Ⅲ型弹条扣压力测试方法

现有e型弹条扣压力测试有2种方法:通过加载使弹条向下产生一定位移时进行测定(方法1);通过提升使弹条向上产生一定位移时进行测定(方法 2)。分别采用2种方法测试不同安装距离下Ⅲ型弹条的扣压力并分析扣压力与安装距离的关系。结果表明:采用方法 1时安装距离为8,10,20 mm测得的弹条扣压力均满足标准要求,弹条扣压力随安装距离的增大而增大;采用方法 2时安装距离为8,10 mm测得的弹条扣压力满足标准要求,安装距离为20 mm时不满足要求,弹条扣压力随安装距离的增大而减小。采用方法2进行扣压力测试时须严格保证弹条与安装座距离处于8~10 mm。

Collagen Ⅲ和Smad2在犬裁剪去粘膜回肠输尿管中的表达

目的探讨1年期犬裁剪去粘膜回肠输尿管中Collagen Ⅲ和Smad2的表达,评估其纤维化。方法用5只比格犬参照前期实验方法,建立裁剪去粘膜回肠代输尿管模型,术后饲养至1年,造影检查与在体观察后切取回肠输尿管;用正常回肠远段部分组织为对照;采用组织病理、免疫组织化学、Western blot和Real-time PCR技术,检测Collagen Ⅲ和Smad2在样本中的表达,比较两组的差异。结果术后模型犬4只持续存活,1只肠梗阻死亡,裁剪去粘膜回肠输尿管显影较好、未见明确狭窄与梗阻;肉眼及镜下观察未发现其与对照组间存在明显差异,管壁各层无显著纤维增生与胶原沉积增加;Collagen Ⅲ和Smad2在两组中均呈阴性表达,其中Smad2实验组低于对照组(P<0.05);Collagen Ⅲ和Smad2在蛋白和基因水平的表达,两组无显著差异(P>0.05)。结论犬裁剪去粘膜回肠输尿管1年仍能保持较好形态结构,Collagen Ⅲ和Smad2表达无显著增加,管壁无明确纤维化改变,具有长期稳定性。

出口柬埔寨BS80A钢轨10号单开道岔主要结构特点分析

道岔产品在适应高速发展的同时,也向着国际化的方向发展。海外道岔产品种类繁多,结构与国内道岔产品有一定的差别。主要研究出口柬埔寨1 000 mm轨距BS80A钢轨10号单开道岔的主要结构特点,通过对出口柬埔寨10号道岔的设计开发,优化了尖轨线型,解决了手动立式扳道器与混凝土岔枕间的连接方式、BS80A钢轨与P43钢轨之间的连接方式,并开发了Ⅲ型弹条用轨撑扣件系统。其理论、方法和设计思路可供同类道岔产品借鉴。

Effect of Chinese Herbal Treatment on Th1- and Th2-Type Cytokines,Progesterone andβ-Human Chorionic Gonadotropin in Early Pregnant Women of Threatened Abortion

Objective： To study the clinical effects of Prescription Zhuyun-Ⅲ （助孕3号方, ZYⅢ） on early pregnant women diagnosed as threatened abortion, and its mechanism in immunity and endocrine by determining serum Th1- and Th2-type cytokines, progesterone, and β-human chorionic gonadotropin （β-HCG）. Methods： The treatment group comprised 30 early pregnant women diagnosed as threatened abortion of deficiency syndrome of Pi （脾）, Shen （肾）, or both. The control group consisted of 20 normal early pregnant women of similar gestational age. Patients in the treatment group were administered with ZYⅢ for 4 weeks. Peripheral blood samples were collected pre- and post-treatment from both the treatment and the control groups. Serum Thl-type cytokine [interleukin-2 （IL-2）] and Th2-type cytokine [interleukin-10 （IL-10）] were determined by flow cytometry, and serum progesterone and 13-HCG were determined by ELISA. Results： （1） The treatment was effective in 26 and ineffective in 4 patients of the treatment group. Therefore, the cure percentage was 86.67%. （2） In the treatment group before the treatment, IL-2 was significantly higher, IL-10 tended to be less, and the Th1/Th2 balance shifted toward Thl compared with those in the control group. （3） After the treatment, IL-2 was decreased, IL-10 was increased, and IL-2/IL-10 was decreased. Both progesterone and β-HCG were increased. Changes of progesterone were positively correlated with changes of IL-10, whereas changes of β-HCG were negatively correlated with changes of IL-2. Conclusions： Our study suggests that ZYⅢ has an evident function of protecting the fetus, and one of its mechanisms is inhibiting the secretion of Thl cytokines, promoting the secretion of Th2 cytokines, and recovering the pathological shift of the Th1/Th2 balance. The other possible mechanism is increasing serum progesterone and β-HCG concentrations. Moreover, there are some correlations between the above two effects.