Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive molecules.Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.These exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic effects.Furthermore,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug encapsulation.Consequently,researchers have turned their attention to exosomes as a novel therapeutic avenue.Nonetheless,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application.To overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system.By exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier.Notably,exosomes,owing to their small size,can readily access the nerve pathways using this method.As a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments.In this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases.Furthermore,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

The Development Trend of Enterprise Business Administration and the Innovation of Management Mode

In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.

Exploring Corporate Tax Compliance in the Era of Digital Tax Collection and Administration:Insights from the“Golden Tax Phase Four”Project

This article primarily examines the current state of tax collection and management,alongside other associated issues.It integrates insights from China’s“14th Five-Year Plan”and anticipates the imminent implementation of the“Golden Tax Phase Four.”With this backdrop,the article offers recommendations for advancing the reform of the tax collection and management system,fostering the development of intelligent taxation,and accelerating the modernization of tax collection and management in China.

How to Optimize the Management of Science and Technology Funds in Colleges and Universities Based on the Policy of Streamlining Administration,Delegating Powers,Improving Regulation,and Strengthening Services

To advance the field of science and technology,we need to revitalize the development of science and technology through innovation.The development of science and technology has many beneficial implications on the revitalization of the country.For this reason,universities in China should give full attention to their role as the main propeller of science and technology.“Streamlining administration,delegating powers,improving regulation,and strengthening services”is a policy issued by the Chinese government for the management of science and technology funds in colleges and universities.Based on the policy of“streamlining administration,delegating powers,improving regulation,and strengthening services,”colleges and universities must optimize the management of science and technology funds for their efficient use.In this paper,we analyzed the importance of the policy and put forward an effective management strategy,aiming to improve the management of science and technology funds in colleges and universities.

Surpass Streamline血流导向术对颅内动脉瘤的疗效

目的了解Surpass Streamline血流导向术对颅内动脉瘤的疗效。方法选取2020年1月至2022年1月安徽医科大学附属宿州医院68例接受Surpass Streamline血流导向装置治疗的颅内动脉瘤患者。收集临床资料,观察患者术前术后血流动力学参数变化,以及术前和术后3、6、12个月的改良Rankin量表(mRS)评分变化,分析患者的影像学资料,观察动脉瘤闭塞情况。结果与术前相比较,患者术后的WSS、瘤颈血流速度降低,LSA、RRT、载瘤动脉及患侧M1的血流速度增加(P<0.05),而患者术前、术后对侧M1血流速度比较差异无统计学意义(P>0.05)。术后,随着时间的延长,患者的mRS评分为低级别占比逐渐增高,差异有统计学意义(P<0.05)。术后6个月及12个月患者的支架内狭窄发生率分别为7.35%、8.82%,动脉瘤完全闭塞发生率分别为52.94%、63.24%,差异无统计学意义(P>0.05)。68例患者经Surpass Streamline血流导向术治疗后,4例出现缺血性并发症,其中2例表现为视物模糊、皮质盲,1例为肢体无力,1例支架内血栓,经干预治疗均得到有效缓解。结论采用Surpass Streamline血流导向术治疗颅内动脉瘤有较好的疗效,能改善血流动力学,术后动脉瘤完全闭塞率较高,且安全性较好,值得临床推广。

America’s Policy towards China under Two Administrations in the Context of Great Changes: Difference, Influence and Enlightenment

Under the great changes unseen in a century,comprehensive containment and suppression of China in the name of strategic competition has become a crossparty consensus in the United States,with the Republican Trump administration initiating the process of containing and suppressing China and the Democratic Biden administration continuing and developing such a strategy.In the process of implementing this strategy,there are some diff erences in the goals and means of the two American administrations.The Trump administration was trying to“crush China”with the super strength of the United States,with more extreme and tougher means,being more unilateralist and even going so far as to launch a“new Cold War”against China.The Biden administration,on the other hand,emphasizes long-term competition with China,and focuses on“managing competition”while suppressing China,accustomed to being double-handed and using both carrot and stick.When it comes to addressing global challenges,the Republican Party completely lacks the will to cooperate with China,while the Democratic Party has a certain need for cooperation and action.

Application of Information Technology in Institutions and Challenges of Human Resources-Case Study: Administration of the Municipality of Ferizaj

This study aims to investigate how information technology is applied in the administration of the municipality of Ferizaj and what are the challenges with human resources, the work was carried out through a case study in the municipality. This paper highlights that the use of information technology provides higher efficiency for the performance of daily work in the municipality, thus also the provision of better services to citizens. However, the level of use of information technology in the Municipality of Ferizaj leaves much to be desired in terms of efficiency because a significant number of employees have not attended adequate training for the effective and efficient use of various IT applications and have not are still adapted to the digital environment in the municipality. Therefore, the recommendation derived from this paper is that the information technology environment in the municipality of Ferizaj needs to be improved by providing staff with adequate qualifications, while for those who are currently engaged in the municipality and who do not have adequate qualifications, training should be provided in a way that all users of IT applications are fully integrated into the digitized environment in order to be effective and efficient in providing services to citizens. This simultaneously gives the municipal staff job security and motivation for better services for citizens. Also, information technology enables a better control over the activity of the municipality because every action is recorded as data which can then be used to analyze the performance of the municipality.

Numerical investigation on the aerodynamic drag reduction based on bottom deflectors and streamlined bogies of a high-speed train

The complex structure of the bottom of a high-speed train is an important source of train aerodynamic drag.Thus,improving the bottom structure is of great significance to reduce the aerodynamic drag of the train.In this study,computational fluid dynamics(CFD)based on three-dimensional steady incompressible Reynolds-average Naiver-Stokes(RANS)equations and Realizable k-ε turbulence model were utilized for numerical simulations.Inspired by the concept of streamlined design and the idea of bottom flow field control,this study iteratively designed the bogies in a streamlined shape and combined them with the bottom deflectors to investigate the joint drag reduction mechanism.Three models,i.e.,single-bogie model,simplified train model,and eight-car high-speed train model,were created and their aerodynamic characteristics were analyzed.The results show that the single-bogie model with streamlined design shows a noticeable drag reduction,whose power bogie and trailer bogie experience 13.92%and 7.63%drag reduction,respectively.The range of positive pressure area on the bogie is reduced.The aerodynamic drag can be further reduced to 15.01%by installing both the streamlined bogie and the deflector on the simplified train model.When the streamlined bogies and deflectors are used on the eight-car model together,the total drag reduction rate reaches 2.90%.Therefore,the proposed aerodynamic kit for the high-speed train bottom is capable to improve the flow structure around the bogie regions,reduce the bottom flow velocity,and narrow the scope of the train’s influence on the surrounding environment,achieving the appreciable reduction of aerodynamic drag.This paper can provide a new idea for the drag reduction of high-speed trains.

Research on passenger flow control at metro transfer stations based on real-time flow calculation of streamlines

Purpose – The volume of passenger traffic at metro transfer stations serves as a pivotal metric for theorchestration of crowd flow management. Given the intricacies of crowd dynamics within these stations andthe recurrent instances of substantial passenger influxes, a methodology predicated on stochastic processesand the principle of user equilibrium is introduced to facilitate real-time traffic flow estimation within transferstation streamlines.Design/methodology/approach – The synthesis of stochastic process theory with streamline analysisengenders a probabilistic model of intra-station pedestrian traffic dynamics. Leveraging real-time passengerflow data procured from monitoring systems within the transfer station, a gradient descent optimizationtechnique is employed to minimize the cost function, thereby deducing the dynamic distribution of categorizedpassenger flows. Subsequently, adhering to the tenets of user equilibrium, the Frank–Wolfe algorithm isimplemented to allocate the intra-station categorized passenger flows across various streamlines, ascertainingthe traffic volume for each.Findings – Utilizing the Xiaozhai Station of the Xi’an Metro as a case study, the Anylogic simulation softwareis engaged to emulate the intra-station crowd dynamics, thereby substantiating the efficacy of the proposedpassenger flow estimation model. The derived solutions are instrumental in formulating a crowd controlstrategy for Xiaozhai Station during the peak interval from 17:30 to 18:00 on a designated day, yielding crowdmanagement interventions that offer insights for the orchestration of passenger flow and operationalgovernance within metro stations.Originality/value – The construction of an estimation methodology for the real-time streamline traffic flowaugments the model’s dataset, supplanting estimated values derived from surveys or historical datasets withreal-time computed traffic data, thereby enhancing the precision and immediacy of crowd flow managementwithin metro stations.

Succession Plan for Nursing Academic Program Administrators

Leadership succession in nursing academic programs poses a significant challenge, primarily due to the limited availability of professionals with the competencies required for effective leadership [1]. This study aims to address this gap by investigating the critical factors in succession planning for nursing program administrators. The research objectives include identifying the competencies necessary for academic administrators, assessing the experience of current administrators, and developing a comprehensive succession plan framework. The research uses qualitative methods, including literature review, interviews with nursing administrators, and analysis of existing succession models. Results highlight the importance of integrating strategic planning into succession processes to ensure smooth transitions and organizational stability. Conclusions suggest that a formalized succession plan, incorporating mentorship and leadership development, can mitigate leadership gaps in nursing academia [2].

Status, Transition, and Impact of the Yoon Suk-yeol Administration’s Trade Policy with China

China is Korea’s main trade partner in East Asia and one of its key economic and trade partners worldwide.The two countries have complementary industrial structure and a long history of trade exchanges.However,against the backdrop of a return to global trade protectionism and the politicization of international affairs with Yoon Suk-yeol coming to power,South Korea has undertaken a strong trade shift toward the United States(US),triggering a change in the pattern of economic cooperation in East Asia and challenging the regional trade structure.A review of the trade policy agenda of the Yoon Suk-yeol administration toward the US and China,along with a comparative review of Korea’s foreign trade stance under Moon Jae-in,allows for an analysis of the turnaround and characteristics of Yoon’s trade policy toward China during his tenure.The implications for global trade governance and regional security are further analyzed with an aim of finding a Nash equilibrium in trade cooperation among East Asian countries.

Adjustment of Administrative Divisions and Upgrading of Industrial Structure in Hefei Metropolitan Area:Taking"Partitions of Chaohu"as a Quasi-natural Experiment

Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.

Design of an E-Administration Platform and Its Cryptography-Based Security Model

E-administration is performing administrative works via computer and its associated technologies such as the Internet. It is administrative efforts that center on the exchange of information and providing services to people and the business sector at high speed and low cost through computers and networks with the assurance of maintaining information security. It is based on the positive investment in information technology and communication in administrative practices. This paper presents the design of the e-administration platform that adopts the concept of cryptography for identity management. The architectural framework of the platform comprises subcomponents for service and forms identification, business process redesign, service architecture, amalgamation, and deployment. The cryptography model for securing the platform was designed based on the combination of authentication criteria presented in the Rijndael-Advanced Encryption Standard (AES), Lattice-based cryptography (LBC), and Secure Hash Algorithm (SHA512). It is required that a record be encrypted prior to its commitment to the database via a double encryption method. The AES algorithm-based encryption’s output will form the input to the LBC algorithm to obtain the final output.

Effects of Oral Administration of Propylene Glycol and Ca-P-Mg Mixture on Milk Quality and SCC of Dairy Cows after Birth

In order to further study the postpartum care technology of dairy cows,the effects of oral administration of propylene glycol or Ca-P-Mg mixture and compound oral rehydration salts on milk quality and SCC of dairy cows after birth were investigated. The results showed that the milk fat and dry matter contents in the dairy cows administered with Ca-P-Mg mixture and compound oral rehydration salts were higher than those in the dairy cows administered with propylene glycol（P 〈0.05）. However, there were no significant differences in milk sugar and protein contents and SCC between the two administration groups.

Administration与Government文化语义辨析及其翻译

本文分析了英语（尤其是美国英语）中administration与government的文化语义差异，认为administration的词义核心是“行政分芰”，将administration翻译为汉语的“政府”不够妥当，该词的恰当汉译为“行府”，而government的汉译是“政府”

“行政”(administration)义考

"行政"一词是行政学的核心概念。作为一个学科,概念梳理和界定是一项基础性工作,如果概念特别是核心概念不清,学科发展必然会受到影响。本文从文字构成、词源、中英文对照的比较视角以及学科发展脉络对"行政"的含义进行考证和梳理。

Current Issues and Development Strategies of Building the Discipline of Pharmacy Administration at Pharmacy Schools in China

The history and current status of Pharmacy Administration discipline atpharmacy schools in China are illustrated. Several current issues are explored including: (1)insufficient teaching organizations and curriculum, (2) faculty deficiency both in quantity andquality, and (3) much improvement needed in the scope, methodology, and sophistication of research.Several development strategies are formulated such as (1) integrating native education resources inorder to better foster quality professionals, (2) accelerating inter-university cooperation both inteaching and research, and (3) studying the regularites of discipline development and enhancinginternational exchange.

基于作者共被引的公共行政研究状况图谱分析——以《Public Administration Review》为研究对象

一门学科的发展离不开优秀专家学者的倾力支持,在公共行政学的形成和发展过程中,同样有一批优秀的公共行政学者推动了公共行政不同分支领域的衍生与发展。运用作者共被引和信息可视化方法,对权威期刊《公共行政评论》(Public Administration Review)于1975—2008年间发表的论文引文中被引频次前50名的学者进行分析。研究结果展现了公共行政领域的主要学术流派,并验证了公共行政研究确实是在沿着范式转移的轨迹更迭交替着。而这种变迁是相对的,大部分时间内,不同范式之间以及和其他学术流派之间是共存、互动甚至交融的。研究还发现,网络化治理正凭借其多中心和网络化的组织基础以及服务治理的先进理念迅速崛起,它将成为公共行政新的研究范式,而基于网络理论的公共行政理论大整合也将很有可能成为公共行政未来的研究热点。此外,实证结果与公共行政范式分类的高度相似性也充分表明了作者共被引和信息可视化方法的科学和有效,它的确为学科范式研究提供了一条定量研究的新思路和一个宏观分析的新视角。

A Comparative Analysis of the Administration of Oral Hypoglycemic Drugs in Second Affiliated Hospital of Guiyang Medical College during 2012-2014

[Objective] This study aimed to analyze the application and administration of oral hypoglycemic drugs in Second Affiliated Hospital of Guiyang Medical College,aiming at providing guidance and reference for clinical medication for treatment of diabetes.[Method] The main types,dosages and prices of oral hypoglycemic drugs in Second Affiliated Hospital of Guiyang Medical College during 2012-2014 were compared and analyzed using the computer network system.[Result] During 2012-2014,sales quantity and sales amount of oral hypoglycemic drugs in Second Affiliated Hospital of Guiyang Medical College demonstrated an upward trend.[Conclusion] Integrative medicine can significantly improve symptoms of diabetes complications.Certain achievements have been made in diabetes treatment by Second Affiliated Hospital of Guiyang Medical College.

“administration”的三大翻译之争

"administration"是一个用法极广、含义丰富的词汇,通常被翻译为"政府"、"管理"、"行政"等意思。本文主要围绕"administration"与"government"、"management"、"executive"等三词的翻译冲突,并较详细地探讨了它们之间的语义及语用区别。