Toward less invasive coloproctology: The future is out there

Medical care has undergone remarkable improvements over the past few decades.One of the most important innovative breakthroughs in modern medicine is the advent of minimally and less invasive treatments.The trend towards employing less invasive treatment has been vividly shown in the field of gastroenterology,particularly coloproctology.Parallel to foregut interventions,colorectal surgery has shifted towards a minimally invasive approach.Coloproctology,including both medical and surgical management of colorectal diseases,has undergone a remarkable paradigm shift.The treatment of both benign and malignant colorectal conditions has gradually transitioned towards more conservative and less inva-sive approaches.An interesting paradigm shift was the trend to avoid the need for radical resection of rectal cancer altogether in patients who showed complete response to neoadjuvant treatment.The trend of adopting less invasive appro-aches to treat various colorectal conditions does not seem to be stopping soon as further research on novel,more effective and safer methods is ongoing.

Traction power systems for electrified railways:evolution,state of the art,and future trends

Traction power systems(TPSs)play a vital role in the operation of electrified railways.The transformation of conventional railway TPSs to novel structures is not only a trend to promote the development of electrified railways toward high-efficiency and resilience but also an inevitable requirement to achieve carbon neutrality target.On the basis of sorting out the power supply structures of conventional AC and DC modes,this paper first reviews the characteristics of the existing TPSs,such as weak power supply flexibility and low-energy efficiency.Furthermore,the power supply structures of various TPSs for future electrified railways are described in detail,which satisfy longer distance,low-carbon,high-efficiency,high-reliability and high-quality power supply requirements.Meanwhile,the application prospects of different traction modes are discussed from both technical and economic aspects.Eventually,this paper introduces the research progress of mixed-system electrified railways and traction power supply technologies without catenary system,speculates on the future development trends and challenges of TPSs and predicts that TPSs will be based on the continuous power supply mode,employing power electronic equipment and intelligent information technology to construct a railway comprehensive energy system with renewable energy.

Advancements in Humanoid Robots: A Comprehensive Review and Future Prospects

This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analyzing various research endeavors and key technologies, encompassing ontology structure,control and decision-making, and perception and interaction, a holistic overview of the current state of humanoid robot research is presented. Furthermore, emerging challenges in the field are identified, emphasizing the necessity for a deeper understanding of biological motion mechanisms, improved structural design,enhanced material applications, advanced drive and control methods, and efficient energy utilization. The integration of bionics, brain-inspired intelligence, mechanics, and control is underscored as a promising direction for the development of advanced humanoid robotic systems. This paper serves as an invaluable resource, offering insightful guidance to researchers in the field,while contributing to the ongoing evolution and potential of humanoid robots across diverse domains.

Spatiotemporal Evaluation and Future Projection of Diurnal Temperature Range over the Tibetan Plateau in CMIP6 Models

The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway(SSP) scenarios for the near,middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal:(1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR,FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI-ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau.(2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large.(3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future.

Thornthwaite moisture index and depth of suction change under current and future climate‒An Australian study

Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical structures.The changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive soils.The volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such soils.Climate change is likely to amplify the ground movement potential and the associated problems are likely to worsen.The effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for Australia.The changes in TMI were then correlated to the depth of suction change(H s),an important input in ground movement calculation.Under all climate scenarios considered,reductions in TMI and increases in H s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is discussed.It is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.

China’s Change through Future Leaders’Eyes

Together for a Shared Future Compiled by Global Young Leaders Dialogue Price:RMB 118 Paperback,250 pages Published by Foreign Languages Press Together for a Shared Future is co-authored by 35 young people from 26 countries who participated in the project China Tour of the Global Young Leaders Dialogue(GYLD),an institutional platform for idea-sharing among young people from different countries.

Emerging molecules,tools,technology,and future of surgical knife in gastroenterology

The 21^(st) century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various tools and technology which has completely changed the patient management including abdominal surgery.Surgery for abdominal diseases has moved from maximally invasive to minimally invasive(laparoscopic and robotic)surgery.Some of the newer medicines have its impact on need for surgical intervention.This article focuses on the development of these emerging molecules,tools,and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.

Young Voices for a Better Future

On September 4,the"Strengthening Youth Exchange to Build a Friendly Future"China-Laos Youth Dialogue was held at the National University of Laos (NUOL) in Vientiane with an aim to consolidate bilateral friendship,promote the building of a ChinaLaos community with a shared future,and strengthen exchanges and cooperation between the youth of both countries.

An Exploration of the Three Dimensions and Epochal Strengths of Building a Human Community With a Shared Future

The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the most important question in today's world:“What is happening to the world and what should we do?”It profoundly answers the question of the world,history,and the times.The theory of a human community with a shared future is an innovative theory with a multidimensional formation logic that guides humanity toward continually seeking common interests and values.This paper dives into the profound motivations behind building a human community with a shared future from historical,cultural,and practical dimensions and analyzes its epochal value from both domestic and international perspectives.This not only helps exert China's role in the international community,contributing Chinese strength to the construction of a peaceful,stable,and prosperous human society,but also enhances the influence of the idea of a human community with a shared future in the international community,accelerating the building of a human community with a shared future that considers the legitimate concerns of all countries,and aiding in solving the crises facing the world.

Anthropogenic influence on the extreme drought in eastern China in 2022 and its future risk

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分析不同外强迫因子作用下此类极端干旱事件的发生概率变化,发现人为强迫使此类极端干旱事件的发生概率提高约56%,这主要与人为强迫下中国东部平均水汽减少和平均上升运动减弱有关.进一步通过分析此类极端干旱事件对不同温室气体排放情景(SSP1-2.6,SSP2-4.5,SSP5-8.5)的响应,发现在低排放情景下类2022年极端干旱事件的发生概率较当今气候显著下降,这主要与中国东部平均水汽的增加和平均环流的变化有关,而在高排放情景(SSP5-8.5)下,此类极端干旱事件的发生概率较当今气候增加约79%,这主要与高排放情景下平均下沉运动增强有关.该研究表明,人为强迫通过调制气候平均背景场从而引起极端事件发生频次的变化是人类活动影响极端气候事件的重要途径之一,极端干旱事件对温室气体排放量的响应可能是非线性的.

Simultaneous portal and hepatic vein embolization is better than portal embolization or ALPPS for hypertrophy of future liver remnant before major hepatectomy: A systematic review and network meta-analysis

Background:Post-hepatectomy liver failure(PHLF)is the Achilles’heel of hepatic resection for colorectal liver metastases.The most commonly used procedure to generate hypertrophy of the functional liver remnant(FLR)is portal vein embolization(PVE),which does not always lead to successful hypertrophy.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been proposed to overcome the limitations of PVE.Liver venous deprivation(LVD),a technique that includes simultaneous portal and hepatic vein embolization,has also been proposed as an alternative to ALPPS.The present study aimed to conduct a systematic review as the first network meta-analysis to compare the efficacy,effectiveness,and safety of the three regenerative techniques.Data sources:A systematic search for literature was conducted using the electronic databases Embase,PubMed(MEDLINE),Google Scholar and Cochrane.Results:The time to operation was significantly shorter in the ALPPS cohort than in the PVE and LVD cohorts by 27 and 22 days,respectively.Intraoperative parameters of blood loss and the Pringle maneuver demonstrated non-significant differences between the PVE and LVD cohorts.There was evidence of a significantly higher FLR hypertrophy rate in the ALPPS cohort when compared to the PVE cohort,but non-significant differences were observed when compared to the LVD cohort.Notably,the LVD cohort demonstrated a significantly better FLR/body weight(BW)ratio compared to both the ALPPS and PVE cohorts.Both the PVE and LVD cohorts demonstrated significantly lower major morbidity rates compared to the ALPPS cohort.The LVD cohort also demonstrated a significantly lower 90-day mortality rate compared to both the PVE and ALPPS cohorts.Conclusions:LVD in adequately selected patients may induce adequate and profound FLR hypertrophy before major hepatectomy.Present evidence demonstrated significantly lower major morbidity and mortality rates in the LVD cohort than in the ALPPS and PVE cohorts.

Future Changes in the Relationship Between the South and East Asian Summer Monsoons in CMIP6 Models

The future changes in the relationship between the South Asian summer monsoon(SASM)and the East Asian summer monsoon(EASM)are investigated by using the high-emissions Shared Socioeconomic Pathway 5-8.5(SSP5-8.5)experiments from 26 coupled models that participated in the phase 6 of the Coupled Model Intercomparison Project(CMIP6).Six models,selected based on their best performance in simulating the upper-and lower-level pathways related to the SASM-EASM teleconnection in the historical run,can capture the positive relationship between the SASM and the rainfall over northern China.In the future scenario,the upper-level teleconnection wave pattern connecting the SASM and the EASM exhibits a significant weakening trend,due to the rainfall anomalies decrease over the northern Indian Peninsula in the future.At the lower level,the western North Pacific anticyclone is projected to strengthen in the warming climate.The positive(negative)rainfall anomalies associated with positive(negative)SASM rainfall anomalies are anticipated to extend southward from northern China to the Yangtze-Huai River valley,the Korea Peninsula,and southern Japan.The connection in the lower-level pathway may be strengthened in the future.

CD4^(+)CD25^(+) regulatory T cells decreased future liver remnant after associating liver partition and portal vein ligation for staged hepatectomy

BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)is an innovative surgical approach for the treatment of massive hepatocellular carcinoma(HCC),the key to successful planned stage 2 ALPPS is future liver remnant(FLR)volume growth,but the exact mechanism has not been elucidated.The correlation between regulatory T cells(Tregs)and postoperative FLR regeneration has not been reported.AIM To investigate the effect of CD4^(+)CD25^(+)Tregs on FLR regeneration after ALPPS.METHODS Clinical data and specimens were collected from 37 patients who developed massive HCC treated with ALPPS.Flow cytometry was performed to detect changes in the proportion of CD4^(+)CD25^(+)Tregs to CD4^(+)T cells in peripheral blood before and after ALPPS.To analyze the relationship between peripheral blood CD4^(+)CD25^(+)Treg proportion and clinicopathological information and liver volume.RESULTS The postoperative CD4^(+)CD25^(+)Treg proportion in stage 1 ALPPS was negatively correlated with the amount of proliferation volume,proliferation rate,and kinetic growth rate(KGR)of the FLR after stage 1 ALPPS.Patients with low Treg proportion had significantly higher KGR than those with high Treg proportion(P=0.006);patients with high Treg proportion had more severe postoperative pathological liver fibrosis than those with low Treg proportion(P=0.043).The area under the receiver operating characteristic curve between the percentage of Tregs and proliferation volume,proliferation rate,and KGR were all greater than 0.70.CONCLUSION CD4^(+)CD25^(+)Tregs in the peripheral blood of patients with massive HCC at stage 1 ALPPS were negatively correlated with indicators of FLR regeneration after stage 1 ALPPS and may influence the degree of fibrosis in patients’livers.Treg percentage was highly accurate in predicting the FLR regeneration after stage 1 ALPPS.

Are life insurance futures a safe haven during COVID‑19?

This study aims to examine whether life insurance futures can serve as a hedge against the COVID-19 pandemic and whether they have the characteristics of a safe haven under the impact of the health shocks of the COVID-19 pandemic.We chose three life insurance stock futures in India and one in Taiwan as samples,including the market index of the two countries and the number of confirmed COVID-19 cases as sample variables.We used the growth rate of COVID-19 cases as the threshold variable,esti-mated the asymmetric threshold vector autoregression model,and found that insur-ance futures in the regime with a significant growth rate of confirmed COVID-19 cases can hedge against COVID-19 risks;therefore,insurance futures are a safe haven for the market.We further estimated the time-varying parameter vector autoregression model,and the impulse response results showed that insurance futures are a safe haven for COVID-19 pandemic risks.

Assessing Future Flooding Risk in a Coastal Lagoon Using Hydrogeological Approaches and Analysis of the 2021 Flood Event: A Case Study of Tasi-Tolu Lagoon, Dili, Timor-Leste

This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the lagoon, which include factors such as size, depth, water quality, and ecosystem composition. Secondly, the influence of precipitation on the water volume in the lagoon will be examined. This analysis involves assessing historical rainfall patterns in the region, as well as the amount and frequency of precipitation during the 2021 flood event. Thirdly, the hydrogeologic and geologic conditions of the lagoon will be evaluated. This involves examining factors such as the type and structure of the soil and bedrock, the presence of aquifers or other underground water sources, and the movement of water through the surrounding landscape. Finally, the study seeks to assess the risk of future flooding in Tasi-Tolu Lagoon, based on the insights gained from the previous analyses. Overall, this study’s goal is to provide a comprehensive understanding of the hydrogeological factors that contribute to flooding in Tasi-Tolu Lagoon. This knowledge could be used to inform flood mitigation strategies or to improve our ability to predict and respond to future flooding events in the region.

Historic and Future Perspectives of Storm and Cyclone

In weather sciences,the two specific terms“storm”and“cyclone”frequently appear in literature and usually refer to the violent nature of a number of weather systems characterized by central low pressure,strong winds,large precipitation amounts in the form of rain,freezing rain,or snow,as well as thunder and lightning.But what is the connection between these two specific terms?In this paper,the historic evolutions of the terms“storm”and“cyclone”are reviewed from the perspective of weather science.The earliest recorded storms in world history are also briefly introduced.Then,the origin of the term“meteorological bomb”,which is the nickname of the“explosive cyclone”is introduced.Later,the various definitions of explosive cyclones given by several researchers are discussed.Also,the climatological features of explosive cyclones,as well as the future trends of explosive cyclones under global climate change,are discussed.

Projecting future precipitation change across the semi-arid Borana lowland,southern Ethiopia

Climate change caused by past,current,and future greenhouse gas emissions has become a major concern for scientists in the field in many countries and regions of the world.This study modelled future precipitation change by downscaling a set of large-scale climate predictor variables(predictors)from the second generation Canadian Earth System Model(CanESM2)under two Representative Concentration Pathway(RCP)emission scenarios(RCP4.5 and RCP8.5)in the semi-arid Borana lowland,southern Ethiopia.The Statistical DownScaling Model(SDSM)4.2.9 was employed to downscale and project future precipitation change in the middle(2036-2065;2050s)and far(2066-2095;2080s)future at the local scale.Historical precipitation observations from eight meteorological stations stretching from 1981 to 1995 and 1996 to 2005 were used for the model calibration and validation,respectively,and the time period of 1981-2018 was considered and used as the baseline period to analyze future precipitation change.The results revealed that the surface-specific humidity and the geopotential height at 500 hPa were the preferred large-scale predictors.Compared to the middle future(2050s),precipitation showed a much greater increase in the far future(2080s)under both RCP4.5 and RCP8.5 scenarios at all meteorological stations(except Teletele and Dillo stations).At Teltele station,the projected annual precipitation will decrease by 26.53%(2050s)and 39.45%(2080s)under RCP4.5 scenario,and 34.99%(2050s)and 60.62%(2080s)under RCP8.5 scenario.Seasonally,the main rainy period would shift from spring(March to May)to autumn(September to November)at Dehas,Dire,Moyale,and Teltele stations,but for Arero and Yabelo stations,spring would consistently receive more precipitation than autumn.It can be concluded that future precipitation in the semi-arid Borana lowland is predicted to differ under the two climate scenarios(RCP4.5 and RCP8.5),showing an increasing trend at most meteorological stations.This information could be helpful for policymakers to design adaptation plans in water resources management,and we suggest that the government should give more attention to improve early warning systems in drought-prone areas by providing dependable climate forecast information as early as possible.

Exploring the Concept of“Build a Community of a Shared Future for Mankind”in International Diplomacy:A Prehistoric Mythological Perspective

According to the historical records of prehistoric civilisation in China and the existing theories of prehistoric history within the academic community,it can be inferred that all human civilisations on Earth have their origins in the period following the Great Flood,during which human civilisation was rebuilt.Furthermore,there are notable parallels between the figure of“Nuwa”in Chinese prehistoric civilisation and that of“Noah”in Western accounts.By treating the prehistoric flood event as a research approach in historical compilation,scholars can extract valuable insights into“building a community of a shared future for mankind”and use it as a symbol of global diplomatic relations.This approach can foster common values of mutual learning and exchange among nations,ultimately creating a more promising future for developing a new form of human civilisation.

The Urban Singularity-Envisioning the Future of Cities

This paper is a hypothetical exploration of the connections between teleological evolution,the Omega Singularity,and the future of cities,weaving together insights from a diverse array of disciplines.Our investigation delves into the possibility that cities are evolving towards a Singularity,a state characterized by infinite knowledge,intelligence,and adaptability,which would bring about a radical transformation of urban environments and their underlying dynamics in the 21st century and beyond.At the heart of this exploration lies the role of language and time as crucial dimensions of the Urban Singularity.Moreover,we examine how linguistic developments and cross-cultural exchanges can foster more inclusive,adaptable,and resilient urban environments,while also highlighting the need for advanced technologies and communication modalities that can support the dynamic needs of future cities.Furthermore,the paper investigates the profound implications and transformative potential of merging human consciousness with the urban Singularity.By examining the interplay between these concepts,we seek for a deeper understanding of the potential trajectories and implications of these concepts for the transformation of human society and our relationship with the built environment.

Artificial intelligence in rectal cancer:What is the future?

Colorectal cancer(CRC)is the third most prevalent cancer in both men and women,and it is the second leading cause of cancer-related deaths globally.Around 60%-70%of CRC patients are diagnosed at advanced stages,with nearly 20%having liver metastases.It is noteworthy that the 5-year survival rates decline significantly from 80%-90%for localized disease to a mere 10%-15%for patients with metastasis at the time of diagnosis.Early diagnosis,appropriate therapeutic strategy,accurate assessment of treatment response,and prognostication is essential for better outcome.There has been significant technological development in the last couple of decades to improve the outcome of rectal cancer including Artificial intelligence(AI).AI is a broad term used to describe the study of machines that mimic human intelligence,such as perceiving the environment,drawing logical conclusions from observations,and performing complex tasks.At present AI has demonstrated a promising role in early diagnosis,prognosis,and treatment outcomes for patients with rectal cancer,a limited role in surgical decision making,and had a bright future.