Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

Attack on Optical Double Random Phase Encryption Based on the Principle of Ptychographical Imaging

The principle of ptychography is applied in known plain text attack on the double random phase encoding （DRPE） system. We find that with several pairs of plain texts and cipher texts, the model of attack on DRPE can be converted to the model of ptyehographical imaging. Owing to the inherent merits of the ptyehographical imaging, the DRPE system can be breached totally in a fast and nearly perfect way, which is unavailable for currently existing attack methods. Further, since the decryption keys can be seen as an object to be imaged from the perspective of imaging, the ptychographical technique may be a kind of new direction to further analysis of the security of other encryption systems based on double random keys.

Antibiotics for lower respiratory tract infection in children presenting in primary care in England (ARTIC PC): a double-blind, randomised, placebo-controlled trial

Methods:ARTIC PC was a double-blind,randomised,placebo-controlled trial done at 56 general practices in England.Eligible children were those aged 6 months to 12 years presenting in primary care with acute uncomplicated LRTI judged to be infective in origin,where pneumonia was not suspected clinically,with symptoms for less than 21 days.Patients were randomly assigned in a 1:1 ratio to receive amoxicillin 50 mg/kg per day or placebo oral suspension,in three divided doses orally for 7 days.Patients and investigators were masked to treatment assignment.The primary outcome was the duration of symptoms rated moderately bad or worse(measured using a validated diary)for up to 28 days or until symptoms resolved.The primary outcome and safety were assessed in the intention-to-treat population.The trial is registered with the ISRCTN Registry(ISRCTN79914298).

Thermal stability and data retention of resistive random access memory with HfOx/ZnO double layers

As an industry accepted storage scheme, hafnium oxide（HfO_x） based resistive random access memory（RRAM）should further improve its thermal stability and data retention for practical applications. We therefore fabricated RRAMs with HfO_x/ZnO double-layer as the storage medium to study their thermal stability as well as data retention. The HfO_x/ZnO double-layer is capable of reversible bipolar switching under ultralow switching current（〈 3 μA） with a Schottky emission dominant conduction for the high resistance state and a Poole–Frenkel emission governed conduction for the low resistance state. Compared with a drastically increased switching current at 120℃ for the single HfO_x layer RRAM, the HfO_x/ZnO double-layer exhibits excellent thermal stability and maintains neglectful fluctuations in switching current at high temperatures（up to 180℃）, which might be attributed to the increased Schottky barrier height to suppress current at high temperatures. Additionally, the HfO_x/ZnO double-layer exhibits 10-year data retention @85℃ that is helpful for the practical applications in RRAMs.

Modeling and Analysis of a Random Excited Double-Clamped Piezoelectric Energy Harvester

A double-clamped piezoelectric energy harvester subjected to random excitation is presented,for which corresponding analytical model is established to predict its output characteristics.With the presented theoretical natural frequency and equivalent stiffness of vibrator,the closed-form expressions of mean power and voltage acquired from the double-clamped piezoelectric energy harvester under random excitation are derived.Finally theoretical analysis is conducted for the output performance of the doubleclamped energy harvester with the change of spectrum density（SD）of acceleration,load resistance,piezoelectric coefficient and natural frequency value,which is found to closely agree with Monte Carlo simulation and experimental results.

The Efficacy and Safety of a Patent Pending Combination of Ginger and Goldenrod Extracts on the Management of Cold Symptoms: A Randomized, Double-Blind Controlled Trial

Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in community-dwelling adults was compared to a combination of standardized amounts of Echinacea (EC) components. Methods: 44 healthy adults, experiencing new onset of cold symptoms were randomly assigned to receive either BDI-630 (900 mg) or EC (500 mg) twice daily for 10 days. The severity of cold symptoms and the quality of life was assessed by self-reporting of subjects using the Wisconsin Upper Respiratory Symptom Survey (WURSS-21? 2004). Results: The intent-to-treat population (ITT) consisted of 44 subjects (n = 22 for BDI-630;n = 22 for EC). The modified ITT (mITT) population consisted of 40 subjects, excluding four subjects with major protocol deviations related to inclusion/exclusion criteria and/or use of prohibited drugs from the efficacy analysis (n = 3 for BDI-630 and n = 1 for EC). Results indicated a sig-nificant difference between the two groups: the superiority of BDI-630 over EC was particularly noticeable between Day 1 and Day 7, as demonstrated by a 14-fold difference of the mean percentage of change of total score from baseline in the mITT population. Adverse events (AEs) following the intake of BDI-630 were mostly limited to mild gastrointestinal intolerance in less than 10% of the subjects. Conclusions: BDI-630 was shown to be more effective than EC in alleviating cold symptoms in the adult population, particularly during the first 7 days of treatment. BDI-630 was very well tolerated by all subjects.

Effects of Depth of Needle Insertion with Risperidone Long-Acting Injectable in Persons with Schizophrenia: A Randomized Double-Blind Study

In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is deeper than anticipated, needle penetration may cause damage to nerves, arteries and veins. Few clinical studies were done to evaluate the depth of needle length insertion reaching the intended gluteal muscle. The aim of this study was to evaluate the suitable depth of injecting RLAI. Twenty-six patients with schizophrenia were treated with RLAI, and randomly divided into two groups: 50 mm needle inserted group (Group-D, deep insertion, n = 13) and 20 mm needle insertion group (Group-S, shallow insertion, n = 13). For Group-S, the needle length was marked with a spacer at exactly 20 mm. Injections were performed by the psychiatrist or nurse, alternating between the two gluteal sites by double-cross method every two weeks. Clinical psychotic symptoms and injection site reactions were recorded throughout the study period. Experienced psychologists who were blinded from the needle-length experimental variable evaluated patients’ psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS) every two weeks. The plasma 9-hydroxyrisperidone (9-OH-RIS) concentrations were measured every two weeks;comparison data were determined on the 8th week and the 14th week. No significant difference was observed in 9-OH-RIS concentrations, psychotic symptoms, injection site skin reactions of subjects in both groups. However, in Group-D, injection site adverse reactions were confirmed in two subjects (15%). In Group-S, injection site reactions were confirmed in six subjects (46%). Although effective 9-OH-RIS concentrations were obtained with the insertion using both depth, it was concluded that the 50 mm insertion length was more suitable for dorsogluteal IM injections in adult patients with schizophrenia as demonstrated by the incidence of local adverse skin reactions.

Evaluation of Harvest Aid Chemicals for the Cotton-Winter Wheat Double Cropping System

Timing of harvest is critical for mechanical picking in cotton production, especially in those regions with double cropping system. Appropriate and safe harvest aids will improve timing and facilitate harvest of cotton in the double cropping system. Three defoliants （dimethipin, thidiazuron, and thidiazuron-diuron） and one boll opener （ethephon） were included in this research. They were evaluated for their effects on defoliation, boll opening, seedcotton yield, seed quality, and fiber quality of field grown cotton when used alone or as a mixture in 2009 and 2010. Defoliation and/or boll opening were increased by all three defoliants and ethephon, especially by mixtures of a defoliant and ethephon. First harvest of seedcotton was significantly increased with defoliant-ethephon mixtures. No significant adverse effects were observed on boll weight, lint percentage, seed quality, and fiber properties. It was estimated that tank mixes of ethephon and one of the three defoliants can improve the adjusted gross revenue. Boll opening can be used as an alternative indicator for the adjusted gross revenue, because, it was linearly and positively correlated with the relative adjusted gross revenue and convenient in measurements. Wheat seedling growth was not affected by thidiazuron, whereas its seedling emergence, root dry weight, relative water content, and electrolyte leakage were adversely affected by dimethipin and thidiazuron- diuron when concentration was above 340 and 100 g （a.i.） ha-1, respectively. 90% defoliation and 80% boll opening were observed with the high rate of thidiazuron-ethephon mixture, but no adverse effects on winter wheat. The results suggested that tank mixes of ethephon with thidiazuron can be used effectively and safely in the cotton-winter wheat double cropping system to improve yield without adverse effects on seed quality and fiber quality.

Double Conditional Expectation

The concept of double conditional expectation is introduced. A series of properties for the double conditional expectation are obtained several convergence theorems and Jensen inequality are proved. Finally we discuss the special cases and application for double conditional expectation. Key words double conditional expectation - covergence theorem - Jensen inequality - branching chain in random environment CLC number O 211.6 Foundation item: Supported by the National Science Foundation of China (10371092) and the Foundation of Wuhan UniversityBiography: HU Di-he (1935-), male, Professor, research direction: stochastic processes and random fractals.

Double Encryption Using Trigonometric Chaotic Map and XOR of an Image

In the most recent decades,a major number of image encryption plans have been proposed.The vast majority of these plans reached a highsecurity level;however,their moderate speeds because of their complicated processes made them of no use in real-time applications.Inspired by this,we propose another efficient and rapid image encryption plan dependent on the Trigonometric chaotic guide.In contrast to the most of current plans,we utilize this basic map to create just a couple of arbitrary rows and columns.Moreover,to additionally speed up,we raise the processing unit from the pixel level to the row/column level.The security of the new plot is accomplished through a substitution permutation network,where we apply a circular shift of rows and columns to break the solid connection of neighboring pixels.At that point,we join the XOR operation with modulo function to cover the pixels values and forestall any leaking of data.High-security tests and simulation analyses are carried out to exhibit that the scheme is very secure and exceptionally quick for real-time image processing at 80 fps(frames per second).

Stochastic period-doubling bifurcation analysis of a Rssler system with a bounded random parameter

This paper aims to study the stochastic period-doubling bifurcation of the three-dimensional Rossler system with an arch-like bounded random parameter. First, we transform the stochastic RSssler system into its equivalent deterministic one in the sense of minimal residual error by the Chebyshev polynomial approximation method. Then, we explore the dynamical behaviour of the stochastic RSssler system through its equivalent deterministic system by numerical simulations. The numerical results show that some stochastic period-doubling bifurcation, akin to the conventional one in the deterministic case, may also appear in the stochastic Rossler system. In addition, we also examine the influence of the random parameter intensity on bifurcation phenomena in the stochastic Rossler system.

Averaging in SU(2) open quantum random walk

We study the average position and the symmetry of the distribution in the SU（2） open quantum random walk （OQRW）. We show that the average position in the central limit theorem （CLT） is non-uniform compared with the average position in the non-CLT. The symmetry of distribution is shown to be even in the CLT.

Double Autocorrelation in Two Way Error Component Models

In this paper, we extend the works by [1-5] accounting for autocorrelation both in the time specific effect as well as the remainder error term. Several transformations are proposed to circumvent the double autocorrelation problem in some specific cases. Estimation procedures are then derived.

L-Moments Based Calibrated Variance Estimators Using Double Stratified Sampling

Variance is one of the most vital measures of dispersion widely employed in practical aspects.A commonly used approach for variance estimation is the traditional method of moments that is strongly influenced by the presence of extreme values,and thus its results cannot be relied on.Finding momentum from Koyuncu’s recent work,the present paper focuses first on proposing two classes of variance estimators based on linear moments(L-moments),and then employing them with auxiliary data under double stratified sampling to introduce a new class of calibration variance estimators using important properties of L-moments(L-location,L-cv,L-variance).Three populations are taken into account to assess the efficiency of the new estimators.The first and second populations are concerned with artificial data,and the third populations is concerned with real data.The percentage relative efficiency of the proposed estimators over existing ones is evaluated.In the presence of extreme values,our findings depict the superiority and high efficiency of the proposed classes over traditional classes.Hence,when auxiliary data is available along with extreme values,the proposed classes of estimators may be implemented in an extensive variety of sampling surveys.

Stochastic period-doubling bifurcation in biharmonic driven Duffing system with random parameter

Stochastic period-doubling bifurcation is explored in a forced Duffing system with a bounded random parameter as an additional weak harmonic perturbation added to the system. Firstly, the biharmonic driven Duffing system with a random parameter is reduced to its equivalent deterministic one, and then the responses of the stochastic system can be obtained by available effective numerical methods. Finally, numerical simulations show that the phase of the additional weak harmonic perturbation has great influence on the stochastic period-doubling bifurcation in the biharmonic driven Duffing system. It is emphasized that, different from the deterministic biharmonic driven Duffing system, the intensity of random parameter in the Duffing system can also be taken as a bifurcation parameter, which can lead to the stochastic period-doubling bifurcations.

APPROXIMATION RATES OF ERROR DISTRIBUTION OF DOUBLE KERNEL ESTIMATES OF CONDITIONAL DENSITY

In this paper, the normal approximation rate and the random weighting approximation rate of error distribution of the kernel estimator of conditional density function f(y|x) are studied. The results may be used to construct the confidence interval of f(y|x) .

应用OpenSees计算双钢管高强砼柱的水平力—位移滞回曲线

应用OpenSees计算外方内圆复合钢管高强混凝土柱(简称双钢管高强混凝土柱)的水平力—位移滞回曲线。分析了双钢管高强混凝土柱的单元和截面纤维划分。钢管材料采用双线性模型Steel02,混凝土模型采用Concrete02,圆钢管内和钢管之间的混凝土采用Susantha模型,考虑钢管对混凝土的约束作用,计算得到的水平力—位移滞回曲线与试验结果符合较好。在此基础上,应用OpenSees对双钢管高强混凝土柱进行参数影响分析,讨论了轴压比、方钢管壁厚(宽厚比)、径宽比、径厚比对双钢管高强混凝土柱抗震性能的影响。结果表明:增大轴压比,延性降低;增大方钢管壁厚(减小宽厚比),水平承载力增大;增大圆钢管直径和壁厚,有助于提高双钢管高强混凝土柱的竖向和水平承载力能力,增大耗能能力。

Some Mean Convergence Theorems for the Maximum of Normed Double Sums of Banach Space Valued Random Elements

In this correspondence,we establish mean convergence theorems for the maximum of normed double sums of Banach space valued random elements.Most of the results pertain to random elements which are M-dependent.We expand and improve a number of particular cases in the literature on mean convergence of random elements in Banach spaces.One of the main contributions of the paper is to simplify and improve a recent result of Li,Presnell,and Rosalsky[Journal of Mathematical Inequalities,16,117–126(2022)].A new maximal inequality for double sums of M-dependent random elements is proved which may be of independent interest.The sharpness of the results is illustrated by four examples.

The investigation of DARC etch back in DRAM capacitor oxide mask opening

Opening the silicon oxide mask of a capacitor in dynamic random access memory is a critical process on a capacitive coupled plasma(CCP)etch tool.Three steps,dielectric anti-reflective coating(DARC)etch back,silicon oxide etch and strip,are contained.To acquire good performance,such as low leakage current and high capacitance,for further fabricating capacitors,we should firstly optimize DARC etch back.We developed some experiments,focusing on etch time and chemistry,to evalu-ate the profile of a silicon oxide mask,DARC remain and critical dimension.The result shows that etch back time should be con-trolled in the range from 50 to 60 s,based on the current equipment and condition.It will make B/T ratio higher than 70%mean-while resolve the DARC remain issue.We also found that CH_(2)F_(2) flow should be~15 sccm to avoid reversed CD trend and keep in-line CD.

Chinese herbal medicine Xinfeng Capsule in treatment of rheumatoid arthritis:study protocol of a multicenter randomized controlled trial

BACKGROUND： Rheumatoid arthritis （RA）, as a common systemic inflammatory autoimmune disease, affects approximately 1 in 100 individuals. Effective treatment for RA is not yet available because current research does not have a clear understanding of the etiology and pathogenesis of RA. Xinfeng Capsule, a patent Chinese herbal medicine, has been used in the treatment of RA in recent years. Despite its reported clinical efficacy, there are no large-sample, multicenter, randomized trials that support the use of Xinfeng Capsule for RA. Therefore, we designed a randomized, double-blind, multicenter, placebo-controlled trial to assess the efficacy and safety of Xinfeng Capsule in the treatment of RA. METHODS AND DESIGN： This is a 12-week, randomized, placebo-controlled, double-blind, multicenter trial on the treatment of RA. The participants will be randomly assigned to the experimental group and the control group at a ratio of 1：1. Participants in the experimental group will receive Xinfeng Capsule and a pharmaceutical placebo （imitation leflunomide）. The control group will receive leflunomide and an herbal placebo （imitation Xinfeng Capsule）. The American College of Rheumatology （ACR） Criteria for RA will be used to measure the efficacy of the Xinfeng Capsule. The primary outcome measure will be the percentage of study participants who achieve an ACR 20% response rate （ACR20）, which will be measured every 4 weeks after randomization. Secondary outcomes will include the ACR50 and ACR70 responses, the side effects of the medications, the Disease Activity Score 28, RA biomarkers, quality of life, and X-rays of the hands and wrists. The first four of the secondary outcomes will be measured every 4 weeks and the others will be measured at baseline and after 12 weeks of treatment. DISCUSSION： The result of this trial will help to evaluate whether Xinfeng Capsule is effective and safe in the treatment of RA. TRIAL REGISTRATION： This trial has been registered in ClinicalTrials.gov. The identifier is N CT01774877.