Synthesis of the spinel structure lithium manganese oxide (LiMn2O4) by supercritical hydrothermal (SH) accelerated solid state reaction (SSR) route was studied. The impacts of the reaction pressure, reaction tem...Synthesis of the spinel structure lithium manganese oxide (LiMn2O4) by supercritical hydrothermal (SH) accelerated solid state reaction (SSR) route was studied. The impacts of the reaction pressure, reaction temperature and reaction time of SH route, and the calcination temperature of SSR route on the purity, particle morphology and electrochemical properties of the prepared LiMn2O4 materials were studied. The experimental results show that after 15 min reaction in SH route at 400 ℃ and 30 MPa, the reaction time of SSR could be significantly decreased, e.g. down to 3 h with the formation temperature of 800 ℃, compared with the conventional solid state reaction method. The prepared LiMn2O4 material exhibits good crystallinity, uniform size distribution and good electrochemical performance, and has an initial specific capacity of 120 mA.h/g at a rate of 0.1C (1C=148 mA/g) and a good rate capability at high rates, even up to 50C.展开更多
The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patie...The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine.Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD.展开更多
A supercritical hydrothermal method was employed to prepare sub-micrometer LiFePO4particles with high purity and crystallinity.The structure and morphology of LiFePO4particles were characterized by X-ray diffraction a...A supercritical hydrothermal method was employed to prepare sub-micrometer LiFePO4particles with high purity and crystallinity.The structure and morphology of LiFePO4particles were characterized by X-ray diffraction and scanning electron microscope.The electrochemical tests were carried out to determine the reversible capacity,rate and cycling performance of the LiFePO4particles as cathode material for lithium ion battery.Experimental results show that solvent and calcining time have significant effects on purity,size and morphology of LiFePO4particles.Mixed solvent contained deionized water and ethanol is conducive to synthesize smaller and more uniform particles.The size of LiFePO4particles as-prepared is about 100-300 nm.The specific discharge capacities of the LiFePO4particles are 151.3 and 128.0 mA·h·g?1 after first cycle at the rates of 0.1 and 1.0 C,respectively.It retains 95.0%of the initial capacity after 100 cycles at 1.0 C.展开更多
基金Project supported by the Research Funds of the Key Laboratory of Fuel Cell Technology of Guangdong Province,ChinaProject(7411793079907)supported by the Guangzhou Special Foundation for Applied Basic Research+1 种基金Project(2013A15GX048)supported by the Dalian Science and Technology Project Foundation,ChinaProject(21376035)supported by the National Natural Science Foundation of China
文摘Synthesis of the spinel structure lithium manganese oxide (LiMn2O4) by supercritical hydrothermal (SH) accelerated solid state reaction (SSR) route was studied. The impacts of the reaction pressure, reaction temperature and reaction time of SH route, and the calcination temperature of SSR route on the purity, particle morphology and electrochemical properties of the prepared LiMn2O4 materials were studied. The experimental results show that after 15 min reaction in SH route at 400 ℃ and 30 MPa, the reaction time of SSR could be significantly decreased, e.g. down to 3 h with the formation temperature of 800 ℃, compared with the conventional solid state reaction method. The prepared LiMn2O4 material exhibits good crystallinity, uniform size distribution and good electrochemical performance, and has an initial specific capacity of 120 mA.h/g at a rate of 0.1C (1C=148 mA/g) and a good rate capability at high rates, even up to 50C.
基金Supported by The Formation of Innovation Center for Fusion of Advanced Technologies in the Special Coordination Funds for Promoting ScienceTechnology from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
文摘The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine.Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD.
文摘A supercritical hydrothermal method was employed to prepare sub-micrometer LiFePO4particles with high purity and crystallinity.The structure and morphology of LiFePO4particles were characterized by X-ray diffraction and scanning electron microscope.The electrochemical tests were carried out to determine the reversible capacity,rate and cycling performance of the LiFePO4particles as cathode material for lithium ion battery.Experimental results show that solvent and calcining time have significant effects on purity,size and morphology of LiFePO4particles.Mixed solvent contained deionized water and ethanol is conducive to synthesize smaller and more uniform particles.The size of LiFePO4particles as-prepared is about 100-300 nm.The specific discharge capacities of the LiFePO4particles are 151.3 and 128.0 mA·h·g?1 after first cycle at the rates of 0.1 and 1.0 C,respectively.It retains 95.0%of the initial capacity after 100 cycles at 1.0 C.