rocks in deep underground engineering.This paper is devoted to studying the anisotropic strength,deformation and failure behavior of gneiss granite from the deep boreholes of a railway tunnel that suffers from high tectonic stress and ground temperature in the eastern tectonic knot in the Tibet Plateau.High-temperature true triaxial compression tests are performed on the samples using a self-developed testing device with five different loading directions and three temperature values that are representative of the geological conditions of the deep underground tunnels in the region.Effect of temperature and loading direction on the strength,elastic modulus,Poisson’s ratio,and failure mode are analyzed.The method for quantitative identification of anisotropic failure is also proposed.The anisotropic mechanical behaviors of the gneiss granite are very sensitive to the changes in loading direction and temperature under true triaxial compression,and the high temperature seems to weaken the inherent anisotropy and stress-induced deformation anisotropy.The strength and deformation show obvious thermal degradation at 200℃due to the weakening of friction between failure surfaces and the transition of the failure pattern in rock grains.In the range of 25℃ 200℃,the failure is mainly governed by the loading direction due to the inherent anisotropy.This study is helpful to the in-depth understanding of the thermal-mechanical behavior of anisotropic rocks in deep underground projects. 展开更多
关键词 Anisotropic strength and deformation true triaxial compression Thermal mechanical coupling Deep rock mechanics High temperature rock mechanics
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Cardiovascular risk factors among older persons with cognitive frailty in middle income country
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作者 Azianah Mohamad Ibrahim Devinder Kaur Ajit Singh +3 位作者 Arimi Fitri Mat Ludin Noor Ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar 《World Journal of Clinical Cases》 SCIE 2024年第17期3076-3085,共10页
BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging population.The role of cardiovascular risk factors in this co... BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging population.The role of cardiovascular risk factors in this complex interplay is not yet fully understood.AIM To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in Malaysia.METHODS A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous studies.Datasets related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for analysis.Cognitive frailty was defined based on the Clinical Dementia Rating scale and Fried frailty score.Cardiovascular risk was determined using Framingham risk score.Statistical analyses were conducted using SPSS version 21.RESULTS Of the study participants,46.3%exhibited cognitive frailty.Cardiovascular risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive frailty.CONCLUSION Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of dementia.Early identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia. 展开更多
关键词 Cognitive frailty Older persons Cardiovascular risk factors FRAILTY Mild cognitive impairment
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THE ETERNITY OF TRUE FRIENDSHIP EXCLUSIVE INTERVIEW WITH CHINESE AMBASSADOR TO MALAYSIA OUYANG YUJING
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作者 Guo Xixian 《China Report ASEAN》 2024年第6期16-19,共4页
China and Malaysia established diplomatic ties fifty years ago.Over the past half-century,the bilateral relationship has made great progress in various fields,delivering tangible benefits to the people of the two coun... China and Malaysia established diplomatic ties fifty years ago.Over the past half-century,the bilateral relationship has made great progress in various fields,delivering tangible benefits to the people of the two countries and making positive contributions to the peace,stability,and prosperity of the region. 展开更多
关键词 true peace AMBA
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Personalized medicine and opioid use disorder
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作者 Dilek Kaya-Akyüzlü 《World Journal of Psychiatry》 SCIE 2024年第9期1285-1288,共4页
Opioid use disorder(OUD)is a major public health problem affecting millions of people worldwide.Although OUD is a chronic and relapsing disorder,a variety of pharmacological and non-pharmacological interventions are a... Opioid use disorder(OUD)is a major public health problem affecting millions of people worldwide.Although OUD is a chronic and relapsing disorder,a variety of pharmacological and non-pharmacological interventions are available.Medication-assisted treatment of OUD generally relies on competition for opioid receptors against the addictive substance.The mechanisms of this competition are to block or inactivate the opioid receptor or activate the receptor with a substance that is intermittent or long acting.Methadone and buprenorphine are two United States Food and Drug Administration-approved medications that have long-term positive effects on the health of opioid-dependent individuals.Although clinical studies of drugs generally demonstrate efficacy in thousands of people and toxicity is excluded,it cannot be predicted whether the given drug will cause side effects in one of the patients at the treatment dose.Individual differences can be explained by many biological and environmental factors.Variations in genes encoding drug metabolism or cellular drug targets significantly explain the variability in drug response between individuals.Therefore,for the effects of candidate genes to be accepted and included in individual treatment protocols,it is important to repeat studies on individuals of different ethnic backgrounds and prove a similar effect. 展开更多
关键词 Opioid use disorder Genetic vulnerability Treatment failures personalized medicine PHARMACOGENETICS
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Enhancing personalized exercise recommendation with student and exercise portraits
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作者 Wei-Wei Gao Hui-Fang Ma +2 位作者 Yan Zhao Jing Wang Quan-Hong Tian 《Journal of Electronic Science and Technology》 EI CAS CSCD 2024年第2期91-109,共19页
The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions gen... The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely ignored.In this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list optimization.Technically,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)relationships.Then,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar portraits.Finally,we propose to optimize the recommendation list to obtain different exercise suggestions.After analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity. 展开更多
关键词 Educational data mining Exercise recommend Joint random walk Nearly uncoupled Markov chains Optimization personalized learning
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