Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reli...Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reliability and accuracy but still faces challenges such as optimization of the multi-clock source selection and the clock source weight calculation at different timescales,and the coupling of synchronization latency jitter and pulse phase difference.In this paper,the multi-timescale MTS model is conducted,and the reinforcement learning(RL)and analytic hierarchy process(AHP)-based multi-timescale MTS algorithm is designed to improve the weighted summation of synchronization latency jitter standard deviation and average pulse phase difference.Specifically,the multi-clock source selection is optimized based on Softmax in the large timescale,and the clock source weight calculation is optimized based on lower confidence bound-assisted AHP in the small timescale.Simulation shows that the proposed algorithm can effectively reduce time synchronization delay standard deviation and average pulse phase difference.展开更多
In the Industrial Internet of Things(IIoT),sensors generate time series data to reflect the working state.When the systems are attacked,timely identification of outliers in time series is critical to ensure security.A...In the Industrial Internet of Things(IIoT),sensors generate time series data to reflect the working state.When the systems are attacked,timely identification of outliers in time series is critical to ensure security.Although many anomaly detection methods have been proposed,the temporal correlation of the time series over the same sensor and the state(spatial)correlation between different sensors are rarely considered simultaneously in these methods.Owing to the superior capability of Transformer in learning time series features.This paper proposes a time series anomaly detection method based on a spatial-temporal network and an improved Transformer.Additionally,the methods based on graph neural networks typically include a graph structure learning module and an anomaly detection module,which are interdependent.However,in the initial phase of training,since neither of the modules has reached an optimal state,their performance may influence each other.This scenario makes the end-to-end training approach hard to effectively direct the learning trajectory of each module.This interdependence between the modules,coupled with the initial instability,may cause the model to find it hard to find the optimal solution during the training process,resulting in unsatisfactory results.We introduce an adaptive graph structure learning method to obtain the optimal model parameters and graph structure.Experiments on two publicly available datasets demonstrate that the proposed method attains higher anomaly detection results than other methods.展开更多
With the proportion of intelligent services in the industrial internet of things(IIoT)rising rapidly,its data dependency and decomposability increase the difficulty of scheduling computing resources.In this paper,we p...With the proportion of intelligent services in the industrial internet of things(IIoT)rising rapidly,its data dependency and decomposability increase the difficulty of scheduling computing resources.In this paper,we propose an intelligent service computing framework.In the framework,we take the long-term rewards of its important participants,edge service providers,as the optimization goal,which is related to service delay and computing cost.Considering the different update frequencies of data deployment and service offloading,double-timescale reinforcement learning is utilized in the framework.In the small-scale strategy,the frequent concurrency of services and the difference in service time lead to the fuzzy relationship between reward and action.To solve the fuzzy reward problem,a reward mapping-based reinforcement learning(RMRL)algorithm is proposed,which enables the agent to learn the relationship between reward and action more clearly.The large time scale strategy adopts the improved Monte Carlo tree search(MCTS)algorithm to improve the learning speed.The simulation results show that the strategy is superior to popular reinforcement learning algorithms such as double Q-learning(DDQN)and dueling Q-learning(dueling-DQN)in learning speed,and the reward is also increased by 14%.展开更多
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.展开更多
Time delay is an problem of intemet congestion important parameter in the control. According to some researches, time delay is not always constant and can be viewed as a periodic function of time for some cases. In th...Time delay is an problem of intemet congestion important parameter in the control. According to some researches, time delay is not always constant and can be viewed as a periodic function of time for some cases. In this work, an internet congestion control model is consid- ered to study the time-varying delay induced bursting-like motion, which consists of a rapid oscillation burst and quies- cent steady state. Then, for the system with periodic delay of small amplitude and low frequency, the method of multiple scales is employed to obtain the amplitude of the oscillation. Based on the expression of the asymptotic solution, it can be found that the relative length of the steady state increases with amplitude of the variation of time delay and decreases with frequency of the variation of time delay. Finally, an effective method to control the bursting-like motion is pro- posed by introducing a periodic gain parameter with appropriate amplitude. Theoretical results are in agreement with that from numerical method.展开更多
Based on the fluid flow time-delayed model proposed by Misra et al in internet congestion control, one modified time-delayed model is presented, where the influence of the communication delay on the router queue lengt...Based on the fluid flow time-delayed model proposed by Misra et al in internet congestion control, one modified time-delayed model is presented, where the influence of the communication delay on the router queue length is investigated in detail. The main advantage of the new model is that its stability domain is larger even without an extra controller. By linear stability analysis and numerical simulation, tbe effectiveness and feasibility of the novel model in internet congestion control are verified.展开更多
Efficient real time data exchange over the Internet plays a crucial role in the successful application of web-based systems. In this paper, a data transfer mechanism over the Internet is proposed for real time web bas...Efficient real time data exchange over the Internet plays a crucial role in the successful application of web-based systems. In this paper, a data transfer mechanism over the Internet is proposed for real time web based applications. The mechanism incorporates the eXtensible Markup Language (XML) and Hierarchical Data Format (HDF) to provide a flexible and efficient data format. Heterogeneous transfer data is classified into light and heavy data, which are stored using XML and HDF respectively; the HDF data format is then mapped to Java Document Object Model (JDOM) objects in XML in the Java environment. These JDOM data objects are sent across computer networks with the support of the Java Remote Method Invocation (RMI) data transfer infrastructure. Client's defined data priority levels are implemented in RMI, which guides a server to transfer data objects at different priorities. A remote monitoring system for an industrial reactor process simulator is used as a case study to illustrate the proposed data transfer mechanism.展开更多
Communication opportunities among vehicles are important for data transmission over the Internet of Vehicles(IoV).Mixture models are appropriate to describe complex spatial-temporal data.By calculating the expectation...Communication opportunities among vehicles are important for data transmission over the Internet of Vehicles(IoV).Mixture models are appropriate to describe complex spatial-temporal data.By calculating the expectation of hidden variables in vehicle communication,Expectation Maximization(EM)algorithm solves the maximum likelihood estimation of parameters,and then obtains the mixture model of vehicle communication opportunities.However,the EM algorithm requires multiple iterations and each iteration needs to process all the data.Thus its computational complexity is high.A parameter estimation algorithm with low computational complexity based on Bin Count(BC)and Differential Evolution(DE)(PEBCDE)is proposed.It overcomes the disadvantages of the EM algorithm in solving mixture models for big data.In order to reduce the computational complexity of the mixture models in the IoV,massive data are divided into relatively few time intervals and then counted.According to these few counted values,the parameters of the mixture model are obtained by using DE algorithm.Through modeling and analysis of simulation data and instance data,the PEBCDE algorithm is verified and discussed from two aspects,i.e.,accuracy and efficiency.The numerical solution of the probability distribution parameters is obtained,which further provides a more detailed statistical model for the distribution of the opportunity interval of the IoV.展开更多
The increasing attention on Bitcoin since 2013 prompts the issue of possible evidence for a causal relationship between the Bitcoin market and internet attention.Taking the Google search volume index as the measure of...The increasing attention on Bitcoin since 2013 prompts the issue of possible evidence for a causal relationship between the Bitcoin market and internet attention.Taking the Google search volume index as the measure of internet attention,time-varying Granger causality between the global Bitcoin market and internet attention is examined.Empirical results show a strong Granger causal relationship between internet attention and trading volume.Moreover,they indicate,beginning in early 2018,an even stronger impact of trading volume on internet attention,which is consistent with the rapid increase in Bitcoin users following the 2017 Bitcoin bubble.Although Bitcoin returns are found to strongly affect internet attention,internet attention only occasionally affects Bitcoin returns.Further investigation reveals that interactions between internet attention and returns can be amplified by extreme changes in prices,and internet attention is more likely to lead to returns during Bitcoin bubbles.These empirical findings shed light on cryptocurrency investor attention theory and imply trading strategy in Bitcoin markets.展开更多
Wireless Sensor Networks(WSNs)are a major element of Internet of Things(IoT)networks which offer seamless sensing and wireless connectivity.Disaster management in smart cities can be considered as a safety critical ap...Wireless Sensor Networks(WSNs)are a major element of Internet of Things(IoT)networks which offer seamless sensing and wireless connectivity.Disaster management in smart cities can be considered as a safety critical application.Therefore,it becomes essential in ensuring network accessibility by improving the lifetime of IoT assisted WSN.Clustering and multihop routing are considered beneficial solutions to accomplish energy efficiency in IoT networks.This article designs an IoT enabled energy aware metaheuristic clustering with routing protocol for real time disaster management(EAMCR-RTDM).The proposed EAMCR-RTDM technique mainly intends to manage the energy utilization of nodes with the consideration of the features of the disaster region.To achieve this,EAMCR-RTDM technique primarily designs a yellow saddle goatfish based clustering(YSGF-C)technique to elect cluster heads(CHs)and organize clusters.In addition,enhanced cockroach swarm optimization(ECSO)based multihop routing(ECSO-MHR)approach was derived for optimal route selection.The YSGF-C and ECSO-MHR techniques compute fitness functions using different input variables for achieving improved energy efficiency and network lifetime.The design of YSGF-C and ECSO-MHR techniques for disaster management in IoT networks shows the novelty of the work.For examining the improved outcomes of the EAMCR-RTDM system,a wide range of simulations were performed and the extensive results are assessed in terms of different measures.The comparative outcomes highlighted the enhanced outcomes of the EAMCRRTDM algorithm over the existing approaches.展开更多
Situated at the intersection of technology and medicine,the Internet of Things(IoT)holds the promise of addressing some of healthcare's most pressing challenges,from medical error,to chronic drug shortages,to over...Situated at the intersection of technology and medicine,the Internet of Things(IoT)holds the promise of addressing some of healthcare's most pressing challenges,from medical error,to chronic drug shortages,to overburdened hospital systems,to dealing with the COVID-19 pandemic.However,despite considerable recent technological advances,the pace of successful implementation of promising IoT healthcare initiatives has been slow.To inspire more productive collaboration,we present here a simple—but surprisingly underrated—problemoriented approach to developing healthcare technologies.To further assist in this effort,we reviewed the various commercial,regulatory,social/cultural,and technological factors in the development of the IoT.We propose that fog computing—a technological paradigm wherein the burden of computing is shifted from a centralized cloud server closer to the data source—offers the greatest promise for building a robust and scalable healthcare IoT ecosystem.To this end,we explore the key enabling technologies that underpin the fog architecture,from the sensing layer all the way up to the cloud.It is our hope that ongoing advances in sensing,communications,cryptography,storage,machine learning,and artificial intelligence will be leveraged in meaningful ways to generate unprecedented medical intelligence and thus drive improvements in the health of many people.展开更多
目的:分析Brain Time Stack图像融合技术在CT中的应用。方法:选取2021年3月—2022年9月衡水市第四人民医院收治的50例CT检查患者作为研究对象。所有患者进行CT检查并进行Brain Time Stack后处理。比较四组不同部位CT值、标准差(SD)、信...目的:分析Brain Time Stack图像融合技术在CT中的应用。方法:选取2021年3月—2022年9月衡水市第四人民医院收治的50例CT检查患者作为研究对象。所有患者进行CT检查并进行Brain Time Stack后处理。比较四组不同部位CT值、标准差(SD)、信噪比(SNR)。比较四组图像主观质量评分。分析不同部位CT值、SD、SNR与图像主观质量评分的相关性。结果:B组的延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显低于A组;C组的延髓、脑室、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值高于A组;D组延髓、额叶灰质、颞肌肌肉CT值明显低于A组,脑室、额叶白质、小脑外侧CT值明显高于A组;C组延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显高于B组;D组延髓、脑室、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显高于B组;D组延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显低于C组;D组脑室CT值明显高于C组,差异有统计学意义(P<0.05)。B组、C组、D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SD值明显低于A组;C组延髓、脑室、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SD值均明显高于B组;C组额叶灰质SD明显低于B组;D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、肌肉SD均明显低于B组、C组,差异有统计学意义(P<0.05)。B组、C组、D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SNR均明显高于A组;C组、D组延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SNR值明显高于B组;C组、D组脑室SNR明显低于B组;D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SNR明显高于C组,差异有统计学意义(P<0.05)。D组图像主观质量评分最高,差异有统计学意义(P<0.05)。延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧及颞肌肌肉SD与主观质量评分呈明显负相关,SNR与主观质量评分间呈明显正相关,差异有统计学意义(P<0.05)。结论:利用Brain Time Stack图像融合技术对头部CT扫描检查图像处理,动脉期结合前一期及后一期的图像数据在处理后具有更好的质量和更少的噪音。展开更多
Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investi...Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.展开更多
The amount of oxygen blown into the converter is one of the key parameters for the control of the converter blowing process,which directly affects the tap-to-tap time of converter. In this study, a hybrid model based ...The amount of oxygen blown into the converter is one of the key parameters for the control of the converter blowing process,which directly affects the tap-to-tap time of converter. In this study, a hybrid model based on oxygen balance mechanism (OBM) and deep neural network (DNN) was established for predicting oxygen blowing time in converter. A three-step method was utilized in the hybrid model. First, the oxygen consumption volume was predicted by the OBM model and DNN model, respectively. Second, a more accurate oxygen consumption volume was obtained by integrating the OBM model and DNN model. Finally, the converter oxygen blowing time was calculated according to the oxygen consumption volume and the oxygen supply intensity of each heat. The proposed hybrid model was verified using the actual data collected from an integrated steel plant in China, and compared with multiple linear regression model, OBM model, and neural network model including extreme learning machine, back propagation neural network, and DNN. The test results indicate that the hybrid model with a network structure of 3 hidden layer layers, 32-16-8 neurons per hidden layer, and 0.1 learning rate has the best prediction accuracy and stronger generalization ability compared with other models. The predicted hit ratio of oxygen consumption volume within the error±300 m^(3)is 96.67%;determination coefficient (R^(2)) and root mean square error (RMSE) are0.6984 and 150.03 m^(3), respectively. The oxygen blow time prediction hit ratio within the error±0.6 min is 89.50%;R2and RMSE are0.9486 and 0.3592 min, respectively. As a result, the proposed model can effectively predict the oxygen consumption volume and oxygen blowing time in the converter.展开更多
The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requ...The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this paper.Herein, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. In addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. It turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.展开更多
基金supported by Science and Technology Project of China Southern Power Grid Company Limited under Grant Number 036000KK52200058(GDKJXM20202001).
文摘Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reliability and accuracy but still faces challenges such as optimization of the multi-clock source selection and the clock source weight calculation at different timescales,and the coupling of synchronization latency jitter and pulse phase difference.In this paper,the multi-timescale MTS model is conducted,and the reinforcement learning(RL)and analytic hierarchy process(AHP)-based multi-timescale MTS algorithm is designed to improve the weighted summation of synchronization latency jitter standard deviation and average pulse phase difference.Specifically,the multi-clock source selection is optimized based on Softmax in the large timescale,and the clock source weight calculation is optimized based on lower confidence bound-assisted AHP in the small timescale.Simulation shows that the proposed algorithm can effectively reduce time synchronization delay standard deviation and average pulse phase difference.
基金This work is partly supported by the National Key Research and Development Program of China(Grant No.2020YFB1805403)the National Natural Science Foundation of China(Grant No.62032002)the 111 Project(Grant No.B21049).
文摘In the Industrial Internet of Things(IIoT),sensors generate time series data to reflect the working state.When the systems are attacked,timely identification of outliers in time series is critical to ensure security.Although many anomaly detection methods have been proposed,the temporal correlation of the time series over the same sensor and the state(spatial)correlation between different sensors are rarely considered simultaneously in these methods.Owing to the superior capability of Transformer in learning time series features.This paper proposes a time series anomaly detection method based on a spatial-temporal network and an improved Transformer.Additionally,the methods based on graph neural networks typically include a graph structure learning module and an anomaly detection module,which are interdependent.However,in the initial phase of training,since neither of the modules has reached an optimal state,their performance may influence each other.This scenario makes the end-to-end training approach hard to effectively direct the learning trajectory of each module.This interdependence between the modules,coupled with the initial instability,may cause the model to find it hard to find the optimal solution during the training process,resulting in unsatisfactory results.We introduce an adaptive graph structure learning method to obtain the optimal model parameters and graph structure.Experiments on two publicly available datasets demonstrate that the proposed method attains higher anomaly detection results than other methods.
基金supported by the National Natural Science Foundation of China(No.62171051)。
文摘With the proportion of intelligent services in the industrial internet of things(IIoT)rising rapidly,its data dependency and decomposability increase the difficulty of scheduling computing resources.In this paper,we propose an intelligent service computing framework.In the framework,we take the long-term rewards of its important participants,edge service providers,as the optimization goal,which is related to service delay and computing cost.Considering the different update frequencies of data deployment and service offloading,double-timescale reinforcement learning is utilized in the framework.In the small-scale strategy,the frequent concurrency of services and the difference in service time lead to the fuzzy relationship between reward and action.To solve the fuzzy reward problem,a reward mapping-based reinforcement learning(RMRL)algorithm is proposed,which enables the agent to learn the relationship between reward and action more clearly.The large time scale strategy adopts the improved Monte Carlo tree search(MCTS)algorithm to improve the learning speed.The simulation results show that the strategy is superior to popular reinforcement learning algorithms such as double Q-learning(DDQN)and dueling Q-learning(dueling-DQN)in learning speed,and the reward is also increased by 14%.
基金supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL)the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH)+2 种基金the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH)the Sino-German Center for Research Promotion,No.M-0759(to YH)a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
文摘Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.
基金supported by the National Natural Science Foundation of China(11032009)the Fundamental Research Funds for the Central UniversitiesShanghai Leading Academic Discipline Project(B302)
文摘Time delay is an problem of intemet congestion important parameter in the control. According to some researches, time delay is not always constant and can be viewed as a periodic function of time for some cases. In this work, an internet congestion control model is consid- ered to study the time-varying delay induced bursting-like motion, which consists of a rapid oscillation burst and quies- cent steady state. Then, for the system with periodic delay of small amplitude and low frequency, the method of multiple scales is employed to obtain the amplitude of the oscillation. Based on the expression of the asymptotic solution, it can be found that the relative length of the steady state increases with amplitude of the variation of time delay and decreases with frequency of the variation of time delay. Finally, an effective method to control the bursting-like motion is pro- posed by introducing a periodic gain parameter with appropriate amplitude. Theoretical results are in agreement with that from numerical method.
基金supported by the National Natural Science Foundation of China (Grant No 70571017)the Research Foundation from Provincial Education Department of Zhejiang of China (Grant No 21186000507)
文摘Based on the fluid flow time-delayed model proposed by Misra et al in internet congestion control, one modified time-delayed model is presented, where the influence of the communication delay on the router queue length is investigated in detail. The main advantage of the new model is that its stability domain is larger even without an extra controller. By linear stability analysis and numerical simulation, tbe effectiveness and feasibility of the novel model in internet congestion control are verified.
文摘Efficient real time data exchange over the Internet plays a crucial role in the successful application of web-based systems. In this paper, a data transfer mechanism over the Internet is proposed for real time web based applications. The mechanism incorporates the eXtensible Markup Language (XML) and Hierarchical Data Format (HDF) to provide a flexible and efficient data format. Heterogeneous transfer data is classified into light and heavy data, which are stored using XML and HDF respectively; the HDF data format is then mapped to Java Document Object Model (JDOM) objects in XML in the Java environment. These JDOM data objects are sent across computer networks with the support of the Java Remote Method Invocation (RMI) data transfer infrastructure. Client's defined data priority levels are implemented in RMI, which guides a server to transfer data objects at different priorities. A remote monitoring system for an industrial reactor process simulator is used as a case study to illustrate the proposed data transfer mechanism.
基金This work was supported by the Fundamental Research Funds for the Central Universities(Grant No.FRF-BD-20-11A)the Scientific and Technological Innovation Foundation of Shunde Graduate School,USTB(Grant No.BK19AF005).
文摘Communication opportunities among vehicles are important for data transmission over the Internet of Vehicles(IoV).Mixture models are appropriate to describe complex spatial-temporal data.By calculating the expectation of hidden variables in vehicle communication,Expectation Maximization(EM)algorithm solves the maximum likelihood estimation of parameters,and then obtains the mixture model of vehicle communication opportunities.However,the EM algorithm requires multiple iterations and each iteration needs to process all the data.Thus its computational complexity is high.A parameter estimation algorithm with low computational complexity based on Bin Count(BC)and Differential Evolution(DE)(PEBCDE)is proposed.It overcomes the disadvantages of the EM algorithm in solving mixture models for big data.In order to reduce the computational complexity of the mixture models in the IoV,massive data are divided into relatively few time intervals and then counted.According to these few counted values,the parameters of the mixture model are obtained by using DE algorithm.Through modeling and analysis of simulation data and instance data,the PEBCDE algorithm is verified and discussed from two aspects,i.e.,accuracy and efficiency.The numerical solution of the probability distribution parameters is obtained,which further provides a more detailed statistical model for the distribution of the opportunity interval of the IoV.
基金The paper received financial support from the National Natural Science Foundation of China(Nos.71422015,71871213)the National Center for Mathematics and Interdisciplinary Sciences,Chinese Academy of Sciences.
文摘The increasing attention on Bitcoin since 2013 prompts the issue of possible evidence for a causal relationship between the Bitcoin market and internet attention.Taking the Google search volume index as the measure of internet attention,time-varying Granger causality between the global Bitcoin market and internet attention is examined.Empirical results show a strong Granger causal relationship between internet attention and trading volume.Moreover,they indicate,beginning in early 2018,an even stronger impact of trading volume on internet attention,which is consistent with the rapid increase in Bitcoin users following the 2017 Bitcoin bubble.Although Bitcoin returns are found to strongly affect internet attention,internet attention only occasionally affects Bitcoin returns.Further investigation reveals that interactions between internet attention and returns can be amplified by extreme changes in prices,and internet attention is more likely to lead to returns during Bitcoin bubbles.These empirical findings shed light on cryptocurrency investor attention theory and imply trading strategy in Bitcoin markets.
基金This research has been funded by Dirección General de Investigaciones of Universidad Santiago de Cali under call No.01–2021.
文摘Wireless Sensor Networks(WSNs)are a major element of Internet of Things(IoT)networks which offer seamless sensing and wireless connectivity.Disaster management in smart cities can be considered as a safety critical application.Therefore,it becomes essential in ensuring network accessibility by improving the lifetime of IoT assisted WSN.Clustering and multihop routing are considered beneficial solutions to accomplish energy efficiency in IoT networks.This article designs an IoT enabled energy aware metaheuristic clustering with routing protocol for real time disaster management(EAMCR-RTDM).The proposed EAMCR-RTDM technique mainly intends to manage the energy utilization of nodes with the consideration of the features of the disaster region.To achieve this,EAMCR-RTDM technique primarily designs a yellow saddle goatfish based clustering(YSGF-C)technique to elect cluster heads(CHs)and organize clusters.In addition,enhanced cockroach swarm optimization(ECSO)based multihop routing(ECSO-MHR)approach was derived for optimal route selection.The YSGF-C and ECSO-MHR techniques compute fitness functions using different input variables for achieving improved energy efficiency and network lifetime.The design of YSGF-C and ECSO-MHR techniques for disaster management in IoT networks shows the novelty of the work.For examining the improved outcomes of the EAMCR-RTDM system,a wide range of simulations were performed and the extensive results are assessed in terms of different measures.The comparative outcomes highlighted the enhanced outcomes of the EAMCRRTDM algorithm over the existing approaches.
基金supported in part by a grant from the Victoria-Jiangsu Program for Technology and Innovation Research and Development。
文摘Situated at the intersection of technology and medicine,the Internet of Things(IoT)holds the promise of addressing some of healthcare's most pressing challenges,from medical error,to chronic drug shortages,to overburdened hospital systems,to dealing with the COVID-19 pandemic.However,despite considerable recent technological advances,the pace of successful implementation of promising IoT healthcare initiatives has been slow.To inspire more productive collaboration,we present here a simple—but surprisingly underrated—problemoriented approach to developing healthcare technologies.To further assist in this effort,we reviewed the various commercial,regulatory,social/cultural,and technological factors in the development of the IoT.We propose that fog computing—a technological paradigm wherein the burden of computing is shifted from a centralized cloud server closer to the data source—offers the greatest promise for building a robust and scalable healthcare IoT ecosystem.To this end,we explore the key enabling technologies that underpin the fog architecture,from the sensing layer all the way up to the cloud.It is our hope that ongoing advances in sensing,communications,cryptography,storage,machine learning,and artificial intelligence will be leveraged in meaningful ways to generate unprecedented medical intelligence and thus drive improvements in the health of many people.
文摘目的:分析Brain Time Stack图像融合技术在CT中的应用。方法:选取2021年3月—2022年9月衡水市第四人民医院收治的50例CT检查患者作为研究对象。所有患者进行CT检查并进行Brain Time Stack后处理。比较四组不同部位CT值、标准差(SD)、信噪比(SNR)。比较四组图像主观质量评分。分析不同部位CT值、SD、SNR与图像主观质量评分的相关性。结果:B组的延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显低于A组;C组的延髓、脑室、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值高于A组;D组延髓、额叶灰质、颞肌肌肉CT值明显低于A组,脑室、额叶白质、小脑外侧CT值明显高于A组;C组延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显高于B组;D组延髓、脑室、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显高于B组;D组延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉CT值明显低于C组;D组脑室CT值明显高于C组,差异有统计学意义(P<0.05)。B组、C组、D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SD值明显低于A组;C组延髓、脑室、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SD值均明显高于B组;C组额叶灰质SD明显低于B组;D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、肌肉SD均明显低于B组、C组,差异有统计学意义(P<0.05)。B组、C组、D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SNR均明显高于A组;C组、D组延髓、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SNR值明显高于B组;C组、D组脑室SNR明显低于B组;D组延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧、颞肌肌肉SNR明显高于C组,差异有统计学意义(P<0.05)。D组图像主观质量评分最高,差异有统计学意义(P<0.05)。延髓、脑室、额叶灰质、额叶白质、小脑内侧、小脑外侧及颞肌肌肉SD与主观质量评分呈明显负相关,SNR与主观质量评分间呈明显正相关,差异有统计学意义(P<0.05)。结论:利用Brain Time Stack图像融合技术对头部CT扫描检查图像处理,动脉期结合前一期及后一期的图像数据在处理后具有更好的质量和更少的噪音。
文摘Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.
基金financially supported by the National Natural Science Foundation of China (Nos.51974023 and52374321)the funding of State Key Laboratory of Advanced Metallurgy,University of Science and Technology Beijing,China (No.41620007)。
文摘The amount of oxygen blown into the converter is one of the key parameters for the control of the converter blowing process,which directly affects the tap-to-tap time of converter. In this study, a hybrid model based on oxygen balance mechanism (OBM) and deep neural network (DNN) was established for predicting oxygen blowing time in converter. A three-step method was utilized in the hybrid model. First, the oxygen consumption volume was predicted by the OBM model and DNN model, respectively. Second, a more accurate oxygen consumption volume was obtained by integrating the OBM model and DNN model. Finally, the converter oxygen blowing time was calculated according to the oxygen consumption volume and the oxygen supply intensity of each heat. The proposed hybrid model was verified using the actual data collected from an integrated steel plant in China, and compared with multiple linear regression model, OBM model, and neural network model including extreme learning machine, back propagation neural network, and DNN. The test results indicate that the hybrid model with a network structure of 3 hidden layer layers, 32-16-8 neurons per hidden layer, and 0.1 learning rate has the best prediction accuracy and stronger generalization ability compared with other models. The predicted hit ratio of oxygen consumption volume within the error±300 m^(3)is 96.67%;determination coefficient (R^(2)) and root mean square error (RMSE) are0.6984 and 150.03 m^(3), respectively. The oxygen blow time prediction hit ratio within the error±0.6 min is 89.50%;R2and RMSE are0.9486 and 0.3592 min, respectively. As a result, the proposed model can effectively predict the oxygen consumption volume and oxygen blowing time in the converter.
基金supported in part by the National Natural Science Foundation of China (62103093)the National Key Research and Development Program of China (2022YFB3305905)+6 种基金the Xingliao Talent Program of Liaoning Province of China (XLYC2203130)the Fundamental Research Funds for the Central Universities of China (N2108003)the Natural Science Foundation of Liaoning Province (2023-MS-087)the BNU Talent Seed Fund,UIC Start-Up Fund (R72021115)the Guangdong Key Laboratory of AI and MM Data Processing (2020KSYS007)the Guangdong Provincial Key Laboratory IRADS for Data Science (2022B1212010006)the Guangdong Higher Education Upgrading Plan 2021–2025 of “Rushing to the Top,Making Up Shortcomings and Strengthening Special Features” with UIC Research,China (R0400001-22,R0400025-21)。
文摘The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this paper.Herein, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. In addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. It turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.