BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and co...BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)analysis.METHODS Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and cognition.In this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger methods.Additionally,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on cognition.IVW served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger methods.RESULTS In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger analyses.MR-Egger regression revealed pleiotropy in the impact of worrier/anxious feelings on cognition,presenting a challenge in identifying the effect.Notably,this study did not demonstrate any significant impact of guilty feelings,nervous feelings,miserableness,or loneliness/isolation on cognition.Due to a limited number of instrumental variables for happiness,this study was unable to analyze the relationship between happiness and cognition.CONCLUSION This MR study finds that sensitivity/hurt feelings are associated with cognitive decline,while the link between worrier/anxious feelings and cognition remains inconclusive.Insufficient evidence supports direct associations between happiness,guilty feelings,nervous feelings,miserableness,loneliness/isolation,and cognition.展开更多
Synaesthesia is both a common daily life phenomenon and a controversial rhetoric one.Respective evidence may be found in 'Wounded fingers may cause pain in heart' and 'The breeze blows away birds' swee...Synaesthesia is both a common daily life phenomenon and a controversial rhetoric one.Respective evidence may be found in 'Wounded fingers may cause pain in heart' and 'The breeze blows away birds' sweet voice from under the flower'.Other examples,like 'the liquid stillness of the night,noise color,sweet voice,icy look,sharp cry,sour remark,oily-tongued…' are so frequently seen in both Chinese and foreign poems especially classic poems.Without doubt,use of synaesthesia blows a fresh air into essay and poem writing,let alone the accurate and aesthetic feelings it arouses among readers.However,when people try to find out the reason why it can arouse such aesthetic feelings,they seem to encounter difficulties.This paper makes an attempt to offer a different explanation based on psychological analysis.展开更多
Recently, the demand of services for architectural space is more increasing due to the diversification and complication of people＇s needs. In this research, it is assumed that the robot will support people＇s various...Recently, the demand of services for architectural space is more increasing due to the diversification and complication of people＇s needs. In this research, it is assumed that the robot will support people＇s various needs and people＇s lives in the near future. In this study, the authors investigated the relationship between a robot and a person in quasi space close to actual life space. The authors carried out an experiment to clarify the feelings of worriment due to a robot in the living room in the case of Japanese males. This research aims to establish architecture techniques for robots and humans living together. In this experiment, the robot approached a male sitting on a sofa in quasi space. At different distances between the robot and the male, the subject evaluated his feelings of worriment from ＂no worriment＂ to ＂worriment＂ in five steps from one to five. The robot used in this experiment is middle-sized （380 mm （L） × 380 mm （W） × 350 mm （H））. In this experiment, it is considered that the robot asks for help outside when an emergency occurs. In this experiment, the authors had three situations for the subject： watching television, reading a magazine and just sitting.展开更多
Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect...Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect the health of employees. My study aims are to improve negative feelings in work place and work functioning and to stimulate better coping mechanisms. Participants were collected from “Mental health daycare facility”, “Regional living assistance center” and “B-type employment assistance office” in Japan. I took interviews with 25 members. The content of the interviews was categorized about negative feelings in work place. A total of 33 small category negative feelings of mental disorder were extracted and were classified into 11 subcategories. These subcategories were then classified into two higher-level categories: inward-directed feelings and outward-directed feelings. Inward-directed feelings include “reserve or timidity,” “hesitation about being open about the illness,” “anxiety about being dismissed,” “regrets about resigning,” “sense of isolation,” “feelings of remorse,” and “suffering.” Outward-directed feelings include “failure in interpersonal relationships,” “distrust,” “frustrations,” “negative feelings toward those with mental disorder.” Employment has been linked to having better social networks, to enhanced quality of life and to overall wellbeing. We will have to defend them legally. The legal and moral obligations placed on the employer require that it provides a healthy, harassment-free work environment.展开更多
Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental b...Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental burden placed on families raising severely disabled children, particularly the primary caregivers, is great in home settings. For families to effectively utilize services and over-come child rearing problems, the families themselves need the “strength” to cooperate with others for the purpose of raising a severely disabled child. The ultimate goal of family support is to enable such families to achieve satisfaction and self-growth in child rearing. Methods: We used a questionnaire to survey 75 primary caregivers to empirically elucidate the empowerment and positive feelings towards child rearing of families raising children with severe motor and intellectual disabilities and the related factors. The t-test and Spearman’s rank correlation coefficient were used to examine the association with bivariates. A multiple regression analysis was conducted for empowerment and positive feelings. Results: Results revealed that life events, livelihood, awareness of social support and the child’s sleep problems were factors related to empowerment. Of these, awareness of social support from outside of the family was found to contribute the most to empowerment. Furthermore, improvement and maintenance of positive feelings towards child rearing reaffirmed the existence of empowerment in addition to reducing negative feelings towards child rearing and ensuring social support. Conclusions: Raising children with severe motor and intellectual disabilities requires specialist knowledge and skills. Support from professionals to empower the entire family is therefore important in order to strengthen positive feelings towards child rearing.展开更多
For centuries, the question of how a physical structure (the brain) generates the subjective feeling of consciousness has plagued neuroscientists, physiologists, psychologists, linguists, and philosophers. This has be...For centuries, the question of how a physical structure (the brain) generates the subjective feeling of consciousness has plagued neuroscientists, physiologists, psychologists, linguists, and philosophers. This has become known as the “hard problem of consciousness” and has been the subject of many publications. Although lots of answers have been proposed, none has been completely satisfactory. The focus of most of these studies has been on the neuronal structures and activities. Experiential consciousness emerges from neural processes, but it has not been explained with models that have been based solely on the electro-mechanical aspects of the processes. There must be some other dynamic features of neuronal activity to explain the emergence of experiential consciousness. I argue that a likely answer to the dilemma resides in the added dimension of the neurochemistry of the brain that has, so far, received little attention.展开更多
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.展开更多
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine. NRR publishes original contributions written by experts and leaders in the fields of neuroanatomy, pathology, physiology, biochemistry, pharmacology, immunology, and auxanology approaches to examine neural regeneration research;展开更多
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.展开更多
The latest research achievements will be presented in each periodical, including articles concerning cerebral structure and function, spinal structure and function, and peripheral nerve structure and function.
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve ceils and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve ceils and tissue elements during development and disease. The joumal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.展开更多
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and展开更多
The latest research achievements will be presented in each periodical, including articles concerning cerebral structure and function, spinal structure and function, and peripheral nerve structure and function.
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineeringand neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.展开更多
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysioiogical changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.展开更多
In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements duri...In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.展开更多
The latest research achievements will be presented in each periodical, including articles conceming cerebral structure and function, spinal structure and function, and peripheral nerve structure and function.
文摘BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)analysis.METHODS Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and cognition.In this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger methods.Additionally,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on cognition.IVW served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger methods.RESULTS In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger analyses.MR-Egger regression revealed pleiotropy in the impact of worrier/anxious feelings on cognition,presenting a challenge in identifying the effect.Notably,this study did not demonstrate any significant impact of guilty feelings,nervous feelings,miserableness,or loneliness/isolation on cognition.Due to a limited number of instrumental variables for happiness,this study was unable to analyze the relationship between happiness and cognition.CONCLUSION This MR study finds that sensitivity/hurt feelings are associated with cognitive decline,while the link between worrier/anxious feelings and cognition remains inconclusive.Insufficient evidence supports direct associations between happiness,guilty feelings,nervous feelings,miserableness,loneliness/isolation,and cognition.
文摘Synaesthesia is both a common daily life phenomenon and a controversial rhetoric one.Respective evidence may be found in 'Wounded fingers may cause pain in heart' and 'The breeze blows away birds' sweet voice from under the flower'.Other examples,like 'the liquid stillness of the night,noise color,sweet voice,icy look,sharp cry,sour remark,oily-tongued…' are so frequently seen in both Chinese and foreign poems especially classic poems.Without doubt,use of synaesthesia blows a fresh air into essay and poem writing,let alone the accurate and aesthetic feelings it arouses among readers.However,when people try to find out the reason why it can arouse such aesthetic feelings,they seem to encounter difficulties.This paper makes an attempt to offer a different explanation based on psychological analysis.
文摘Recently, the demand of services for architectural space is more increasing due to the diversification and complication of people＇s needs. In this research, it is assumed that the robot will support people＇s various needs and people＇s lives in the near future. In this study, the authors investigated the relationship between a robot and a person in quasi space close to actual life space. The authors carried out an experiment to clarify the feelings of worriment due to a robot in the living room in the case of Japanese males. This research aims to establish architecture techniques for robots and humans living together. In this experiment, the robot approached a male sitting on a sofa in quasi space. At different distances between the robot and the male, the subject evaluated his feelings of worriment from ＂no worriment＂ to ＂worriment＂ in five steps from one to five. The robot used in this experiment is middle-sized （380 mm （L） × 380 mm （W） × 350 mm （H））. In this experiment, it is considered that the robot asks for help outside when an emergency occurs. In this experiment, the authors had three situations for the subject： watching television, reading a magazine and just sitting.
文摘Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect the health of employees. My study aims are to improve negative feelings in work place and work functioning and to stimulate better coping mechanisms. Participants were collected from “Mental health daycare facility”, “Regional living assistance center” and “B-type employment assistance office” in Japan. I took interviews with 25 members. The content of the interviews was categorized about negative feelings in work place. A total of 33 small category negative feelings of mental disorder were extracted and were classified into 11 subcategories. These subcategories were then classified into two higher-level categories: inward-directed feelings and outward-directed feelings. Inward-directed feelings include “reserve or timidity,” “hesitation about being open about the illness,” “anxiety about being dismissed,” “regrets about resigning,” “sense of isolation,” “feelings of remorse,” and “suffering.” Outward-directed feelings include “failure in interpersonal relationships,” “distrust,” “frustrations,” “negative feelings toward those with mental disorder.” Employment has been linked to having better social networks, to enhanced quality of life and to overall wellbeing. We will have to defend them legally. The legal and moral obligations placed on the employer require that it provides a healthy, harassment-free work environment.
文摘Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental burden placed on families raising severely disabled children, particularly the primary caregivers, is great in home settings. For families to effectively utilize services and over-come child rearing problems, the families themselves need the “strength” to cooperate with others for the purpose of raising a severely disabled child. The ultimate goal of family support is to enable such families to achieve satisfaction and self-growth in child rearing. Methods: We used a questionnaire to survey 75 primary caregivers to empirically elucidate the empowerment and positive feelings towards child rearing of families raising children with severe motor and intellectual disabilities and the related factors. The t-test and Spearman’s rank correlation coefficient were used to examine the association with bivariates. A multiple regression analysis was conducted for empowerment and positive feelings. Results: Results revealed that life events, livelihood, awareness of social support and the child’s sleep problems were factors related to empowerment. Of these, awareness of social support from outside of the family was found to contribute the most to empowerment. Furthermore, improvement and maintenance of positive feelings towards child rearing reaffirmed the existence of empowerment in addition to reducing negative feelings towards child rearing and ensuring social support. Conclusions: Raising children with severe motor and intellectual disabilities requires specialist knowledge and skills. Support from professionals to empower the entire family is therefore important in order to strengthen positive feelings towards child rearing.
文摘For centuries, the question of how a physical structure (the brain) generates the subjective feeling of consciousness has plagued neuroscientists, physiologists, psychologists, linguists, and philosophers. This has become known as the “hard problem of consciousness” and has been the subject of many publications. Although lots of answers have been proposed, none has been completely satisfactory. The focus of most of these studies has been on the neuronal structures and activities. Experiential consciousness emerges from neural processes, but it has not been explained with models that have been based solely on the electro-mechanical aspects of the processes. There must be some other dynamic features of neuronal activity to explain the emergence of experiential consciousness. I argue that a likely answer to the dilemma resides in the added dimension of the neurochemistry of the brain that has, so far, received little attention.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine. NRR publishes original contributions written by experts and leaders in the fields of neuroanatomy, pathology, physiology, biochemistry, pharmacology, immunology, and auxanology approaches to examine neural regeneration research;
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.
文摘The latest research achievements will be presented in each periodical, including articles concerning cerebral structure and function, spinal structure and function, and peripheral nerve structure and function.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve ceils and tissue elements during development and disease. The joumal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and
文摘The latest research achievements will be presented in each periodical, including articles concerning cerebral structure and function, spinal structure and function, and peripheral nerve structure and function.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineeringand neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysioiogical changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.
文摘In 2009, NRR will emphasis on novel findings in the mechanism research of nerve cells and tissue regeneration, involved in structure change, interactions and specific properties of nerve cells and tissue elements during development and disease. The journal has focused on research concerning the histomorphological changes of nerve cells, neural tissue engineering and neurodegeneration, and also the pathophysiological changes during nerve cells and tissue regeneration with treatment of traditional Chinese medicine.
文摘The latest research achievements will be presented in each periodical, including articles conceming cerebral structure and function, spinal structure and function, and peripheral nerve structure and function.
