The proposed work aims to study phenol components （flavonoids） of bee bread and pollen obtained in Georgia using the HPLC （high-performance liquid chromatography） method, and to determine the content of biological...The proposed work aims to study phenol components （flavonoids） of bee bread and pollen obtained in Georgia using the HPLC （high-performance liquid chromatography） method, and to determine the content of biologically active compounds in them. The samples were taken in lmereti region （west Georgia）. After extraction of samples, there were carried out spectral and HPLC analysis of compounds for the sake of qualitative and quantitative research of them. There are studied the flavonoid compounds of bee bread and pollen by using the HPLC methods, and naringin, rutin and quercetin are identified. Their amount counts about 20% of full content of flavonoids. The content of flavonols in bee bread and pollen has been established. It also has been determined that the amount of flavonoids during the storage period of products reduces to 6.17-5.03 g.kg-1.展开更多
Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets ＂Apimun＂ in the form of antibodies formation in response to the EB a...Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets ＂Apimun＂ in the form of antibodies formation in response to the EB antigen were studied. Clear immunostimulatory properties of pellets ＂Apimun＂ were reproduced in mature rats and mice with normal immune status. Pellets ＂Apimun＂ at doses 1.5 and 2.0 g/kg showed increased activity ofphagocytosis and processes of antibody formation inhibition of delayed hypersensitivity reactions. Antimicrobial activity of pellets ＂Apimun＂ was studied. It was proved that it did not have antimicrobial properties. Derivate studies were conducted and showed that the active substance and composition of the IMP was stable at normal temperature. The results of pharmacological, microbiological and derivate studies show the effectiveness of the pellets ＂Apimun＂ and prospects for further research in order to create a product for immune status improvement.展开更多
基金The authors express their gratitude to Shota Rustaveli National Science Foundation （Grant 11/16） for financial provision.
文摘The proposed work aims to study phenol components （flavonoids） of bee bread and pollen obtained in Georgia using the HPLC （high-performance liquid chromatography） method, and to determine the content of biologically active compounds in them. The samples were taken in lmereti region （west Georgia）. After extraction of samples, there were carried out spectral and HPLC analysis of compounds for the sake of qualitative and quantitative research of them. There are studied the flavonoid compounds of bee bread and pollen by using the HPLC methods, and naringin, rutin and quercetin are identified. Their amount counts about 20% of full content of flavonoids. The content of flavonols in bee bread and pollen has been established. It also has been determined that the amount of flavonoids during the storage period of products reduces to 6.17-5.03 g.kg-1.
文摘Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets ＂Apimun＂ in the form of antibodies formation in response to the EB antigen were studied. Clear immunostimulatory properties of pellets ＂Apimun＂ were reproduced in mature rats and mice with normal immune status. Pellets ＂Apimun＂ at doses 1.5 and 2.0 g/kg showed increased activity ofphagocytosis and processes of antibody formation inhibition of delayed hypersensitivity reactions. Antimicrobial activity of pellets ＂Apimun＂ was studied. It was proved that it did not have antimicrobial properties. Derivate studies were conducted and showed that the active substance and composition of the IMP was stable at normal temperature. The results of pharmacological, microbiological and derivate studies show the effectiveness of the pellets ＂Apimun＂ and prospects for further research in order to create a product for immune status improvement.
