白藜芦醇(Resveratrol,RES)具有多种药理活性,是一种天然植物抗毒素多酚,主要通过Sirt1蛋白介导FoxO3a蛋白、NF-κB/RANKL信号,Wnt/β-catenin、PI3K/AKT、MAPK信号通路、雌激素受体、AMPK、氧化应激反应影响成骨细胞分化,抑制破骨细胞...白藜芦醇(Resveratrol,RES)具有多种药理活性,是一种天然植物抗毒素多酚,主要通过Sirt1蛋白介导FoxO3a蛋白、NF-κB/RANKL信号,Wnt/β-catenin、PI3K/AKT、MAPK信号通路、雌激素受体、AMPK、氧化应激反应影响成骨细胞分化,抑制破骨细胞生成,改善骨关节组织结构及机体骨质流失,改善骨质疏松,保护骨骼健康。白藜芦醇增加了老年人和绝经后人群的骨骼生长,减少骨质流失,未来可能成为治疗骨质疏松的新型潜力药物。该文通过CNKI、中华医学期刊全文数据库、万方数据库、PubMed、Web of Science数据库检索最近10年关于RES防治OP的文献报道,多方面对RES防治OP的作用机制作一综述,以期为白藜芦醇在未来临床中的应用提供新的思路和方向。展开更多
多囊卵巢综合征是临床导致育龄期女性不孕最常见的一种生殖内分泌疾病,其发病机制尚不清楚。流行病学调查显示,本病患病率逐年上升,患病群体趋于年轻化,严重影响女性身心健康。白藜芦醇作为一种天然类雌激素,具有降糖降脂、抗炎抗氧化...多囊卵巢综合征是临床导致育龄期女性不孕最常见的一种生殖内分泌疾病,其发病机制尚不清楚。流行病学调查显示,本病患病率逐年上升,患病群体趋于年轻化,严重影响女性身心健康。白藜芦醇作为一种天然类雌激素,具有降糖降脂、抗炎抗氧化、抗肿瘤、心脏保护等多方面药理作用。最近研究发现,白藜芦醇可能通过多途径多靶点影响糖脂代谢及激素调节,这为临床治疗PCOS提供了新思路。笔者结合近几年国内外研究,探讨白藜芦醇对多囊卵巢综合征的调节作用,分析其作用机制,为白藜芦醇在多囊卵巢综合征治疗方面提供进一步的理论基础和研究依据。Polycystic ovary syndrome is the most common reproductive endocrine disease causing infertility in women of childbearing age, and its pathogenesis is still unclear. Epidemiological surveys show that the prevalence of this disease is increasing year by year, and the group of patients tends to be younger, which seriously affects women’s physical and mental health. As a natural estrogen, resveratrol has various pharmacological effects such as hypoglycemic and hypolipidemic, anti-inflammatory and antioxidant, anti-tumor and cardioprotective effects. Recent studies have found that resveratrol may affect glucose-lipid metabolism and hormone regulation through multiple pathways and targets, which provides new ideas for the clinical treatment of PCOS. The author combines domestic and international studies in recent years to explore the regulatory effects of resveratrol on polycystic ovary syndrome (PCOS) and analyze its mechanism of action, so as to provide further theoretical foundation and research basis for resveratrol in the treatment of PCOS.展开更多
文摘白藜芦醇(Resveratrol,RES)具有多种药理活性,是一种天然植物抗毒素多酚,主要通过Sirt1蛋白介导FoxO3a蛋白、NF-κB/RANKL信号,Wnt/β-catenin、PI3K/AKT、MAPK信号通路、雌激素受体、AMPK、氧化应激反应影响成骨细胞分化,抑制破骨细胞生成,改善骨关节组织结构及机体骨质流失,改善骨质疏松,保护骨骼健康。白藜芦醇增加了老年人和绝经后人群的骨骼生长,减少骨质流失,未来可能成为治疗骨质疏松的新型潜力药物。该文通过CNKI、中华医学期刊全文数据库、万方数据库、PubMed、Web of Science数据库检索最近10年关于RES防治OP的文献报道,多方面对RES防治OP的作用机制作一综述,以期为白藜芦醇在未来临床中的应用提供新的思路和方向。
文摘多囊卵巢综合征是临床导致育龄期女性不孕最常见的一种生殖内分泌疾病,其发病机制尚不清楚。流行病学调查显示,本病患病率逐年上升,患病群体趋于年轻化,严重影响女性身心健康。白藜芦醇作为一种天然类雌激素,具有降糖降脂、抗炎抗氧化、抗肿瘤、心脏保护等多方面药理作用。最近研究发现,白藜芦醇可能通过多途径多靶点影响糖脂代谢及激素调节,这为临床治疗PCOS提供了新思路。笔者结合近几年国内外研究,探讨白藜芦醇对多囊卵巢综合征的调节作用,分析其作用机制,为白藜芦醇在多囊卵巢综合征治疗方面提供进一步的理论基础和研究依据。Polycystic ovary syndrome is the most common reproductive endocrine disease causing infertility in women of childbearing age, and its pathogenesis is still unclear. Epidemiological surveys show that the prevalence of this disease is increasing year by year, and the group of patients tends to be younger, which seriously affects women’s physical and mental health. As a natural estrogen, resveratrol has various pharmacological effects such as hypoglycemic and hypolipidemic, anti-inflammatory and antioxidant, anti-tumor and cardioprotective effects. Recent studies have found that resveratrol may affect glucose-lipid metabolism and hormone regulation through multiple pathways and targets, which provides new ideas for the clinical treatment of PCOS. The author combines domestic and international studies in recent years to explore the regulatory effects of resveratrol on polycystic ovary syndrome (PCOS) and analyze its mechanism of action, so as to provide further theoretical foundation and research basis for resveratrol in the treatment of PCOS.
