AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after rad...AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after radical surgery. Immunohistochemical (IHC) analysis was performed to detect the expression of 14 pathway-related markers (p53, APC, p21ras, E-cadherin, endothelin-B receptor, Shp2, ADCY-2, SPARCL1, neuroligin1, hsp27, mmp-9, MAPK, MSH2 and rho) in specimens from these patients. Bioinformatics analysis involving a Support Vector Machine (SVM) was used to determine the best prognostic model from combinations of these markers. RESULTS: Seven markers (SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK) were significantly related to the prognosis and clinical pathological features of the CRC patients (P < 0.05). Prognostic models were established through SVM from combinations of these 7 markers and proved able to differentiate patients with dissimilar survival, especially in stage Ⅱ/Ⅲ patients. According to the best prognostic model, the p53/SPARCL1 model, patients having high p53 and low SPARCL1 expression had about 50% lower 3-year survival than others (P < 0.001). CONCLUSION: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in CRC. A p53/SPARCL1 bioinformatics model may be used as a supplement to tumor-nodes-metastasis staging.展开更多
The Forest Department in the State of Uttar Pradesh, India developed Forest Management Information System (FMIS) for achieving organizational goals of improved financial and human resource management, improvement in t...The Forest Department in the State of Uttar Pradesh, India developed Forest Management Information System (FMIS) for achieving organizational goals of improved financial and human resource management, improvement in the management of forests and wildlife, and for achieving responsive administration. This paper, based on field research, presents an assessment of the dynamics of FMIS in organizational context for a better understanding of such systems in forestry organizations. The paper also investigates the success of FMIS in assisting decision makers in achieving organizational goals. Based on the knowledge developed during the course of the study, key learning elements have been highlighted for the benefit of the stakeholders in information systems in forest sector.展开更多
The integration of information technology and the continuous development of the information network make the college physical education degree of information technology constantly improving. College physical education...The integration of information technology and the continuous development of the information network make the college physical education degree of information technology constantly improving. College physical education is not only formed in the internal network, then sharing information resources and making sports teaching organization efficient as a whole, but communicate with the external network, formatting the Internet and producing significant changes in the teaching environment of college sports and sports teaching. College physical education is facing the reformation of better educated and digitization, virtualization, molecules, networking, agile and globalization. Physical education and sports teaching degree of information is closely related.展开更多
Business ethics has been growing from a philosophy discipline to an applied science. That explains its significance for more efficient functioning of various systems in business world. For that reason, organized socie...Business ethics has been growing from a philosophy discipline to an applied science. That explains its significance for more efficient functioning of various systems in business world. For that reason, organized societies with developed economies invest in empiric, theoretic, and theoretic-empiric investigations of various sectors and applied dimensions of business ethics. Its epistemological sense reflects to increasing productivity, more successful establishing of the system of hierarchy within an enterprise, appropriate formulating the strategy of management, improving the market reputation, increasing profitability, and strengthening social responsibility. The complexity of modem and successful business is based on a series of social factors which spread in the arch from anthropological, socially-psychological, and cultural characteristics of a human being, to quality characteristics of the global society. That is why the scientific information available to business ethics is synthesized from various scientific perspectives. This paradigm is a starting point of this project which is about the above subject. Its cognitive aim is presented through the description, classification, and explanation of the influence of business ethics to successful functioning of every kind of business institution. As a theoretic investigation which grows from verified scientific information and their critical analysis, it relies on standard, general scientific, basic special and general methods which are characteristic to the applied scientific disciplines. Business ethics has clearly established two key cognitive bases of its investigations： 1） personal value attitude; and 2） interests of a company, groups, and individuals in them. This project is only a small contribution to explaining elementary functions of this applied ethics in business world.展开更多
The development of modem information technology has brought unprecedented impact on mathematics teaching, which affects the content of the curriculum, and teaching and its manifestations, affecting the role of teacher...The development of modem information technology has brought unprecedented impact on mathematics teaching, which affects the content of the curriculum, and teaching and its manifestations, affecting the role of teachers in the teaching process and its relationship with the students, teaching methods and impacting policies the selection and use, affecting organizational form of teaching. Mathematics curriculum standards clearly stated： the design and implementation of the mathematics curriculum should pay attention to the use of modern information technology, particularly to fully consider the impact on mathematics learning content and methods, and to provide students with a more vigorous development of rich learning resources, the modem information technology as a powerful tool for students to learn math and problem-solving, working to change the way students learn, students willing and more energy into reality, exploratory math activities.展开更多
基金Supported by Grants from the Major State Basic Research Development Program of China, 973 Program No. 2004CB518707the Zhejiang Provincial Natural Science Foundation of China,No. R2090353the Fundamental Research Funds for the Central Universities, No. KYJD09007
文摘AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after radical surgery. Immunohistochemical (IHC) analysis was performed to detect the expression of 14 pathway-related markers (p53, APC, p21ras, E-cadherin, endothelin-B receptor, Shp2, ADCY-2, SPARCL1, neuroligin1, hsp27, mmp-9, MAPK, MSH2 and rho) in specimens from these patients. Bioinformatics analysis involving a Support Vector Machine (SVM) was used to determine the best prognostic model from combinations of these markers. RESULTS: Seven markers (SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK) were significantly related to the prognosis and clinical pathological features of the CRC patients (P < 0.05). Prognostic models were established through SVM from combinations of these 7 markers and proved able to differentiate patients with dissimilar survival, especially in stage Ⅱ/Ⅲ patients. According to the best prognostic model, the p53/SPARCL1 model, patients having high p53 and low SPARCL1 expression had about 50% lower 3-year survival than others (P < 0.001). CONCLUSION: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in CRC. A p53/SPARCL1 bioinformatics model may be used as a supplement to tumor-nodes-metastasis staging.
文摘The Forest Department in the State of Uttar Pradesh, India developed Forest Management Information System (FMIS) for achieving organizational goals of improved financial and human resource management, improvement in the management of forests and wildlife, and for achieving responsive administration. This paper, based on field research, presents an assessment of the dynamics of FMIS in organizational context for a better understanding of such systems in forestry organizations. The paper also investigates the success of FMIS in assisting decision makers in achieving organizational goals. Based on the knowledge developed during the course of the study, key learning elements have been highlighted for the benefit of the stakeholders in information systems in forest sector.
文摘The integration of information technology and the continuous development of the information network make the college physical education degree of information technology constantly improving. College physical education is not only formed in the internal network, then sharing information resources and making sports teaching organization efficient as a whole, but communicate with the external network, formatting the Internet and producing significant changes in the teaching environment of college sports and sports teaching. College physical education is facing the reformation of better educated and digitization, virtualization, molecules, networking, agile and globalization. Physical education and sports teaching degree of information is closely related.
文摘Business ethics has been growing from a philosophy discipline to an applied science. That explains its significance for more efficient functioning of various systems in business world. For that reason, organized societies with developed economies invest in empiric, theoretic, and theoretic-empiric investigations of various sectors and applied dimensions of business ethics. Its epistemological sense reflects to increasing productivity, more successful establishing of the system of hierarchy within an enterprise, appropriate formulating the strategy of management, improving the market reputation, increasing profitability, and strengthening social responsibility. The complexity of modem and successful business is based on a series of social factors which spread in the arch from anthropological, socially-psychological, and cultural characteristics of a human being, to quality characteristics of the global society. That is why the scientific information available to business ethics is synthesized from various scientific perspectives. This paradigm is a starting point of this project which is about the above subject. Its cognitive aim is presented through the description, classification, and explanation of the influence of business ethics to successful functioning of every kind of business institution. As a theoretic investigation which grows from verified scientific information and their critical analysis, it relies on standard, general scientific, basic special and general methods which are characteristic to the applied scientific disciplines. Business ethics has clearly established two key cognitive bases of its investigations： 1） personal value attitude; and 2） interests of a company, groups, and individuals in them. This project is only a small contribution to explaining elementary functions of this applied ethics in business world.
文摘The development of modem information technology has brought unprecedented impact on mathematics teaching, which affects the content of the curriculum, and teaching and its manifestations, affecting the role of teachers in the teaching process and its relationship with the students, teaching methods and impacting policies the selection and use, affecting organizational form of teaching. Mathematics curriculum standards clearly stated： the design and implementation of the mathematics curriculum should pay attention to the use of modern information technology, particularly to fully consider the impact on mathematics learning content and methods, and to provide students with a more vigorous development of rich learning resources, the modem information technology as a powerful tool for students to learn math and problem-solving, working to change the way students learn, students willing and more energy into reality, exploratory math activities.
