POEMS(polyneuropathy,organomegaly,endocrinopathy,M-protein and skin changes)综合征是一种单克隆浆细胞异常增殖的副肿瘤综合征,患病率约为0.3/10万[1]。该病累积神经、内分泌、骨骼、免疫及造血等系统,临床上诊断需要2个基本要素...POEMS(polyneuropathy,organomegaly,endocrinopathy,M-protein and skin changes)综合征是一种单克隆浆细胞异常增殖的副肿瘤综合征,患病率约为0.3/10万[1]。该病累积神经、内分泌、骨骼、免疫及造血等系统,临床上诊断需要2个基本要素:多发性周围神经病和单克隆浆细胞病[2]。周围神经病变是超过60%的POEMS综合征患者的首发症状,不少患者早期就诊于神经内科并被误诊为慢性炎性脱髓鞘性多发性神经根神经病(chronic inflammatory demyelinating polyneuropathy,CIDP)等原发性神经系统疾病[3]。由于神经病变进展缓慢、致残率高,多数患者就诊时症状严重且已造成神经不可逆性损伤,给患者生活带来极大不便,因此早识别、早诊断、及时治疗至关重要。本文报告1例采用达雷妥尤单抗(Daratumumab,Dara)联合方案治疗伴有严重周围神经病变的POEMS综合征,分析了神经病变的发病机制,并强调了POEMS综合征诊断的复杂性以及Daratumumab作为新一代药物在治疗中的潜在优势。展开更多
There is currently great optimism within the electronics community that gallium oxide(Ga_(2)O_(3)) ultra-wide bandgap semiconductors have unprecedented prospects for eventually revolutionizing a rich variety of power ...There is currently great optimism within the electronics community that gallium oxide(Ga_(2)O_(3)) ultra-wide bandgap semiconductors have unprecedented prospects for eventually revolutionizing a rich variety of power electronic applications. Specially, benefiting from its ultra-high bandgap of around 4.8 eV, it is expected that the emerging Ga_(2)O_(3) technology would offer an exciting platform to deliver massively enhanced device performance for power electronics and even completely new applications.展开更多
Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“r...Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance.展开更多
Based on Leech's maxims of politeness, this paper conducts a contrastive study between the use of politeness strategies in 30 Chinese prefaces and that in 30 English prefaces which are published about English study.
For celebrating the 70th birthday of Professor Kang Li-shan,we edit and publish this Special Issue to report ourrecent researches in parallel computing and evolutionary computation. Professor Kang is one of the pionee...For celebrating the 70th birthday of Professor Kang Li-shan,we edit and publish this Special Issue to report ourrecent researches in parallel computing and evolutionary computation. Professor Kang is one of the pioneers in parallel computing researches in China.In 1970ms he creatd the SchwarzAlternating Procedure and developed a class of asynchronous parallel algorithms for solving mathematical physics prob-lems called the domain decomposition methods(DDM).Then he and his colleagues continued to set up theoretic foun-展开更多
Materials science and technology is the basis and driving force in the progress of human society,where a great number of research frontiers represented by nanomaterials。
The 9th Scientific Assembly of the International Association of Meteorology and Atmospheric Sciences （IAMAS-2005） was held at the Beijing International Convention Center （BICC）, Beijing, China from August 2-11, 20...The 9th Scientific Assembly of the International Association of Meteorology and Atmospheric Sciences （IAMAS-2005） was held at the Beijing International Convention Center （BICC）, Beijing, China from August 2-11, 2005. The Theme of IAMAS-2005 is： The Fascinating Atmosphere： Changeable and Changing.展开更多
The Climate System Model Development and Application Studies （CSMDA for short） is an International Partnership Program for Creative Research Teams that was started in October 2004 and is supported by the Chinese Aca...The Climate System Model Development and Application Studies （CSMDA for short） is an International Partnership Program for Creative Research Teams that was started in October 2004 and is supported by the Chinese Academy of Sciences （CAS）. The initial objectives are ＂to develop a sustainable climate system model that can represent the interaction of different spheres in the climate system, to provide a cross-cut research platform for atmospheric sciences, oceanography and other related fields, and to offer theoretical support for developing and improving reasonable short-range climate prediction systems＂.展开更多
Kaschin-Beck disease (KBD) is regarded as an endemic, chronic, high incidence and degenerative osteoarthropathie disease. The areas of endemic KBD are relatively stable and are correlated with specific geographical en...Kaschin-Beck disease (KBD) is regarded as an endemic, chronic, high incidence and degenerative osteoarthropathie disease. The areas of endemic KBD are relatively stable and are correlated with specific geographical environments. In China, estimation of KBD patients in 1985 indicated more than 2 million people were severely affected in a broad region inhibited by over 30 million people. KBD endemic areas form a broad belt extending from northeast to southwest. The disease mostly appears in mountainous and hilly regions, and farmers are the major potentially affected ones. Hence KBD has been designated a national health priori-ty problem in China since 60’s.展开更多
China is a country that is frequently affected by severe convective weather. Here, severe convective weather mainly refers to intense local heavy precipitation, thunderstorm-induced gale-force winds including those fr...China is a country that is frequently affected by severe convective weather. Here, severe convective weather mainly refers to intense local heavy precipitation, thunderstorm-induced gale-force winds including those from tornadoes and downbursts, and hail and lightning. These types of severe weather are usually small in spatial scale and rapid in their development, and are therefore difficult to capture by observational networks and are poorly resolved in typical operational numerical weather prediction （NWP） models. Furthermore, many of the important dynamic and physical processes involved are not well understood. Within China, the impacts of severe convective weather rank only after those of landfalling typhoons and widespread heavy precipitation and flooding. Studies （e.g., Zhang and Zhai, 2011） have shown tendencies for an increased frequency in short-duration extreme precipitation during the past several decades over most of eastern China, where the population is most dense. An in-depth understanding of severe convective weather in China, as well as being able to accurately predict it, is clearly of great importance.展开更多
文摘There is currently great optimism within the electronics community that gallium oxide(Ga_(2)O_(3)) ultra-wide bandgap semiconductors have unprecedented prospects for eventually revolutionizing a rich variety of power electronic applications. Specially, benefiting from its ultra-high bandgap of around 4.8 eV, it is expected that the emerging Ga_(2)O_(3) technology would offer an exciting platform to deliver massively enhanced device performance for power electronics and even completely new applications.
文摘Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance.
文摘Based on Leech's maxims of politeness, this paper conducts a contrastive study between the use of politeness strategies in 30 Chinese prefaces and that in 30 English prefaces which are published about English study.
文摘For celebrating the 70th birthday of Professor Kang Li-shan,we edit and publish this Special Issue to report ourrecent researches in parallel computing and evolutionary computation. Professor Kang is one of the pioneers in parallel computing researches in China.In 1970ms he creatd the SchwarzAlternating Procedure and developed a class of asynchronous parallel algorithms for solving mathematical physics prob-lems called the domain decomposition methods(DDM).Then he and his colleagues continued to set up theoretic foun-
文摘Materials science and technology is the basis and driving force in the progress of human society,where a great number of research frontiers represented by nanomaterials。
文摘The International Conference of Nonferrous Materials (ICNFM) ’2007 was held in Changsha and Zhangjiajie, China, from November 25 to November 30, 2007.
文摘The 9th Scientific Assembly of the International Association of Meteorology and Atmospheric Sciences （IAMAS-2005） was held at the Beijing International Convention Center （BICC）, Beijing, China from August 2-11, 2005. The Theme of IAMAS-2005 is： The Fascinating Atmosphere： Changeable and Changing.
文摘The Climate System Model Development and Application Studies （CSMDA for short） is an International Partnership Program for Creative Research Teams that was started in October 2004 and is supported by the Chinese Academy of Sciences （CAS）. The initial objectives are ＂to develop a sustainable climate system model that can represent the interaction of different spheres in the climate system, to provide a cross-cut research platform for atmospheric sciences, oceanography and other related fields, and to offer theoretical support for developing and improving reasonable short-range climate prediction systems＂.
文摘Kaschin-Beck disease (KBD) is regarded as an endemic, chronic, high incidence and degenerative osteoarthropathie disease. The areas of endemic KBD are relatively stable and are correlated with specific geographical environments. In China, estimation of KBD patients in 1985 indicated more than 2 million people were severely affected in a broad region inhibited by over 30 million people. KBD endemic areas form a broad belt extending from northeast to southwest. The disease mostly appears in mountainous and hilly regions, and farmers are the major potentially affected ones. Hence KBD has been designated a national health priori-ty problem in China since 60’s.
基金supported by the Ministry of Science and Technology of China National "973" Fundamental Research Program(Grant No.2013CB430103)
文摘China is a country that is frequently affected by severe convective weather. Here, severe convective weather mainly refers to intense local heavy precipitation, thunderstorm-induced gale-force winds including those from tornadoes and downbursts, and hail and lightning. These types of severe weather are usually small in spatial scale and rapid in their development, and are therefore difficult to capture by observational networks and are poorly resolved in typical operational numerical weather prediction （NWP） models. Furthermore, many of the important dynamic and physical processes involved are not well understood. Within China, the impacts of severe convective weather rank only after those of landfalling typhoons and widespread heavy precipitation and flooding. Studies （e.g., Zhang and Zhai, 2011） have shown tendencies for an increased frequency in short-duration extreme precipitation during the past several decades over most of eastern China, where the population is most dense. An in-depth understanding of severe convective weather in China, as well as being able to accurately predict it, is clearly of great importance.
