On May 14,China Institute of International Studies(CIIS)and World Affairs Press jointly launched International Situation and China’s Foreign Policy Blue Book(2023/2024)(referred to as the“Blue Book”)and held a semi...On May 14,China Institute of International Studies(CIIS)and World Affairs Press jointly launched International Situation and China’s Foreign Policy Blue Book(2023/2024)(referred to as the“Blue Book”)and held a seminar on China’s diplomacy amid global changes.展开更多
As China continues to open up to the outside world,new words in every aspect of our daily life are emerging at a rapid speed.However,the quality of translation at present is not very satisfactory.This paper analyzes t...As China continues to open up to the outside world,new words in every aspect of our daily life are emerging at a rapid speed.However,the quality of translation at present is not very satisfactory.This paper analyzes the features of these words,the errors in their translation and discusses the translation strategies based on the Functional Theory of Germany.展开更多
With the vigorous development of higher vocational education,public elective courses,as one of the core components of the higher vocational curriculum system,occupy a pivotal position.Based on the perspective of acade...With the vigorous development of higher vocational education,public elective courses,as one of the core components of the higher vocational curriculum system,occupy a pivotal position.Based on the perspective of academic affairs management and taking Guangdong C Vocational College as an example,this paper meticulously analyzes the operational problems in the declaration,setting,teaching,and management of public elective courses through questionnaire surveys and other methods.It also puts forward a series of targeted solutions,with a view to continuously improving the teaching quality and management level of public elective courses.展开更多
Accelerating modernization with informatization strategic choices for achieving "Two Centenary Goals" and the and facilitating the construction of "network giant" are the significant rejuvenation of China. It is u...Accelerating modernization with informatization strategic choices for achieving "Two Centenary Goals" and the and facilitating the construction of "network giant" are the significant rejuvenation of China. It is urgent to build a united information service network so as to provide integrated network service for overseas Chinese, to achieve the subject transition from overseas Chinese affairs department to platform mechanism network and endogenous power of overseas Chinese community. The information service network for overseas Chinese affairs is now confronting a valuable opportunity departments and feeble foundation of informatization. However, it also faces hidden dangers resulting from disunity of various展开更多
Based on the status quo of political education in high school,current affairs and politics materials are utilized as an example in this paper to analyze and discuss the value of the proper use of current affairs and p...Based on the status quo of political education in high school,current affairs and politics materials are utilized as an example in this paper to analyze and discuss the value of the proper use of current affairs and politics materials in high school political classroom teaching.In addition,the paper also discusses the principles that should be adhered to in selecting materials for use in political classroom teaching.The purpose of this article is to provide guidelines to high school political subject teachers in selecting and applying the current affairs and politics materials reasonably.展开更多
通过对澳大利亚学术期刊The Australian Journal of Chinese Affairs的考察,发现中国文学研究在该刊占有很高的比例。从编辑和作者来看,澳大利亚汉学家中中国文学研究的学者占有显著地位,他们翻译、研究中国当代文学和当代中国社会。从...通过对澳大利亚学术期刊The Australian Journal of Chinese Affairs的考察,发现中国文学研究在该刊占有很高的比例。从编辑和作者来看,澳大利亚汉学家中中国文学研究的学者占有显著地位,他们翻译、研究中国当代文学和当代中国社会。从研究内容来看,主要包括作家作品研究、文学流派研究、文学体裁研究和中国文学的海外传播研究。从创新程度来看,澳大利亚当代中国文学研究扩大了汉学概念所包含的范围,提升了中国当代文学在学术话语系统中的地位,扩大了中国当代文学在世界上的影响。展开更多
Background:Inflammatory bowel diseases(IBDs) are group of chronic inflammatory illnesses with a remitting and relapsing course that may result in appreciable morbidity and high medical costs secondary to repeated hosp...Background:Inflammatory bowel diseases(IBDs) are group of chronic inflammatory illnesses with a remitting and relapsing course that may result in appreciable morbidity and high medical costs secondary to repeated hospitalizations.The study's objectives were to identify the reasons for hospitalization among patients with IBDs,and compare inpatient courses and readmission rates for IBD-related admissions versus non-IBD-related admissions.Methods:A retrospective chart review was performed on all patients with IBD admitted to the Minneapolis Veterans Affairs(VA) Medical Center between September 2010 and September 2012.Results:A total of 111 patients with IBD were admitted during the 2-year study period.IBD flares/complications accounted for 36.9% of the index admissions.Atherothrombotic events comprised the second most common cause of admissions(14.4%) in IBD patients.Patients with an index admission directly related to IBD were significantly younger and had developed IBD more recently.Unsurprisingly,the IBD admission group had significantly more gastrointestinal endoscopies and abdominal surgeries,and was more likely to be started on medication for IBD during the index stay.The median length of stay(LOS) for the index hospitalization for an IBD flare or complication was 4(2–8) days compared with 2(1–4) days for the other patients(P=0.001).A smaller percentage of the group admitted for an IBD flare/complication had a shorter ICU stay compared with the other patients(9.8% vs.15.7%,respectively); however,their ICU LOSs tended to be longer(4.5 vs.2.0 days,respectively,P=0.17).Compared to the other admission types,an insignificantly greater percentage of the group whose index admission was related to an IBD flare or complication had at least one readmission within 6 months of discharge(29% versus 21%; P=0.35).The rate of admission was approximately 80% greater in the group whose index admission was related to an IBD flare or complication compared to the other types of admission(rate ratio 1.8,95% confidence interval 0.96 to 3.4),although this difference did not reach statistical significance(P=0.07).Conclusion:Identifying the reasons for the patients' index admission,IBD flares versus all other causes,may provide valuable information concerning admission care and the subsequent admission history.展开更多
Theodore Dreiser was a controversial writer whose novel Sister Carrie was condemned hardly. This paper aims to conduct a detailed analysis of Sister Carrie and expose the evil nature of bourgeoisie society. At the sam...Theodore Dreiser was a controversial writer whose novel Sister Carrie was condemned hardly. This paper aims to conduct a detailed analysis of Sister Carrie and expose the evil nature of bourgeoisie society. At the same time, Dreiser's great insight and perplexitywere clearly reviewed as a realist and naturalist writer.展开更多
From the perspective of cultural background and cross-cultural communicative awareness, this paper discusses the cultural factors in the context of foreign affairs translation. It points out translator should adapt th...From the perspective of cultural background and cross-cultural communicative awareness, this paper discusses the cultural factors in the context of foreign affairs translation. It points out translator should adapt themselves to different cultural backgrounds and fully convey the cultural denotations and connotations in foreign affairs texts, which can achieve successful conversation from the source language to the target language.展开更多
Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial dynamics.However,the specific associations between these patholog...Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial dynamics.However,the specific associations between these pathological changes remain unclear.In this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro models.The investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular docking.The results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD models.Remarkably,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic transmission.The cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular cortex.DZSM intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and length.Moreover,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial morphology.In conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.展开更多
Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events a...Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events are significantly slower than the excitatory postsynaptic currents.Parameters of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto rs.Astrocytes are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback loop.Mostly as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological conditions.There is a growing body of evidence on the roles of slow inward currents on a single neuron or local network level.These events often occur in synchro ny on neurons located in the same astrocytic domain.Besides synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic plasticity.In addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory inputs.Of note,there might be important regionspecific differences in the roles and actions triggering slow inward currents.In greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological ones.Slow inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural networks.Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes.These events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive functions.Events with features overlapping with slow inward currents(excitatory,N-methyl-Daspartate-receptor mediated currents with astrocytic contribution) as ischemic currents and spreading depolarization also have a well-known pathophysiological role in worsening consequences of stroke,traumatic brain injury,or epilepsy.One might assume that slow inward currents occurring with low frequency under physiological conditions might contribute to synaptic plasticity and memory formation.However,to state this,more experimental evidence from greater neuronal networks or the level of the individual is needed.In this review,I aimed to summarize findings on slow inward currents and to speculate on the potential functions of it.展开更多
Recently,the U.S.House of Representatives flagrantly passed the so-called“Uygur Human Rights Policy Act of 2019,”interfering in China’s internal affairs by disregarding the facts.Such hegemonic acts and power logic...Recently,the U.S.House of Representatives flagrantly passed the so-called“Uygur Human Rights Policy Act of 2019,”interfering in China’s internal affairs by disregarding the facts.Such hegemonic acts and power logic have aroused great indignation and strong condemnation from Chinese people of all ethnic groups.As a senior diplomat familiar with Middle East affairs,the act immediately reminded me that some people in the United States have carried out“street revolutions”in many Middle East countries under the guise of“human rights”and“democracy.”To overthrow the governments they dislike,they do not hesitate to use terrorist organizations to stir up endless wars and turmoil,thus bringing about a series of disasters in some countries,which had been in perfectly good conditions,causing untold suffering to the people and serious humanitarian disasters.It is the United States that has double standards on the fight against terrorism and human rights issues and uses anti-terrorism as a means of implementing geopolitics,resulting in regional turmoil and unrest.展开更多
On March 12,CIIS held the press conference for the Blue Book on International Situation and China’s Foreign Affairs(2020/2021).CIIS President Xu Bu,Chairman of the World Affairs Press Su Wen,former Dean of the School...On March 12,CIIS held the press conference for the Blue Book on International Situation and China’s Foreign Affairs(2020/2021).CIIS President Xu Bu,Chairman of the World Affairs Press Su Wen,former Dean of the School of International Studies at Peking University Jia Qingguo,President of Shanghai Institutes for International Studies Chen Dongxiao,and CIIS Executive Vice President Ruan Zongze attended the press conference.Also present were about 80 representatives from Chinese and international media organizations.展开更多
Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in undergroun...Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.展开更多
Invoice tax affairs sharing, which is based on the relying on invoice tax information management system, with the aims of avoiding the risk of tax affairs, optimizing the organizational structure, standardizing the pr...Invoice tax affairs sharing, which is based on the relying on invoice tax information management system, with the aims of avoiding the risk of tax affairs, optimizing the organizational structure, standardizing the process, improving the efficiency, reducing the operating costs and supporting the planning of tax affairs, is dedicated to providing internal and external customers with specialized, centralized and shareable management services of invoice tax affairs.展开更多
Viral hepatitis represents a major danger to public health,and is a globally leading cause of death.The five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis...Viral hepatitis represents a major danger to public health,and is a globally leading cause of death.The five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral therapies.There remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver disease.Furthermore,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’complications.In 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral hepatitis.Today,treatment is sufficiently able to prevent the disease from reaching advanced phases.However,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral hepatitis.This review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.展开更多
To guarantee a unified response to disasters, humanitarian organizations work together via the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Although the OCHA has made great strides to imp...To guarantee a unified response to disasters, humanitarian organizations work together via the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Although the OCHA has made great strides to improve its information management and increase the availability of accurate, real-time data for disaster and humanitarian response teams, significant gaps persist. There are inefficiencies in the emergency management of data at every stage of its lifecycle: collection, processing, analysis, distribution, storage, and retrieval. Disaster risk reduction and disaster risk management are the two main tenets of the United Nations’ worldwide plan for disaster management. Information systems are crucial because of the crucial roles they play in capturing, processing, and transmitting data. The management of information is seldom discussed in published works. The goal of this study is to employ qualitative research methods to provide insight by facilitating an expanded comprehension of relevant contexts, phenomena, and individual experiences. Humanitarian workers and OCHA staffers will take part in the research. The study subjects will be chosen using a random selection procedure. Online surveys with both closed- and open-ended questions will be used to compile the data. UN OCHA offers a structure for the handling of information via which all humanitarian actors may contribute to the overall response. This research will enable the UN Office for OCHA better gather, process, analyze, disseminate, store, and retrieve data in the event of a catastrophe or humanitarian crisis.展开更多
China has become an increasingly important player across the African continent since the end of the Cold War. Given the scale and breadth of its political and economic involvement in Africa, some Western scholars clai...China has become an increasingly important player across the African continent since the end of the Cold War. Given the scale and breadth of its political and economic involvement in Africa, some Western scholars claim that China's "return to Africa" has been one of the most important developments the region has witnessed in the past two decades. One phenomenon worthy of particular attention is that, other than strengthening economic ties with African states, China has been playing a more active role in helping promote peace and stability on the continent. In other words, Sino-Afi-ican coordination on security-related issues has been intensified since the end of the Cold War. What kind of role has China been playing or sought to play in this area? What factors have motivated China to engage more actively in African security affairs? And are there any challenges Beijing has to face when pursuing common security interests with its African counterparts? Seeking to provide preliminary answers to these questions, this article mainly investigates China's increasing role in promoting peace and safeguarding security in Africa.展开更多
This research aimed to study on the people and the local government. The samples were 395 respondents over 18 years old, selected locally of Mahasarakham Municipality, Thailand. The research found that the level of kn...This research aimed to study on the people and the local government. The samples were 395 respondents over 18 years old, selected locally of Mahasarakham Municipality, Thailand. The research found that the level of knowledge, understanding, and attitudes toward civic rights and duties of administrative affairs was at a high level but participation in the local administration was rated at a low level. The relationship between knowledge, understanding, and attitudes toward civic rights and duties of administrative affairs of the community was positive correlated. The relationship between knowledge and understanding toward civic rights and duties and participation in the community administration and the relationship between attitudes toward civic rights and duties in administrative affairs and participation in the local government administration were not correlated. Some recommendations were the local government organizations should promote and provide more information to build the right understandings and improve good attitudes toward civic rights and duties in administrative affairs. Local administrators and local leaders should play an important role to advocate and encourage public opinions toward a political ideology to ensure the public mind and make the vision "people-centered". Most importantly, the State shall pursue directive principles of State policies in relation to public participation.展开更多
文摘On May 14,China Institute of International Studies(CIIS)and World Affairs Press jointly launched International Situation and China’s Foreign Policy Blue Book(2023/2024)(referred to as the“Blue Book”)and held a seminar on China’s diplomacy amid global changes.
文摘As China continues to open up to the outside world,new words in every aspect of our daily life are emerging at a rapid speed.However,the quality of translation at present is not very satisfactory.This paper analyzes the features of these words,the errors in their translation and discusses the translation strategies based on the Functional Theory of Germany.
文摘With the vigorous development of higher vocational education,public elective courses,as one of the core components of the higher vocational curriculum system,occupy a pivotal position.Based on the perspective of academic affairs management and taking Guangdong C Vocational College as an example,this paper meticulously analyzes the operational problems in the declaration,setting,teaching,and management of public elective courses through questionnaire surveys and other methods.It also puts forward a series of targeted solutions,with a view to continuously improving the teaching quality and management level of public elective courses.
文摘Accelerating modernization with informatization strategic choices for achieving "Two Centenary Goals" and the and facilitating the construction of "network giant" are the significant rejuvenation of China. It is urgent to build a united information service network so as to provide integrated network service for overseas Chinese, to achieve the subject transition from overseas Chinese affairs department to platform mechanism network and endogenous power of overseas Chinese community. The information service network for overseas Chinese affairs is now confronting a valuable opportunity departments and feeble foundation of informatization. However, it also faces hidden dangers resulting from disunity of various
文摘Based on the status quo of political education in high school,current affairs and politics materials are utilized as an example in this paper to analyze and discuss the value of the proper use of current affairs and politics materials in high school political classroom teaching.In addition,the paper also discusses the principles that should be adhered to in selecting materials for use in political classroom teaching.The purpose of this article is to provide guidelines to high school political subject teachers in selecting and applying the current affairs and politics materials reasonably.
文摘通过对澳大利亚学术期刊The Australian Journal of Chinese Affairs的考察,发现中国文学研究在该刊占有很高的比例。从编辑和作者来看,澳大利亚汉学家中中国文学研究的学者占有显著地位,他们翻译、研究中国当代文学和当代中国社会。从研究内容来看,主要包括作家作品研究、文学流派研究、文学体裁研究和中国文学的海外传播研究。从创新程度来看,澳大利亚当代中国文学研究扩大了汉学概念所包含的范围,提升了中国当代文学在学术话语系统中的地位,扩大了中国当代文学在世界上的影响。
基金supported by the Department of Veterans Affairs,Veterans Health Administrationthe Health Services Research and Development (HSR & D) Service through the Minneapolis Center of Innovation
文摘Background:Inflammatory bowel diseases(IBDs) are group of chronic inflammatory illnesses with a remitting and relapsing course that may result in appreciable morbidity and high medical costs secondary to repeated hospitalizations.The study's objectives were to identify the reasons for hospitalization among patients with IBDs,and compare inpatient courses and readmission rates for IBD-related admissions versus non-IBD-related admissions.Methods:A retrospective chart review was performed on all patients with IBD admitted to the Minneapolis Veterans Affairs(VA) Medical Center between September 2010 and September 2012.Results:A total of 111 patients with IBD were admitted during the 2-year study period.IBD flares/complications accounted for 36.9% of the index admissions.Atherothrombotic events comprised the second most common cause of admissions(14.4%) in IBD patients.Patients with an index admission directly related to IBD were significantly younger and had developed IBD more recently.Unsurprisingly,the IBD admission group had significantly more gastrointestinal endoscopies and abdominal surgeries,and was more likely to be started on medication for IBD during the index stay.The median length of stay(LOS) for the index hospitalization for an IBD flare or complication was 4(2–8) days compared with 2(1–4) days for the other patients(P=0.001).A smaller percentage of the group admitted for an IBD flare/complication had a shorter ICU stay compared with the other patients(9.8% vs.15.7%,respectively); however,their ICU LOSs tended to be longer(4.5 vs.2.0 days,respectively,P=0.17).Compared to the other admission types,an insignificantly greater percentage of the group whose index admission was related to an IBD flare or complication had at least one readmission within 6 months of discharge(29% versus 21%; P=0.35).The rate of admission was approximately 80% greater in the group whose index admission was related to an IBD flare or complication compared to the other types of admission(rate ratio 1.8,95% confidence interval 0.96 to 3.4),although this difference did not reach statistical significance(P=0.07).Conclusion:Identifying the reasons for the patients' index admission,IBD flares versus all other causes,may provide valuable information concerning admission care and the subsequent admission history.
文摘Theodore Dreiser was a controversial writer whose novel Sister Carrie was condemned hardly. This paper aims to conduct a detailed analysis of Sister Carrie and expose the evil nature of bourgeoisie society. At the same time, Dreiser's great insight and perplexitywere clearly reviewed as a realist and naturalist writer.
文摘From the perspective of cultural background and cross-cultural communicative awareness, this paper discusses the cultural factors in the context of foreign affairs translation. It points out translator should adapt themselves to different cultural backgrounds and fully convey the cultural denotations and connotations in foreign affairs texts, which can achieve successful conversation from the source language to the target language.
基金National Natural Science Foundation of China(Grant No.:82374317)State Key Program of National Natural Science of China(Grant Nos.:82130119 and 82130118)+4 种基金Postdoctoral Research Foundation of China(Grant No.:2021M690450)Traditional Chinese Medicine Research Project of Health Commission of Hubei Province(Grant No.:ZY2021M017)Hubei University of Chinese Medicine Funds for Distinguished Young Scholars(Grant No.:2022ZZXJ004)National Natural Science Foundation of China(Grant No.:82174210)Fundamental Research Funds for the Central Public Welfare Research Institutes(Grant No.:ZZ14-FL-005).
文摘Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial dynamics.However,the specific associations between these pathological changes remain unclear.In this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro models.The investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular docking.The results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD models.Remarkably,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic transmission.The cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular cortex.DZSM intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and length.Moreover,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial morphology.In conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.
基金funded by the National Research Developm ent and Innovation Office (NKFIH-K1468 73) (to BP)。
文摘Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events are significantly slower than the excitatory postsynaptic currents.Parameters of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto rs.Astrocytes are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback loop.Mostly as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological conditions.There is a growing body of evidence on the roles of slow inward currents on a single neuron or local network level.These events often occur in synchro ny on neurons located in the same astrocytic domain.Besides synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic plasticity.In addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory inputs.Of note,there might be important regionspecific differences in the roles and actions triggering slow inward currents.In greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological ones.Slow inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural networks.Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes.These events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive functions.Events with features overlapping with slow inward currents(excitatory,N-methyl-Daspartate-receptor mediated currents with astrocytic contribution) as ischemic currents and spreading depolarization also have a well-known pathophysiological role in worsening consequences of stroke,traumatic brain injury,or epilepsy.One might assume that slow inward currents occurring with low frequency under physiological conditions might contribute to synaptic plasticity and memory formation.However,to state this,more experimental evidence from greater neuronal networks or the level of the individual is needed.In this review,I aimed to summarize findings on slow inward currents and to speculate on the potential functions of it.
文摘Recently,the U.S.House of Representatives flagrantly passed the so-called“Uygur Human Rights Policy Act of 2019,”interfering in China’s internal affairs by disregarding the facts.Such hegemonic acts and power logic have aroused great indignation and strong condemnation from Chinese people of all ethnic groups.As a senior diplomat familiar with Middle East affairs,the act immediately reminded me that some people in the United States have carried out“street revolutions”in many Middle East countries under the guise of“human rights”and“democracy.”To overthrow the governments they dislike,they do not hesitate to use terrorist organizations to stir up endless wars and turmoil,thus bringing about a series of disasters in some countries,which had been in perfectly good conditions,causing untold suffering to the people and serious humanitarian disasters.It is the United States that has double standards on the fight against terrorism and human rights issues and uses anti-terrorism as a means of implementing geopolitics,resulting in regional turmoil and unrest.
文摘On March 12,CIIS held the press conference for the Blue Book on International Situation and China’s Foreign Affairs(2020/2021).CIIS President Xu Bu,Chairman of the World Affairs Press Su Wen,former Dean of the School of International Studies at Peking University Jia Qingguo,President of Shanghai Institutes for International Studies Chen Dongxiao,and CIIS Executive Vice President Ruan Zongze attended the press conference.Also present were about 80 representatives from Chinese and international media organizations.
基金supported by National Key R&D Program of China(No.2022YFC3004705)the National Natural Science Foundation of China(Nos.52074280,52227901 and 52204249)National Natural Science Foundation of China Youth Fund(No.52104230).
文摘Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.
文摘Invoice tax affairs sharing, which is based on the relying on invoice tax information management system, with the aims of avoiding the risk of tax affairs, optimizing the organizational structure, standardizing the process, improving the efficiency, reducing the operating costs and supporting the planning of tax affairs, is dedicated to providing internal and external customers with specialized, centralized and shareable management services of invoice tax affairs.
基金Supported by the JSPS Kakenhi Grant,No.JP24K15491.
文摘Viral hepatitis represents a major danger to public health,and is a globally leading cause of death.The five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral therapies.There remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver disease.Furthermore,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’complications.In 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral hepatitis.Today,treatment is sufficiently able to prevent the disease from reaching advanced phases.However,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral hepatitis.This review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.
文摘To guarantee a unified response to disasters, humanitarian organizations work together via the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Although the OCHA has made great strides to improve its information management and increase the availability of accurate, real-time data for disaster and humanitarian response teams, significant gaps persist. There are inefficiencies in the emergency management of data at every stage of its lifecycle: collection, processing, analysis, distribution, storage, and retrieval. Disaster risk reduction and disaster risk management are the two main tenets of the United Nations’ worldwide plan for disaster management. Information systems are crucial because of the crucial roles they play in capturing, processing, and transmitting data. The management of information is seldom discussed in published works. The goal of this study is to employ qualitative research methods to provide insight by facilitating an expanded comprehension of relevant contexts, phenomena, and individual experiences. Humanitarian workers and OCHA staffers will take part in the research. The study subjects will be chosen using a random selection procedure. Online surveys with both closed- and open-ended questions will be used to compile the data. UN OCHA offers a structure for the handling of information via which all humanitarian actors may contribute to the overall response. This research will enable the UN Office for OCHA better gather, process, analyze, disseminate, store, and retrieve data in the event of a catastrophe or humanitarian crisis.
文摘China has become an increasingly important player across the African continent since the end of the Cold War. Given the scale and breadth of its political and economic involvement in Africa, some Western scholars claim that China's "return to Africa" has been one of the most important developments the region has witnessed in the past two decades. One phenomenon worthy of particular attention is that, other than strengthening economic ties with African states, China has been playing a more active role in helping promote peace and stability on the continent. In other words, Sino-Afi-ican coordination on security-related issues has been intensified since the end of the Cold War. What kind of role has China been playing or sought to play in this area? What factors have motivated China to engage more actively in African security affairs? And are there any challenges Beijing has to face when pursuing common security interests with its African counterparts? Seeking to provide preliminary answers to these questions, this article mainly investigates China's increasing role in promoting peace and safeguarding security in Africa.
文摘This research aimed to study on the people and the local government. The samples were 395 respondents over 18 years old, selected locally of Mahasarakham Municipality, Thailand. The research found that the level of knowledge, understanding, and attitudes toward civic rights and duties of administrative affairs was at a high level but participation in the local administration was rated at a low level. The relationship between knowledge, understanding, and attitudes toward civic rights and duties of administrative affairs of the community was positive correlated. The relationship between knowledge and understanding toward civic rights and duties and participation in the community administration and the relationship between attitudes toward civic rights and duties in administrative affairs and participation in the local government administration were not correlated. Some recommendations were the local government organizations should promote and provide more information to build the right understandings and improve good attitudes toward civic rights and duties in administrative affairs. Local administrators and local leaders should play an important role to advocate and encourage public opinions toward a political ideology to ensure the public mind and make the vision "people-centered". Most importantly, the State shall pursue directive principles of State policies in relation to public participation.