BACKGROUND Hypertension is a major risk factor for cardiovascular disease and stroke,and its prevalence is increasing worldwide.Health education interventions based on the health belief model(HBM)can improve the knowl...BACKGROUND Hypertension is a major risk factor for cardiovascular disease and stroke,and its prevalence is increasing worldwide.Health education interventions based on the health belief model(HBM)can improve the knowledge,attitudes,and behaviors of patients with hypertension and help them control their blood pressure.AIM To evaluate the effects of health education interventions based on the HBM in patients with hypertension in China.METHODS Between 2021 and 2023,140 patients with hypertension were randomly assigned to either the intervention or control group.The intervention group received health education based on the HBM,including lectures,brochures,videos,and counseling sessions,whereas the control group received routine care.Outcomes were measured at baseline,three months,and six months after the intervention and included blood pressure,medication adherence,self-efficacy,and perceived benefits,barriers,susceptibility,and severity.RESULTS The intervention group had significantly lower systolic blood pressure[mean difference(MD):-8.2 mmHg,P<0.001]and diastolic blood pressure(MD:-5.1 mmHg,P=0.002)compared to the control group at six months.The intervention group also had higher medication adherence(MD:1.8,P<0.001),self-efficacy(MD:12.4,P<0.001),perceived benefits(MD:3.2,P<0.001),lower perceived barriers(MD:-2.6,P=0.001),higher perceived susceptibility(MD:2.8,P=0.002),and higher perceived severity(MD:3.1,P<0.001)than the control group at six months.CONCLUSION Health education interventions based on the HBM effectively improve blood pressure control and health beliefs in patients with hypertension and should be implemented in clinical practice and community settings.展开更多
Based on the review and comparison of main statistical analysis models for estimating variety-environment cell means in regional crop trials, a new statistical model, LR-PCA composite model was proposed, and the predi...Based on the review and comparison of main statistical analysis models for estimating variety-environment cell means in regional crop trials, a new statistical model, LR-PCA composite model was proposed, and the predictive precision of these models were compared by cross validation of an example data. Results showed that the order of model precision was LR-PCA model > AMMI model > PCA model > Treatment Means (TM) model > Linear Regression (LR) model > Additive Main Effects ANOVA model. The precision gain factor of LR-PCA model was 1.55, increasing by 8.4% compared with AMMI.展开更多
This study aimed to construct a quality management model for phase I clinical drug trials.A cross-sectional survey was conducted and data were collected from 604 respondents at 69 institutions in China engaged in phas...This study aimed to construct a quality management model for phase I clinical drug trials.A cross-sectional survey was conducted and data were collected from 604 respondents at 69 institutions in China engaged in phase I clinical drug trials.Exploratory and confirmatory factor analyses were used to develop the survey tool.Structural equation modeling was used to construct a quality management model for phase I clinical drug trials.The results showed that the final survey tool had good reliability and validity(Cronbach’sα=0.938,root mean square error of approximation=0.074,comparative fit index=0.962,and Tucker—Lewis index=0.955).The model included five dimensions:government regulation,industry management,medical institution management,research team management,and contract research organization(CRO)management.In total,22 measurement items were obtained.The structural equation model indicated government regulation,industry management,medical institution management,and CRO management significantly affected the quality of phase I clinical drug trials(β=0.195,β=0.331,β=0.279,andβ=−0.267,respectively;P<0.05).Research team management had no effect on the quality of trials(β=0.041,P=0.610).In conclusion,the model is valuable for identifying factors influencing phase I clinical drug trials and guiding quality management practices.展开更多
An efficient approach was proposed for discriminating shadows from moving objects. In the background subtraction stage, moving objects were extracted. Then, the initial classification for moving shadow pixels and fore...An efficient approach was proposed for discriminating shadows from moving objects. In the background subtraction stage, moving objects were extracted. Then, the initial classification for moving shadow pixels and foreground object pixels was performed by using color invariant features. In the shadow model learning stage, instead of a single Gaussian distribution, it was assumed that the density function computed on the values of chromaticity difference or bright difference, can be modeled as a mixture of Gaussian consisting of two density functions. Meanwhile, the Gaussian parameter estimation was performed by using EM algorithm. The estimates were used to obtain shadow mask according to two constraints. Finally, experiments were carried out. The visual experiment results confirm the effectiveness of proposed method. Quantitative results in terms of the shadow detection rate and the shadow discrimination rate(the maximum values are 85.79% and 97.56%, respectively) show that the proposed approach achieves a satisfying result with post-processing step.展开更多
Percutaneous electrical nerve stimulation of an injured nerve can promote and accelerate peripheral nerve regeneration and improve function.When performing acupuncture and moxibustion,locating the injured nerve using ...Percutaneous electrical nerve stimulation of an injured nerve can promote and accelerate peripheral nerve regeneration and improve function.When performing acupuncture and moxibustion,locating the injured nerve using ultrasound before percutaneous nerve stimulation can help prevent further injury to an already injured nerve.However,stimulation parameters have not been standardized.In this study,we constructed a multi-layer human forearm model using finite element modeling.Taking current density and activated function as optimization indicators,the optimal percutaneous nerve stimulation parameters were established.The optimal parameters were parallel placement located 3 cm apart with the injury site at the midpoint between the needles.To validate the efficacy of this regimen,we performed a randomized controlled trial in 23 patients with median nerve transection who underwent neurorrhaphy.Patients who received conventional rehabilitation combined with percutaneous electrical nerve stimulation experienced greater improvement in sensory function,motor function,and grip strength than those who received conventional rehabilitation combined with transcutaneous electrical nerve stimulation.These findings suggest that the percutaneous electrical nerve stimulation regimen established in this study can improve global median nerve function in patients with median nerve transection.展开更多
Objective:This study was to evaluate the quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction in China.Methods:We systematically searche...Objective:This study was to evaluate the quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction in China.Methods:We systematically searched the Cnki,Wanfang and Vipdatabases,to get randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction.The search period was from inception to October 2020.According to the Cochrane risk bias assessment tool,the quality of the studies included was appraised.Results:A total of 55 studies were retrieved,and 11 were eventually included in the study.Among the studies included,the first study was published in 2008.The overall quality of the 11 studies included was relatively low.Conclusions:The overall quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction was not high,which would hinder the evidence transformation as well as clinical practice.展开更多
In several instances of statistical practice, it is not uncommon to use the same data for both model selection and inference, without taking account of the variability induced by model selection step. This is usually ...In several instances of statistical practice, it is not uncommon to use the same data for both model selection and inference, without taking account of the variability induced by model selection step. This is usually referred to as post-model selection inference. The shortcomings of such practice are widely recognized, finding a general solution is extremely challenging. We propose a model averaging alternative consisting on taking into account model selection probability and the like-lihood in assigning the weights. The approach is applied to Bernoulli trials and outperforms Akaike weights model averaging and post-model selection estimators.展开更多
The primary aim of clinical trials is to investigate whether a treatment is effective for a particular disease or condition. Randomized controlled clinical trials are considered to be the gold standard for evaluating ...The primary aim of clinical trials is to investigate whether a treatment is effective for a particular disease or condition. Randomized controlled clinical trials are considered to be the gold standard for evaluating the effect of a certain intervention. However, in clinical trials, even after randomization, there are situations where the patients differ substantially with respect to the baseline value of the outcome variable. Many a times the response to interventions depends on the baseline values of the outcome variable. When there are baseline-dependent treatment effects, differences among treatments vary as a function of baseline level. Although variation in outcome associated with baseline value is accounted for in ANCOVA, analysis of individual differences in treatment effect is precluded by the homogeneity of regression assumption. This assumption requires that expected differences in outcome among treatments be constant across all baseline levels. To overcome this difficulty, Weigel and Narvaez [7] proposed a regression model for two treatment groups to analyze individual response to treatments in randomized controlled clinical trials. The authors reviewed the model suggested by Weigel and Narvaez and extended further for three or more treatment groups. The utility of the model was demonstrated with real life data from a randomized controlled clinical trial of bronchial asthma.展开更多
The deep learning models hold considerable potential for clinical applications, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently...The deep learning models hold considerable potential for clinical applications, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently only possible through multi-institutional cooperation. Building large central repositories is one strategy for multi-institution studies. However, this is hampered by issues regarding data sharing, including patient privacy, data de-identification, regulation, intellectual property, and data storage. These difficulties have lessened the impracticality of central data storage. In this survey, we will look at 24 research publications that concentrate on machine learning approaches linked to privacy preservation techniques for multi-institutional data, highlighting the multiple shortcomings of the existing methodologies. Researching different approaches will be made simpler in this case based on a number of factors, such as performance measures, year of publication and journals, achievements of the strategies in numerical assessments, and other factors. A technique analysis that considers the benefits and drawbacks of the strategies is additionally provided. The article also looks at some potential areas for future research as well as the challenges associated with increasing the accuracy of privacy protection techniques. The comparative evaluation of the approaches offers a thorough justification for the research’s purpose.展开更多
“双碳”目标下,各类可再生能源发电技术发展迅速,综合权衡不同可再生能源发电方案的综合效益对可再生能源的优化设计具有重要意义。综合考虑经济效益、环境效益、能源效益和社会效益4个层面,提出了一种基于模糊决策试验和评价实验(deci...“双碳”目标下,各类可再生能源发电技术发展迅速,综合权衡不同可再生能源发电方案的综合效益对可再生能源的优化设计具有重要意义。综合考虑经济效益、环境效益、能源效益和社会效益4个层面,提出了一种基于模糊决策试验和评价实验(decision making trial and evaluation laboratory,DEMATEL)与超效率数据包络分析(data envelopment analysis,DEA)模型的可再生能源发电技术综合效益评估方法。该方法分为投入-产出指标体系构建和综合评估2个阶段。首先,利用三角直觉模糊数处理模糊评价信息,将其与DEMATEL相结合量化各指标之间相互影响关系,基于指标间逻辑分析结果建立投入-产出评估指标体系。然后,基于超效率DEA模型对各可再生能源发电方案进行评估排序,结合投入冗余和产出不足分析结果给出各方案的针对性改善建议,以期为进一步选择和确定可再生能源产业发展战略提供参考。最后以某省10类可再生能源发电单元为研究对象,基于所提研究方法进行综合评估和分析,并与多准则妥协解排序法和熵权法进行对比分析,验证了所提方法的有效性。展开更多
为从系统整体角度完成对起落架收放系统的风险辨识和影响分析,将系统理论过程分析(Systematic Theory Process Analysis,STPA)与决策实验室分析-解释结构模型(Decision Making Trial and Evaluation Laboratory Interpretive Structural...为从系统整体角度完成对起落架收放系统的风险辨识和影响分析,将系统理论过程分析(Systematic Theory Process Analysis,STPA)与决策实验室分析-解释结构模型(Decision Making Trial and Evaluation Laboratory Interpretive Structural Modeling,DEMATEL-ISM)相结合来开展分析。首先,定义事故和系统级危险,以民机进近阶段放下起落架为例,运用STPA完成对风险因素的系统化辨识;其次,基于最大平均熵减(Maximum Mean De-entropy,MMDE)算法帮助DEMATEL-ISM模型确定阈值,完成对风险因素影响的重要性分析并识别可能引发系统级危险的风险传递路径,据此挖掘关键致因场景,以给出风险预防建议。结果显示:线路性能退化或失效、位置作动控制组件(Position Action Control Unit,PACU)核心处理器故障为关键原因因素,收放作动筒作动异常、机组成员操作不当、起落架指示灯显示异常、起落架液压选择阀作动异常、PACU信息接收有误为关键结果因素,这些因素均涉及多条可能引发系统级危险的风险传递路径,应予以重点控制。展开更多
文摘BACKGROUND Hypertension is a major risk factor for cardiovascular disease and stroke,and its prevalence is increasing worldwide.Health education interventions based on the health belief model(HBM)can improve the knowledge,attitudes,and behaviors of patients with hypertension and help them control their blood pressure.AIM To evaluate the effects of health education interventions based on the HBM in patients with hypertension in China.METHODS Between 2021 and 2023,140 patients with hypertension were randomly assigned to either the intervention or control group.The intervention group received health education based on the HBM,including lectures,brochures,videos,and counseling sessions,whereas the control group received routine care.Outcomes were measured at baseline,three months,and six months after the intervention and included blood pressure,medication adherence,self-efficacy,and perceived benefits,barriers,susceptibility,and severity.RESULTS The intervention group had significantly lower systolic blood pressure[mean difference(MD):-8.2 mmHg,P<0.001]and diastolic blood pressure(MD:-5.1 mmHg,P=0.002)compared to the control group at six months.The intervention group also had higher medication adherence(MD:1.8,P<0.001),self-efficacy(MD:12.4,P<0.001),perceived benefits(MD:3.2,P<0.001),lower perceived barriers(MD:-2.6,P=0.001),higher perceived susceptibility(MD:2.8,P=0.002),and higher perceived severity(MD:3.1,P<0.001)than the control group at six months.CONCLUSION Health education interventions based on the HBM effectively improve blood pressure control and health beliefs in patients with hypertension and should be implemented in clinical practice and community settings.
文摘Based on the review and comparison of main statistical analysis models for estimating variety-environment cell means in regional crop trials, a new statistical model, LR-PCA composite model was proposed, and the predictive precision of these models were compared by cross validation of an example data. Results showed that the order of model precision was LR-PCA model > AMMI model > PCA model > Treatment Means (TM) model > Linear Regression (LR) model > Additive Main Effects ANOVA model. The precision gain factor of LR-PCA model was 1.55, increasing by 8.4% compared with AMMI.
基金This study was supported by the Fundamental Research Funds for the Central Universities(No.5003516009).
文摘This study aimed to construct a quality management model for phase I clinical drug trials.A cross-sectional survey was conducted and data were collected from 604 respondents at 69 institutions in China engaged in phase I clinical drug trials.Exploratory and confirmatory factor analyses were used to develop the survey tool.Structural equation modeling was used to construct a quality management model for phase I clinical drug trials.The results showed that the final survey tool had good reliability and validity(Cronbach’sα=0.938,root mean square error of approximation=0.074,comparative fit index=0.962,and Tucker—Lewis index=0.955).The model included five dimensions:government regulation,industry management,medical institution management,research team management,and contract research organization(CRO)management.In total,22 measurement items were obtained.The structural equation model indicated government regulation,industry management,medical institution management,and CRO management significantly affected the quality of phase I clinical drug trials(β=0.195,β=0.331,β=0.279,andβ=−0.267,respectively;P<0.05).Research team management had no effect on the quality of trials(β=0.041,P=0.610).In conclusion,the model is valuable for identifying factors influencing phase I clinical drug trials and guiding quality management practices.
基金Project(50805023)supported by the National Natural Science Foundation of ChinaProject(BA2010093)supported by the Special Fund of Jiangsu Province for the Transformation of Scientific and Technological Achievements,ChinaProject(2008144)supported by the Hexa-type Elites Peak Program of Jiangsu Province,China
文摘An efficient approach was proposed for discriminating shadows from moving objects. In the background subtraction stage, moving objects were extracted. Then, the initial classification for moving shadow pixels and foreground object pixels was performed by using color invariant features. In the shadow model learning stage, instead of a single Gaussian distribution, it was assumed that the density function computed on the values of chromaticity difference or bright difference, can be modeled as a mixture of Gaussian consisting of two density functions. Meanwhile, the Gaussian parameter estimation was performed by using EM algorithm. The estimates were used to obtain shadow mask according to two constraints. Finally, experiments were carried out. The visual experiment results confirm the effectiveness of proposed method. Quantitative results in terms of the shadow detection rate and the shadow discrimination rate(the maximum values are 85.79% and 97.56%, respectively) show that the proposed approach achieves a satisfying result with post-processing step.
基金supported by the National Natural Science Foundation of China,No.81801787(to XZS)China Postdoctoral Science Foundation,No.2018M640238(to XZS)the Natural Science Foundation of Tianjin,No.20JCQNJC01690(to XLC)。
文摘Percutaneous electrical nerve stimulation of an injured nerve can promote and accelerate peripheral nerve regeneration and improve function.When performing acupuncture and moxibustion,locating the injured nerve using ultrasound before percutaneous nerve stimulation can help prevent further injury to an already injured nerve.However,stimulation parameters have not been standardized.In this study,we constructed a multi-layer human forearm model using finite element modeling.Taking current density and activated function as optimization indicators,the optimal percutaneous nerve stimulation parameters were established.The optimal parameters were parallel placement located 3 cm apart with the injury site at the midpoint between the needles.To validate the efficacy of this regimen,we performed a randomized controlled trial in 23 patients with median nerve transection who underwent neurorrhaphy.Patients who received conventional rehabilitation combined with percutaneous electrical nerve stimulation experienced greater improvement in sensory function,motor function,and grip strength than those who received conventional rehabilitation combined with transcutaneous electrical nerve stimulation.These findings suggest that the percutaneous electrical nerve stimulation regimen established in this study can improve global median nerve function in patients with median nerve transection.
基金This research was supported by National Natural Science Foundation of China(No.81603565)Tianjin University of Traditional Chinese Medicine Postgraduate Research Innovation Project(YJSKC-20201032).
文摘Objective:This study was to evaluate the quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction in China.Methods:We systematically searched the Cnki,Wanfang and Vipdatabases,to get randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction.The search period was from inception to October 2020.According to the Cochrane risk bias assessment tool,the quality of the studies included was appraised.Results:A total of 55 studies were retrieved,and 11 were eventually included in the study.Among the studies included,the first study was published in 2008.The overall quality of the 11 studies included was relatively low.Conclusions:The overall quality of the randomized controlled trials on Roy adaptation model nursing in individuals suffering from acute myocardial infarction was not high,which would hinder the evidence transformation as well as clinical practice.
文摘In several instances of statistical practice, it is not uncommon to use the same data for both model selection and inference, without taking account of the variability induced by model selection step. This is usually referred to as post-model selection inference. The shortcomings of such practice are widely recognized, finding a general solution is extremely challenging. We propose a model averaging alternative consisting on taking into account model selection probability and the like-lihood in assigning the weights. The approach is applied to Bernoulli trials and outperforms Akaike weights model averaging and post-model selection estimators.
文摘The primary aim of clinical trials is to investigate whether a treatment is effective for a particular disease or condition. Randomized controlled clinical trials are considered to be the gold standard for evaluating the effect of a certain intervention. However, in clinical trials, even after randomization, there are situations where the patients differ substantially with respect to the baseline value of the outcome variable. Many a times the response to interventions depends on the baseline values of the outcome variable. When there are baseline-dependent treatment effects, differences among treatments vary as a function of baseline level. Although variation in outcome associated with baseline value is accounted for in ANCOVA, analysis of individual differences in treatment effect is precluded by the homogeneity of regression assumption. This assumption requires that expected differences in outcome among treatments be constant across all baseline levels. To overcome this difficulty, Weigel and Narvaez [7] proposed a regression model for two treatment groups to analyze individual response to treatments in randomized controlled clinical trials. The authors reviewed the model suggested by Weigel and Narvaez and extended further for three or more treatment groups. The utility of the model was demonstrated with real life data from a randomized controlled clinical trial of bronchial asthma.
文摘The deep learning models hold considerable potential for clinical applications, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently only possible through multi-institutional cooperation. Building large central repositories is one strategy for multi-institution studies. However, this is hampered by issues regarding data sharing, including patient privacy, data de-identification, regulation, intellectual property, and data storage. These difficulties have lessened the impracticality of central data storage. In this survey, we will look at 24 research publications that concentrate on machine learning approaches linked to privacy preservation techniques for multi-institutional data, highlighting the multiple shortcomings of the existing methodologies. Researching different approaches will be made simpler in this case based on a number of factors, such as performance measures, year of publication and journals, achievements of the strategies in numerical assessments, and other factors. A technique analysis that considers the benefits and drawbacks of the strategies is additionally provided. The article also looks at some potential areas for future research as well as the challenges associated with increasing the accuracy of privacy protection techniques. The comparative evaluation of the approaches offers a thorough justification for the research’s purpose.
文摘“双碳”目标下,各类可再生能源发电技术发展迅速,综合权衡不同可再生能源发电方案的综合效益对可再生能源的优化设计具有重要意义。综合考虑经济效益、环境效益、能源效益和社会效益4个层面,提出了一种基于模糊决策试验和评价实验(decision making trial and evaluation laboratory,DEMATEL)与超效率数据包络分析(data envelopment analysis,DEA)模型的可再生能源发电技术综合效益评估方法。该方法分为投入-产出指标体系构建和综合评估2个阶段。首先,利用三角直觉模糊数处理模糊评价信息,将其与DEMATEL相结合量化各指标之间相互影响关系,基于指标间逻辑分析结果建立投入-产出评估指标体系。然后,基于超效率DEA模型对各可再生能源发电方案进行评估排序,结合投入冗余和产出不足分析结果给出各方案的针对性改善建议,以期为进一步选择和确定可再生能源产业发展战略提供参考。最后以某省10类可再生能源发电单元为研究对象,基于所提研究方法进行综合评估和分析,并与多准则妥协解排序法和熵权法进行对比分析,验证了所提方法的有效性。
文摘为从系统整体角度完成对起落架收放系统的风险辨识和影响分析,将系统理论过程分析(Systematic Theory Process Analysis,STPA)与决策实验室分析-解释结构模型(Decision Making Trial and Evaluation Laboratory Interpretive Structural Modeling,DEMATEL-ISM)相结合来开展分析。首先,定义事故和系统级危险,以民机进近阶段放下起落架为例,运用STPA完成对风险因素的系统化辨识;其次,基于最大平均熵减(Maximum Mean De-entropy,MMDE)算法帮助DEMATEL-ISM模型确定阈值,完成对风险因素影响的重要性分析并识别可能引发系统级危险的风险传递路径,据此挖掘关键致因场景,以给出风险预防建议。结果显示:线路性能退化或失效、位置作动控制组件(Position Action Control Unit,PACU)核心处理器故障为关键原因因素,收放作动筒作动异常、机组成员操作不当、起落架指示灯显示异常、起落架液压选择阀作动异常、PACU信息接收有误为关键结果因素,这些因素均涉及多条可能引发系统级危险的风险传递路径,应予以重点控制。