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Simultaneous Courvoisier's and double duct signs
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作者 Shefali Agrawal Sandeep Vohra 《World Journal of Gastrointestinal Endoscopy》 CAS 2017年第8期425-427,共3页
Presence of Courvoisier's or double duct signs in a jaundiced patient is suggestive of malignant obstruction of the pancreaticobiliary ductal system.The oncologic impact of the simultaneous occurrence of these sig... Presence of Courvoisier's or double duct signs in a jaundiced patient is suggestive of malignant obstruction of the pancreaticobiliary ductal system.The oncologic impact of the simultaneous occurrence of these signs on the survival of patients with periampullary cancer is unknown.We report a case of obstructive jaundice secondary to an ampullary cancer demonstrating the Courvoisier's sign on clinical examination and a double duct sign on imaging.The patient underwent a pancreaticoduodenectomy which confirmed an ampullary adenocarcinoma. 展开更多
关键词 Ampullary cancer Obstructive jaundice double duct sign Courvoisier’s law PROGNOSIS
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IDENTIFICATION OF DOUBLE BOND POSITION IN HEXADECENYL ACETATES BY MASS SPECTROMETRY
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作者 Gu YUAN a Department of Chemistry,Peking University,Beijing,100871Michio HORIIKE Chisato HIRANO b Department of Agricultural Chemistry,Kochi University,Nankoku-shi 783,Japan 《Chinese Chemical Letters》 SCIE CAS CSCD 1993年第4期351-352,共2页
A method for locating double bond in hexadecenyl acetates has been developed by analyzing the mass spectral patterns on a fuzzy classification. The procedure was tested with the spectra of Δ~2- to Δ^(15)-isomers and... A method for locating double bond in hexadecenyl acetates has been developed by analyzing the mass spectral patterns on a fuzzy classification. The procedure was tested with the spectra of Δ~2- to Δ^(15)-isomers and the original double-bond position in these acetates was located unambiguously. 展开更多
关键词 IDENTIFICATION OF double BOND POSITION IN HEXADECENYL ACETATES BY mass SPECTROMETRY
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Research on the structure design of double eccentric coaxial spherical robot
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作者 Xuelai Shang 《International Journal of Technology Management》 2013年第2期76-78,共3页
The paper design a double eccentric mass driven spherical robot, the ball is also subject to eccentric force and inertia force that generate by internal drive units in movement. Due to the unique spherical shell, the ... The paper design a double eccentric mass driven spherical robot, the ball is also subject to eccentric force and inertia force that generate by internal drive units in movement. Due to the unique spherical shell, the robot in the dynamic state transition process, Friction cannot offset the robot motion state change due to internal driving motion error of small units. In order to make linear movement of the spherical robot that can smooth start, stop and speed control, the paper design a method for linear motion driven spherical robot with double eccentric mass control. The improved driving eccentric mass of robot total mass ratio is larger, that can provide the eccentric torque and inertia moment more, the robot has higher motion velocity. 展开更多
关键词 Spherical robot double eccentric mass dynamic analysis
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关于Double图的符号控制数 被引量:4
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作者 孔祥阳 徐保根 《河南科技学院学报(自然科学版)》 2012年第4期54-57,共4页
图的符号控制数在现实生活中有许多应用背景,但图的符号控制数的计算是NP完全问题.给出了一般图G的Double图的符号控制数下界,确定了圈和路的Double图的符号控制数.
关键词 符号控制函数 符号控制数 double
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Observational analysis of the double-diffusive convection in the deep Canada Basin 被引量:2
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作者 XIE Lingling LI Mingming LI Min 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2015年第11期71-79,共9页
The Canada Basin (CB) is the largest sub-basin in the Arctic, with the deepest abyssal plain of 3 850 m. The double-diffusive process is the possible passage through which the geothermal energy affects the above iso... The Canada Basin (CB) is the largest sub-basin in the Arctic, with the deepest abyssal plain of 3 850 m. The double-diffusive process is the possible passage through which the geothermal energy affects the above isolated deep waters. With the temperature-salinity-pressure observations in 2003, 500-m-thick transition layers and lower 1 000-m-thick bottom homogenous layers were found below 2 400 m in the central deep CB. Staircases with downward-increasing temperature and salinity are prominent in the transition layers, suggesting the double- diffusive convection in deep CB. The interface of the stairs is about 10 m thick with 0.001-0.002℃ temperature difference, while the thicknesses of the homogenous layers in the steps decrease upward from about 60 to 20 m. The density ratio in the deep central CB is generally smaller than 2, indicating stronger double-diffusive convection than that in the upper ocean of 200-400 m. The heat flux through the deepest staircases in the deep CB varies between 0.014 and 0.031 W/m2, which is one-two orders smaller than the upper double-diffusive heat flux, but comparable to the estimates of geothermal heat flux. 展开更多
关键词 double diffusion Canada Basin STAIRCASE heat flux water mass
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Study on Hydrodynamic Coefficients of Double Submerged Inclined Plates 被引量:3
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作者 WANG Ke ZHANG Zhi-qiang 《China Ocean Engineering》 SCIE EI CSCD 2018年第1期85-89,共5页
Added mass and damping coefficients are very important in hydrodynamic analysis of naval structures. In this paper,a double submerged inclined plates with ‘/\’ configuration is firstly considered. By use of the boun... Added mass and damping coefficients are very important in hydrodynamic analysis of naval structures. In this paper,a double submerged inclined plates with ‘/\’ configuration is firstly considered. By use of the boundary element method(BEM) based on Green function with the wave term, the radiation problem of this special type structure is investigated. The added mass and damping coefficients due to different plate lengths and inclined angles are obtained. The results show that: the added mass and damping coefficients for sway are the largest. Heave is the most sensitive mode to inclined angles. The wave frequencies of the maximal added mass and damping coefficients for sway and roll are the same. 展开更多
关键词 double submerged inclined plates boundary element method(BEM) added mass and damping coefficients GMRES method
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Asymptotic Inference for the Weak Stationary Double AR(1) Model 被引量:3
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作者 Fang Chang Augustine C. M. Wong Yanyan Wu 《Open Journal of Statistics》 2012年第2期141-152,共12页
An AR(1) model with ARCH(1) error structure is known as the first-order double autoregressive (DAR(1)) model. In this paper, a conditional likelihood based method is proposed to obtain inference for the two scalar par... An AR(1) model with ARCH(1) error structure is known as the first-order double autoregressive (DAR(1)) model. In this paper, a conditional likelihood based method is proposed to obtain inference for the two scalar parameters of interest of the DAR(1) model. Theoretically, the proposed method has rate of convergence O(n-3/2). Applying the proposed method to a real-life data set shows that the results obtained by the proposed method can be quite different from the results obtained by the existing methods. Results from Monte Carlo simulation studies illustrate the supreme accuracy of the proposed method even when the sample size is small. 展开更多
关键词 CANONICAL Parameter double AUTOREGRESSIVE Model P-VALUE Function signED Log-Likelihood Ratio Statistic
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Numerical Simulation of Double Diffusive Mixed Convection in a Horizontal Annulus with Finned Inner Cylinder 被引量:3
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作者 Cherfi Ryad Sadaoui Djamel +1 位作者 Sahi Adel Mouloud Smail 《Fluid Dynamics & Materials Processing》 EI 2019年第2期153-169,共17页
The present work relates to a numerical investigation of double diffusive mixed convection around a horizontal annulus with a finned inner cylinder.The solutal and thermal buoyancy forces are sustained by maintaining ... The present work relates to a numerical investigation of double diffusive mixed convection around a horizontal annulus with a finned inner cylinder.The solutal and thermal buoyancy forces are sustained by maintaining the inner and outer cylinders at uniform temperatures and concentrations.Buoyancy effects are also considered,with the Boussinesq approximation.The forced convection effect is induced by the outer cylinder rotating with an angular velocity(ω)in an anti-clockwise direction.The studies are made for various combinations of dimensionless numbers;buoyancy ratio number(N),Lewis number(Le),Richardson number(Ri)and Grashof number(Gr).The isotherms,isoconcentrations and streamlines as well as both average and local Nusselt and Sherwood numbers were studied.A finite volume scheme is adopted to solve the transport equations for continuity,momentum,energy and mass transfer.The results indicate that the use of fins on the inner cylinder with outer cylinder rotation,significantly improves the heat and mass transfer in the annulus. 展开更多
关键词 Finned INNER CYLINDER double diffusive flow heat and mass TRANSFER ROTATING ANNULUS mixed CONVECTION numerical simulation
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Numerical simulation for 2D double-diffusive convection(DDC) in rectangular enclosures based on a high resolution upwind compact streamfunction model Ⅰ: numerical method and code validation
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作者 Yaping YAN Shuang WU +1 位作者 Kaiyuan TIAN Zhenfu TIAN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2022年第9期1431-1448,共18页
A high resolution upwind compact streamfunction numerical algorithm for two-dimensional(2D)double-diffusive convection(DDC)is developed.The unsteady Navier-Stokes(N-S)equations in the streamfunction-velocity form and ... A high resolution upwind compact streamfunction numerical algorithm for two-dimensional(2D)double-diffusive convection(DDC)is developed.The unsteady Navier-Stokes(N-S)equations in the streamfunction-velocity form and the scalar temperature and concentration equations are used.An optimized third-order upwind compact(UCD3 opt)scheme with a low dispersion error for the first derivatives is utilized to approximate the third derivatives of the streamfunction in the advection terms of the N-S equations and the first derivatives in the advection terms of the scalar temperature and concentration equations.The remaining first derivatives of the streamfunction(velocity),temperature,and concentration variables used in the governing equations are discretized by the fourth-order compact Pade(SCD4)schemes.With the temperature and concentration variables and their approximate values of the first derivatives obtained by the SCD4 schemes,the explicit fourth-order compact schemes are suggested to approximate the second derivatives of temperature and concentration in the diffusion terms of the energy and concentration equations.The discretization of the temporal term is executed with the second-order Crank-Nicolson(C-N)scheme.To assess the spatial behavior capability of the established numerical algorithm and verify the developed computer code,the DDC flow is numerically solved.The obtained results agree well with the benchmark solutions and some accurate results available in the literature,verifying the accuracy,effectiveness,and robustness of the provided algorithm.Finally,a preliminary application of the proposed method to the DDC is carried out. 展开更多
关键词 double diffusive convection(DDC) high resolution heat and mass transfer upwind compact difference streamfunction formulation
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DOUBLE LOOP ACTIVE VIBRATION CONTROL OF PNEUMATIC ISOLATOR WITH TWO SEPARATE CHAMBERS
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作者 YANG Qingjun LI Jun WANG Zuwen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第4期610-613,共4页
A newly designed pneumatic spring with two separate chambers is promoted and double-loop active control is introduced to overcome the following drawbacks of passive pneumatic isolation: ① The low frequency resonance... A newly designed pneumatic spring with two separate chambers is promoted and double-loop active control is introduced to overcome the following drawbacks of passive pneumatic isolation: ① The low frequency resonances introduced into the system; ② Conflict between lower isolation frequency and stiffness high enough to limit quasi-static stroke;③ Inconsistent isolation level with different force load. The design of two separate chambers is for the purpose of tuning support frequency and force independently and each chamber is controlled by a different valve. The inner one of double-loop structure is pressure control, and in order to obtain good performance, nonlinearities compensation and motion flow rate compensation (MFRC) are added besides the basic cascade compensation, and the influence of tube length is studied. The outer loop has two functions: one is to eliminate the resonance caused by isolation support and to broaden the isolation frequency band by payload velocity feedback and base velocity feed forward, and the other is to tune support force and support stiffness simultaneously and independently, which means the support force will have no effect on support stiffness. Theoretical analysis and experiment results show that the three drawbacks are overcome simultaneously. 展开更多
关键词 Pneumatic isolator Active vibration control double-loop control Two separate chambers mass flow rate compensation (MFRC)
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无中微子双贝塔衰变:新物理探索和宇宙学观测
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作者 周顺 《物理》 CAS 北大核心 2024年第5期317-321,共5页
近二十多年来,太阳、大气、反应堆和加速器的中微子振荡实验提供了大量确凿的证据表明中微子有质量。然而,粒子物理学标准模型却预言中微子质量为零。这意味着中微子质量的产生必然要求引入超出标准模型的新物理。文章将介绍无中微子双... 近二十多年来,太阳、大气、反应堆和加速器的中微子振荡实验提供了大量确凿的证据表明中微子有质量。然而,粒子物理学标准模型却预言中微子质量为零。这意味着中微子质量的产生必然要求引入超出标准模型的新物理。文章将介绍无中微子双贝塔衰变对新物理探索和宇宙学观测的重要影响,尤其是该稀有衰变过程的实验观测在突破粒子物理学和宇宙学标准模型的前沿研究中扮演的独一无二的角色。 展开更多
关键词 无中微子双贝塔衰变 中微子质量 马约拉纳粒子 宇宙物质—反物质不对称
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空位有序双钙钛矿A2BX6的弹性和热电性质的第一性原理研究 被引量:1
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作者 Muhammad Faizan 赵国琪 +3 位作者 张天旭 王啸宇 贺欣 张立军 《物理化学学报》 SCIE CAS CSCD 北大核心 2024年第1期46-47,共2页
卤化物钙钛矿在热电应用中表现出了巨大的潜力。准确了解卤化物钙钛矿的热电传输性质对于进一步提高热电设备的应用效率至关重要。本研究采用了Perdew-Burke-Ernzerhof(PBE)和修正的Becke Johnson(mBJ)交换关联泛函探究了卤化物双钙钛矿... 卤化物钙钛矿在热电应用中表现出了巨大的潜力。准确了解卤化物钙钛矿的热电传输性质对于进一步提高热电设备的应用效率至关重要。本研究采用了Perdew-Burke-Ernzerhof(PBE)和修正的Becke Johnson(mBJ)交换关联泛函探究了卤化物双钙钛矿Rb_(2)SnI6、Rb_(2)PdI6和Cs_(2)PtI6的弹性和热电性质。通过对这些材料的力学稳定性、有效质量、塞贝克系数、功率因子和热电品质因数的研究,我们发现,这三种化合物都是力学稳定的,并且具有可塑性。这些化合物是窄带隙半导体,具有简并的带边结构,结合低的载流子有效质量使得它们具有热电应用潜力。Cs_(2)PtI6在空穴掺杂在500 K温度下可以达到0.76 mV·K^(−1)的高塞贝克系数。由于高塞贝克系数和最大功率因子,Rb_(2)SnI6、Rb_(2)PdI6和Cs_(2)PtI6在p型掺杂下具有高的热电品质因数,分别为0.91、0.96和0.98。总体而言,我们的研究为卤化物钙钛矿的热电性能提供了新的见解,为这些化合物的实验合成提供了有价值的参考。 展开更多
关键词 电子结构 有效质量 SEEBECK系数 热电品质因数 卤化物双钙钛矿
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磁铁矿矿浆的矿石质量流量检测新技术
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作者 曾理 黄宋魏 +3 位作者 田妞 陈永春 高徐辉 钟婷婷 《化工自动化及仪表》 CAS 2024年第4期607-613,共7页
针对选矿过程中强磁性磁铁矿矿浆所包含矿石质量流量难以检测的问题,在分析现有主要检测技术的基础上,结合应用现场流程的特点,创新性提出一种单流量-双浓度的矿浆质量流量检测法,通过检测流程加水的流量以及加水前后矿浆浓度的变化,实... 针对选矿过程中强磁性磁铁矿矿浆所包含矿石质量流量难以检测的问题,在分析现有主要检测技术的基础上,结合应用现场流程的特点,创新性提出一种单流量-双浓度的矿浆质量流量检测法,通过检测流程加水的流量以及加水前后矿浆浓度的变化,实现对强磁性磁铁矿矿浆所包含矿石质量流量进行精确检测。实际应用表明:该方法具有检测精度高、适应性强、稳定性好等特点,特别适用于含有磁铁矿的矿浆。 展开更多
关键词 单流量-双浓度质量流量检测法 矿石质量流量 磁铁矿矿浆 矿浆浓度 水流量
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桥式起重机分布式质量吊重系统双摆滑模控制
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作者 靳国良 孙茂凱 +3 位作者 王生海 黄哲 王丙昱 孙玉清 《机电工程》 CAS 北大核心 2024年第3期494-503,共10页
随着吊装作业的多元化发展,起重机吊装对象也从传统的质点式吊重向分布式质量吊重方向发展。针对桥式起重机在吊装分布式质量吊重时吊重的大摆角抑制和小车定位控制问题,提出了两种基于滑模控制理论的、用于吊重消摆和小车快速定位的方... 随着吊装作业的多元化发展,起重机吊装对象也从传统的质点式吊重向分布式质量吊重方向发展。针对桥式起重机在吊装分布式质量吊重时吊重的大摆角抑制和小车定位控制问题,提出了两种基于滑模控制理论的、用于吊重消摆和小车快速定位的方法。首先,综合考虑了桥式起重机吊装对象的结构特征、小车电机的驱动特性、摩擦阻力以及环境中的随机扰动对吊装作业的影响,建立了桥式起重机分布式质量吊重系统的非线性双摆动力学模型;然后,设计了桥式起重机分布式质量吊重系统的非线性双摆动力学普通滑模控制器(OSMC)和分层滑模控制器(HSMC),采用Lyapunov函数和Barbalat引理证明了闭环系统的稳定性;最后,利用数值仿真研究了OSMC和HSMC在分布式质量吊重减摆控制方面的性能差异。仿真及研究结果表明:与OSMC相比,采用HSMC不仅可以在12 s内实现小车精确定位目的,而且可以实现对分布式质量吊重在5°~9°摆动范围下的快速抑制目的,完成了对系统状态变量的有效控制;同时,对比结果表明HSMC对起重机系统内部和外部扰动变化有很强的鲁棒性和抗干扰性。 展开更多
关键词 起重机械 桥式起重机 防摆控制 分布式质量吊重 普通滑模控制器 分层滑模控制器 非线性双摆动力学模型
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鸟嘴征:环状胰腺产前超声诊断新征象
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作者 盛璇 韩厚美 +3 位作者 刘德泉 高阳 郭丹 尹虹 《中国医学影像学杂志》 CSCD 北大核心 2024年第2期162-165,167,共5页
目的分析胎儿环状胰腺(AP)产前超声表现,探讨鸟嘴征对胎儿AP的诊断价值。资料与方法回顾性分析2019年9月—2021年12月山东省妇幼保健院经产前超声诊断结合出生后手术确诊的13例胎儿AP的超声图像及临床资料,观察梗阻处十二指肠的狭窄程度... 目的分析胎儿环状胰腺(AP)产前超声表现,探讨鸟嘴征对胎儿AP的诊断价值。资料与方法回顾性分析2019年9月—2021年12月山东省妇幼保健院经产前超声诊断结合出生后手术确诊的13例胎儿AP的超声图像及临床资料,观察梗阻处十二指肠的狭窄程度,特别是肠管内壁所成夹角能否识别胎儿AP,总结并分析其超声特征。结果13例胎儿AP的产前超声图像均出现双泡征,胰腺形态失常呈钳夹征3例,十二指肠扩张末端呈鸟嘴征7例。13例患儿出生后均行手术治疗,其中2例合并十二指肠闭锁,1例合并不典型肠旋转不良,术后患儿均预后良好。结论通过观察十二指肠扩张末端及其与胰头的关系,产前超声联合鸟嘴征及双泡征可提高胎儿AP的诊断率,对产前诊断胎儿AP具有重要价值。 展开更多
关键词 胎儿环状胰腺 鸟嘴征 双泡征 超声检查 产前 胎儿
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基于高分辨液质联用的双标记氨基酸同位素丰度测定方法研究
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作者 赵雅梦 徐增益 +5 位作者 范若宁 解龙 侯静华 李良君 刘建军 雷雯 《化学试剂》 CAS 2024年第6期83-88,共6页
近年来,稳定同位素标记化合物,尤其是同位素标记氨基酸在合成生物学、蛋白质组学、代谢组学等前沿科学研究中发挥着越来越重要的作用。建立了一种基于高分辨液质联用的双标记氨基酸同位素丰度检测方法,以^(13)C_(2),^(15)N-甘氨酸为例,... 近年来,稳定同位素标记化合物,尤其是同位素标记氨基酸在合成生物学、蛋白质组学、代谢组学等前沿科学研究中发挥着越来越重要的作用。建立了一种基于高分辨液质联用的双标记氨基酸同位素丰度检测方法,以^(13)C_(2),^(15)N-甘氨酸为例,考察了样品浓度、质谱扫描张数等影响因素对同位素丰度计算结果的影响,结果表明该方法具有良好的准确性和稳定性,所需样品用量少,操作简单,有望成为一种简便、通用的同位素试剂质控方法;也将为代谢组学、海洋学等同位素示踪技术应用研究提供数据支持。 展开更多
关键词 双标记氨基酸 同位素丰度 高分辨液质联用仪 质量控制 13 C 2 15 N-甘氨酸
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Dynamics of a Quantum Dissipative System Coupled with an Oscillator
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作者 Emmanouil George Thrapsaniotis 《Journal of Applied Mathematics and Physics》 2024年第4期1472-1491,共20页
We study the dynamics of a quantum dissipative system. Besides its linear coupling with a harmonic bath modelling the dissipation, we suppose that it is coupled with an oscillator with an interaction of the form s 2 x... We study the dynamics of a quantum dissipative system. Besides its linear coupling with a harmonic bath modelling the dissipation, we suppose that it is coupled with an oscillator with an interaction of the form s 2 x 2 . In our study, we integrate over the bath and the oscillator, extract the corresponding influence functionals and then solve the system’s sign problem. We apply the theory to the case of a double well and study the time evolution of the expectation value of the position. 展开更多
关键词 double Well Harmonic Bath OSCILLATOR Influence Functional sign Solved Propagator POSITION
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页岩气开采中的压力变化与气液传质规律
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作者 卢志炜 李熙喆 +1 位作者 赵圣贤 郝有志 《力学与实践》 2024年第5期1004-1014,共11页
根据页岩气的赋存及流动机理,建立考虑页岩渗吸与吸附、渗流与扩散的流动方程,采用线段源叠加解等效为压裂产生的压力分布作为方程的初始条件,使用非结构PEBI(perpendicular bisection)网格对水平井多段压裂井进行网格划分,有限体积法... 根据页岩气的赋存及流动机理,建立考虑页岩渗吸与吸附、渗流与扩散的流动方程,采用线段源叠加解等效为压裂产生的压力分布作为方程的初始条件,使用非结构PEBI(perpendicular bisection)网格对水平井多段压裂井进行网格划分,有限体积法进行离散。利用高频压力监测的闷井压力数据验证了算法程序的可靠性。研究得出以下结果:(1)发现页岩气开发的压力双漏斗及气液双向传质流动规律;(2)依据这一规律给出页岩气压最佳闷井时间和最优排采制度。 展开更多
关键词 页岩气排采 PEBI(perpendicular bisection)网格 压力双漏斗 气液双向传质 高频压力监测
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肌肉骨骼超声对痛风诊断价值的Meta分析
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作者 从惠琴 曾鸽 《浙江实用医学》 2024年第4期304-310,共7页
目的 肌肉骨骼超声(musculoskeletal ultrasound,MSUS)广泛用于痛风的诊断,但其准确性仍存在争议。本研究通过Meta分析定量评估MSUS在痛风诊断中的价值。方法 系统性检索和收集截至2023年1月在PubMed、Embase、Web of science、Cochrane... 目的 肌肉骨骼超声(musculoskeletal ultrasound,MSUS)广泛用于痛风的诊断,但其准确性仍存在争议。本研究通过Meta分析定量评估MSUS在痛风诊断中的价值。方法 系统性检索和收集截至2023年1月在PubMed、Embase、Web of science、Cochrane Library、中国知网、万方和维普数据库发表的MSUS诊断痛风的临床试验文献。对文献进行异质性检验和质量评价,合并效应量,绘制ROC曲线并进行综合分析,并按照检查的关节数量和检查诊断者的专业进行亚组分析。结果 共纳入18篇文献,其中痛风1434例,对照组1236例。汇总合并MSUS双轨征诊断痛风的敏感度为74%、特异度为86%、阳性似然比为4.85、阴性似然比为0.30、诊断比值比为16.17,AUC为0.8752,Cochran Q指数为0.8057。亚组分析结果显示,增加检查关节数量(≤5个vs.>5个)、风湿科和超声医生共同检查和诊断,敏感度和特异度无显著性改变。结论 对已发表研究的Meta分析表明,MSUS在痛风的诊断中敏感度和特异度较高,具有良好的准确性。 展开更多
关键词 痛风 肌肉骨骼超声 诊断 双轨征 META分析
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不饱和脂质氮杂环丙烷化反应中间体的原位质谱分析
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作者 陈凯祥 魏是奇 陈素明 《质谱学报》 EI CSCD 北大核心 2024年第1期149-156,I0005,共9页
脂质结构决定生物功能,对不饱和脂质C C双键异构体的鉴定面临着挑战。直接的氮-甲基(N-Me)氮杂环丙烷化反应可以对不饱和脂质双键进行衍生,通过与串联质谱结合可实现不饱和脂质双键位置的解析。然而,目前N-Me氮杂环丙烷化反应机理研究... 脂质结构决定生物功能,对不饱和脂质C C双键异构体的鉴定面临着挑战。直接的氮-甲基(N-Me)氮杂环丙烷化反应可以对不饱和脂质双键进行衍生,通过与串联质谱结合可实现不饱和脂质双键位置的解析。然而,目前N-Me氮杂环丙烷化反应机理研究尚缺乏中间过程的直接证据。本工作采用一种基于θ毛细管的纳升静电喷雾离子化质谱(nESTASI-MS)分析装置,研究不饱和磷脂酰胆碱的氮杂环丙烷化反应过程,捕获并鉴定了反应过程中的关键中间体,为阐明氮杂环丙烷化反应机理提供了直接证据。 展开更多
关键词 质谱(MS) 化学反应中间体 氮杂环丙烷化反应 双键位置鉴定
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