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Application of Elzaki Transform Method to Market Volatility Using the Black-Scholes Model
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作者 Henrietta Ify Ojarikre Ideh Rapheal Ebimene James Mamadu 《Journal of Applied Mathematics and Physics》 2024年第3期819-828,共10页
Black-Scholes Model (B-SM) simulates the dynamics of financial market and contains instruments such as options and puts which are major indices requiring solution. B-SM is known to estimate the correct prices of Europ... Black-Scholes Model (B-SM) simulates the dynamics of financial market and contains instruments such as options and puts which are major indices requiring solution. B-SM is known to estimate the correct prices of European Stock options and establish the theoretical foundation for Option pricing. Therefore, this paper evaluates the Black-Schole model in simulating the European call in a cash flow in the dependent drift and focuses on obtaining analytic and then approximate solution for the model. The work also examines Fokker Planck Equation (FPE) and extracts the link between FPE and B-SM for non equilibrium systems. The B-SM is then solved via the Elzaki transform method (ETM). The computational procedures were obtained using MAPLE 18 with the solution provided in the form of convergent series. 展开更多
关键词 Elzaki Transform method European Call black-Scholes Model Fokker-Planck Equation Market Volatility
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基于Box-Behnken响应面法优化方便藜麦粥制备工艺
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作者 郑守晶 黄思梅 +2 位作者 岳文杰 黄子建 郑明锋 《武夷科学》 2024年第1期73-80,共8页
以复水率、复水时间和感官品质为指标,通过单因素试验优选方便藜麦粥的最佳浸泡温度、料水比和蒸煮时间;利用Box-Behnken响应面法优化其制备工艺,并采用加权法计算综合得分。结果表明,最佳制备工艺为浸泡温度41℃,料水比1∶9,蒸煮时间23... 以复水率、复水时间和感官品质为指标,通过单因素试验优选方便藜麦粥的最佳浸泡温度、料水比和蒸煮时间;利用Box-Behnken响应面法优化其制备工艺,并采用加权法计算综合得分。结果表明,最佳制备工艺为浸泡温度41℃,料水比1∶9,蒸煮时间23 min。经验证试验,其综合得分为96.08,与理论预测值(96.43)的相对偏差为0.35%(<5.0%)。优化的方便藜麦粥制备工艺为其开发应用提供重要支撑。 展开更多
关键词 藜麦 方便粥 box-Behnken响应面法 制备工艺
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Operating room black box:Scrutinizer of theatre practices
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作者 Prem Kumar A PI Pragyan Pratik Nithya Ravichandran 《Laparoscopic, Endoscopic and Robotic Surgery》 2023年第4期142-146,共5页
Objective:Adverse surgical events are a major cause of morbidity,mortality,and disability worldw ide.The cause of many such events can be attributed to interruptions in the operating room(OR),muli-tasking by surgeons,... Objective:Adverse surgical events are a major cause of morbidity,mortality,and disability worldw ide.The cause of many such events can be attributed to interruptions in the operating room(OR),muli-tasking by surgeons,etc.The objective of this study was to observe the types and frequency of intra-operative wor kflow interruptions in our ORs.Method:This ccoss-sectional study was conducted from March Do April of 2023.An observational approach using an audio-video recording device was employed to record OR flow disr uptions.One elective OR and one emergency OR under the Department of General Surgery were selected for the study.All open and laparoscopic surger ies conducted in the selected ORs were included.An Internet Protocol camera'was installed in the selec ted ORS with a view of the entire room,including the anesthesia station.Audio-video recording was started after the first indsion and stopped after closure of the surgical site.Result:Of the 51 cases that were studied,45(88.2%)were elective,and 18(35.3%)were laparoscopic cases.They could be classified into 8 types of open procedures and 4 types of lapar oscopic procedures.The mean maximum headcount inside the OR was 15.5土3.6 and doors opened on average of 15.8土6.0 times during a procedure.Other interruptions were surgeons attending phone calls(24,47.1%),leaving the sterile area(21,41.2%),technical disturbances(32,62.7%),anesthetic interruptions(18,35.3%),and faulty instruments(29,56.9%)Elective procedures had a signifcandy higher average number of in-terruptions per operating hour than emergency procedures(175±8.6vs.7.1±2.9,p<0.01).Condusion:Preventable factors such as faulty instruments,anesthetic interruption,and attending phone calls by the surgeon are commonly observed in ORs.They need to be addressed by timely surgical audits or the adoption of continued sureillance methods that can help take measures to minimize their occurrence. 展开更多
关键词 INTERRUPTION black box CAMERA Surgical audit Operation theatre
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Optimization of Supercritical Extraction Process of Laoshan Black Tea by Response Surface Methodology
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作者 Yongxin LIU Zhiguang LIU +11 位作者 Zengyu WANG Shuai ZHANG Guofeng YU Jianhong SUN Shoutao CAO Qiulin LIU Xulun WEI Cuishu LENG Fuhua MA Xuegang LI Yinlong WANG Shoujie NIE 《Agricultural Biotechnology》 CAS 2023年第1期98-101,共4页
[Objectives]Laoshan black tea was subjected to supercritical CO_(2) extraction. [Methods]The extraction conditions of Laoshan black tea were studied by an orthogonal experiment and optimized by response surface method... [Objectives]Laoshan black tea was subjected to supercritical CO_(2) extraction. [Methods]The extraction conditions of Laoshan black tea were studied by an orthogonal experiment and optimized by response surface methodology. [Results] The optimum extraction conditions of black tea extract by supercritical CO_(2) extraction were as follows: extraction pressure 23.53 MPa, extraction time 1.73 h, and extraction temperature 49.75 ℃, with which the extract yield could reach 5.15% theoretically. [Conclusions] Based on the traditional extraction process, a supercritical extraction method optimized by response surface methodology and a unique extraction process were formed, which enriches the extraction processes and methods of natural raw materials. 展开更多
关键词 Laoshan black tea Supercritical extraction Response surface method
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基于Box-Behnken响应面法优化膝痛康β-蜕皮甾酮的提取工艺
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作者 高建辉 张舜华 +5 位作者 张宇 范元赫 闵冬雨 叶恒 赵龙山 关雪峰 《沈阳药科大学学报》 CAS CSCD 2024年第4期451-456,共6页
目的优化膝痛康方剂中β-蜕皮甾酮的提取工艺。方法采用Box-Behnken响应面法和单因素试验,对提取过程中的浸泡时间、提取次数、提取时间和甲醇倍量等进行优化,通过响应面模型分析与预测,得到最佳的提取工艺条件,并对最优条件进行验证。... 目的优化膝痛康方剂中β-蜕皮甾酮的提取工艺。方法采用Box-Behnken响应面法和单因素试验,对提取过程中的浸泡时间、提取次数、提取时间和甲醇倍量等进行优化,通过响应面模型分析与预测,得到最佳的提取工艺条件,并对最优条件进行验证。结果饮片浸泡96 min,提取100 min,反复2次,甲醇倍数为16倍,此时牛膝的提取工艺达到最佳,在此提取工艺下β-蜕皮甾酮的提取量达到最大。结论该提取方法具有设备简单、成本低、提取工艺稳定等特点,此外,该提取工艺具有较好的应用价值,以其为膝痛康的应用提供实验依据。 展开更多
关键词 牛膝 β-蜕皮甾酮 box-Behnken响应面法 提取工艺
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Box-Behnken响应面法优化羟基红花黄色素A纳米粒处方工艺及体外释放评价
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作者 肖奕菲 杜利新 +3 位作者 魏起东 陆慧玲 郭志华 李雅 《中药新药与临床药理》 CAS CSCD 北大核心 2024年第1期122-131,共10页
目的优化羟基红花黄色素A(hydroxysafflor yellow A,HSYA)纳米粒制备工艺,并对其进行体外释放评价。方法以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolicacid),PLGA]为载体,利用改良的复乳法制备HSYA纳米粒,通过Plackett-Burman设计实... 目的优化羟基红花黄色素A(hydroxysafflor yellow A,HSYA)纳米粒制备工艺,并对其进行体外释放评价。方法以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolicacid),PLGA]为载体,利用改良的复乳法制备HSYA纳米粒,通过Plackett-Burman设计实验联用Box-Behnken响应面法优选最佳制备工艺;利用粒径测定仪、TEM扫描电镜仪、傅里叶红外光谱(FT-IR)仪、X-射线粉末衍射(XRD)仪对纳米粒进行表征;并对其进行4℃储藏稳定性、生理介质中稳定性、冻干保护剂及体外释放率考察。结果优选出纳米粒最佳工艺处方为:pH为6.95,投药量为2.8 mg,载体用量为18.2 mg;在此条件下制备出的纳米粒粒径为(176.4±1.29)nm,多分散系数(Polydiseperse Index,PDI)为(0.152±0.014),Zeta电位为(-17.6±0.46)mV,包封率为(78.5±0.49)%,载药量为(7.3±0.07)%,纳米粒形态圆整,分散性好;在4℃储存环境下、不同生理介质中稳定性良好,最佳冻干保护剂为1%葡萄糖;纳米粒48 h体外释放率为85%。结论该优化方法合理可靠,所得纳米粒稳定性良好,具有一定的缓释作用,体外释放符合一级动力学模型。 展开更多
关键词 羟基红花黄色素A PLGA纳米粒 Plackett-Burman设计实验 box-Behnken响应面法 体外释放
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G1-熵权法结合Box-Behnken响应面法优化银星养脑方醇提工艺
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作者 熊丹 蒋翠平 +5 位作者 牛江进 严建业 王平杰 谢宗明 高明果 陶叶琴 《中南药学》 CAS 2024年第7期1742-1747,共6页
目的优化银星养脑方醇提工艺。方法基于单因素实验,以乙醇浓度、提取时间、提取溶剂倍数为影响因素,采用Box-Behnken响应面法,以阿魏酸、3,6'-二芥子酰基蔗糖、金松双黄酮、异银杏素的转移率和浸膏得率为评价指标,结合G1-熵权法计... 目的优化银星养脑方醇提工艺。方法基于单因素实验,以乙醇浓度、提取时间、提取溶剂倍数为影响因素,采用Box-Behnken响应面法,以阿魏酸、3,6'-二芥子酰基蔗糖、金松双黄酮、异银杏素的转移率和浸膏得率为评价指标,结合G1-熵权法计算综合评分,优选银星养脑方最佳醇提工艺。结果建立了工艺评价函数模型,模型预测最佳提取工艺为6倍量60%的乙醇提取1.4 h,提取2次。结论该提取方法稳定可行,可为银星养脑方的批量生产提供参考。 展开更多
关键词 银星养脑方 醇提工艺:G1-熵权法 box-Behnken响应面法
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Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方研究
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作者 程索婷 黄莉 +3 位作者 邹纯才 鄢海燕 任佩 王紫彤 《安徽中医药大学学报》 CAS 2024年第3期93-99,共7页
目的采用Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方。方法在前期预试验的基础上,以载药量、促渗剂用量、聚乙二醇(polyethylene glycol,PEG)6000与微粉硅胶的比例为影响因素,进行单因素试验。结合体外透皮试验,利用高效液... 目的采用Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方。方法在前期预试验的基础上,以载药量、促渗剂用量、聚乙二醇(polyethylene glycol,PEG)6000与微粉硅胶的比例为影响因素,进行单因素试验。结合体外透皮试验,利用高效液相色谱法测定胡椒碱的含量,对胡椒碱峰面积、指纹图谱的总峰面积和脐贴的成型性、剥离残留度和基质填充情况赋以权重,所得结果为综合评价指标。在单因素试验的基础上利用Box-Behnken响应面法结合BP神经网络优化脐贴处方。结果黑胡椒脐贴的最佳处方为载药量7%、氮酮4.5%、PEG6000与微粉硅胶的质量比为43∶1。结论黑胡椒脐贴的处方合理,可为后续贴剂的药效学研究提供基础。 展开更多
关键词 黑胡椒 脐贴 box-Behnken响应面法 BP神经网络
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Highly Defective Dark TiO_(2) Modified with Pt: Effects of Precursor Nature and Preparation Method on Photocatalytic Properties
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作者 E.D.Fakhrutdinova O.A.Reutova +6 位作者 T.A.Bugrova I.Yu.Ovsyuk L.S.Kibis O.A.Stonkus D.B.Vasilchenko O.V.Vodyankina V.A.Svetlychnyi 《Transactions of Tianjin University》 EI CAS 2024年第2期198-209,共12页
The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. Both the method of Pt introduction and the nature of the Pt precursor were varied. All samples exhibite... The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. Both the method of Pt introduction and the nature of the Pt precursor were varied. All samples exhibited similar phase compositions, specific surface areas, and Pt contents. High-resolution transmission electron microscopy coupled with pulsed CO adsorption revealed increased dispersity when photoreduction and the hydroxonitrate complex (Me _(4) N) _(2) [Pt _(2) (OH) _(2) (NO _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and subnano-sized Pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of Pt ^(2+) states, which appeared owing to the strong metal-support interaction (SMSI) eff ect of the transfer of electron density from the electron-saturated defects on the TiO _(2) surface to Pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the Pt ^(2+) ionic component, capable of generating short-lived Pt^(0) single-atom sites under irradiation due to the SMSI eff ect, exhibited the highest photocatalytic activity. The 0.5Pt(C)/TiO_(2) -Ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation. 展开更多
关键词 Dark(black)TiO_(2) Pulsed laser ablation Platinum reduction method Precursor type PHOTOCATALYSIS Hydrogen evolution reaction
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Black Box Modeling Method and Its Application in Refractories Techniques
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作者 WANG Jiezeng YUAN Lin YE Yahong LI Penghai WANG Juntao 《China's Refractories》 CAS 2012年第4期1-6,共6页
Concept of black box, condition of modeling and control methods were introduced. Taking high purity silica brick as an example, the silica brick featured with high purity, low porosity, low true density and high stren... Concept of black box, condition of modeling and control methods were introduced. Taking high purity silica brick as an example, the silica brick featured with high purity, low porosity, low true density and high strength was developed through problem analysis, test design, modeling and optimization. Using information technology to upgrade refractories industry was discussed. 展开更多
关键词 black box MODELING OPTIMIZATION TECHNIQUES REFRACTORIES
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Electric power generation technology of natural gas pressure reduction:Insights from black box-gray box hierarchical exergy analysis and evaluation method
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作者 Zhi-Dong Li Qing-Lin Cheng +4 位作者 You-Wang Chen Jiang-Dong Wei Li-Li Lv Hao Wu Yang Liu 《Petroleum Science》 SCIE CAS CSCD 2022年第1期329-338,共10页
Based on the“three box”exergy analysis model,a black box-gray box hierarchical exergy analysis and evaluation method is put forward in this paper,which is applied to evaluate the power generation technology of diffe... Based on the“three box”exergy analysis model,a black box-gray box hierarchical exergy analysis and evaluation method is put forward in this paper,which is applied to evaluate the power generation technology of differential pressure produced by natural gas expansion.By using the exergy analysis theory,the black box-gray box hierarchical exergy analysis models of three differential pressure power generation technologies are established respectively.Firstly,the“black box”analysis models of main energy consuming equipment are established,and then the“gray box”analysis model of the total system is established.Based on the calculation results of exergy analysis indexes,the weak energy consumption equipment in the whole power generation process is accurately located.Taking a gas field in southwest China as an example,the comprehensive energy consumption evaluation of the three power generation technologies is carried out,and the technology with the best energy consumption condition among the three technologies is determined.Finally,the rationalization improvement measures are put forward from improving the air tightness,replacing the deflector and reducing the flow loss. 展开更多
关键词 Expansion differential pressure power generation black box-gray box hierarchy Exergy analysis method Weak link of energy consumption
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基于AHP-CRITIC权重分析法结合Box-Behnken设计-响应面法优化盐橘核水提取工艺
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作者 缪怡烨 周叶 +5 位作者 过科家 陈盛君 王仁杰 常运军 王凯玉 刘新宇 《亚太传统医药》 2024年第7期40-45,共6页
目的:优化盐橘核水提取工艺。方法:以柠檬苦素、诺米林、黄柏酮的转移率及出膏率为评价指标,利用混合加权法(AHP-CRITIC法)确定权重系数,计算多指标综合评分,并结合Box-Behnken设计-响应面法考察饮片粒度、加水量、提取时间的影响,优选... 目的:优化盐橘核水提取工艺。方法:以柠檬苦素、诺米林、黄柏酮的转移率及出膏率为评价指标,利用混合加权法(AHP-CRITIC法)确定权重系数,计算多指标综合评分,并结合Box-Behnken设计-响应面法考察饮片粒度、加水量、提取时间的影响,优选盐橘核水提取工艺。结果:优选提取工艺为饮片粒度过6目筛网,一、二煎加水量分别为12倍、10倍,提取时间分别为1.0 h、0.5 h。结论:优选出的提取工艺稳定可行,可为盐橘核工业化生产提供参考。 展开更多
关键词 盐橘核 AHP法 CRTICT法 box-Behnken设计-响应面法 提取工艺
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基于AHP-熵权法与Box-Behnken优化陈皮挥发油提取及包合工艺
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作者 许玲 岳亚楠 +2 位作者 牛晓静 吴延娆 段晓颖 《亚太传统医药》 2024年第3期53-59,共7页
目的:筛选陈皮挥发油最佳提取、包合工艺。方法:运用Box-Behnken响应面设计法优化陈皮挥发油提取工艺;采用层次分析法(AHP)-熵权法和L 9(34)正交实验,以羟丙基-β-环糊精与挥发油的比例、包合温度、包合时间为影响因素,以含油率、包合... 目的:筛选陈皮挥发油最佳提取、包合工艺。方法:运用Box-Behnken响应面设计法优化陈皮挥发油提取工艺;采用层次分析法(AHP)-熵权法和L 9(34)正交实验,以羟丙基-β-环糊精与挥发油的比例、包合温度、包合时间为影响因素,以含油率、包合物得率和包合率为评价指标,优选陈皮挥发油最佳包合工艺。结果:挥发油最佳提取工艺为液料比为10∶1、浸泡时间为1.5 h、提取时间为4 h。挥发油最佳包合工艺为羟丙基-β-环糊精与挥发油的比例为6∶1,包合温度30℃,搅拌时间为1 h。结论:优化得到的陈皮挥发油提取及包合工艺,稳定可靠,能够为工业化生产提供依据。 展开更多
关键词 陈皮挥发油 提取及包合工艺 box-Behnken AHP-熵权法
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CRITIC-AHP复合赋权法结合Box-Behnken响应面法优选蜜桑叶炒制工艺
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作者 陈泽键 徐晓青 +1 位作者 韩燕全 朋汤义 《中国药业》 CAS 2024年第10期48-55,共8页
目的优选蜜桑叶的炒制工艺。方法以炒制温度、炒制时间、辅料用量为考察因素,以绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮、水分为指标成分,采用CRITIC熵权法及层次分析法(AHP)确定各指标成分的权重,以上述指标成分的综... 目的优选蜜桑叶的炒制工艺。方法以炒制温度、炒制时间、辅料用量为考察因素,以绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮、水分为指标成分,采用CRITIC熵权法及层次分析法(AHP)确定各指标成分的权重,以上述指标成分的综合评分为评价指标,采用Box-Behnken响应面法优选蜜桑叶炒制工艺并验证。结果优选的炒制工艺为加25%辅料,170℃炒制10 min。绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮平均含量分别为1.412,1.038,2.207,1.231,31.816,106.702 mg/g,水分平均含量为10.99%。综合评分的理论值为98.019分,实测值(97.585分)与之接近(RSD为0.843%)。结论优选出的蜜桑叶炒制工艺稳定、合理、可行,可为蜜桑叶的工业化生产提供依据。 展开更多
关键词 蜜桑叶 炒制工艺 box-Behnken响应面法 CRITIC熵权法 层次分析法 超高效液相色谱法
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Box-Behnken响应面法优选改良型正骨灵活血止痛膏成型工艺
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作者 易晓霞 刘志友 +3 位作者 崔虹 黄海军 付萍 谢晓 《中国民族民间医药》 2024年第6期37-42,共6页
目的:优选改良型正骨灵活血止痛膏成型工艺。方法:基于Box–Behnken响应面法,以蜂蜡用量、混合温度、料液比为影响因素,以传统经验鉴别法与客观物理参数法的综合评分为评价指标,在单因素试验基础上,考察各因素对综合评分的影响,优选最... 目的:优选改良型正骨灵活血止痛膏成型工艺。方法:基于Box–Behnken响应面法,以蜂蜡用量、混合温度、料液比为影响因素,以传统经验鉴别法与客观物理参数法的综合评分为评价指标,在单因素试验基础上,考察各因素对综合评分的影响,优选最佳的成型工艺条件。结果:蜂蜡用量为1.9%,混合温度为81℃,料液比为2.5∶1 g/mL。验证试验结果综合评分RSD为0.86%。结论:优选得到的改良型正骨灵活血止痛膏成型工艺稳定可行。 展开更多
关键词 改良型正骨灵活血止痛膏 成型工艺 box–Behnken响应面法
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Box-Behnken响应面法优选平痤滴丸制备工艺及药效研究
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作者 张欣荣 董人华 +1 位作者 王洁煊 程杰 《中国处方药》 2024年第4期6-12,共7页
目的在平痤散中药处方基础上,研制平痤滴丸,并对比研究平痤散和平痤滴丸对痤疮的作用。方法以综合评分为评价指标,考察因素为药物与基质质量比、药液温度、冷凝温度,采用Box-Behnken响应面法,对平痤滴丸的制备工艺进行优化;考察平痤散... 目的在平痤散中药处方基础上,研制平痤滴丸,并对比研究平痤散和平痤滴丸对痤疮的作用。方法以综合评分为评价指标,考察因素为药物与基质质量比、药液温度、冷凝温度,采用Box-Behnken响应面法,对平痤滴丸的制备工艺进行优化;考察平痤散和平痤滴丸对小鼠激素水平、皮脂腺斑组织的影响,对耳肿胀的抗炎作用、对金色葡萄球菌和痤疮丙酸杆菌的抑制作用。结果最优滴丸制备工艺料液比为5∶1,药液温度为80℃,冷凝温度为0℃;平痤滴丸组体内激素水平睾酮(T)值、雌二醇(E2)值、T/E2值、小鼠耳肿胀程度及抑菌作用,均与阳性药组差异无统计学意义(P>0.05),且优于平痤散组。结论平痤滴丸组治疗痤疮效果显著,优于平痤散组,能够有效调节小鼠体内激素水平、减轻小鼠耳肿胀程度、抑制痤疮致病菌。 展开更多
关键词 滴丸 box-Behnken响应面法 痤疮 耳肿胀 抑菌
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On the Effectiveness of the System Validation Based on the Black Box Testing Methodology
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作者 Dusica Marijan Nikola Teslic +1 位作者 Miodrag Temerinac Vukota Pekovic 《Journal of Electronic Science and Technology of China》 2009年第4期385-389,共5页
With the advancement of technology in recent years, effective fault diagnosis became a necessity to verify the performance and ensure the quality of complex systems. In this paper, an original verification methodology... With the advancement of technology in recent years, effective fault diagnosis became a necessity to verify the performance and ensure the quality of complex systems. In this paper, an original verification methodology for complex consumer electronic devices is presented. Verification of the system which consists of hardware (integrated circuit) and corresponding software within a flat panel TV set is in the focus. Proposed methodology provides reliable functional failure detection using the concept of black box testing. Further, the approach is fully automated, improving the reliability and speed of failure detection. The methodology effectiveness has been experimentally evaluated and the analysis results have been reported. 展开更多
关键词 Automated verification black box testiug system failure detection system fault diagnosis.
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AHP-熵权法结合Box-Behnken设计-响应面法优选党参精准煮散工艺
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作者 周晶晶 周洁 +1 位作者 窦霞 靳子明 《中国中医药信息杂志》 CAS CSCD 2024年第1期135-141,共7页
目的优选党参煮散的最佳粒度及煎煮工艺。方法以加水量、浸泡时间及煎煮时间为考察因素,以总黄酮、总多糖、干膏率为考察指标,运用AHP-熵权法结合Box-Behnken设计-响应面法确定党参煮散饮片的最佳粒度及煎煮工艺参数。结果党参煮散饮片... 目的优选党参煮散的最佳粒度及煎煮工艺。方法以加水量、浸泡时间及煎煮时间为考察因素,以总黄酮、总多糖、干膏率为考察指标,运用AHP-熵权法结合Box-Behnken设计-响应面法确定党参煮散饮片的最佳粒度及煎煮工艺参数。结果党参煮散饮片的最佳粒度为4.00~4.75 mm(4~5目),最优煎煮工艺为加水量13倍,浸泡时间15 min,煎煮时间10 min。结论本研究优选出的党参煮散粒度科学合理,切合实际生产;确定的煎煮工艺方便快捷,合理可行,可为煮散的工业化生产提供依据。 展开更多
关键词 党参 精准煮散 AHP-熵权法 box-Behnken设计-响应面法 最佳粒度 煎煮工艺
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Box-Behnken响应面法结合BP神经网络多指标优化胡椒荜茇提取工艺
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作者 肖皖晴 邹纯才 鄢海燕 《大理大学学报》 2024年第8期33-40,共8页
目的:基于谱效关联及熵权法赋值的Box-Behnken响应面法结合BP神经网络多指标优化胡椒荜茇提取工艺。方法:采用Box-Behnken响应面法考察料液比、提取次数、超声时间对胡椒荜茇超声提取工艺的影响,计算干膏得率、DPPH·清除率,建立胡... 目的:基于谱效关联及熵权法赋值的Box-Behnken响应面法结合BP神经网络多指标优化胡椒荜茇提取工艺。方法:采用Box-Behnken响应面法考察料液比、提取次数、超声时间对胡椒荜茇超声提取工艺的影响,计算干膏得率、DPPH·清除率,建立胡椒荜茇HPLC指纹图谱并采用灰关联度法确定指纹图谱和DPPH·清除率之间的谱效关系,计算关联度。以关联度对胡椒碱峰面积和指纹图谱共有峰总峰面积进行校正,获得校正后的峰面积。通过熵权法为各评价指标所占的权重赋值,计算综合评价指标。建立BP神经网络模型对试验结果进行目标寻优,最终获得胡椒荜茇的最佳提取工艺。结果:通过Box-Behnken响应面法和BP神经网络模型预测得到的胡椒荜茇最佳提取工艺为:料液比为1∶30(g/mL),提取次数为4次,超声时间为40 min。结论:基于谱效关联及熵权法赋值的Box-Behnken响应面法结合BP神经网络模型可用于优化胡椒荜茇的提取工艺,为胡椒荜茇提取物的制备及相关剂型的研究奠定了基础。 展开更多
关键词 胡椒 荜茇 熵权法 box-Behnken响应面法 谱效关系 灰色关联度 BP神经网络
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Box-Behnken设计-响应面法优化芦笋粉中黄酮的提取工艺
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作者 张巍元 杨哲 +6 位作者 王丁丁 闫鹏宇 陈正佳 孙梦影 孙昊雪 赵琰 刘艳平 《河北科技师范学院学报》 CAS 2024年第2期52-58,共7页
采用低共熔溶剂法从芦笋粉末中提取黄酮,通过Box-Behnken设计-响应面法对提取工艺进行了优化。结果表明:低共熔溶剂氢键供体与受体的选择以及氢键供体和受体的比例,对黄酮的提取有较为显著的影响,其中氢键供体选择尿素,受体选择氯化胆碱... 采用低共熔溶剂法从芦笋粉末中提取黄酮,通过Box-Behnken设计-响应面法对提取工艺进行了优化。结果表明:低共熔溶剂氢键供体与受体的选择以及氢键供体和受体的比例,对黄酮的提取有较为显著的影响,其中氢键供体选择尿素,受体选择氯化胆碱,供体受体比例为1∶2对黄酮的提取效率最佳,此外提取工艺的3个因素,提取时间、提取温度、料液比对黄酮的提取效率也有一定的影响,其影响程度按照由大到小的次序为:料液比、提取时间、提取温度。提取芦笋粉中黄酮的最优条件为:料液比1∶2,提取时间2 h,提取温度50℃。此工艺条件下得到总黄酮提取率为25.99%,响应面模型预测值为21.63%。 展开更多
关键词 黄酮 提取工艺 芦笋粉 box-Behnken设计-响应面法
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