The US administration's foreign policy embodies the strategic framework of great power competition,the slogan of“America First,”and fragmented decision-making.An alignment of factors such as the response to chan...The US administration's foreign policy embodies the strategic framework of great power competition,the slogan of“America First,”and fragmented decision-making.An alignment of factors such as the response to changes in international and domestic environments,the reconstruction of US national identity,the electoral political pressure that Donald Trump faces,and the confluence of Trump and establishment elites creates complex outcomes.Inherently political and partisan,Trump's foreign policy may already have had some irreversible negative impacts,and it is certain that US foreign strategy and policy have entered a major directional adjustment phase.展开更多
The Biden administration’s political platform,set during the 2020 US presidential campaign,called for"a foreign policy for the middle class"and this has subsequently been instituted as a policy commitment.T...The Biden administration’s political platform,set during the 2020 US presidential campaign,called for"a foreign policy for the middle class"and this has subsequently been instituted as a policy commitment.The new administration’s economic and trade policy targets enhancing US competitiveness,setting rules for economic globalization and keeping good relations with democratic states.Security policy emphasizes diplomatic means over military practices.The foreign policy for the middle class aims to resolve differences in the Democratic Party between traditional Democrats and progressives.It is also crafted to solve domestic and international problems and burnish America’s international image,but it faces an uphill battle if it wishes to restructure foreign policy to serve the needs of the American middle class.展开更多
BACKGROUND: Expression of Fos in neurons of periaqueductal gray (PAG) is used to reflect the excitability. However, changes of expression of Fos in neurons of PAG are caused by injured electrostimulation after simu...BACKGROUND: Expression of Fos in neurons of periaqueductal gray (PAG) is used to reflect the excitability. However, changes of expression of Fos in neurons of PAG are caused by injured electrostimulation after simulated weightlessness, and the relationship between pretreatment and injection of succinylcholine has not been determined yet. OBJECTIVE : To investigate the changes of expression of Fos in PAG induced by injured electrostimulation pretreatment and injection of succinylcholine at 2 weeks after simulated weightlessness.DESIGN: Observational and controlled animal study.SETTING: Department of Physiology, Medical School, Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education. MATERIALS: A total of 24 adult female SD rats, of clean grade and weighing 180-220 g, were selected in this study. METHODS: The experiment was completed in the Experimental Animal Center of Xi'an Jiaotong University.① All rats were randomly divided into 2 groups according to body mass: simulated weightlessness group and control group with 12 in each group. And then, each group was also divided into 3 subgroups: electrostimulation group, succinylcholine-pretreatment group and succinylcholine-injection group with 4 in each subgroup. ②The model of weightlessness was simulated by tail-suspended female rats, which were described and modified by Cheng Jie. Rats in normal control group were given the same interventions as simulated weightlessness group except for tail-suspended. ③ Experimental method: The rats in electrostimulation group were given nociceptive stimulus by a pair of subcutaneous electrodes inserted into 1 and 5 claw of left hindlimb. The stimulus (current: 10 mA; duration: 1 ms; interval: 1 s) lasted for 30 minutes. The rats in succinylcholine-pretreatment group received stimulus after intravenous administration of succinylcholine, rats in succinylcholine-injection group were not given stimulus, just received succinylcholine. ④ All rats were perfused and fixed after 2 hours from the end of stimulation. The brains were removed, and serial frozen sections of midbrain were stained using immunocytochemical method, observed and taken photos under light-microscope. The number and morphological characters of Fos-immunoreactive (Fos-IR) neurons in ventrolateral part of PAG were investigated. MAIN OUTCOME MEASURES: The alterations in number and morphological characters of Fos-IR neurons in ventrolateral PAG of all rats.RESULTS: A total of 24 rats were involved in the final analysis. ① The morphological changes of Fos-IR neurons: The expressions of Fos in ventrolateral part of PAG were observed in both control and simulated weightlessness groups rats after being given nociceptive stimulus. As compared with control group, Fos-IR neurons in simulated weightlessness group were dyed lightly, cellular integrity was impaired, and cellular verge was unclear. ② The numbers of Fos-IR neurons: In control group, the numbers of Fos-IR neurons in ventrolateral part of PAG in simulated weightlessness group were obviously lower than succinylcholine-pretreatment group, but obviously higher than succinylcholine-injection group (46.94±3.38, 71.06±8.96 and 35.04±4.62, respectively, P 〈 0.05). In 14-day simulated weightlessness group, the numbers of Fos-IR neurons in electrostimulation group were also obviously lower than succinylcholine-pretreatment group, and obviously higher than succinylcholine-injection group (27.77±3.27, 32.91±2.99 and 11.75±1.00, respectively, P 〈 0.05). The numbers of Fos-IR neurons in all subgroups in control group were obviously higher than those subgroups in simulated weightlessness group. Compared with electrostimulation group, the percentage of expression of Fos in ventrolateral part of PAG responsed to nociceptive stimulus after administration of succinylcholine (SCH) was increased to 51.83% in control group and 18.51% in simulated weightlessness group.CONCLUSION :① The expression of Fos in neurons in ventrolateral part of PAG were increased by the pretreatment of SCH before nociceptive stimulus.② Nociceptive stimulus could increase the expression of Fos in neurons in ventrolateral part of PAG. ③ The numbers of Fos-IR neurons in ventrolateral part of PAG were decreased obviously after 2-week simulated weightlessness.展开更多
With Shinzo Abe's re-election as the president of Japan's Liberal Democratic Party (LDP), the LDP regime appears to have entered on a stable trend of long-term governance. This also marks a later phase of the ...With Shinzo Abe's re-election as the president of Japan's Liberal Democratic Party (LDP), the LDP regime appears to have entered on a stable trend of long-term governance. This also marks a later phase of the Abe administration has solidified its later phase, following Abe's second rise to power. The supremacy of the LDP and the administration of the basket of economic policies termed Abenomics have produced initial effects, and the overall climate of political opinion in Japan remains largely conservative, all factors favorable the continuance of Abe's regime. A major task in the future to cement AbeJ s political legacy would be amendment of Japan’ s pacifist constitution. Abe’ s political and security policies are likely not to change, namely, the promotion of multilateral cooperation in the US-Japan alliance, a moderate adjustment of Japan's China policy, and a return to utilitarian diplomacy to maximize Japan’s national interests. Thanks to the return of the Sino-Japanese relationship to the right track, the healthy development of bilateral relations depends on the consolidation of the political foundation, deepening mutually beneficial cooperation, and constructively managing and controlling disagreement.展开更多
Conflict between India and China at the Galwan Valley has brought their bilateral relations to the lowest point since the border war in 1962.Although this conflict appeared incidental,it in fact was the inevitable res...Conflict between India and China at the Galwan Valley has brought their bilateral relations to the lowest point since the border war in 1962.Although this conflict appeared incidental,it in fact was the inevitable result of India's tough foreign policy featuring"high risk,high yield"pursued by the Modi administration toward China.The subsequent measures of India's tough diplomacy toward China have become more frequent,reflecting both a desire to seek revenge and a deep level of India's logic.Such logic considers not only the policy inertia of India's long-term pursuit of absolute security and dominance in the regional order.but also the intention of Modi's government to overtake China by taking advantages of India's favorable external strategic environment.The existing structural contradictions in China-India relations and the right-leaning tendencies in India's domestic political ecology have laid the groundwork for this conflict to occur and for the Modi administration to pursue a tough foreign policy toward China.This conflict has once again shown the rapid decay of the existing operational mechanism and architecture of thei bilateral relations,which can no longer smooth over the complex interactions between the two major emerging neighbors.As a result,the moment has arrived for China and India to restructure their relations,otherwise their relationship can hardly be continued.展开更多
文摘The US administration's foreign policy embodies the strategic framework of great power competition,the slogan of“America First,”and fragmented decision-making.An alignment of factors such as the response to changes in international and domestic environments,the reconstruction of US national identity,the electoral political pressure that Donald Trump faces,and the confluence of Trump and establishment elites creates complex outcomes.Inherently political and partisan,Trump's foreign policy may already have had some irreversible negative impacts,and it is certain that US foreign strategy and policy have entered a major directional adjustment phase.
文摘The Biden administration’s political platform,set during the 2020 US presidential campaign,called for"a foreign policy for the middle class"and this has subsequently been instituted as a policy commitment.The new administration’s economic and trade policy targets enhancing US competitiveness,setting rules for economic globalization and keeping good relations with democratic states.Security policy emphasizes diplomatic means over military practices.The foreign policy for the middle class aims to resolve differences in the Democratic Party between traditional Democrats and progressives.It is also crafted to solve domestic and international problems and burnish America’s international image,but it faces an uphill battle if it wishes to restructure foreign policy to serve the needs of the American middle class.
基金the National Natural Science Foundation of China, No. 30300106
文摘BACKGROUND: Expression of Fos in neurons of periaqueductal gray (PAG) is used to reflect the excitability. However, changes of expression of Fos in neurons of PAG are caused by injured electrostimulation after simulated weightlessness, and the relationship between pretreatment and injection of succinylcholine has not been determined yet. OBJECTIVE : To investigate the changes of expression of Fos in PAG induced by injured electrostimulation pretreatment and injection of succinylcholine at 2 weeks after simulated weightlessness.DESIGN: Observational and controlled animal study.SETTING: Department of Physiology, Medical School, Xi'an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education. MATERIALS: A total of 24 adult female SD rats, of clean grade and weighing 180-220 g, were selected in this study. METHODS: The experiment was completed in the Experimental Animal Center of Xi'an Jiaotong University.① All rats were randomly divided into 2 groups according to body mass: simulated weightlessness group and control group with 12 in each group. And then, each group was also divided into 3 subgroups: electrostimulation group, succinylcholine-pretreatment group and succinylcholine-injection group with 4 in each subgroup. ②The model of weightlessness was simulated by tail-suspended female rats, which were described and modified by Cheng Jie. Rats in normal control group were given the same interventions as simulated weightlessness group except for tail-suspended. ③ Experimental method: The rats in electrostimulation group were given nociceptive stimulus by a pair of subcutaneous electrodes inserted into 1 and 5 claw of left hindlimb. The stimulus (current: 10 mA; duration: 1 ms; interval: 1 s) lasted for 30 minutes. The rats in succinylcholine-pretreatment group received stimulus after intravenous administration of succinylcholine, rats in succinylcholine-injection group were not given stimulus, just received succinylcholine. ④ All rats were perfused and fixed after 2 hours from the end of stimulation. The brains were removed, and serial frozen sections of midbrain were stained using immunocytochemical method, observed and taken photos under light-microscope. The number and morphological characters of Fos-immunoreactive (Fos-IR) neurons in ventrolateral part of PAG were investigated. MAIN OUTCOME MEASURES: The alterations in number and morphological characters of Fos-IR neurons in ventrolateral PAG of all rats.RESULTS: A total of 24 rats were involved in the final analysis. ① The morphological changes of Fos-IR neurons: The expressions of Fos in ventrolateral part of PAG were observed in both control and simulated weightlessness groups rats after being given nociceptive stimulus. As compared with control group, Fos-IR neurons in simulated weightlessness group were dyed lightly, cellular integrity was impaired, and cellular verge was unclear. ② The numbers of Fos-IR neurons: In control group, the numbers of Fos-IR neurons in ventrolateral part of PAG in simulated weightlessness group were obviously lower than succinylcholine-pretreatment group, but obviously higher than succinylcholine-injection group (46.94±3.38, 71.06±8.96 and 35.04±4.62, respectively, P 〈 0.05). In 14-day simulated weightlessness group, the numbers of Fos-IR neurons in electrostimulation group were also obviously lower than succinylcholine-pretreatment group, and obviously higher than succinylcholine-injection group (27.77±3.27, 32.91±2.99 and 11.75±1.00, respectively, P 〈 0.05). The numbers of Fos-IR neurons in all subgroups in control group were obviously higher than those subgroups in simulated weightlessness group. Compared with electrostimulation group, the percentage of expression of Fos in ventrolateral part of PAG responsed to nociceptive stimulus after administration of succinylcholine (SCH) was increased to 51.83% in control group and 18.51% in simulated weightlessness group.CONCLUSION :① The expression of Fos in neurons in ventrolateral part of PAG were increased by the pretreatment of SCH before nociceptive stimulus.② Nociceptive stimulus could increase the expression of Fos in neurons in ventrolateral part of PAG. ③ The numbers of Fos-IR neurons in ventrolateral part of PAG were decreased obviously after 2-week simulated weightlessness.
基金the initial findings of a research project entitled A Research on Japan’s Indo-Pacific Strategy and China’s Responses,funded by the 2018 Basic Research Fund of the Central Universities (Project Number: 3262018T32)
文摘With Shinzo Abe's re-election as the president of Japan's Liberal Democratic Party (LDP), the LDP regime appears to have entered on a stable trend of long-term governance. This also marks a later phase of the Abe administration has solidified its later phase, following Abe's second rise to power. The supremacy of the LDP and the administration of the basket of economic policies termed Abenomics have produced initial effects, and the overall climate of political opinion in Japan remains largely conservative, all factors favorable the continuance of Abe's regime. A major task in the future to cement AbeJ s political legacy would be amendment of Japan’ s pacifist constitution. Abe’ s political and security policies are likely not to change, namely, the promotion of multilateral cooperation in the US-Japan alliance, a moderate adjustment of Japan's China policy, and a return to utilitarian diplomacy to maximize Japan’s national interests. Thanks to the return of the Sino-Japanese relationship to the right track, the healthy development of bilateral relations depends on the consolidation of the political foundation, deepening mutually beneficial cooperation, and constructively managing and controlling disagreement.
文摘Conflict between India and China at the Galwan Valley has brought their bilateral relations to the lowest point since the border war in 1962.Although this conflict appeared incidental,it in fact was the inevitable result of India's tough foreign policy featuring"high risk,high yield"pursued by the Modi administration toward China.The subsequent measures of India's tough diplomacy toward China have become more frequent,reflecting both a desire to seek revenge and a deep level of India's logic.Such logic considers not only the policy inertia of India's long-term pursuit of absolute security and dominance in the regional order.but also the intention of Modi's government to overtake China by taking advantages of India's favorable external strategic environment.The existing structural contradictions in China-India relations and the right-leaning tendencies in India's domestic political ecology have laid the groundwork for this conflict to occur and for the Modi administration to pursue a tough foreign policy toward China.This conflict has once again shown the rapid decay of the existing operational mechanism and architecture of thei bilateral relations,which can no longer smooth over the complex interactions between the two major emerging neighbors.As a result,the moment has arrived for China and India to restructure their relations,otherwise their relationship can hardly be continued.