依达拉奉右莰醇治疗缺血性脑卒中的有效性和安全性研究进展

急性缺血性脑卒中特异性治疗策略包括改善脑血循环、他汀药物及神经保护等。神经保护剂理论上可以阻断缺血级联反应并阻止神经细胞死亡,在缺血性脑卒中的治疗中有很大的应用前景,但是既往对神经保护剂的临床研究结论并不一致。近期,越来越多临床研究结果显示,与依达拉奉相比,依达拉奉右莰醇改善缺血性脑卒中患者神经功能缺损的远期疗效更好,安全性相似,临床应用价值更优。本文将对多靶点神经保护剂依达拉奉右莰醇的作用机制、治疗缺血性脑卒中的有效性及安全性进行综述,以期为该药的临床合理应用提供参考。

Characteristics of Soil Organic Carbon and Total Nitrogen in Rubber Plantations Soil at Different Age Stages in the Western Region of Hainan Island

[Objective]The aim was to study on the characteristics of soil organic carbon and nitrogen in rubber （Hevea brasiliensis Muell-Arg） plantations at different age stages in the western region of Hainan Island,so as to evaluate the ecological benefits of rubber plantations and provide basic data for studying the effect of tropical land utilization/cover change on the global carbon and nitrogen cycle. [Method]The situs was in Danzhou city,western region of Hainan Island,and the samples were four kinds of rubber plantations soil at different ages and one kind of control check （pepper,Piper nigrum L.） soil. In this research,four quadrats were set up in each sample,and the size of each was 20 cm×20 cm. Four specimens were gathered from four layers of 0-15,15-30,30-45,45-60,and the average of them was the last analysis result of each sample. Soil density was measured by cutting ring method,soil containing and hygroscopic water was detected by oven drying method,soil organic carbon （SOC） was measured by low temperature heated outside potassium dichromate oxidation-colorimetry method,and soil total nitrogen （STN） was detected by semimicro Kjeldahl method. [Result]SOC contents of different layers in rubber plantations soil at different age stages （including the CK pepper soil,the same as below） varied little,and the content of SOC in surface layer （0-15 cm） was higher,while the underlayer （45-60 cm） was lower than the average value; there was significant difference in SOC content among different kinds of soil,and the content was of 6.03-7.78 g/kg,tapping young trees （7 years） CK pepper mature age trees （30 years） prophase of young trees （2 years） tapping trees （16 years）; there was no significant difference in SOC storage among different kinds of soil,and the storage was of 61.33-74.29 t/hm2,mature age trees （30 years） tapping young trees （7 years） prophase of young trees （2 years） CK pepper tapping trees （16 years）; there was significant difference in STN content among rubber plantations soil at different age stages,the content was of 410.86-664.14 mg/kg2,CK pepper tapping young trees （7 years） prophase of young trees （2 years） mature age trees （30 years） tapping trees （16 years）,and STN content of tapping trees （16 years） soil was extremely lowest; there was significant difference in C/N ratio among different kinds of soil,the ratio was of 10.94-14.47,and the ratio of tapping trees （16 years） mature age trees （30 years） tapping young trees （7 years） CK pepper prophase of young trees （2 years）. [Conclusion]There wasn＇t unhealthy effect of rubber trees planted in tropical area on the content and storage of SOC,the content of STN and the ratio of C/N. there was no significant difference between rubber plantations and CK pepper soil,and the effects of rubber plantation on soil carbon-nitrogen was similar to that of other tropical crops （such as pepper）.

Electromagnetic holographic sensitivity field of two-phase flow in horizontal wells

Electromagnetic holographic data are characterized by two modes, suggesting that image reconstruction requires a dual-mode sensitivity field as well. We analyze an electromagnetic holographic field based on tomography theory and Radon inverse transform to derive the expression of the electromagnetic holographic sensitivity field （EMHSF）. Then, we apply the EMHSF calculated by using finite-element methods to flow simulations and holographic imaging. The results suggest that the EMHSF based on the partial derivative of radius of the complex electric potential φ is closely linked to the Radon inverse transform and encompasses the sensitivities of the amplitude and phase data. The flow images obtained with inversion using EMHSF better agree with the actual flow patterns. The EMHSF overcomes the limitations of traditional single-mode sensitivity fields.

Perfectly matched layer-absorbing boundary condition for finite-element time-domain modeling of elastic wave equations

The perfectly matched layer （PML） is a highly efficient absorbing boundary condition used for the numerical modeling of seismic wave equation. The article focuses on the application of this technique to finite-element time-domain numerical modeling of elastic wave equation. However, the finite-element time-domain scheme is based on the second- order wave equation in displacement formulation. Thus, the first-order PML in velocity-stress formulation cannot be directly applied to this scheme. In this article, we derive the finite- element matrix equations of second-order PML in displacement formulation, and accomplish the implementation of PML in finite-element time-domain modeling of elastic wave equation. The PML has an approximate zero reflection coefficients for bulk and surface waves in the finite-element modeling of P-SV and SH wave propagation in the 2D homogeneous elastic media. The numerical experiments using a two-layer model with irregular topography validate the efficiency of PML in the modeling of seismic wave propagation in geological models with complex structures and heterogeneous media.

Analysis on Variation of Soil Organic Carbon and Total Nitrogen Content and Carbon Storage in the Oasis Cotton Field of Manas River Valley

Objective] The research aimed to study soil organic carbon and total ni-trogen distribution in oasis cotton farmland. [Method] With the oasis cotton field of Manas River Val ey in Tianshan Mountains as the research area and abandoned farmland as a control, the distribution characteristics of soil organic carbon and total nitrogen content in the cotton field of Manas River Val ey in the last 23 years were investigated by using geographic methods. [Result] Presenting vertical distribution, cotton soil organic carbon and total nitrogen content in Manas River Val ey de-creased with the increase of soil depth, and those in 0-30 cm soil layer was sig-nificantly higher than those in soil layer of below 30 cm, while organic carbon stor-age showed the trend of increase. Also in vertical distribution, soil organic carbon and total nitrogen decreased significantly with the increase of soil depth, and soil organic carbon content in abandoned farmland decreased month by month. Howev-er, cotton soil organic carbon storage firstly decreased and then increased in the oasis cotton field that in the early growth of cotton, soil organic carbon in the layers of 0-30 and 30-100 cm decreased to the lowest in the bloom stage, and then or-ganic carbon increased with the reproductive growth of cotton into the later stages. However, due to no input of plant litter in the abandoned farmland, the soil organic carbon storage decreased month by month. There were significantly differences be-tween oasis cotton field and abandoned farmland in organic carbon contents. [Con-clusion] The soil organic carbon content and total nitrogen content in oasis cotton field were significantly higher than those in the abandoned farmland. The soil organ-ic carbon storage increased in the layer of 0-30 cm, while there was no significant change of soil organic carbon and total nitrogen content in the layer of 30-100 cm, which was consistent with the previous study on the distribution characteristics of soil organic carbon and total nitrogen content profile.

On the Existence of Periodic Solutions of a Class Nonlinear Differential Systems

One method to show the existence of ω-periodic system is given. This method is based on the ultimately boundedness of the solution of the systems. By using comparing theorem and discussing some one dimensional equations the main results are obtained.

Improved hybrid iterative optimization method for seismic full waveform inversion

In full waveform inversion （FWI）, Hessian information of the misfit function is of vital importance for accelerating the convergence of the inversion; however, it usually is not feasible to directly calculate the Hessian matrix and its inverse. Although the limited memory Broyden-Fletcher-Goldfarb-Shanno （L-BFGS） or Hessian-free inexact Newton （HFN） methods are able to use approximate Hessian information, the information they collect is limited. The two methods can be interlaced because they are able to provide Hessian information for each other; however, the performance of the hybrid iterative method is dependent on the effective switch between the two methods. We have designed a new scheme to realize the dynamic switch between the two methods based on the decrease ratio （DR） of the misfit function （objective function）, and we propose a modified hybrid iterative optimization method. In the new scheme, we compare the DR of the two methods for a given computational cost, and choose the method with a faster DR. Using these steps, the modified method always implements the most efficient method. The results of Marmousi and overthrust model testings indicate that the convergence with our modified method is significantly faster than that in the L-BFGS method with no loss of inversion quality. Moreover, our modified outperforms the enriched method by a little speedup of the convergence. It also exhibits better efficiency than the HFN method.

NOTE ON FUNCTIONS WITH DIFFERENCE UNIFORMITY

Functions with difference uniformity have important applications in cryptography. Some planar functions and almost perfect nonlinear（APN） functions are presented in the note. In addition, an upper bound of the uniformity of some power mappings is provided by using an interesting identity on Dickson polynomials. When the character of the finite field is less than 11, the upper bound is proved to be the best possibility.

Chinese herbal medicine for treatment of dislipidemia

Prevalence of dislipidemia is increasing rapidly in China and there has been a growing interest in Chinese herbal medicine for the treatment of hyperlipidemia both inside and outside China. In this article, lipids regulating effects of 9 herbs or their extracts and 5 herbal formulae which have been published in English-language literature are reviewed. Although evidence from animals and humans consistently supports the therapeutic activities of these Chinese herbal medicines, few multi-center large-scale clinical trials have been conducted to confirm the efficacy and evaluate their safety.

Systemic immune-inflammation index for predicting prognosis of colorectal cancer

AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII =(P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) in patients with CRC.RESULTS The optimal cut-off point for SII was defined as 340. The overall survival(OS) and disease-free survival(DFS) were better in patients with low NLR, PLR, and SII(P < 0.05). The SII was an independent predictor of OS and DFS in multivariate analysis. The area under the receiver-operating characteristics(ROC) curve for SII(0.707) was larger than those for NLR(0.602) and PLR(0.566). In contrast to NLR and PLR, SII could effectively discriminate between the TNM subgroups. CONCLUSION SII is a more powerful tool for predicting survival outcome in patients with CRC. It might assist the identification of high-risk patients among patients with the same TNM stage.

Variation in Enzymes Activities of Rhizospheric Substrate and Influencing Factors during Nursing of Watermelon Seedlings

[Objective] This study aimed to investigate the effects of substrate en- zymes activities on nursing of watermelon seedlings. [Method] The composted mushroom residue was mixed with garden soil according to a certain proportion to prepare nursing substrate for watermelon seedlings. During the nursing, the activity variation in alkaline phosphatase, acid phosphatase, neutral phosphatase and urease was investigated. In addition, the correlations between pH value, total nitrogen con- tent, total phosphorus content and organic matter content in substrate and enzyme activity were studied. At different young seedling stages, the rhizospheric substrates with different formulas were sampled for determination of enzymes activities. [Result] The enzyme activity differed significantly among different substrates. The correlation analysis results showed that the higher the organic matter content and total nitrogen content in substrate are, the higher the urease activity is; the phosphatase activity was significantly related to the organic matter content, total nitrogen content and to- tal phosphorus content in substrate; the pH value of substrate was significantly relat- ed to rhizospheric alkaline phosphatase activity; the shoot dry weight was positively related to urease activity; there was a significant correlation between phosphatase activity and root dry weight. [Conclusion] Through determining enzymes activities in the rhizospheric substrate for nursing watermelon seedlings, the optimum substrate M3 was screened out. The activities of rhizospheric urease, alkaline phosphatase, acid phosphatase and neutral phosphatase in the substrate M3 were all higher than those in the substrate fertilized with manure.

Effects of Conservation Tillage on the Content of Carbon, Nitrogen in Fluvo-aquic Soil

In order to verify organic carbon cycle under conservation tillage condition and the promotion mechanism of soil fertility and offer scientific theory support for the popularization and application of conservation tillage technological, the research investigated effects of different tillage treatments on the content of total organic car- bon, total nitrogen and different components of them in fluvo-aquic soil based on a long-term experiment site of conservation tillage. The research revealed effects of conservation tillage on the content of carbon, nitrogen in fluvo-aquic soil by study the distribution of soil total organic carbon, total nitrogen, dissolved organic carbon, dissolved organic nitrogen, microbial biomass carbon, liable carbon in different soil depth under different tillage treatments. The results showed that compared to con- ventional tillage treatment, contents of soil total organic carbon under intermittent tillage （tillage once every 2 or 4 years） and no-tillage treatment improved by 1.81%, 6.43%, 14.04%, respectively and contents of soil total nitrogen went up by 0.80%, 10.04%, 7.93%, respectively. Contents of soil total organic carbon and total nitrogen in 10-20 cm soil layer under no-tillage treatment were significantly lower than the other treatments. Under the condition of straw returned, intermittent tillage and no- tillage could significantly improve the content of soil dissolved organic carbon and ni- trogen in 0-5 cm and 5-10 cm soil. Compared to conventional tillage treatment, content of soil microbial biomass carbon and liable carbon in 0-5 cm soil under in- termittent tillage and no-tillage were improved in varying degrees. Content of soil microbial biomass carbon in 10-20 cm soil layer under no-tillage treatment was sig- nificantly lower than the other treatments. Straw returning had improved the content of soil total organic carbon, total nitrogen, dissolved organic carbon and other com- ponents of active organic carbon in varying degrees. In general, conservation tillage measures could increase carbon and nitrogen storage in 0-5 cm soil layer, the negative effects of ＂nutrients enrichment in surface＂ under no-tillage condition could be ameliorated by intermittent tillage.

Emission and Fixation of CO_2 from Soil System as Influenced by Long-Term Application of Organic Manure in Paddy Soils

The observations of 25-yr long-term experiment in Zhejiang paddy soils showed that the soil organic matter could increase continuously with applying organic manure, and the increase in rate enhanced along with the application rates of organic manure. By mathematical modeling, the soil organic matter increased by 22 kg when 1 t of fresh FYM was applied. The CO2 emission resulting from the mineralization of soil organic matter increased with the increase in the application rate of the organic manure as well as the increase in the root residues. It is expected that the CO2 emission will be at 10.04-21.61 t ha-1 yr-1 when 16.5-49.5 t ha-1 yr-1 of fresh FYM is applied. The soil organic carbon from mineralization and release of applied organic carbon (fresh FYM and root residues) will affect the CO2 concentration in the atmosphere. So, the higher the application rate of organic manure, the more is the fixed organic carbon. The CO2 fixation will be at 1.885-3.463 t ha-1 yr-1 when 16.5-49.5 t ha-1 yr-1 of fresh FYM is applied. Thus, the CO2 fixation will increase by 46.7 kg by applying 1 t fresh FYM. To apply organic manure continuously in rice fields may reduce the contribution to the increase of CO2 concentration in the atmosphere.

Stability of finite difference numerical simulations of acoustic logging-while-drilling with different perfectly matched layer schemes

In acoustic logging-while-drilling （ALWD） finite difference in time domain （FDTD） simulations, large drill collar occupies, most of the fluid-filled borehole and divides the borehole fluid into two thin fluid columns （radius -27 mm）. Fine grids and large computational models are required to model the thin fluid region between the tool and the formation. As a result, small time step and more iterations are needed, which increases the cumulative numerical error. Furthermore, due to high impedance contrast between the drill collar and fluid in the borehole （the difference is 〉30 times）, the stability and efficiency of the perfectly matched layer （PML） scheme is critical to simulate complicated wave modes accurately. In this paper, we compared four different PML implementations in a staggered grid finite difference in time domain （FDTD） in the ALWD simulation, including field-splitting PML （SPML）, multiaxial PML（M- PML）, non-splitting PML （NPML）, and complex frequency-shifted PML （CFS-PML）. The comparison indicated that NPML and CFS-PML can absorb the guided wave reflection from the computational boundaries more efficiently than SPML and M-PML. For large simulation time, SPML, M-PML, and NPML are numerically unstable. However, the stability of M-PML can be improved further to some extent. Based on the analysis, we proposed that the CFS-PML method is used in FDTD to eliminate the numerical instability and to improve the efficiency of absorption in the PML layers for LWD modeling. The optimal values of CFS-PML parameters in the LWD simulation were investigated based on thousands of 3D simulations. For typical LWD cases, the best maximum value of the quadratic damping profile was obtained using one do. The optimal parameter space for the maximum value of the linear frequency-shifted factor （a0） and the scaling factor （β0） depended on the thickness of the PML layer. For typical formations, if the PML thickness is 10 grid points, the global error can be reduced to 〈1% using the optimal PML parameters, and the error will decrease as the PML thickness increases.

POSITIVE ENTIRE SOLUTIONS TO SINGULAR SEMILINEAR ELLIPTIC EQUATIONS OF MIXED TYPE

In this paper, we are concerned with positive entire solutions to elliptic equations of the form Δu+ f(x,u)= 0 x∈ RN N ≥ 3 where u →f(x,u) is not assumed to be regular near u = 0 and f(x,u) may be more general involving both singular and sublinear terms. Some sufficient conditions are given with the aid of the barrier method and ODE approach, which guarantee the existence of positive entire solutions that tend to any sufficiently large constants arbitrarily prescribed in advance.

Security in gas discharge while unsealing a closed stope

Given the problem of harmful gas discharge in unsealing coal mining faces, we numerically simulated the process of change of gas flows and movements, We have pointed out that, at the moment of unsealing a closed stope, the gas discharge is naturally divided into two parts, i.e., the discharge of gas in the working face and that in the goaf, because of the difference in the spatial medium. The absolute volume of gas discharged has a tendency to decrease from its initial peak value to a final stable value. The rate of decrease and the time needed to reach a stable discharge are related to the scale of the mining stope. The discharge of gas from the working face is closely related to the amount of air distributed in the air return way. The most important thing in unsealing a stope is to have the initial peak volume of gas discharged well under control. A commonly used method in solving this problem is at first to use a small amount of air and then increasing it gradually. Our study shows that, by extracting gas from the upper corner, we can use a large volume of air at first in order to shorten considerably the discharge time and improve efficiency, thereby making mining, activitv safer.

Effects of Grazing Exclusion on Soil Carbon and Nitrogen Storage in Semi-arid Grassland in Inner Mongolia, China

The semi-arid grasslands in Inner Mongolia, China have been degraded by long-term grazing. A series of ecological restoration strategies have been implemented to improve grassland service. However, little is known about the effect of these ecological restoration practices on soil carbon and nitrogen storage. In this study, characteristics of vegetation and soil properties under continued grazing and exclusion of livestock for six years due to a nationwide conservation program—′Returning Grazing Lands to Grasslands(RGLG)′ were examined in semi-arid Hulun Buir grassland in Inner Mongolia, China. The results show that removal of grazing for six years resulted in a significant recovery in vegetation with higher above and below-ground biomass, but a lower soil bulk density and pH value. After six years of grazing exclusion, soil organic C and total N storage increased by 13.9% and 17.1%, respectively, which could be partly explained by decreased loss and increased input of C and N to soil. The effects of grazing exclusion on soil C and N concentration and storage primarily occurred in the upper soil depths. The results indicate that removal of grazing pressure within the RGLG program was an effective restoration approach to control grassland degradation in this region. However, more comprehensive studies are needed to evaluate the effectiveness of the RGLG program and to improve the management strategies for grassland restoration in this area.

SMART： The First Licensed Advanced Integral Reactor

SMART （system-integrated modular advanced reactor） is a small-sized advanced integral reactor with a rated thermal power of 330 MW. It can produce 100 MW of electricity, or 90 MW of electricity and 40,000 t of desalinated water concurrently, which is sufficient for 100,000 residents. SMART technology is a sensible mixture of new innovative design features and proven technologies through a PWR. The enhancement of safety and reliability is realized by incorporating inherent safety features and reliable passive safety systems. The improvement in the economics is achieved through system simplification, component modularization, construction time reduction, and increased plant availability. All technologies and design features implemented into SMART have been proven in industries and/or qualified through the SMART design verification program including comprehensive test and experiments. The full scope of the safety analyses carried out to confirm that the inherent safety-improvement design characteristics and safety systems of SMART ensure reactor safety. After a thorough licensing review, SDA （standard design approval） for SMART was granted on July 4th, 2012 by the Korea NSSC （Nuclear Safety and Security Commission）. This marks the first license for an integral-type reactor in the world. This paper presents the SMART characteristics, safety features and technology validation. The licensing process of SMART is also described.

Calculation and application of full-wave airborne transient electromagnetic data in electromagnetic detection

Airborne electromagnetic transient method enjoys the advantages of high-efficiency and the high resolution of electromagnetic anomalies,especially suitable for mining detection around goaf areas and deep exploration of minerals.In this paper,we calculated the full-wave airborne transient electromagnetic data,according to the result of numerical research,the advantage of switch-off time response in electromagnetic detection was proofed via experiments.Firstly,based on the full-wave airborne transient electromagnetic system developed by Jilin University(JLU-ATEMI),we proposed a method to compute the full-waveform electromagnetic(EM)data of 3D model using the FDTD approach and convolution algorithm,and verify the calculation by the response of homogenous half-space.Then,through comparison of switch-off-time response and off-time response,we studied the effect of ramp time on anomaly detection.Finally,we arranged two experimental electromagnetic detection,the results indicated that the switch-off-time response can reveal the shallow target more effectively,and the full-waveform airborne electromagnetic system is an effective technique for shallow target detection.