THE ancient town of Huangyao located in Zhaoping County,Hezhou City,south China’s Guangxi Zhuang Autonomous Region,is renown for its time-honored Douchi processing techniques.Douchi is a kind of popular Chinese food ...THE ancient town of Huangyao located in Zhaoping County,Hezhou City,south China’s Guangxi Zhuang Autonomous Region,is renown for its time-honored Douchi processing techniques.Douchi is a kind of popular Chinese food made from fermented and salted black beans,which is commonly used as a condiment or seasoning for a variety of dishes.The history of Huangyao’s Douchi processing techniques can be traced back to the late Yuan Dynasty(1271-1368)and the early Ming Dynasty(1368-1644).According to a historical record of the Qing Dynasty(1644-1911),“Huangyao is famous for its Douchi and has no rivals.”展开更多
Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agric...Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agricultural science and technology,problems of rural drinking water safety,problems of rural roads and transportation,low levels of health care,weak rural public culture,short supply of farmers' education.Secondly,the system and level of urban public goods provision can't meet migrant workers' demand,for example,less migrant workers are employed by the governments' direction;migrant workers are isolated by urban housing project and these workers have difficulty in receiving city social security.One reason of new generation migrant workers facing the double marginalization of rural and urban crisis is that urban and rural public goods supply are different in particular the inadequate supply of public goods in rural areas.Three countermeasures are put forward in order to relieve new generation migrant workers' double marginalization of urban and rural,which include increasing financial input in rural areas in order to achieve equalization of urban and rural public goods,perfecting the preferential agricultural policy to increase rural public goods supply,making urban public goods supply as a guide to promote the new generation migrant workers into the city.展开更多
Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corres...Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.展开更多
With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredi...With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.展开更多
OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mi...OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mice with a western diet.The mice were orally administered with differ.ent doses of DYL or vehicle daily for 28 d.The anti-atherosclerotic effect was evaluated by measuring the aortic atherosclerotic lesion area and media thickness with ultrasound imaging and histological sec.tions staining method.The effect on blood lipid was investigated by determining TC,TG,LDL,HDL,Apo-A1,Apo-B,etc.The anti-oxidative activity as assessed by determining the level of SOD,CAT,GSH,GSH-Px and MDA.Western blot analysis was used to determine the effect on ICAM-1,VCAM-1,MMP-2 and TNF-α.RESULTS In Dan-yi-lian administered ApoE(-/-) mice,the plaque area and media thickness were significantly reduced.Meanwhile,serum TC,TG,LDL and Apo-B were decreased,in contrast to the increased level of HDL and Apo-A1.On the other hand,SOD,CAT,GSH and GSH-Px were increased,while MDA was reduced in liver homogenate.In addition,the expression of ICAM-1,VCAM-1,MMP-2 and TNF-α was obviously inhibited by Dan-yi-lian.CONCLUSION Dan-yi-lian exhibit.ed potent anti-athero-sclerotic efficacy,in which the lipid-regulating,anti-oxidative and anti-inflammato.ry mechanism might be involved.展开更多
At 19:45 Beijing time on November 5,a LM-3B/Yuanzheng 1 launch vehicle lifted off from the Xichang Satellite Launch Center,putting the first two Bei Dou 3 satellites into orbit after the separation of the rocket upper...At 19:45 Beijing time on November 5,a LM-3B/Yuanzheng 1 launch vehicle lifted off from the Xichang Satellite Launch Center,putting the first two Bei Dou 3 satellites into orbit after the separation of the rocket upper stage and the satellites.The launch opens up a new era for the global networking of the Bei Dou Navigation Satellite system(Bei Dou system),which is the final step of the"three-step development strategy"of the system.展开更多
文摘THE ancient town of Huangyao located in Zhaoping County,Hezhou City,south China’s Guangxi Zhuang Autonomous Region,is renown for its time-honored Douchi processing techniques.Douchi is a kind of popular Chinese food made from fermented and salted black beans,which is commonly used as a condiment or seasoning for a variety of dishes.The history of Huangyao’s Douchi processing techniques can be traced back to the late Yuan Dynasty(1271-1368)and the early Ming Dynasty(1368-1644).According to a historical record of the Qing Dynasty(1644-1911),“Huangyao is famous for its Douchi and has no rivals.”
基金Supported by Research Projects of Guangxi Provincial Education Department(200911LX465)
文摘Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agricultural science and technology,problems of rural drinking water safety,problems of rural roads and transportation,low levels of health care,weak rural public culture,short supply of farmers' education.Secondly,the system and level of urban public goods provision can't meet migrant workers' demand,for example,less migrant workers are employed by the governments' direction;migrant workers are isolated by urban housing project and these workers have difficulty in receiving city social security.One reason of new generation migrant workers facing the double marginalization of rural and urban crisis is that urban and rural public goods supply are different in particular the inadequate supply of public goods in rural areas.Three countermeasures are put forward in order to relieve new generation migrant workers' double marginalization of urban and rural,which include increasing financial input in rural areas in order to achieve equalization of urban and rural public goods,perfecting the preferential agricultural policy to increase rural public goods supply,making urban public goods supply as a guide to promote the new generation migrant workers into the city.
基金supported by the National Natural Science Foundation of China(No.81973825)the Natural Science Research Foundation of Anhui Province Universities(No.KJ2020A0436)。
文摘Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.
文摘With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.
基金supported by National Natural Science Foundation of China(8137344181673464)
文摘OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mice with a western diet.The mice were orally administered with differ.ent doses of DYL or vehicle daily for 28 d.The anti-atherosclerotic effect was evaluated by measuring the aortic atherosclerotic lesion area and media thickness with ultrasound imaging and histological sec.tions staining method.The effect on blood lipid was investigated by determining TC,TG,LDL,HDL,Apo-A1,Apo-B,etc.The anti-oxidative activity as assessed by determining the level of SOD,CAT,GSH,GSH-Px and MDA.Western blot analysis was used to determine the effect on ICAM-1,VCAM-1,MMP-2 and TNF-α.RESULTS In Dan-yi-lian administered ApoE(-/-) mice,the plaque area and media thickness were significantly reduced.Meanwhile,serum TC,TG,LDL and Apo-B were decreased,in contrast to the increased level of HDL and Apo-A1.On the other hand,SOD,CAT,GSH and GSH-Px were increased,while MDA was reduced in liver homogenate.In addition,the expression of ICAM-1,VCAM-1,MMP-2 and TNF-α was obviously inhibited by Dan-yi-lian.CONCLUSION Dan-yi-lian exhibit.ed potent anti-athero-sclerotic efficacy,in which the lipid-regulating,anti-oxidative and anti-inflammato.ry mechanism might be involved.
文摘At 19:45 Beijing time on November 5,a LM-3B/Yuanzheng 1 launch vehicle lifted off from the Xichang Satellite Launch Center,putting the first two Bei Dou 3 satellites into orbit after the separation of the rocket upper stage and the satellites.The launch opens up a new era for the global networking of the Bei Dou Navigation Satellite system(Bei Dou system),which is the final step of the"three-step development strategy"of the system.
