基于改进Black-Litterman模型的投资组合优化

考虑到金融市场“非完全有效性”且投资者“非完全理性”,通过贝叶斯框架建立了投资者观点与多渠道信息相结合的改进Black-Litterman模型,由此确定了最优的个性化投资策略.在中国股票市场的实证研究中,利用SVM-ARIMA-GARCH模型解决了投资者观点量化的问题.对比几类参考策略,改进Black-Litterman模型所确定的最优投资策略的样本外绩效表现更加稳健,在不同市场行情下均能获得较高的夏普比率和较低的换手率.

Vibration Reduction by a Partitioned Dynamic Vibration Absorber with Acoustic Black Hole Features

Vibration quality is a vital indicator for assessing the progress of modern equipment.The dynamic vibration absorber(DVA)based on the acoustic black hole(ABH)feature is a new passive control method that manipulates waves.It offers efficient energy focalization and broad-spectrum vibration suppression,making it highly promising for applications in large equipment such as aircraft,trains,and ships.Despite previous advancements in ABH-DVA development,certain challenges remain,particularly in ensuring effective coupling with host structures during control.To address these issues,this study proposes a partitioned ABH-featured dynamic vibration absorber(PABH-DVA)with partitions in the radial direction of the disc.By employing a plate as the host structure,simulations and experiments were conducted,demonstrating that the PABH-DVA outperforms the original symmetric ABH-DVA in terms of damping performance.The study also calculated and compared the coupling coefficients of the two ABH-DVAs to uncover the mechanism behind the enhanced damping.Simulation results revealed that the PABH-DVA exhibits more coupled modes,occasionally with lower coupling coefficients than the symmetric ABH-DVA.The influence of frequency ratio and modal mass was further analyzed to explain the reasons behind the PABH-DVA's superior damping performance.Additionally,the study discussed the impact of the number of slits and their orientation.This research further explains the coupling mechanism between the ABH-DVA and the controlled structure,and provides new ideas for the further application of ABH in engineering.

Early Triassic Volcanic Rocks in the Western Yarlung Zangbo Suture Zone:Implications for the Opening of the Neo-Tethys Ocean

In this study,zircon U-Pb dating of volcanic rocks from the Zhongba ophiolite of the Yarlung Zangbo Suture Zone(YZSZ)in southern Xizang(Tibet)yielded an age of 247±3 Ma.According to whole rock geochemical and Sr-NdPb isotopic data,the Early Triassic samples could be divided into two groups:Group 1 with P-MORB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70253–0.70602,ε_(Nd)(t)values of 4.2–5.3,(^(206)Pb/^(204)Pb)_(t)ratios of 16.353–18.222,(^(207)Pb/^(204)Pb)_(t)ratios of 15.454–15.564,and(^(208)Pb/^(204)Pb)_(t)ratios of 35.665–38.136;Group 2 with OIB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70249–0.70513,ε_(Nd)(t)values of 4.4–4.9,(^(206)Pb/^(204)Pb)_(t)ratios of 17.140–18.328,(^(207)Pb/^(204)Pb)_(t)ratios of 15.491–15.575,and(^(208)Pb/^(204)Pb)_(t)ratios of 36.051–38.247.Group 2 rocks formed by partial melting of the mantle source enriched by a former plume,and assimilated continental crustal material during melt ascension.The formation of Group 1 rocks corresponds to the mixing of OIB melts,with the same components as Group 2 and N-MORBs.The Zhongba Early Triassic rocks belong to the continental margin type ophiolite and formed in the continental–oceanic transition zone during the initial opening of the Neo-Tethys in southern Xizang(Tibet).

Improving creep strength of the fine-grained heat-affected zone of novel 9Cr martensitic heat-resistant steel via modified thermo-mechanical treatment

The infamous type Ⅳ failure within the fine-grained heat-affected zone (FGHAZ) in G115 steel weldments seriously threatens the safe operation of ultra-supercritical (USC) power plants.In this work,the traditional thermo-mechanical treatment was modified via the replacement of hot-rolling with cold rolling,i.e.,normalizing,cold rolling,and tempering (NCT),which was developed to improve the creep strength of the FGHAZ in G115 steel weldments.The NCT treatment effectively promoted the dissolution of preformed M_(23)C_(6)particles and relieved the boundary segregation of C and Cr during welding thermal cycling,which accelerated the dispersed reprecipitation of M_(23)C_(6) particles within the fresh reaustenitized grains during post-weld heat treatment.In addition,the precipitation of Cu-rich phases and MX particles was promoted evidently due to the deformation-induced dislocations.As a result,the interacting actions between precipitates,dislocations,and boundaries during creep were reinforced considerably.Following this strategy,the creep rupture life of the FGHAZ in G115 steel weldments can be prolonged by 18.6%,which can further push the application of G115 steel in USC power plants.

A progress review of black carbon deposition on Arctic snow and ice and its impact on climate change

The rapid warming of the Arctic,accompanied by glacier and sea ice melt,has significant consequences for the Earth’s climate,ecosystems,and economy.Black carbon(BC)deposition on snow and ice can trigger a significant reduction in snow albedo and accelerate melting of snow and ice in the Arctic.By reviewing the published literatures over the past decades,this work provides an overview of the progress in both the measurement and modeling of BC deposition and its impact on Arctic climate change.In summary,the maximum value of BC deposition appears in the western Russian Arctic(26 ng·g^(–1)),and the minimum value appears in Greenland(3 ng·g^(–1)).BC records in the Arctic ice core already peaked in 1920s and 1970s,and shows a regional difference between Greenland and Canadian Arctic.The different temporal variations of Arctic BC ice core records in different regions are closely related to the large variability of BC emissions and transportation processes across the Arctic region.Model simulations usually underestimate the concentration of BC in snow and ice by 2–3 times,and cannot accurately reflect the seasonal and regional changes in BC deposition.Wet deposition is the main removal mechanism of BC in the Arctic,and observations show different seasonal variations in BC wet deposition in Ny-Ålesund and Barrow.This discrepancy may result from varying contributions of anthropogenic and biomass burning(BB)emissions,given the strong influence by BC from BB emissions at Barrow.Arctic BC deposition significantly influences regional climate change in the Arctic,increasing fire activities in the Arctic have made BB source of Arctic BC more crucial.On average,BC in Arctic snow and ice causes an increase of+0.17 W·m^(–2)in radiative forcing and 8 Gt·a^(–1)in runoff in Greenland.As stressed in the latest Arctic Monitoring and Assessment Programme report,reliable source information and long-term and high-resolution observations on Arctic BC deposition will be crucial for a more comprehensive understanding and a better mitigation strategy of Arctic BC.In the future,it is necessary to collect more observations on BC deposition and the corresponding physical processes(e.g.,snow/ice melting,surface energy balance)in the Arctic to provide reliable data for understanding and clarifying the mechanism of the climatic impacts of BC deposition on Arctic snow and ice.

Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

One-year results for myopia control of orthokeratology with different back optic zone diameters: a randomized trial using a novel multispectral-based topographer

AIM:To present the 1-year results of a prospective cohort study investigating the efficacy,potential mechanism,and safety of orthokeratology(ortho-k)with different back optic zone diameters(BOZD)for myopia control in children.METHODS:This randomized clinical study was performed between Dec.2020 and Dec.2021.Participants were randomly assigned to three groups wearing ortho-k:5 mm BOZD(5-MM group),5.5 mm BOZD(5.5-MM group),and 6 mm BOZD(6-MM group).The 1-year data were recorded,including axial length,relative peripheral refraction(RPR,measured by multispectral refractive topography,MRT),and visual quality.The contrast sensitivity(CS)was evaluated by CSV-1000 instrument with spatial frequencies of 3,6,12,and 18 cycles/degree(c/d);the corneal higher-order aberrations(HOAs)were measured by iTrace aberration analyzer.The one-way ANOVA was performed to assess the differences between the three groups.The correlation between the change in AL and RPR was calculated by Pearson’s correlation coefficient.RESULTS:The 1-year results of 20,21,and 21 subjects in the 5-MM,5.5-MM,and 6-MM groups,respectively,were presented.There were no statistical differences in baseline age,sex,or ocular parameters between the three groups(all P>0.05).At the 1-year visit,the 5-MM group had lower axial elongation than the 6-MM group(0.07±0.09 vs 0.18±0.11 mm,P=0.001).The 5-MM group had more myopic total RPR(TRPR,P=0.014),with RPR in the 15°–30°(RPR 15–30,P=0.015),30°–45°(RPR 30–45,P=0.011),temporal(RPR-T,P=0.008),and nasal area(RPR-N,P<0.001)than the 6-MM group.RPR 15–30 in the 5.5-MM group was more myopic than that in the 6-MM group(P=0.002),and RPR-N in the 5-MM group was more myopic than that in the 5.5-MM group(P<0.001).There were positive correlations between the axial elongation and the change in TRPR(r=0.756,P<0.001),RPR 15–30(r=0.364,P=0.004),RPR 30–45(r=0.306,P=0.016),and RPR-N(r=0.253,P=0.047).The CS decreased at 3 c/d(P<0.001),and the corneal HOAs increased in the 5-MM group(P=0.030).CONCLUSION:Ortho-k with 5 mm BOZD can control myopia progression more effectively.The mechanism may be associated with greater myopic shifts in RPR.

Contour Farming Suitability of the Black Soil Region in Northeast China and Its Spatial Characteristics

Contour farming technology plays a key role in reducing soil erosion,enhancing water use efficiency,and fostering sustain-able agricultural development,Despite being a straightforward yet efficacious farming technique,it has not seen widespread implement-ation in China.Considering the deteriorating quality of arable lands in the Black Soil Region of Northeast China(BSR-NEC),it is ne-cessary to investigate spatial patterns and identify suitable areas for contour farming in this region.To achieve this objective,spatial autocorrelation and grouping analysis methods were employed to classify the land into four categories of suitability for contour farming:highly suitable,moderately suitable,generally suitable,and unsuitable.The results reveal that:1)the contour farming suitable area in BSR-NEC covers 89861.32 km^(2),accounting for 21.59%of arable land as of 2020.Heilongjiang Province owns the largest suitable area of 32853.68 km^(2),and Inner Mongolia has the highest proportion of 28.89%.2)In terms of the spatial distribution,regions with higher suitability for contour farming are concentrated in the Da Hinggan Mountains region,particularly Nenjiang City(Heilongjiang Province),which has the highest area of 2593.07 km^(2).Areas with a high proportion of suitable arable lands for contour farming are mainly found in the Da Hinggan Mountains and Changbai Mountains regions,with Ergun City(Inner Mongolia)having the highest pro-portion at 47.2%.Regions with higher suitability and proportion are concentrated in the Da Hinggan Mountains region,primarily cover-ing the Inner Mongolia and Heilongjiang.3)Regarding spatial clustering,both the area and proportion of suitable contour farming areas exhibit noticeable clustering effects,though not entirely consistent.4)Group analysis results designate 148 counties in BSR-NEC as highly suitable areas,predominantly located in the Changbai Mountains region,Liaodong Peninsula,Hulun Buir Plateau,and the north and south regions of the Da Hinggan Mountains.The zoning of suitable areas for contour farming in BSR-NEC informs the strategic de-velopment of policies and measures,allowing for the implementation of targeted policies in distinct areas suitable for contour farming.This provides a valuable reference for promoting contour farming technology more effectively and efficiently.re effectively and effi-ciently.

The Influence of the Closure of the East Paleo-Tethys Ocean on Southern South China:Evidences from Kinematics and^(40)Ar/^(39)Ar Geochronology of the Rongxian Ductile Shear Zone in Southeastern Guangxi

The Triassic was a crucial period in the tectonic evolution of the South China Block.Research on tectonic deformation during this period provides information on intracontinental orogenic mechanisms in South China.In this study,alongside thermochronological analyses,we examine the macroscopic and microscopic structural features of the Rongxian ductile shear zone,located south of the Darongshan granite in the southeastern part of Guangxi Province,on the southern margin of South China.Sinistral shear is indicated by the characteristics of rotatedσ-type feldspar porphyroclasts,stretching lineations defined by elongated quartz grains and the orientations of quartz c-axes.LA-ICP-MS U-Pb dating of zircons from two samples of granitic mylonite and one of granite yielded ages of ca.256 Ma.Furthermore,two samples of granitic mylonite yield muscovite^(40)Ar/^(39)Ar plateau ages of 249-246 Ma.These results indicate that the Rongxian ductile shear zone resulted from Early Triassic deformation of the late Permian Darongshan granite.This deformation was likely related to the closure of the eastern Paleo-Tethys Ocean and the subsequent collision of the South China and Indochina blocks,during the early stage of the Indosinian orogeny.

Dynamic Identification and Evolution of Urban-suburban-rural Transition Zones Based on the Blender of Natural and Humanistic Factors: A Case Study of Chengdu, China

Urban-suburban-rural(U-S-R)zones exhibit distinctive transitional characteristics in interaction between human and nature.U-S-R transition zones(U-S-RTZ)are also highlighting the function diversity and landscape heterogeneity across territorial spaces.As a super megacity in western China,Chengdu’s rapid urbanization has driven the evolution of U-S-R spaces,resulting in a sequential structure.To promote the high-quality spatial development of urban-rural region in a structured and efficient manner,it is essential to con-duct a scientific examination of the multidimensional interconnection within the U-S-RTZ framework.By proposing a novel identifica-tion method of U-S-RTZ and taking Chengdu,China as a case study,grounded in a blender of natural and humanistic factors,this study quantitatively delineated and explored the spatial evolutions of U-S-RTZ and stated the optimization orientation and sustainable devel-opment strategies of the production-living-ecological spaces along the U-S-R gradients.The results show that:1)it is suitable for the quantitative analysis of U-S-RTZ by established three-dimensional identification system in this study.2)In 1990-2020,the urban-sub-urban transition zones(U-STZ)in Chengdu have continuously undergone a substantial increase,and the scale of the suburban-rural transition zones(S-RTZ)has continued to expand slightly,while the space of rural-ecological transition zones(R-ETZ)has noticeably compressed.3)The landuse dynamics within U-S-RTZ has gradually increased in 1990-2020.The main direction of landuse transition was from farmland to construction land or woodlands,with the expansion of construction land being the most significant.4)R-ETZ primarily focus on ecological functions,and there is a trade-off relationship between the production-ecological function within the S-RTZ,and in the U-STZ,production-living composite functions are prioritized.This study emphasizes the importance of elastic planning and precise governance within the U-S-RTZ in a rapid urbanization region,particularly highlighting the role of suburbs as landscape corridors and service hubs in urban-rural integration.It elucidates to the practical implications for achieving high-quality development of integrated U-S-R territorial spaces.

Advances in seismological methods for characterizing fault zone structure

Large earthquakes frequently occur along complex fault systems.Understanding seismic rupture and long-term fault evolution requires constraining the geometric and material properties of fault zone structures.We provide a comprehensive overview of recent advancements in seismological methods used to study fault zone structures,including seismic tomography,fault zone seismic wave analysis,and seismicity analysis.Observational conditions limit our current ability to fully characterize fault zones,for example,insufficient imaging resolution to discern small-scale anomalies,incomplete capture of crucial fault zone seismic waves,and limited precision in event location accuracy.Dense seismic arrays can overcome these limitations and enable more detailed investigations of fault zone structures.Moreover,we present new insights into the structure of the Anninghe-Xiaojiang fault zone in the southeastern margin of the Qinghai-Xizang Plateau based on data collected from a dense seismic array.We found that utilizing a dense seismic array can identify small-scale features within fault zones,aiding in the interpretation of fault zone geometry and material properties.

How is a black hole created from nothing?

Using the synchronous coordinates,the creation of a Schwarzschild black hole immersed in a de Sitter spacetime can be viewed as a coherent creation of a collection of timelike geodesics.The previously supposed conical singularities do not exist at the horizons of the constrained instanton.Instead,the unavoidable irregularity is presented as a nonvanishing second fundamental form elsewhere at the quantum transition 3-surface.The same arguments can be applied to charged,topological,or higher dimensional black hole cases.

Assessing the Efficacy of Lemongrass (Cymbopogon citratus) and Sambong (Blumea balsamifera) Extracts in Combating Black Pod Disease: Sustainable Solutions for Controlling Phytophthora megakarya in Cameroon’s Cocoa Plantations

The use of plant extracts as antifungal agents is gaining increasing attention, particularly for the control of black pod disease in cocoa. Despite extensive research, current strategies haven’t been entirely effective. This study evaluated the effectiveness of Cymbopogon citratus and Blumea balsamifora leaf extracts, both individually and in combination, against Phytophthora megakarya. We assessed the efficacy of the most promising combination (75% B. balsamifera, 25% C. citratus) after storage at room temperature for up to 9 days. Agar microdilution and in vivo bioassays were conducted to determine antifungal susceptibility and effectiveness. Blumea extract exhibited the highest overall inhibitory activity, with the lowest minimum inhibitory concentration (117 µl mL−1) while C. citratus had a narrower range of MIC (146 to 233 µl mL−1). The combination of C. citratus and B. balsamifera demonstrated a synergistic effect against P. megakarya, achieving growth inhibition on V8 media (92.72 ± 4.20% to 100%) and on artificially infected detached pod cortex (92.24 ± 4.53% to 98.75 ± 1.25%), which was not significantly different from the positive control (Ridomil). Furthermore, this combination maintained its effectiveness for up to 9 days at room temperature. These findings suggest that combining plant extracts can enhance their antifungal properties.

Adaptive Integrated Coastal Zone Planning:History,Challenges,Advances,and Perspectives

Coastal zones are dynamic,rich environments,now densely populated,and increasingly challenged by human and climatechange pressures.Effective long-term integrated coastal zone planning is needed to ensure sustainable environmental protection and economic development.In this study,we reviewed the history of coastal zone planning since its birth in the 1950s based on the literature retrieved from the Web of Science(Core Collection)from 2000–2023,then summarized the tools and spatial allocation methods commonly used in the planning process,and finally proposed potential solutions to the challenges faced.The results show that after decades of development,coastal zone planning has changed from a decentralized activity to a targeted and integrated one,with an increasing emphasis on the ecosystem approach and the use of multiple planning tools.Spatial analysis techniques and environmental modelling software have become increasingly popular.Linear programming and overlay analysis are common approaches when performing spatial optimization,but land-sea interactions and planning in the marine parts still lack in-depth analysis and practical experience.We are also aware that the challenges posed by the integration of administrative hierarchies,scoping and conservation objectives,stakeholder participation,consideration of social dimensions,and climate change are pervasive throughout the planning process.There is an urgent need to develop more flexible and accurate spatial modelling tools,as well as more efficient participatory methods,and to focus on the holistic nature of the land-sea system to create more resilient and sustainable coastal zones.

Marginal zone lymphoma with severe rashes: A case report

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.

Black Garlic as an Antiviral for Herpes Simplex Virus-2 in Lung Cells

Allicin, an antioxidant, is known for providing garlic with its unique fragrance and taste, as well as for its antimicrobial properties. Black garlic, a fermented form of garlic, contains higher levels of antioxidants than fresh garlic. Antioxidants play a vital role in alleviating cellular stress during viral infections. Viral infections result in oxidative stress through the production of reactive oxidative species (ROS). A prolonged state of oxidative stress can result in cell death, DNA damage, and disease progression. In this study, black garlic extract (BGE) is evaluated for its ability to mitigate cytopathic effects and oxidative stress caused by herpes simplex virus-2 (HSV-2) infections in vitro. Antiviral assays were performed to determine the percent of viral inhibition resulting from treatment with the BGE. ROS-GloTM H2O2 assays were then completed to measure the post-infection ROS levels of BGE-treated virus and cells. The results thus far suggest that BGE may inhibit viral infection and decrease levels of oxidative stress.

Multiverse/Hyperverse Models: (4 + 1)-Dimensional Landscape (Black Saturns, Bousso-Hawking Nucleation, Gogberashvili Multiverses, Schwarzschild-De Sitter Nurseries) and a (3 + 1)-Dimensional Model for Dark Energy

We consider the Hyperverse as a collection of multiverses in a (4 + 1)-dimensional spacetime with gravitational constant G. Multiverses in our model are bouquets of thin shells (with synchronized intrinsic times). If gis the gravitational constant of a shell Sand εits thickness, then G~εg. The physical universe is supposed to be one of those thin shells inside the local bouquet called Local Multiverse. Other remarkable objects of the Hyperverse are supposed to be black holes, black lenses, black rings and (generalized) Black Saturns. In addition, Schwarzschild-de Sitter multiversal nurseries can be hidden inside those Black Saturns, leading to their Bousso-Hawking nucleation. It also suggests that black holes in our physical universe might harbor embedded (2 + 1)-dimensional multiverses. This is compatible with outstanding ideas and results of Bekenstein, Hawking-Vaz and Corda about “black holes as atoms” and the condensation of matter on “apparent horizons”. It allows us to formulate conjecture 12.1 about the origin of the Local Multiverse. As an alternative model, we examine spacetime warping of our universe by external universes. It gives data for the accelerated expansion and the cosmological constant Λ, which are in agreement with observation, thus opening a possibility for verification of the multiverse model.

Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults structure.Increasing numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation areas.This study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical modeling.Using three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation zones.Combined with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben basin.Integrating the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were summarized.Influenced by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale faults.During the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly developed.The junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation zones.During the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were furtherly inherited and developed.This stage was the molded and formative period of the FAZ,the low-order faults,and the depression in the DXFZ.

Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic acid.Because of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy diseases.This study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human body.On this basis,the disease control functions that have been proved effective in clinical research were reviewed and analyzed.These studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and inflammation.Because there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator

Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a“disease”.Brown adipose tissue(BAT)thermogenesis and white adipose tissue(WAT)browning emerge as a potential strategy of anti-obesity by dissipating energy as heat.However,drugs based on adipose tissue thermogenesis have not been successfully approved yet.In current study,we found that black tea extract(BTE)obtained by patentauthorized manufacturing process prevented body weight gain as novel thermogenic activator with reduction of adiposity,improvement of adipose distribution,and glucose metabolism improvement in diet-induced obesity mice.Mechanismly,anti-obesity effect of BTE depends on promoting BAT thermogenesis and WAT browning with upregulation of uncoupling protein 1(UCP1),especially visceral adipose tissue(VAT)with browning resistance.Specifically,utilizing in silico approach of network pharmacology and molecular docking,we identified carbonic anhydrase 2(CA2)in nitrogen metabolism as anti-obesity target of BTE and further elucidated that protein kinase B(AKT)signaling pathway linked CA2 and UCP1.Meanwhile gut microbiota regulation may prompt the CA2-dependent thermogenesis activation.Our findings demonstrated anti-obesity effect of BTE as thermogenic activator through CA2-mediated BAT thermogenesis and WAT browning via CA2-AKT-UCP1 signaling pathway,which could be developed as promising anti-obesity agent with good safety and efficacy.