Efficacy of fexuprazan compared with rebamipide in Korean patients with gastritis:A matching-adjusted indirect comparison

BACKGROUND Gastritis is one of the most frequently diagnosed diseases requiring medical treatment in South Korea.Fexuprazan,a novel potassium-competitive acid blocker,has been approved for treating gastritis and erosive esophagitis.Meanwhile,rebamipide is the most commonly used mucoprotective agent for acute and chronic gastritis in real-world settings in South Korea.However,there have been no studies comparing the efficacy of these two drugs yet.AIM To compare the efficacy of fexuprazan with that of rebamipide for acute and chronic gastritis.METHODS This was a matching-adjusted indirect comparison.Individual patient data from a phase III study of fexuprazan(10 mg BID)were compared with cumulative data from two matching studies of rebamipide(100 mg TID).Erosion improvement and healing rates were compared between two weeks of fexurapan,two weeks of rebamipide,and four weeks of rebamipide.The two main outcome variables were presented as percentages,and the risk differences(RD)and 95%confidence intervals(CI)were calculated for the relative treatment effects.RESULTS In the primary analysis,the erosion improvement and healing rates after a twoweek treatment with fexuprazan were 64.5%and 53.2%,respectively,while a twoweek treatment with rebamipide resulted in erosion improvement and healing rates of 43.6%(RD:21.0%;95%CI:9.6-32.3;P<0.01)and 35.6%(RD:17.6%;95%CI:6.1-29.2;P=0.003),respectively.In the additional analysis,the erosion improvement and healing rates for the two-week fexuprazan treatment(64.2%and 51.2%,respectively)were similar to those obtained during a four-week treatment with rebamipide(60.6%;RD:3.6%;95%CI:-9.8,17.0;P=0.600 and 53.5%;RD:-2.3%;95%CI:-16.1,11.5;P=0.744,respectively).CONCLUSION The two-week fexuprazan treatment was superior to the two-week rebamipide treatment and similar to the fourweek rebamipide treatment for patients with gastritis.

Accuracy comparison and improvement for state of health estimation of lithium-ion battery based on random partial recharges and feature engineering

State of health(SOH)estimation of e-mobilities operated in real and dynamic conditions is essential and challenging.Most of existing estimations are based on a fixed constant current charging and discharging aging profiles,which overlooked the fact that the charging and discharging profiles are random and not complete in real application.This work investigates the influence of feature engineering on the accuracy of different machine learning(ML)-based SOH estimations acting on different recharging sub-profiles where a realistic battery mission profile is considered.Fifteen features were extracted from the battery partial recharging profiles,considering different factors such as starting voltage values,charge amount,and charging sliding windows.Then,features were selected based on a feature selection pipeline consisting of filtering and supervised ML-based subset selection.Multiple linear regression(MLR),Gaussian process regression(GPR),and support vector regression(SVR)were applied to estimate SOH,and root mean square error(RMSE)was used to evaluate and compare the estimation performance.The results showed that the feature selection pipeline can improve SOH estimation accuracy by 55.05%,2.57%,and 2.82%for MLR,GPR and SVR respectively.It was demonstrated that the estimation based on partial charging profiles with lower starting voltage,large charge,and large sliding window size is more likely to achieve higher accuracy.This work hopes to give some insights into the supervised ML-based feature engineering acting on random partial recharges on SOH estimation performance and tries to fill the gap of effective SOH estimation between theoretical study and real dynamic application.

Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

BACKGROUND Non-proliferative diabetic retinopathy(NPDR)poses a significant challenge in diabetes management due to its microvascular changes in the retina.Laser photocoagulation,a conventional therapy,aims to mitigate the risk of progressing to proliferative diabetic retinopathy(PDR).AIM To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in NPDR patients.METHODS Forty-nine NPDR patients(86 eyes)treated between September 2020 and July 2022 were included.They were randomly allocated into single-spot(n=23,40 eyes)and multi-spot(n=26,46 eyes)groups.Treatment outcomes,including bestcorrected visual acuity(BCVA),central macular thickness(CMT),and mean threshold sensitivity,were assessed at predetermined intervals over 12 months.Adverse reactions were also recorded.RESULTS Energy levels did not significantly differ between groups(P>0.05),but the multi-spot group exhibited lower energy density(P<0.05).BCVA and CMT improvements were noted in the multi-spot group at one-month posttreatment(P<0.05).Adverse reaction incidence was similar between groups(P>0.05).CONCLUSION While energy intensity and safety were comparable between modalities,multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for NPDR patients,with reduced laser-induced damage.

Global Research Progress on Municipal Waste and Future Prospect Based on the Cross-national Comparisons

Due to the acceleration of urbanization,the municipal waste(MW)problem has transformed into a global challenge for urb-an sustainability.To elucidate historical trends,current focal points,and future directions in MW research,we conducted a bibliometric analysis and employed knowledge graph visualization to scrutinize a total of 34212 articles,which were published between 1991 and 2021 in the Web of Science(WoS)core database.The results indicated that current major research themes encompass waste classifica-tion and recycling,waste management and public behavior,waste disposal methods and technologies,as well as environmental impact and evaluation.There has been a shift in the research focus from the environmental impacts of waste incineration to sustainable manage-ment related issues.A comparison of research from six typical countries revealed the differences in research priorities and techniques advantages.Scholars from the USA and Britain initiated MW research earlier than other countries and investigated management issues in depth,such as public behavior and willingness to pay.Meanwhile,Japanese,German,and Swedish scholars conducted extensive studies on advanced waste treatment technologies,such as disposal and recycling,risk assessment,and waste-to-energy techniques.Chinese scholars placed particular emphasis on end-of-pipe treatments and their associated environmental impacts.Hotspots and poten-tial future frontiers were identified by burst detection analysis.Keywords with high value of burst index(BI)worldwide are food waste and circular economy.Chinese scholars have put great efforts on waste environmental impact and its recycling technologies,while we’re expecting to further investigating vulnerable population.Furthermore,this study contributes to bridging the regional gap of scientific research among different countries and fostering international collaboration.

Comparison and Selection of Water Restoration Techniques for Artificial Landscape Lakes in Nantong City

As an important part of urban infrastructure,urban water system is of great and far-reaching significance for ensuring urban flood control and waterlogging safety,protecting ecological environment and building livable homes.Taking the urban water system of Nantong as an example,Nantong Water Resources Bureau issued R evision of Nantong Urban Water System Planning in 2017,and put forward the construction of the"two circles,eight lakes and nine veins"water system layout,giving new vitality to the urban water system.In view of problems existing in newly excavated artificial landscape lakes,such as fragile water ecosystem,strong eutrophication trend,poor environmental sensory effect and unsatisfactory water landscape effect,it is urgent to study the in-situ water ecological restoration technique of"algae-controlling zooplankton+submerged plant community"to build a"grass-type clear water"ecosystem for artificial landscape lakes,so as to improve the water sensory index and self-purification ability and finally realize the double improvement of"sensory effect and water quality"of artificial landscape lakes.

Direct Pointwise Comparison of FE Predictions to StereoDIC Measurements:Developments and Validation Using Double Edge-Notched Tensile Specimen

To compare finite element analysis(FEA)predictions and stereovision digital image correlation(StereoDIC)strain measurements at the same spatial positions throughout a region of interest,a field comparison procedure is developed.The procedure includes(a)conversion of the finite element data into a triangular mesh,(b)selection of a common coordinate system,(c)determination of the rigid body transformation to place both measurements and FEA data in the same system and(d)interpolation of the FEA nodal information to the same spatial locations as the StereoDIC measurements using barycentric coordinates.For an aluminum Al-6061 double edge notched tensile specimen,FEA results are obtained using both the von Mises isotropic yield criterion and Hill’s quadratic anisotropic yield criterion,with the unknown Hill model parameters determined using full-field specimen strain measurements for the nominally plane stress specimen.Using Hill’s quadratic anisotropic yield criterion,the point-by-point comparison of experimentally based full-field strains and stresses to finite element predictions are shown to be in excellent agreement,confirming the effectiveness of the field comparison process.

Does US Dollar Supply Trigger House Price Fluctuations?An International Comparison

Cyclical fluctuations in asset prices are closely related to the overall stability of the macroeconomy and have thus become a significant topic in academic and professional exploration.Among these fluctuations,changes in the supply of the U.S.dollar,the global reserve,and primary settlement currency have a broad and far-reaching impact on international financial markets.Since COVID-19,asset prices across various countries have shown differing trends due to fluctuations in the U.S.dollar supply.Housing prices,a key focus in asset pricing research,have been affected to varying degrees.This thesis utilizes seven house price indices from representative cities worldwide from 2020 to 2023 to compare the differential impacts across various countries using an empirical approach.The results indicate that the impact of the U.S.dollar money supply(M2)diminishes in a gradient from the U.S.to East Asia,and then to Europe.

Comparison of the Development of CDMO at Home and Abroad and Its Enlightment to China

Objective To analyze the development status of contract development manufacturing organization(CDMO)at home and abroad,and to make some suggestions for the development of CDMO in China.Methods The relevant literature was searched and reviewed,and the development status of CDMOs in the United States,France,Japan and China was compared from the aspects of market scale,development process,development focus,advantages and disadvantages,and policy support.Then,some suggestions for the development of CDMO enterprises in China were summarized.Results and Conclusion Through the comparison of CDMO development at home and abroad,it can be seen that China started CDMO late,there were many technical barriers and its globalization layout were not sufficient.However,the development trend was good and it focused on the field of chemical drugs and biological drugs to constantly develop innovative drugs.China needs to continuously improve its own technical capabilities to carry out innovative research.Therefore,cost reduction and efficiency increase will be the key elements for the development of CDMOs,and they are expected to have a rapid and comprehensive development in the future.

平“语”近人中课程思政元素comparison的应用及分析

文章的研究目的是理解平“语”近人中comparison(比喻)的用法,平“语”近人中课程思政的内容和其背后的真实含义具有重要的教育意义。文章以话语中课程思政元素的comparison主要例子作为研究对象,来探讨和研究平“语”近人话语中的关于comparison的应用并且加以分析。

Multiomics comparison among populations of three plant sources of Amomi Fructus

Amomi Fructus(Sharen,AF)is a traditional Chinese medicine(TCM)from three source species(or varieties),including Wurfbainia villosa var.villosa(WVV),W.villosa var.xanthioides(WVX),or W.longiligularis(WL).Among them,WVV has been transplanted from its top-geoherb region,Guangdong,to its current main production area,Yunnan,for>50 years in China.However,the genetic and transcriptomic differentiation among multiple AF source species(or varieties)and between the origin and transplanted populations of WVV is unknown.In our study,the observed overall higher expression of terpenoid biosynthesis genes in WVV than in WVX provided possible evidence for the better pharmacological effect of WVV.We also screened six candidate borneol dehydrogenases(BDHs)that potentially catalyzed borneol into camphor in WVV and functionally verified them.Highly expressed genes at the P2 stage of WVV,Wv05G1424 and Wv05G1438,were capable of catalyzing the formation of camphor from(+)-borneol,(-)-borneol and DL-isoborneol.Moreover,the BDH genes may experience independent evolution after acquiring the ancestral copies,and the following tandem duplications might account for the abundant camphor content in WVV.Furthermore,four populations of WVV,WVX,and WL are genetically differentiated,and the gene flow from WVX to WVV in Yunnan contributed to the greater genetic diversity in the introduced population(WVV-JH)than in its top-geoherb region(WVV-YC),which showed the lowest genetic diversity and might undergo genetic degradation.In addition,terpene synthesis(TPS)and BDH genes were selected among populations of multiple AF source species(or varieties)and between the top-and non-top-geoherb regions,which might explain the difference in metabolites between these populations.Our findings provide important guidance for the conservation,genetic improvement,and industrial development of the three source species(or varieties)and for identifying top-geoherbalism with molecular markers,and proper clinical application of AF.

First acceptance testing of multiple A10 absolute gravimeters in China and analysis of the comparison results

Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the purchase and simultaneous testing of 3 A10 absolute gravimeters is unprecedented in China. This study conducted the first acceptance testing of the AGs at 3 locations(the Jiufengshan Gravity Observation Station, the Global Navigation Satellite System Observation Station in Wuhan, and the Jiugongshan Observation Station in Xianning). The results were compared using a method based on expert validation, and the acceptance testing scheme was formulated by referring to the Technical Regulations for Tectonic Environment Monitoring Networks in China and Specifications for Gravimetry Control. Based on the repeatability, precision, and consistency of the measured g values, the results from each instrument were evaluated using the air pressure precision test. Comparing the instrument reference values, the final test results can identify the indicator parameters for 3 A10 AGs, the effects of the surrounding environment, and the related parameters on measurement precision. The precision of A10-059, A10-058, and A10-057 exceeded 0.78 μGal, 0.79 μGal, and 0.42 μGal, respectively.This testing scheme can be used as a reference for conducting acceptance testing of AGs in the future and obtaining absolute gravimetric measurements.

Natural gas characteristics and gas-source comparisons of the Lower Triassic Feixianguan Formation,Eastern Sichuan Basin,China

There is great controversy regarding the origin and source of natural gas in the Lower Triassic Feix-ianguan Formation in the Eastern Sichuan Basin.This seriously restricts the study of natural gas dy-namics in the Feixianguan Formation and thus hampers natural gas exploration in the region,so further study is urgently required.Using experimental tests of natural gas composition,stable isotopes,and noble gas isotopes with gas chromatography(GC)and mass spectrometry(MS)studies of source rock and reservoir asphalt saturated hydrocarbons,the natural gas geochemical characteristics,the genetic identification and a gas-source comparison of the Feixianguan Formation were studied.Then,con-strained by the thermal history,the histories of gas generation and expulsion were restored by basin simulation technology.Finally,a gas accumulation model was established for the Feixianguan Formation.The results showed that(1)the H_(2)S-rich and H2S-poor gas reservoirs of the Feixianguan Formation are distributed on the east and west sides of the Kaijiang-Liangping trough in the Eastern Sichuan Basin,respectively.The carbon and hydrogen isotope compositions of the natural gas in the gas reservoirs are generally heavy and have typical characteristics of high-maturity dry gas reservoirs.(2)The natural gas of the Feixianguan Formation is organic thermogenic gas,which is mainly oil-type gas generated by the secondary cracking of crude oil.The gas-generating parent material is mainly type II kerogen.(3)The natural gas of the Feixianguan Formation in the Eastern Sichuan Basin was mainly generated by argil-laceous source rocks of the Upper Permian Longtan Formation.(4)Natural gas accumulation occurred as follows:the paleo-structure heights were filled with crude oil in the Early Jurassic,and paleo-oil res-ervoirs were formed in the Feixianguan Formation;during the Middle-Late Jurassic,the paleo-oil res-ervoirs were cracked when the reservoir temperatures rose above 160 C,and paleo-gas reservoirs were formed.Since the end of the Late Jurassic,the paleo-gas reservoirs have been adjusted and reformed to form the present-day natural gas reservoirs.These results provide a basis for studying natural gas accumulation dynamics of the Feixianguan Formation in the Eastern Sichuan Basin.

跨海桥梁基础波浪力断面对比与研究

桥梁基础在波浪环境下的施工安全关乎桥梁建设的稳定性,需要给予足够的重视。利用数值模拟手段,基于改进的RNG κ-ε模型,采用VOF法模拟自由液面,在保持相同迎浪断面的情况下,建立圆形、圆端形、矩形和多边形4种不同断面形式桥梁基础受波浪作用的三维数值模型,对比其受力差异,并结合流场数据加以分析。结果表明:相同波浪条件下4种不同断面形式的结构所受到水平波浪力中以圆形结构为最小,矩形结构为最大,其总水平波浪力幅值较圆形结构增大10%左右;桥梁基础结构在波浪的作用下,基础周围会受到绕流作用,使得结构部分位置处的流速增大并出现流速集中现象,在矩形结构周围这一现象最为突出,多边形结构的情况与之类似,而圆形及圆端形结构的流速集中现象则相对较弱;按规范计算得到的等效圆柱波浪力相较于数值模拟结果大23%~29%,按等效方柱计算得到的波浪力相较于数值模拟结果大10%~13%。从工程设计的角度看,采用圆弧形的结构设计有助于减小波浪荷载和削弱桥梁基础局部的流速增大与流速集中现象。

基于深度学习的无锚框目标检测算法综述

近年来,基于深度学习的无锚框目标检测算法备受关注。为了深入理解无锚框检测算法,对比分析了基于深度学习的无锚框检测算法的原理机制、网络结构、核心特性以及优缺点,归纳总结了无锚框检测算法的核心技术,并在同一数据集上通过性能实验研究上述算法的性能,总结提出基于深度学习的目标检测算法未来的研究方向。

中、美、日、韩新能源汽车产业竞争优势测度与比较研究——以锂电池汽车为例

本文基于中、美、日、韩近30年在锂电池汽车领域的专利数据,选取20个关键指标构建“技术-经济-法律”三维分析模型,并划分出关键核心专利,在此基础上应用景气综合指数法计算四国在锂电池汽车产业的竞争优势指数,并对其进行比较与分析。结果表明,中、美、日、韩在锂电池汽车领域的总体发展布局已基本到达顶峰,且于近两年呈现波动下降趋势。总体来看,美国获得竞争优势时间最早且指数发展趋势最为稳定,连续多年稳居第一;中国获得竞争优势时间最晚,但指数发展速度最快,截至2021年末,中国总体竞争优势指数与美国持平,远超日、韩两国。分维度来看,中、美分别于经济、技术维度具有绝对竞争优势;韩国在经济、法律维度发展较为稳定,但技术维度影响整体,导致整体呈现波动下降趋势;日本在各维度均呈现出明显下降趋势,仅在技术维度下降幅度较小。由此得出结论:中国经济发展带动整体,已基本实现锂电池汽车产业的技术赶超,技术维度的发展是获得持续性竞争优势的基础,因此应在保持现有锂电池汽车领域竞争优势的同时注重相关技术轨道的跨越与变迁,以获取新能源汽车产业的持续性竞争优势。

高校教师数字素养框架:全球图景与本土建议

培养高校教师数字素养是当前我国高校教师发展的重要工作,但学界对高校教师数字素养的概念和框架维度尚未达成共识。梳理国内外教师数字素养框架发现,它们以促进教师全过程发展为目标,并根据每一素养维度划分难度等级,但在内容上又基于教师的多种角色各有侧重。对比国内外教师数字素养框架可知,高校教师数字素养框架应强调教师的数字化教学实践、数字领导力、数字福祉、数字化意识及其对学生数字化就业能力的培养。基于国际经验和高校教师的独特性,本研究针对我国教师数字素养框架提出了维度补充、维度调整和维度拓展三个方面的优化建议。

区块链产业发展:经济特性与中美路径差异

区块链具有去中心化、可追溯性两大核心特征和不可篡改、去信任化、信息透明、可匿名性四大衍生特征,并进一步引致出能够作用于经济领域的五大经济特性:减少信息不对称、降低组织的集中度、提供可置信的承诺、生成新的价值标的、减少交易成本。区块链是否能与产业良好融合是其能否有效发挥上述重要经济特性的一个重要因素。本文通过对中美区块链行业的对比分析发现,中国对于区块链的应用领域态度更为审慎,同时也具有更强的政策导向,主要应用领域为实体经济;而美国虽然对区块链的政策导向不如中国明显,但其在技术、人才培养等方面都具有显著优势,区块链应用规模在全球范围内处于绝对领先地位。总的来看,中国区块链产业发展面临审慎的金融政策与区块链特征不匹配、结合区块链与实体经济的配套设施相对缺失、区块链适用领域有待细化、区块链技术有待提升等问题。为进一步推动中国区块链产业发展,需要推动央行数字货币发展、加强数字化基础设施建设、针对性推动区块链行业发展、加强区块链技术基础研究。

对标高等教育强国:我国高等教育系统关键指标的国际对比分析

对标世界高等教育强国,可以从发展水平和贡献能力两个方面来把握我国高等教育系统的发展状况。在发展水平方面,从体量规模、经费投入、师资队伍、国际化四个维度选择了十个关键指标进行国际对比分析;在贡献能力方面,从教育机会获得、满足社会发展需要、促进科技创新发展三个维度选择了七个关键指标进行国际对比分析。结果表明,改革开放以来,我国高等教育发展取得了一些成就,但是仍存在诸多问题,只有客观认识成就、准确研判问题,才能找到未来建设教育强国的发力点和突破点。

上行社会比较对大学生学习内卷的影响:焦虑的中介与自我肯定的调节作用

目的:探讨上行社会比较与大学生学习内卷的关系,并考察焦虑和自我肯定在其中的中介和调节作用。方法:采用上行社会比较量表、焦虑量表、自我肯定问卷和大学生学习内卷问卷对826名在校大学生进行问卷调查。结果:①上行社会比较和大学生学习内卷呈显著的正相关(r=0.22,P<0.01);②焦虑在上行社会比较与大学生学习内卷之间起部分中介作用(β=0.33,P<0.01),中介作用占总效应的13.64%;③自我肯定对中介模型的前半段起显著的调节作用(β=-0.25,P<0.01),当自我肯定水平越高,上行社会比较对焦虑的影响越弱;④自我肯定对直接路径起显著的调节作用(β=-0.07,P<0.05),当自我肯定水平越高,上行社会比较对大学生学习内卷的影响越弱。结论:上行社会比较能显著正向预测大学生学习内卷,焦虑在上行社会比较和大学生学习内卷之间起着部分中介作用,上行社会比较-焦虑-大学生学习内卷这一中介路径的前半段和直接路径受到自我肯定的调节。

体育场馆促进城市更新:驱动场景、中美比较及中国方案

体育场馆是城市更新的重要内容,也是实施城市更新行动的重要抓手。通过文献资料、实地考察、专家访谈、比较研究等方法,就体育场馆促进城市更新问题进行了研究。研究总结了体育场馆促进城市更新的5类驱动场景:大型体育场馆新建与升级、工业遗产通过体育再利用、老旧小区补齐体育场馆短板、体育业态盘活商业闲置空间、体育场景激活城市金边银角。通过对中美两国体育场馆促进城市更新的背景、目的、方式、资金、主体、效益进行较为全面的比较分析,研究提出了体育场馆促进城市更新的中国方案,以经济为导向的更新项目应充分发挥触媒效应:融入城市规划,带动区域共同更新;拓宽投资渠道,吸引社会力量参与;提升更新效益,建设体育服务综合体;走微更新之路,保护传承文化遗产;多元主体参与,提升社会治理水平;以民生为导向的更新项目应补齐公共服务短板:坚持政府引导,纳入民生实事工程;财政资金兜底,鼓励社会资本投入;加强居民自治,实现共同缔造目标;借力城市更新,补齐健身设施短板,以期为探索体育场馆促进城市更新的中国道路提供理论依据与参考。