To understand potential ecotoxicological effects of electrical and electronic equipment waste （e-waste） recycling and polybrominated diphenyl ethers （PBDEs） bioaccumulation in loaches, a semi-field experiment usin...To understand potential ecotoxicological effects of electrical and electronic equipment waste （e-waste） recycling and polybrominated diphenyl ethers （PBDEs） bioaccumulation in loaches, a semi-field experiment using Chinese loach （Misgurnus anguiUicaudatus） as experimental fish was performed. Larval loaches were kept in net-cage for three months in an e-wastes recycling site and a reference site in Southeastern China. There was significant difference of the survival rate between the loaches from the e-wastes recycling site （27%, 19/70） and from reference site （70%, 49/70）. Histopathological responses were also found in all the livers examined in loaches from the e-wastes recycling site. These results showed that mixed pollutants resulted from e-wastes recycling led to ecotoxicological effects on loaches. The bioaccumulation of polybrominated diphenyl ethers （PBDEs）, the main pollutants in e-waste, in loaches was also studied, the mean concentration of total PBDEs in sediment was 6726.17 ng/g wet weight and in water samples was 4.08 ng/L （dissolved phase）. BDE 209 was the dominant congener in sediment and with relatively high concentration in water. Relatively low concentration of BDE 209 （less than 0.01% of total PBDEs） and high concentration of BDE47 （up to 39.34% of total PBDEs） were detected in loaches.展开更多
A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer＇s disease （AD）. In particular, dysregulation of cholesterol homeostasis in the brain ...A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer＇s disease （AD）. In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeostasis may increase the amyloid β （Aβ） levels by affecting amyloid precursor protein （APP） cleavage, which is the most important risk factor involved in the pathogenesis of AD. Previous research demonstrated that Aβ can trigger neuronal insulin resistance, which plays an important role in response to Aβ-induced neurotoxicity in AD. Epidemiological studies also suggested that statin use is associated with a decreased incidence of AD. Therefore, statins are believed to be a good candidate for conferring neuropro- tective effects against AD. Statins may play a beneficial role in reducing A^-induced neurotoxicity. Their effect involves a putative mechanism beyond its cholesterol-lowering effects in preventing A[3-induced neurotoxicity. However, the underlying molecular mechanisms of the protective effect of statins have not been clearly determined in Aβ-induced neurotoxicity. Given that statins may provide benefits beyond the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A （HMG-CoA） reductase, these drugs may also improve the brain. Thus, statins may have beneficial effects on impaired insulin signaling by activating AMP-activated protein kinase （AMPK） in neuronal cells. They play a potential therapeutic role in targeting Aβ-mediated neurotoxicity.展开更多
Shaping effects of the E-fishbone in tokamaks are investigated. Coordinates related to the Solov＇ev configuration are used to calculate the precession frequency and kinetic contribu- tion. It is shown that elongation...Shaping effects of the E-fishbone in tokamaks are investigated. Coordinates related to the Solov＇ev configuration are used to calculate the precession frequency and kinetic contribu- tion. It is shown that elongation does not change the precession frequency and the kinetic energy. Growth rates of the E-fishbone vary with elongation which essentially has destabilizing effects. For elongated tokamaks, triangularity has a stabilizing effect on the modes which play a compensative role. The results may apply to Sunist.展开更多
A basically topological interpretation of the Casimir effect is given as a natural intrinsic property of the geometrical topological structure of the quantum-Cantorian micro spacetime. This new interpretation complime...A basically topological interpretation of the Casimir effect is given as a natural intrinsic property of the geometrical topological structure of the quantum-Cantorian micro spacetime. This new interpretation compliments the earlier conventional interpretation as vacuum fluctuation or as a Schwinger source and links the Casimir energy to the so called missing dark energy density of the cosmos. We start with a general outline of the theoretical principle and basic design concepts of a proposed Casimir dark energy nano reactor. In a nutshell the theory and consequently the actual design depends crucially upon the equivalence between the dark energy density of the cosmos and the faint local Casimir effect produced by two sides boundary condition quantum waves. This Casimir effect is then colossally amplified as a one sided quantum wave pushing from the inside on the one sided M?bius-like boundary with nothing balancing it from the non-existent outside. In view of the present theory, this one sided M?bius-like boundary of the holographic boundary of the universe is essentially what leads to the observed accelerated expansion of the cosmos. Thus in principle we will restructure the local topology of space using material nanoscience technology to create an artificial local high dimensionality with a Dvoretzky theorem like volume measure concentration. Needless to say the entire design is based completely on the theory of quantum wave dark energy proposed by the present author. The quintessence of the present theory is easily explained as the intrinsic Casimir topological energy where produced from the zero set of the quantum particle when we extract the empty set quantum wave from it and find by restructuring space via plates similar to that of the classical Casimir experiments but with some modification.展开更多
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No. KZCX2-YW-420-3)the National Basic Research Program (973) of China (No. 2003CB415005)the National Natural Science Foundation of China (No.20437020, 20677074)
文摘To understand potential ecotoxicological effects of electrical and electronic equipment waste （e-waste） recycling and polybrominated diphenyl ethers （PBDEs） bioaccumulation in loaches, a semi-field experiment using Chinese loach （Misgurnus anguiUicaudatus） as experimental fish was performed. Larval loaches were kept in net-cage for three months in an e-wastes recycling site and a reference site in Southeastern China. There was significant difference of the survival rate between the loaches from the e-wastes recycling site （27%, 19/70） and from reference site （70%, 49/70）. Histopathological responses were also found in all the livers examined in loaches from the e-wastes recycling site. These results showed that mixed pollutants resulted from e-wastes recycling led to ecotoxicological effects on loaches. The bioaccumulation of polybrominated diphenyl ethers （PBDEs）, the main pollutants in e-waste, in loaches was also studied, the mean concentration of total PBDEs in sediment was 6726.17 ng/g wet weight and in water samples was 4.08 ng/L （dissolved phase）. BDE 209 was the dominant congener in sediment and with relatively high concentration in water. Relatively low concentration of BDE 209 （less than 0.01% of total PBDEs） and high concentration of BDE47 （up to 39.34% of total PBDEs） were detected in loaches.
基金supported by the grants from the Ministry of Science and Technology of Taiwan,China(MOST 105-2314-B-013-MY3 and MOST 106-2320-B-040-021-MY3)
文摘A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer＇s disease （AD）. In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeostasis may increase the amyloid β （Aβ） levels by affecting amyloid precursor protein （APP） cleavage, which is the most important risk factor involved in the pathogenesis of AD. Previous research demonstrated that Aβ can trigger neuronal insulin resistance, which plays an important role in response to Aβ-induced neurotoxicity in AD. Epidemiological studies also suggested that statin use is associated with a decreased incidence of AD. Therefore, statins are believed to be a good candidate for conferring neuropro- tective effects against AD. Statins may play a beneficial role in reducing A^-induced neurotoxicity. Their effect involves a putative mechanism beyond its cholesterol-lowering effects in preventing A[3-induced neurotoxicity. However, the underlying molecular mechanisms of the protective effect of statins have not been clearly determined in Aβ-induced neurotoxicity. Given that statins may provide benefits beyond the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A （HMG-CoA） reductase, these drugs may also improve the brain. Thus, statins may have beneficial effects on impaired insulin signaling by activating AMP-activated protein kinase （AMPK） in neuronal cells. They play a potential therapeutic role in targeting Aβ-mediated neurotoxicity.
基金supported by National Natural Science Foundation of China (Nos. 11261140327, 11005035, 11175058)National Magnetic Confinement Fusion Science Program of China (No. 2009GB105002)
文摘Shaping effects of the E-fishbone in tokamaks are investigated. Coordinates related to the Solov＇ev configuration are used to calculate the precession frequency and kinetic contribu- tion. It is shown that elongation does not change the precession frequency and the kinetic energy. Growth rates of the E-fishbone vary with elongation which essentially has destabilizing effects. For elongated tokamaks, triangularity has a stabilizing effect on the modes which play a compensative role. The results may apply to Sunist.
文摘A basically topological interpretation of the Casimir effect is given as a natural intrinsic property of the geometrical topological structure of the quantum-Cantorian micro spacetime. This new interpretation compliments the earlier conventional interpretation as vacuum fluctuation or as a Schwinger source and links the Casimir energy to the so called missing dark energy density of the cosmos. We start with a general outline of the theoretical principle and basic design concepts of a proposed Casimir dark energy nano reactor. In a nutshell the theory and consequently the actual design depends crucially upon the equivalence between the dark energy density of the cosmos and the faint local Casimir effect produced by two sides boundary condition quantum waves. This Casimir effect is then colossally amplified as a one sided quantum wave pushing from the inside on the one sided M?bius-like boundary with nothing balancing it from the non-existent outside. In view of the present theory, this one sided M?bius-like boundary of the holographic boundary of the universe is essentially what leads to the observed accelerated expansion of the cosmos. Thus in principle we will restructure the local topology of space using material nanoscience technology to create an artificial local high dimensionality with a Dvoretzky theorem like volume measure concentration. Needless to say the entire design is based completely on the theory of quantum wave dark energy proposed by the present author. The quintessence of the present theory is easily explained as the intrinsic Casimir topological energy where produced from the zero set of the quantum particle when we extract the empty set quantum wave from it and find by restructuring space via plates similar to that of the classical Casimir experiments but with some modification.
