Gut inflammation can occur in 30%-60% of patients with spondyloarthropathies.However, the presence of such gut inflammation is underestimated, only 27% of patients with histological evidence of gut inflammation have i...Gut inflammation can occur in 30%-60% of patients with spondyloarthropathies.However, the presence of such gut inflammation is underestimated, only 27% of patients with histological evidence of gut inflammation have intestinal symptoms, but subclinical gut inflammation is documented in two-thirds of patients with inflammatory joint disease.There are common genetic and immunological mechanisms behind concomitant inflammation in the joints and intestinal tract.A number of blood tests, e.g.erythrocyte sedimentation rate, orosomucoid, C-reactive protein, and white cell and platelet counts, are probably the most commonly used laboratory markers of inflammatory disease, however, these tests are difficult to interpret in arthropathies associated with gut inflammation, since any increases in their blood levels might be attributable to either the joint disease or to gut inflammation.Consequently, it would be useful to have a marker capable of separately identifying gut inflammation.Fecal proteins, which are indirect markers of neutrophil migration in the gut wall, and intestinal permeability, seem to be ideal for monitoring intestinal inflammation:they are easy to measure non-invasively and are specific for intestinal disease in the absence of gastrointestinal infections.Alongside the traditional markers for characterizing intestinal inflammation, there are also antibodies, in all probability generated by the immune response to microbial antigens and auto-antigens, which have proved useful in establishing the diagnosis and assessing the severity of the condition, as well as the prognosis and the risk of complications.In short, noninvasive investigations on the gut in patients with rheumatic disease may be useful in clinical practice for a preliminary assessment of patients with suspected intestinal disease.展开更多
OBJECTIVE To explore the clinical and therapeutic effects of cervical plexus reinnervation for infiltrated or injured unilateral recurrent laryngeal nerve (URLN). METHODS Functional neck dissection for removal of di...OBJECTIVE To explore the clinical and therapeutic effects of cervical plexus reinnervation for infiltrated or injured unilateral recurrent laryngeal nerve (URLN). METHODS Functional neck dissection for removal of differentiated thyroid carcinoma (DTC) in patients was performed, in which cervical plexus reinnervation was adopted for patients with stage I disease and URLN with injury or with tumor invasion. Outcomes of surgery were evaluated by examination under fibrolaryngoscope, and the patients' voices were evaluated before and after surgery. RESULTS All cases were followed up for 3 mon-2 years (average 8 mon). Abductory motion of the vocal cords of 15 patients was completely or partly restored, but 3 patients' vocal cords were immovable. The recovery rate of abductory motion of the paralyzed vocal cords was 83.33% (15/18). The function of phonation in the 16 patients was restored to normal or near normal limits, and their hoarseness was improved significantly. CONCLUSION Cervical plexus-URLN reinnervation should be considered when treating patients with unilateral vocal cord paralysis. Removing the tumor simultaneously with cervical plexus reinnervation during surgery for repair of unilateral recurrent laryngeal nerve injury was convenient and easy to perform with less functional damage compared with other methods of reinnervation. The abductory motion of vocal cord could be satisfactorily restored by this reinnervation. Surgical performance skills and application of neurotrophic drugs were important for the success of the surgery.展开更多
The aim of this work is to prove the AMF (anomalous magnetic fields) from the environment cause of AID (autoimmune diseases). The therapeutic possibilities of natural EMF (Earth's magnetic field) is pointed out...The aim of this work is to prove the AMF (anomalous magnetic fields) from the environment cause of AID (autoimmune diseases). The therapeutic possibilities of natural EMF (Earth's magnetic field) is pointed out and how to act to prevent AID is determined. Authors indicate in which magnetic fields the IS (immune system) defends the body. They also explain why, in medical literature, risk factors are mistakenly declared pathogens of AID. The magnetic fields intensity in 20 peoples' beds, suffering from Type 1 diabetes, was measured with proton magnetometer (accuracy of 100 nT). The measurement results are presented on sketches, patients were transferred to the natural EMF, medical condition was monitored, and AID function IS ethiopathology was studied. The correlation between AMF and organ location where AID occurred was determined by measuring. The cells of an organism, formed in natural EMF, are in magnetic balance. When an intruder enters the body, magnetic balance disappears and leukocytes with its MF (magnetic forces) destroy intruders. In the AMF, cells get enlarged MF without magnetic balance, causing IS with its MF to attack own cells, resulting AID. When an intruder enters a tissue, tissue cells and cells of intruders gain enhanced MF. IS with its MF destroys intruders. In the literature (The China Study by T. Colin Campbell), the food is presented as cause of number of diseases. It was found what led to such a misinterpretation. It has been proven that causes of mentioned diseases are only AMF, which can be located in any organ, and with Type 1 diabetes its spread to the whole body with strongest intensity on pancreas. AMF give tissue cells reinforced MF without magnetic balance causing IS to deplete own tissues, resulting AID. IS works perfectly without AMF and risk factors are only a consequence of AMF.展开更多
In this paper, we conduct research on the essential network equipment risk assessment method based on vulnerability scanning technology. A growing number of hackers wanton invasion of the computer, through the network...In this paper, we conduct research on the essential network equipment risk assessment method based on vulnerability scanning technology. A growing number of hackers wanton invasion of the computer, through the network to steal important information, or destroy the network, the paralyzed which caused huge losses to the state and society. Find a known vulnerability rather than to find the unknown vulnerabilities much easier, which means that most of the attacker' s use is common vulnerabilities. Therefore, we adopt the advantages of the technique to finalize the methodology for the essential network equipment risk assessment which will be meaningful.展开更多
We investigated how exposure duration (time that two individuals initially interact) and separation interval (time be- tween the initial interaction and a subsequent interaction) affect recognition memory of consp...We investigated how exposure duration (time that two individuals initially interact) and separation interval (time be- tween the initial interaction and a subsequent interaction) affect recognition memory of conspecifics in male red-backed sala- manders Plethodon cinereus. Previous studies have demonstrated that this species aggressively defends territories. We recorded aggressive behavior to assess recognition memory, because aggression is more intense toward previously unencountered indi- viduals compared to previously encountered individuals in this species. We found that with 15-min exposures and 5-day separa- tion intervals, focal males did not spend significantly more time threatening 'unfamiliar' intruders than 'familiar' intruders. After either 8-hour exposures and 5-day separation intervals and 5-day exposures and 5-day separation intervals, focal males spent sig- nificantly more time threatening unfamiliar intruders than familiar intruders. These results suggest that male red-backed salaman- ders can remember familiar conspecifics (e.g., territorial neighbors) after at least an 8-hour exposure duration and that memory persists at least as long as 5 days. After 5-day exposure and 15-day separation intervals, we found no significant difference in ag- gressive behavior toward familiar and unfamiliar intruders. Long separation intervals (15 days) may lead either to loss of memory of previously familiar individuals or, alternatively, aggressive reassessment of individuals as only a change in behavior indicates positively that memory has occurred. Thus, variance in territorial defense within an individual may depend on its ability to recog- nize conspecific males .展开更多
Aims Established invasive plant species have more diverse gene pools than single populations in their home range.This genetic and often phenotypic variation allows for natural selection to act and produce rapid adapta...Aims Established invasive plant species have more diverse gene pools than single populations in their home range.This genetic and often phenotypic variation allows for natural selection to act and produce rapid adaptations as an invasive species interacts with other members of the community.For an invasive flowering plant,interactions with pollinators may lead to adaptations to a heterogeneous pollinator community.The variation in the pollinator community in the invaded range is similar to variation in the native range,suggesting that adaptations may mirror patterns seen in the home range.In this study,we investigated variation in flower size in Cytisus scoparius,an invasive leguminous shrub,along an elevation gradient.Methods This study took place in the Capitol State Forest in Washington State.We measured flower widths and the proportion of visited flowers,using 10 plants per field site.Sites were located along an elevation gradient and were visited three times to measure phenological variation on a per-plant basis.Important Findings We saw positive selection for flower size,albeit without a distinct pattern of higher selection at higher elevations.The pattern of natural selection could be seen both in terms of pollinator visitation rates and in seed production.We also found that the largest contributor to changes in seed production was not elevation or flower size but management practices.展开更多
Although it is well known that birds can assess predation risk through visual and auditory cues, there has been little research into whether similar processes occur with olfactory cues. We examined the role of odor cu...Although it is well known that birds can assess predation risk through visual and auditory cues, there has been little research into whether similar processes occur with olfactory cues. We examined the role of odor cues in assessing nest predation risk in four species of passerine birds in New Zealand. We compared the ability of two introduced European species (common starling Sturnus vulgaris and song thrush Turdus philomelos) and two native New Zealand species (rifleman Acanthisitta chloris and South Island robin Petroica australis) to respond to the scent of rat urine placed in the nest. Rats are an introduced predator in New Zealand and we expected the native birds, which did not co-evolve with any mammalian predators, to lack behavioral adaptations to the scent of rats at their nest. As expected, both riflemen and robins failed to show any change in their behavior at their nest when rat urine was present compared to a control period in which no scent was present. However, a similar lack of re- sponse was observed in the introduced song thrush; only the common starling changed its behavior in the presence of the rat urine Starlings with rat urine at the nest box were more likely to hesitate before entering and they also approached the nest, but refused to enter more often in the presence of rat scent. Both responses suggest they detected the presence of a predator and changed their behavior to minimize risk to themselves. Although based on a small number of species, our results suggest that responses to pre- dator scent may be less common in New Zealand species, and may be a factor contributing to the vulnerability of native birds to introduced mammalian predators [Current Zoology 61 (1): 34-41, 2015].展开更多
Plants growing in nutrient-rich environment are predicted to be less defended than conspecifics under nutrient limitation.However,less is known about the effects of nutrient levels on tolerance and induced resistance,...Plants growing in nutrient-rich environment are predicted to be less defended than conspecifics under nutrient limitation.However,less is known about the effects of nutrient levels on tolerance and induced resistance,and whether the effects differ between native and introduced populations of invasive plants.We performed a greenhouse experiment with introduced(the USA)and native(Argentina)genotypes of Alternanthera philoxeroides in order to study the effects of soil nitrogen levels on plant growth,constitutive and herbivore(Agasicles hygrophila)-induced chemical defense,and herbivory tolerance.We measured total biomass,elongation rate(as proxy of growth rate),carbon and nitrogen,and the concentration of triterpenoid saponins(defensive chemicals)in leaves and roots.Constitutive resistance(+33%higher leaf triterpenoid saponins in control treatment at low nitrogen level)and tolerance[less decreased total biomass after herbivory treatment(−24%and−15%for high and low nitrogen levels)]were favored at lower nitrogen level,while induced resistance was favored at higher nitrogen level(+24%increased leaf triterpenoid saponins after herbivory treatment at high nitrogen level).Constitutive resistance and tolerance exhibited trade-offs with growth rate,while induced resistance positively correlated with growth rate.Additionally,the introduced genotypes had−6%lower content of leaf carbon in the presence of herbivores than the native genotypes at low nitrogen level,but such difference was absent at high nitrogen level.Our results indicate that soil nitrogen levels influence the preference of different defensive strategies of plant,and interweave with herbivory to determine the performance of introduced genotypes.展开更多
文摘Gut inflammation can occur in 30%-60% of patients with spondyloarthropathies.However, the presence of such gut inflammation is underestimated, only 27% of patients with histological evidence of gut inflammation have intestinal symptoms, but subclinical gut inflammation is documented in two-thirds of patients with inflammatory joint disease.There are common genetic and immunological mechanisms behind concomitant inflammation in the joints and intestinal tract.A number of blood tests, e.g.erythrocyte sedimentation rate, orosomucoid, C-reactive protein, and white cell and platelet counts, are probably the most commonly used laboratory markers of inflammatory disease, however, these tests are difficult to interpret in arthropathies associated with gut inflammation, since any increases in their blood levels might be attributable to either the joint disease or to gut inflammation.Consequently, it would be useful to have a marker capable of separately identifying gut inflammation.Fecal proteins, which are indirect markers of neutrophil migration in the gut wall, and intestinal permeability, seem to be ideal for monitoring intestinal inflammation:they are easy to measure non-invasively and are specific for intestinal disease in the absence of gastrointestinal infections.Alongside the traditional markers for characterizing intestinal inflammation, there are also antibodies, in all probability generated by the immune response to microbial antigens and auto-antigens, which have proved useful in establishing the diagnosis and assessing the severity of the condition, as well as the prognosis and the risk of complications.In short, noninvasive investigations on the gut in patients with rheumatic disease may be useful in clinical practice for a preliminary assessment of patients with suspected intestinal disease.
文摘OBJECTIVE To explore the clinical and therapeutic effects of cervical plexus reinnervation for infiltrated or injured unilateral recurrent laryngeal nerve (URLN). METHODS Functional neck dissection for removal of differentiated thyroid carcinoma (DTC) in patients was performed, in which cervical plexus reinnervation was adopted for patients with stage I disease and URLN with injury or with tumor invasion. Outcomes of surgery were evaluated by examination under fibrolaryngoscope, and the patients' voices were evaluated before and after surgery. RESULTS All cases were followed up for 3 mon-2 years (average 8 mon). Abductory motion of the vocal cords of 15 patients was completely or partly restored, but 3 patients' vocal cords were immovable. The recovery rate of abductory motion of the paralyzed vocal cords was 83.33% (15/18). The function of phonation in the 16 patients was restored to normal or near normal limits, and their hoarseness was improved significantly. CONCLUSION Cervical plexus-URLN reinnervation should be considered when treating patients with unilateral vocal cord paralysis. Removing the tumor simultaneously with cervical plexus reinnervation during surgery for repair of unilateral recurrent laryngeal nerve injury was convenient and easy to perform with less functional damage compared with other methods of reinnervation. The abductory motion of vocal cord could be satisfactorily restored by this reinnervation. Surgical performance skills and application of neurotrophic drugs were important for the success of the surgery.
文摘The aim of this work is to prove the AMF (anomalous magnetic fields) from the environment cause of AID (autoimmune diseases). The therapeutic possibilities of natural EMF (Earth's magnetic field) is pointed out and how to act to prevent AID is determined. Authors indicate in which magnetic fields the IS (immune system) defends the body. They also explain why, in medical literature, risk factors are mistakenly declared pathogens of AID. The magnetic fields intensity in 20 peoples' beds, suffering from Type 1 diabetes, was measured with proton magnetometer (accuracy of 100 nT). The measurement results are presented on sketches, patients were transferred to the natural EMF, medical condition was monitored, and AID function IS ethiopathology was studied. The correlation between AMF and organ location where AID occurred was determined by measuring. The cells of an organism, formed in natural EMF, are in magnetic balance. When an intruder enters the body, magnetic balance disappears and leukocytes with its MF (magnetic forces) destroy intruders. In the AMF, cells get enlarged MF without magnetic balance, causing IS with its MF to attack own cells, resulting AID. When an intruder enters a tissue, tissue cells and cells of intruders gain enhanced MF. IS with its MF destroys intruders. In the literature (The China Study by T. Colin Campbell), the food is presented as cause of number of diseases. It was found what led to such a misinterpretation. It has been proven that causes of mentioned diseases are only AMF, which can be located in any organ, and with Type 1 diabetes its spread to the whole body with strongest intensity on pancreas. AMF give tissue cells reinforced MF without magnetic balance causing IS to deplete own tissues, resulting AID. IS works perfectly without AMF and risk factors are only a consequence of AMF.
文摘In this paper, we conduct research on the essential network equipment risk assessment method based on vulnerability scanning technology. A growing number of hackers wanton invasion of the computer, through the network to steal important information, or destroy the network, the paralyzed which caused huge losses to the state and society. Find a known vulnerability rather than to find the unknown vulnerabilities much easier, which means that most of the attacker' s use is common vulnerabilities. Therefore, we adopt the advantages of the technique to finalize the methodology for the essential network equipment risk assessment which will be meaningful.
文摘We investigated how exposure duration (time that two individuals initially interact) and separation interval (time be- tween the initial interaction and a subsequent interaction) affect recognition memory of conspecifics in male red-backed sala- manders Plethodon cinereus. Previous studies have demonstrated that this species aggressively defends territories. We recorded aggressive behavior to assess recognition memory, because aggression is more intense toward previously unencountered indi- viduals compared to previously encountered individuals in this species. We found that with 15-min exposures and 5-day separa- tion intervals, focal males did not spend significantly more time threatening 'unfamiliar' intruders than 'familiar' intruders. After either 8-hour exposures and 5-day separation intervals and 5-day exposures and 5-day separation intervals, focal males spent sig- nificantly more time threatening unfamiliar intruders than familiar intruders. These results suggest that male red-backed salaman- ders can remember familiar conspecifics (e.g., territorial neighbors) after at least an 8-hour exposure duration and that memory persists at least as long as 5 days. After 5-day exposure and 15-day separation intervals, we found no significant difference in ag- gressive behavior toward familiar and unfamiliar intruders. Long separation intervals (15 days) may lead either to loss of memory of previously familiar individuals or, alternatively, aggressive reassessment of individuals as only a change in behavior indicates positively that memory has occurred. Thus, variance in territorial defense within an individual may depend on its ability to recog- nize conspecific males .
基金supported by the Murdock Charitable Trust[grant number 2015277]Saint Martin’s University.
文摘Aims Established invasive plant species have more diverse gene pools than single populations in their home range.This genetic and often phenotypic variation allows for natural selection to act and produce rapid adaptations as an invasive species interacts with other members of the community.For an invasive flowering plant,interactions with pollinators may lead to adaptations to a heterogeneous pollinator community.The variation in the pollinator community in the invaded range is similar to variation in the native range,suggesting that adaptations may mirror patterns seen in the home range.In this study,we investigated variation in flower size in Cytisus scoparius,an invasive leguminous shrub,along an elevation gradient.Methods This study took place in the Capitol State Forest in Washington State.We measured flower widths and the proportion of visited flowers,using 10 plants per field site.Sites were located along an elevation gradient and were visited three times to measure phenological variation on a per-plant basis.Important Findings We saw positive selection for flower size,albeit without a distinct pattern of higher selection at higher elevations.The pattern of natural selection could be seen both in terms of pollinator visitation rates and in seed production.We also found that the largest contributor to changes in seed production was not elevation or flower size but management practices.
文摘Although it is well known that birds can assess predation risk through visual and auditory cues, there has been little research into whether similar processes occur with olfactory cues. We examined the role of odor cues in assessing nest predation risk in four species of passerine birds in New Zealand. We compared the ability of two introduced European species (common starling Sturnus vulgaris and song thrush Turdus philomelos) and two native New Zealand species (rifleman Acanthisitta chloris and South Island robin Petroica australis) to respond to the scent of rat urine placed in the nest. Rats are an introduced predator in New Zealand and we expected the native birds, which did not co-evolve with any mammalian predators, to lack behavioral adaptations to the scent of rats at their nest. As expected, both riflemen and robins failed to show any change in their behavior at their nest when rat urine was present compared to a control period in which no scent was present. However, a similar lack of re- sponse was observed in the introduced song thrush; only the common starling changed its behavior in the presence of the rat urine Starlings with rat urine at the nest box were more likely to hesitate before entering and they also approached the nest, but refused to enter more often in the presence of rat scent. Both responses suggest they detected the presence of a predator and changed their behavior to minimize risk to themselves. Although based on a small number of species, our results suggest that responses to pre- dator scent may be less common in New Zealand species, and may be a factor contributing to the vulnerability of native birds to introduced mammalian predators [Current Zoology 61 (1): 34-41, 2015].
基金supported by the National Natural Science Foundation of China(grant no.41771053,32071659,31961133028 and 32030067).
文摘Plants growing in nutrient-rich environment are predicted to be less defended than conspecifics under nutrient limitation.However,less is known about the effects of nutrient levels on tolerance and induced resistance,and whether the effects differ between native and introduced populations of invasive plants.We performed a greenhouse experiment with introduced(the USA)and native(Argentina)genotypes of Alternanthera philoxeroides in order to study the effects of soil nitrogen levels on plant growth,constitutive and herbivore(Agasicles hygrophila)-induced chemical defense,and herbivory tolerance.We measured total biomass,elongation rate(as proxy of growth rate),carbon and nitrogen,and the concentration of triterpenoid saponins(defensive chemicals)in leaves and roots.Constitutive resistance(+33%higher leaf triterpenoid saponins in control treatment at low nitrogen level)and tolerance[less decreased total biomass after herbivory treatment(−24%and−15%for high and low nitrogen levels)]were favored at lower nitrogen level,while induced resistance was favored at higher nitrogen level(+24%increased leaf triterpenoid saponins after herbivory treatment at high nitrogen level).Constitutive resistance and tolerance exhibited trade-offs with growth rate,while induced resistance positively correlated with growth rate.Additionally,the introduced genotypes had−6%lower content of leaf carbon in the presence of herbivores than the native genotypes at low nitrogen level,but such difference was absent at high nitrogen level.Our results indicate that soil nitrogen levels influence the preference of different defensive strategies of plant,and interweave with herbivory to determine the performance of introduced genotypes.