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Generalized Newton’s Theory of Universal Gravitation and Black Holes
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作者 Lenser Aghalovyan 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第1期126-137,共12页
The Newton’s theory of universal gravitation is generalized. Significantly strong at short distances central interaction of bodies and particles is established in comparison with Newtonian. A connection is found with... The Newton’s theory of universal gravitation is generalized. Significantly strong at short distances central interaction of bodies and particles is established in comparison with Newtonian. A connection is found with Black Holes, with the horizon of events. Possibility of systematization of all Black Holes is shown. An illustration is given on the example of Black Hole S<sub>gr</sub>A*. 展开更多
关键词 GRAVITATION Central Interaction Escape Velocity black Hole Horizon of events
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The Tragedy Prototype of the Paradox between Apollo and Dionysius -- on the Split Personality in Black Swan
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作者 He Rong 《学术界》 CSSCI 北大核心 2013年第11期262-267,共6页
The deep structure and manifestation of the western traditional culture have always been constructed on its various binary oppositions,among which the dichotomy between Apollo and Dionysius of the ancient Greek mythol... The deep structure and manifestation of the western traditional culture have always been constructed on its various binary oppositions,among which the dichotomy between Apollo and Dionysius of the ancient Greek mythology is typical.The conflicts of the two are not only the origin of the early tragedies,but also the enduring factors affecting the formation of the western social and psychic structures.The mental struggle and the tragedy of the heroine Nina in Black Swan reflect the dichotomy between Apollo and Dionysius.A retrospect to the prototype of such a binary opposition is the best way to understand Nina’s split personality and further reveal the irreconcilable conflict between human being’s pursuit for beauty and virtue on the one hand,and lost of self-control on the other hand,which generates the power of both creativity and devastation. 展开更多
关键词 阿波罗 黑天鹅 悲剧 原型 分裂 人格 悖论 二元对立
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ZA PLSs' Performance and Black Swan Approach
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作者 Tumellano Sebehela 《Journal of Modern Accounting and Auditing》 2011年第3期305-309,共5页
关键词 薪酬水平 黑天鹅 基金投资 房地产 投资策略 股票指数 上市 阿尔法
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An Analysis of the Figurative Meanings of Colors in Black Swan
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作者 罗玲 《海外英语》 2016年第20期155-157,共3页
Under tremendous pressure, the heroine Nina of the movie Black Swan transformed from purity to complexity, from depression to release. Her attitude towards art changed from imperfection into perfection. Though she fin... Under tremendous pressure, the heroine Nina of the movie Black Swan transformed from purity to complexity, from depression to release. Her attitude towards art changed from imperfection into perfection. Though she finally gets success for her perfect performance, yet she gets it at the cost of her life. From the standpoints of figurative meanings of, the four main colorsblack, white, pink, grey, this paper tries to analyze the relationship between colors, the connection of their roles, the multiple meanings of black swan and the death of black swan. A conclusion can be reached as follows: white represents purity and innocence of Nina; pink stands for her girlishness and na?ve; grey, the transitional color in movie, represents Thomas and his overwhelmingly primitive temptation; the typical representatives of black are Lily, Beth and changed Nina and it also stands for ferity, release and sexual temptation. 展开更多
关键词 figurative meaning black swan COLOR
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Identifying the Spatial Structure of Black Hole and Tropical Cyclone Based on a Theoretical Analysis of Orthogonal Interaction
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作者 Weihong Qian 《Journal of Modern Physics》 CAS 2023年第6期933-952,共20页
Black holes are recognized by Newton’s gravitational theory and Einstein’s general relativity, but there is still a lack of understanding the spatial structure of events, especially the nature of event horizon. In t... Black holes are recognized by Newton’s gravitational theory and Einstein’s general relativity, but there is still a lack of understanding the spatial structure of events, especially the nature of event horizon. In this paper, a theoretical analysis is used to compare the structures of tropical cyclone in the atmosphere and black hole in the astronomy so that five results are: 1) Both of them share the similar spatial structure, with tropical cyclone and black hole having the outflow cloud shield and the horizon sphere in the central part, respectively, while four spiral material bands exist in the rotating plane around them;2) In theoretically, the energy density formed by the orthogonal interaction of the four spiral material bands is as times as the total kinetic energy of the head-on interaction;3) This region of high energy density can lead to the conversion from mass to energy and the creation of new physical states of matter, which is a black hole event;4) The outer horizon of a black hole is the outermost interface of events, or the orthogonal interaction interface of particles;5) High-speed plasma jets extended at the poles of the black hole are directly associated with the shear stress of orthogonal interaction. 展开更多
关键词 black Hole event Horizon Tropical Cyclone Spatial Structure Orthographic Interaction
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2024年1月1日能登半岛M_(W)7.5地震作为一个可能的“龙王”事件 被引量:1
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作者 刘月 吴忠良 张永仙 《地球与行星物理论评(中英文)》 2024年第4期493-499,共7页
本文试图探讨,从“龙王”理论的角度看,2024年1月1日日本能登半岛M_(W)7.5地震是否可被视为一次“龙王”事件.本文分析了日本气象厅(JMA)2004年以来的地震矩张量解目录,针对样本数不够多的情况,用“级序分析”方法确定这一M_(W)7.5事件... 本文试图探讨,从“龙王”理论的角度看,2024年1月1日日本能登半岛M_(W)7.5地震是否可被视为一次“龙王”事件.本文分析了日本气象厅(JMA)2004年以来的地震矩张量解目录,针对样本数不够多的情况,用“级序分析”方法确定这一M_(W)7.5事件是否显著偏离Gutenberg-Richter幂律.结果表明在2006至2024年期间,M_(W)7.5地震还不能被视为显著的“龙王”事件;但在2021至2024年期间,该地震作为一次“龙王”事件特点十分明显,这一结果似乎与2020年底以来出现了复杂的前兆行为的报道吻合,标志着“龙王”事件的某种可预报性.本文建议,根据以往的研究结果,对这次地震的震源过程和余震序列进行详细刻画,附之以对地震前兆的回溯性研究,或可有助于“地震龙王”理论本身的发展和地震预测研究的进步.本文还讨论了“黑天鹅”事件、“龙王”事件及“灰犀牛”事件的相互关系,这几个概念是近年来减灾领域讨论较多的概念. 展开更多
关键词 能登半岛M_(W)7.5地震 级序分析 “黑天鹅” “龙王” “灰犀牛” 震群
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风险动物园(VI):黑天鹅的隐喻溯源、嬗变历程与研究展望
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作者 佟瑞鹏 梁梵洁 +1 位作者 孟子尧 王益艳 《中国安全科学学报》 CAS CSCD 北大核心 2024年第6期10-19,共10页
为防范黑天鹅带来的不确定性风险和极端影响,在隐喻理论视角下深入研究黑天鹅的溯源、嬗变与展望。首先,从历史源流与发展态势2方面,采用概念整合理论分析黑天鹅风险隐喻的认知构建机制,总结黑天鹅总体发展态势,在此基础上划分黑天鹅创... 为防范黑天鹅带来的不确定性风险和极端影响,在隐喻理论视角下深入研究黑天鹅的溯源、嬗变与展望。首先,从历史源流与发展态势2方面,采用概念整合理论分析黑天鹅风险隐喻的认知构建机制,总结黑天鹅总体发展态势,在此基础上划分黑天鹅创建奠基、探索发展、创新完善3个重要嬗变阶段,提出数智赋能背景下黑天鹅的研究困境与未来展望。研究结果表明:黑天鹅的风险隐喻含义是具有稀有性、偶发性,出人意料且无法预测,并产生极端负面影响的风险事件;黑天鹅风险隐喻的发展将进入数量波动变化的理论分化阶段,研究方向应从泛化应用到精准应用、从单一风险到复合风险、从孤岛研究到群体研究。 展开更多
关键词 风险动物园 黑天鹅 风险隐喻 嬗变历程 概念整合 不确定性
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基于事件驱动的液流电池控制系统实现方式
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作者 练润哲 董树锋 《电力工程技术》 北大核心 2024年第1期32-40,共9页
液流电池具有充放电循环次数大、容量高及寿命长等优点,是长时大规模储能的理想选择,但是其复杂的结构对电池控制系统的要求较高,传统开发方式难以满足其多样的控制需求,因此提出精准度更高、实时性更好的基于事件驱动技术的液流电池控... 液流电池具有充放电循环次数大、容量高及寿命长等优点,是长时大规模储能的理想选择,但是其复杂的结构对电池控制系统的要求较高,传统开发方式难以满足其多样的控制需求,因此提出精准度更高、实时性更好的基于事件驱动技术的液流电池控制系统开发方法。首先针对液流电池稳定性需求高、内部损耗大等问题,提出了主/辅助电堆协同架构,并对该架构系统进行建模分析;然后基于事件驱动技术对控制系统进行模块化设计,包括柔性充放电控制、辅助电堆参与的黑启动控制、基于卡尔曼滤波的电池荷电状态(state of charge,SOC)估计等;最后搭建半实物仿真平台,对所提架构和策略进行验证,证明了该架构和策略能提高系统的能量转换效率和稳定性。 展开更多
关键词 液流电池 事件驱动 储能 柔性充放电控制 卡尔曼滤波 电池荷电状态(SOC)估计 黑启动
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“走近黑天鹅”生态道德教育实践活动的实施策略
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作者 杨玲 《生物学教学》 北大核心 2024年第3期66-69,共4页
在建设生态文明国家背景下,利用地域资源开展黑天鹅治理水葫芦的生态道德教育实践活动。在学生兴趣和初步探究成果的基础上,指导学生确定探究课题,以不同食量梯度的水葫芦作为自变量,设置黑天鹅实验区和对照实验区进行实验,分析不同条... 在建设生态文明国家背景下,利用地域资源开展黑天鹅治理水葫芦的生态道德教育实践活动。在学生兴趣和初步探究成果的基础上,指导学生确定探究课题,以不同食量梯度的水葫芦作为自变量,设置黑天鹅实验区和对照实验区进行实验,分析不同条件下水葫芦的减重率和黑天鹅的增重率并得出结论。本次活动学习内容具有生成性,以实践和探究为主,让学生能运用所学解决生态保护问题。 展开更多
关键词 生态道德教育 黑天鹅 水葫芦 生态治理
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基于FDA不良事件报告系统的乌帕替尼药物警戒研究
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作者 葛素素 王方海 +1 位作者 孙雨菡 袁忠 《中国麻风皮肤病杂志》 2024年第7期466-470,共5页
目的:通过评估来自FDA不良事件报告系统(FAERS)乌帕替尼的不良反应信号,促进乌帕替尼的安全处方。方法:在FAERS中,以“upadacitinib”作为检索词,筛选以乌帕替尼为首要怀疑对象的不良反应事件(ADE),收集从2019年8月至2023年3月的ADE信... 目的:通过评估来自FDA不良事件报告系统(FAERS)乌帕替尼的不良反应信号,促进乌帕替尼的安全处方。方法:在FAERS中,以“upadacitinib”作为检索词,筛选以乌帕替尼为首要怀疑对象的不良反应事件(ADE),收集从2019年8月至2023年3月的ADE信号。采用报告比值比(ROR)、比例报告比(PRR)、贝叶斯置信传播神经网络(BCPNN)和多项伽马泊松缩减法(MGPS)四种算法。根据《国际医学用语词典》(24.1版)中的系统器官分类(SOC)和首选术语(PT)对ADE报告进行描述和分类。结果:检索到报告期内乌帕替尼ADEs 21 213例,呈递增趋势,其中肿瘤245例、血栓形成78例。通过四种算法共获得357个ADE信号,信号强度排名前4位为类风湿因子阳性、疱疹性湿疹、脊髓感染、口腔扁平苔藓,其中类风湿因子阳性、脊髓感染、口腔扁平苔藓未在说明书中收录。ADE信号报告例次较多的主要涉及关节痛、新型冠状病毒感染、鼻咽炎、尿路感染,其中关节痛、新型冠状病毒感染、尿路感染未在说明书中收录。ADE共涉及15个SOC,主要为感染性疾病(5490例,占37.57%)、肌肉骨骼及结缔组织疾病(3370例,占23.06%)。结论:发现乌帕替尼在新型冠状病毒感染、尿路感染等新的ADE信号,此外,该药在恶性肿瘤、血栓形成方面的风险也不容忽视。 展开更多
关键词 乌帕替尼 FAERS 不良反应事件 数据挖掘 黑框警告 药物警戒
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The Unified Field
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作者 Joseph H. (Cass) Forrington 《Journal of Modern Physics》 2024年第7期1010-1035,共26页
This is a Unified Field description based on the holographic Time Dilation Cosmology, TDC, model, which is an eternal continuum evolving forward in the forward direction of time, at the speed of light, c, at an invari... This is a Unified Field description based on the holographic Time Dilation Cosmology, TDC, model, which is an eternal continuum evolving forward in the forward direction of time, at the speed of light, c, at an invariant 1 s/s rate of time. This is the Fundamental Direction of Evolution, FDE. There is also an evolution down time dilation gradients, the Gravitational Direction of Evolution, GDE. These evolutions are gravity, which is the evolutionary force in time. Gravitational velocities are compensation for the difference in the rate of time, dRt, in a dilation field, and the dRtis equal to the compensatory velocity’s percentage of c, and is a measure of the force in time inducing the velocity. In applied force induced velocities, the dRt is a measure of the resistance in time to the induced velocity, which might be called “anti-gravity” or “negative gravity”. The two effects keep the continuum uniformly evolving forward at c. It is demonstrated that gravity is already a part of the electromagnetic field equations in way of the dRt element contained in the TDC velocity formula. Einstein’s energy formula is defined as a velocity formula and a modified version is used for charged elementary particle solutions. A time dilation-based derivation of the Lorentz force ties gravity directly to the electromagnetic field proving the unified field of gravity and the EMF. It is noted how we could possibly create gravity drives. This is followed by a discussion of black holes, proving supermassive objects, like massive black hole singularities, are impossible, and that black holes are massless Magnetospheric Eternally Collapsing Objects (MECOs) that are vortices in spacetime. . 展开更多
关键词 Unified Field GRAVITY Anti-Gravity Astrophysics Einstein General Relativity Special Relativity Galactic Rotation Velocities Time Dilation SPACETIME Space Time Spacetime Continuum Quantum Continuum MECO black Hole event Horizon Timelike Spacelike Lightlike
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Black shale formation enviro nment and its control on shale oil enrichment in Triassic Chang 7 Member,Ordos Basin,NW China 被引量:1
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作者 ZHANG Bin MAO Zhiguo +5 位作者 ZHANG Zhongyi YUAN Yilin CHEN Xiaoliang SHI Yuxin LIU Guanglin SHAO Xiaozhou 《Petroleum Exploration and Development》 CSCD 2021年第6期1304-1314,共11页
Based on geochemical analysis results of core samples from the Triassic Chang 7 Member of Well Feng 75 drilled in the northwest margin of Ordos Basin,combined with geological characteristics of this region,the formati... Based on geochemical analysis results of core samples from the Triassic Chang 7 Member of Well Feng 75 drilled in the northwest margin of Ordos Basin,combined with geological characteristics of this region,the formation environment of the black shale and its control on shale oil enrichment are comprehensively studied.From the Chang 73 to Chang 71 Sub-members,the black shale have organic carbon contents decreasing from 5.70%to 3.55%,hydrogen indexes decreasing from 345 mg/g to 269 mg/g,while the oxygen indexes increasing gradually from 6 mg/g to 29 mg/g,indicating that the sedimentary environment during the depositional period of Chang 72 and Chang 73 Sub-members was anoxic.Biomarkers in the black shale change regu-larly,and have an obvious“inflection point”at the depth of 2753–2777 m in the Chang 73 Sub-member,indicating that the input of terrigenous organic matter increased.However,there is a negative drift about 2%of organic carbon isotopic composition near the“inflection point”,which is in conflict with the results of biomarker compounds.This is because the extreme thermal and anoxic events caused by continental volcanic activity in the ancient Qinling region caused negative drift of carbon isotopic composition of the black shale in the Ordos Basin.The volcanic activity caused rise of temperature,polluted air,extreme weathers,more floods and thus more input of terrigenous organic matter,and gave rise to extremely anoxic environment con-ducive to the preservation of organic matter.Terrigenous organic matter is more conducive to the formation of light oil than aquatic organic matter,so these sections in Yanchang Formation are major“sweet spots”for shale oil enrichment. 展开更多
关键词 black shale TRIASSIC sedimentary environment volcanic ash anoxic event shale oil Ordos Basin Chang 7 Member
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Information entropy for static spherically symmetric black holes
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作者 蒋继建 李传安 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第2期451-456,共6页
By using the new equation of state density derived from the generalized uncertainty relation, the number of the quantum states near event horizon is obtained, with which then the information entropy of static spherica... By using the new equation of state density derived from the generalized uncertainty relation, the number of the quantum states near event horizon is obtained, with which then the information entropy of static spherically symmetric black holes has been discussed. It is found that the divergent integral of quantum states near the event horizon can be naturally avoided if using the new equation of state density without introducing the ultraviolet cut-off. The information entropy of black holes can be obtained precisely by the residue theorem, which is shown to be proportional to the horizon area. The information entropy of black holes obtained agrees with the Bechenstein-Hawking entropy when the suitable cutoff factor is adopted. 展开更多
关键词 black hole event horizon generalized uncertainty relation information entropy
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Hawking radiation from the charged and magnetized BTZ black hole via covariant anomaly
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作者 曾晓雄 杨树政 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第2期462-467,共6页
This paper discusses Hawking radiation from the charged and magnetized Bafiados-Teitelboim-Zanelli (BTZ) black hole from the viewpoint of anomaly, initiated by Robinson and Wilczek recently. It reconstructs the elec... This paper discusses Hawking radiation from the charged and magnetized Bafiados-Teitelboim-Zanelli (BTZ) black hole from the viewpoint of anomaly, initiated by Robinson and Wilczek recently. It reconstructs the electromagnetic field tensor and the Lagrangian of the field corresponding to the source with electric and magnetic charges to redefine an equivalent charge and gauge potential. It employs the covariant anomaly cancellation method to determine the compensating fluxes of charge flow and energy-momentum tensor, which are shown to match with those of the 2- dimensional blackbody radiation at the Hawking temperature exactly. 展开更多
关键词 Hawking radiation covariant anomaly event horizon BTZ black hole
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The quantum nonthermal radiation and horizon surface gravity of an arbitrarily accelerating black hole with electric charge and magnetic charge
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作者 谢志堃 潘伟珍 杨学军 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第3期567-571,共5页
Using a new tortoise coordinate transformation,we discuss the quantum nonthermal radiation characteristics near an event horizon by studying the Hamilton-Jacobi equation of a scalar particle in curved space-time,and o... Using a new tortoise coordinate transformation,we discuss the quantum nonthermal radiation characteristics near an event horizon by studying the Hamilton-Jacobi equation of a scalar particle in curved space-time,and obtain the event horizon surface gravity and the Hawking temperature on that event horizon.The results show that there is a crossing of particle energy near the event horizon.We derive the maximum overlap of the positive and negative energy levels.It is also found that the Hawking temperature of a black hole depends not only on the time,but also on the angle.There is a problem of dimension in the usual tortoise coordinate,so the present results obtained by using a correct-dimension new tortoise coordinate transformation may be more reasonable. 展开更多
关键词 tortoise coordinate transformation black hole quantum nonthermal radiation event horizon surface gravity
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Redefining the Event Horizon
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作者 Shiv Raj Aryan 《International Journal of Astronomy and Astrophysics》 2013年第4期392-394,共3页
Presented herein is a new and independent derivation of equation for the radius of Black Holes, i.e. the event horizon of black holes. The equation has been derived by formulating the relativistic equation of escape v... Presented herein is a new and independent derivation of equation for the radius of Black Holes, i.e. the event horizon of black holes. The equation has been derived by formulating the relativistic equation of escape velocity derived from the relativistic equations for gravitational potential and kinetic energy. Based upon that, it is now shown that the actual size of a black hole, as determined by its event horizon, is exactly half the value predicted by the escape velocity equation used in the Newtonian mechanics. It proves that the actual radius of a black hole is exactly one half of the Schwarzschild radius. 展开更多
关键词 event HORIZON black HOLE LORENTZ Transformation RELATIVITY
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Growing a Kerr Black Hole
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作者 Leon F. Phillips 《Journal of Modern Physics》 2015年第13期1789-1792,共4页
Growth of a black hole requires the participation of a near-by accretion disk if it is to occur at a significant rate. The Kerr solution of Einstein’s equation is a vacuum solution, but the center of a realistic Kerr... Growth of a black hole requires the participation of a near-by accretion disk if it is to occur at a significant rate. The Kerr solution of Einstein’s equation is a vacuum solution, but the center of a realistic Kerr black hole is not a vacuum, so the predicted disk singularity does not exist. Instead, the center of a black hole is occupied by an ultra-dense, spheroidal core whose diameter is greater than that of the theoretical disk singularity. The surface of a black hole’s core is continually bombarded by energetic particles from the external universe. Hence the cold remnant of a gravitationally-collapsed star that has often been assumed to be present at the center of a black hole must be replaced conceptually by a quark-gluon plasma whose temperature is of the order of 1012 K or more. The gravitational potential well of a black hole is extremely deep (TeV), but the number of discrete energy levels below the infinite-red-shift surface is finite. Information can be conveyed to observers in the external universe by thermally-excited fermions that escape from levels near the top of a black hole potential well. 展开更多
关键词 KERR black Hole No SINGULARITY Ultra-Dense Core Deep (Teravolts) Potential Well HIGH-ENERGY Incoming Particles QUARK-GLUON Plasma Information Flow through event HORIZON
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What Connects Dark Matter and Black Holes?
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作者 Russell Bagdoo 《Journal of Modern Physics》 2020年第2期168-195,共28页
Dark matter is a major component of the universe, about six times more abundant than ordinary visible matter. We measure the effects of its mass, but it escapes the telescopes. It has the particularity of emitting no ... Dark matter is a major component of the universe, about six times more abundant than ordinary visible matter. We measure the effects of its mass, but it escapes the telescopes. It has the particularity of emitting no radiation and interacting only by the action of gravity. The main purpose of this article is to try to answer what dark matter is: we conjecture that it is composed of magnetically charged neutrinos, true magnetic monopoles. But that requires a huge conceptual leap: Maxwell’s laws must be inverted and the electric charge becomes a magnetic charge. Asymmetric “reversed” Maxwell’s laws would provide the “dark” magnetic charge that would replace the electric charge. The very form of the Dirac equation, which imposed on ordinary matter that the particle carries an electric charge and obeys the principal properties of the electron, would impose in the dark matter that the “dark” particle obeys the main properties of a neutrino associated with a magnetic charge. The second aim of the article is to show that dark matter is derived from black holes, mainly from active supermassive black holes. This requires a second conceptual leap: the horizon of the black hole undergoes a high temperature and an intense pressure of magnetic fields which cause a blackout and a phase transition (or broken symmetry) when the matter crosses the horizon. The result is a reversal of Maxwell’s laws: a magnetic charge is substituted for the electric charge, and the electric current becomes a tributary of the magnetic current. A third important conceptual leap follows: sterile magnetic neutrinos created inside the black hole would cross the horizon to the outside to constitute dark matter. 展开更多
关键词 Dark Matter MAGNETIC MONOPOLE Inverted Maxwell’s Equations Magneto-Electric DIRAC Equation MAGNETIC STERILE NEUTRINO Active black Hole event Horizon
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Absolute Zero Occurs in Black Holes
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作者 Sanjay Sastry 《Journal of Modern Physics》 2016年第11期1375-1377,共4页
The black hole is a region in space in which nothing can escape its pull. The two important parts of the anatomy of a stable black hole are the event horizon and gravitational singularity. The main discussion is regar... The black hole is a region in space in which nothing can escape its pull. The two important parts of the anatomy of a stable black hole are the event horizon and gravitational singularity. The main discussion is regarding the temperature of a black hole. Absolute zero is a state which enthalpy and entropy is zero. The temperature of a black hole approaches the gravitational singularity in which space-time possibly ceases and entropy is zero producing absolute zero or possible sub- absolute zero. 展开更多
关键词 black Hole Absolute Zero event Horizon Gravitational Singularity
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抗体药物偶联物相关眼毒性的研究进展 被引量:1
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作者 夏凡 张晶晶 +2 位作者 杭永付 朱建国 缪丽燕 《药物流行病学杂志》 CAS 2023年第9期985-990,共6页
抗体药物偶联物(ADC)是一类具有独特作用机制的抗肿瘤新药,目前已成为肿瘤领域的焦点和热点。在ADC药物相关临床研究中,眼毒性是其特征性不良事件之一,虽然大多数眼部不良事件程度轻微且可逆,但部分患者的治疗进程可能受到影响。因此美... 抗体药物偶联物(ADC)是一类具有独特作用机制的抗肿瘤新药,目前已成为肿瘤领域的焦点和热点。在ADC药物相关临床研究中,眼毒性是其特征性不良事件之一,虽然大多数眼部不良事件程度轻微且可逆,但部分患者的治疗进程可能受到影响。因此美国食品药品管理局要求在该类药物说明书中增加眼毒性的黑框警示。本研究对ADC药物眼毒性的流行病学、临床表现、发生机制和防治策略进行综述,旨在提高临床医务人员对ADC药物相关眼毒性的认识,为临床ADC药物的个体化风险评估、早期诊断和医学管理提供参考。 展开更多
关键词 抗体药物偶联物 眼毒性 黑框警告 药品不良事件
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