目的研究马来酸罗格列酮对大鼠Tan is mRNA表达及血浆白细胞介素-6(IL-6)水平的影响。方法W istar大鼠24只,随机分为模型组(A)、给药组(B)和对照组(C),每组8只。A、B两组高糖高脂喂养6周建立胰岛素抵抗模型,C组常规饲喂。模型制作成功后...目的研究马来酸罗格列酮对大鼠Tan is mRNA表达及血浆白细胞介素-6(IL-6)水平的影响。方法W istar大鼠24只,随机分为模型组(A)、给药组(B)和对照组(C),每组8只。A、B两组高糖高脂喂养6周建立胰岛素抵抗模型,C组常规饲喂。模型制作成功后B组喂食马来酸罗格列酮,4 mg.kg-1.d-1;A组喂以常规饲料。两周后所有大鼠禁食12 h后称重,测空腹血糖(FBG)、空腹胰岛素(FINS),并按Hom a公式计算胰岛素抵抗指数(IR);应用RT-PCR方法测定大鼠肝组织Tan is mRNA的表达;ELISA法测定IL-6水平。结果与C组相比,A组大鼠血清IL-6水平明显升高(P<0.05)。Tan is mRNA的表达明显增强(P<0.05);B组大鼠血清IL-6水平、Tan is mRNA的表达较A组明显降低(P<0.05)。多元回归分析显示,IL-6与FINS、IR正相关(r1=0.633,P=0.014;r2=0.638,P=0.015),Tan is mRNA的表达与IL-6、FINS、IR正相关(r1=0.606,P=0.022;r2=0.651,P=0.012;r3=0.584,P=0.028)。结论Tan is mRNA的高表达可能是胰岛素抵抗和糖尿病的发生机制之一,马来酸罗格列酮可有效改善胰岛素抵抗,降低血浆IL-6水平及Tan ismRNA表达。展开更多
We study here a quantum version of Foldy-Wouthuysen-Tani （FWT） transformation and compare the similarities and differences between the quantum and the classic FWT theories. Then the improvement of action on lattice ...We study here a quantum version of Foldy-Wouthuysen-Tani （FWT） transformation and compare the similarities and differences between the quantum and the classic FWT theories. Then the improvement of action on lattice is discussed. The result shows that it is not necessary to improve the covariant difference along the time direction on lattice. Finally we discuss briefly the structure of physical vacuum and give a model independent of field condensate.展开更多
Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus...Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus （T2DM）, and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level. Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）. Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.展开更多
文摘目的研究马来酸罗格列酮对大鼠Tan is mRNA表达及血浆白细胞介素-6(IL-6)水平的影响。方法W istar大鼠24只,随机分为模型组(A)、给药组(B)和对照组(C),每组8只。A、B两组高糖高脂喂养6周建立胰岛素抵抗模型,C组常规饲喂。模型制作成功后B组喂食马来酸罗格列酮,4 mg.kg-1.d-1;A组喂以常规饲料。两周后所有大鼠禁食12 h后称重,测空腹血糖(FBG)、空腹胰岛素(FINS),并按Hom a公式计算胰岛素抵抗指数(IR);应用RT-PCR方法测定大鼠肝组织Tan is mRNA的表达;ELISA法测定IL-6水平。结果与C组相比,A组大鼠血清IL-6水平明显升高(P<0.05)。Tan is mRNA的表达明显增强(P<0.05);B组大鼠血清IL-6水平、Tan is mRNA的表达较A组明显降低(P<0.05)。多元回归分析显示,IL-6与FINS、IR正相关(r1=0.633,P=0.014;r2=0.638,P=0.015),Tan is mRNA的表达与IL-6、FINS、IR正相关(r1=0.606,P=0.022;r2=0.651,P=0.012;r3=0.584,P=0.028)。结论Tan is mRNA的高表达可能是胰岛素抵抗和糖尿病的发生机制之一,马来酸罗格列酮可有效改善胰岛素抵抗,降低血浆IL-6水平及Tan ismRNA表达。
文摘We study here a quantum version of Foldy-Wouthuysen-Tani （FWT） transformation and compare the similarities and differences between the quantum and the classic FWT theories. Then the improvement of action on lattice is discussed. The result shows that it is not necessary to improve the covariant difference along the time direction on lattice. Finally we discuss briefly the structure of physical vacuum and give a model independent of field condensate.
基金This study was supported by grants from National Natural Science Foundation of China （No. 30670649, No. 30470682）, National Key Research Project for the Tenth Five Year Plan （No. 2001BA702B01）, and Key Research Project of Liaoning Province Bureau of Science and Technology （No. 2002225003-6）.
文摘Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus （T2DM）, and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level. Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）. Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.
