miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found tha...miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-p. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-β post-transcriptionally, while CEBP-βpositively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223--CEBP-β-LMO2-- miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.展开更多
A good mechanical model of magnetorheological damper (MRD) is essential to predict the shock isolation performance of MRD in numerical simulation. But at present, the mechanical models of MRD were all derived from the...A good mechanical model of magnetorheological damper (MRD) is essential to predict the shock isolation performance of MRD in numerical simulation. But at present, the mechanical models of MRD were all derived from the experiment subjected to harmonic vibration loads. In this paper, a commercial MRD (type RD-1005-3) manufactured by Lord Corporation was studied ex-perimentally in order to investigate its isolation performance under the impact loads. A new me-chanical model of MRD was proposed according to the data obtained by impact test. A good agreement between the numerical results and test data was observed, which showed that the model was good to simulate the dynamic properties of MRD under impact loads. It is also demon-strated that MRD can improve the acceleration and displacement response of the structure obvi-ously under impact loads.展开更多
As a star representative of transition metal sulfides, Sn S is viewed as a promising anode-material candidate for sodium ion batteries due to its high theoretical capacity and unique layered structure. However,the ext...As a star representative of transition metal sulfides, Sn S is viewed as a promising anode-material candidate for sodium ion batteries due to its high theoretical capacity and unique layered structure. However,the extremely poor electrical conductivity and severe volume expansion strongly hinder its practical application while achieving a high reversible capacity with long-cyclic stability still remains a grand challenge. Herein, different from the conventional enhancement method of elemental doping, we report a rational strategy to introduce PO_(4)^(3-)into the Sn S layers using phytic acid as the special phosphorus source.Intriguingly, the presence of PO_(4)^(3-)in the form of Sn–O–P covalent bonds can act as a conductive pillar to buffer the volume expansion of Sn S while expanding its interlay spacing to allow more Na+storage, supported by both experimental and theoretical evidences. Profiting from this effect combined with microstructural metrics by loading on high pyridine N-doped reduced graphene oxide, the as-prepared material presented an unprecedented ultra-long cyclic stability even after 10,000 cycles along with high reversible capacity and excellent full-cell performances. The findings herein open up new opportunities for elevating electrochemical performances of metal sulfides and provide inspirations for the fabrication of advanced electrode materials for broad energy use.展开更多
基金This work was supported by the National Natural Science Foundation of China （Grant No. 30771054）.
文摘miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-p. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-β post-transcriptionally, while CEBP-βpositively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223--CEBP-β-LMO2-- miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.
基金Supported by National Natural Science Foundation of China (No.50638030,50525825)the National Science and Technology SupportProgram (No.2006BAJ13B02)
文摘A good mechanical model of magnetorheological damper (MRD) is essential to predict the shock isolation performance of MRD in numerical simulation. But at present, the mechanical models of MRD were all derived from the experiment subjected to harmonic vibration loads. In this paper, a commercial MRD (type RD-1005-3) manufactured by Lord Corporation was studied ex-perimentally in order to investigate its isolation performance under the impact loads. A new me-chanical model of MRD was proposed according to the data obtained by impact test. A good agreement between the numerical results and test data was observed, which showed that the model was good to simulate the dynamic properties of MRD under impact loads. It is also demon-strated that MRD can improve the acceleration and displacement response of the structure obvi-ously under impact loads.
基金supported by the National Natural Science Foundation of China(51904059)Fundamental Research Funds for the Central Universities(N2002005,N2125004,and N2225044)+1 种基金Applied Basic Research Program of Liaoning(2022JH2/101300200)。
文摘As a star representative of transition metal sulfides, Sn S is viewed as a promising anode-material candidate for sodium ion batteries due to its high theoretical capacity and unique layered structure. However,the extremely poor electrical conductivity and severe volume expansion strongly hinder its practical application while achieving a high reversible capacity with long-cyclic stability still remains a grand challenge. Herein, different from the conventional enhancement method of elemental doping, we report a rational strategy to introduce PO_(4)^(3-)into the Sn S layers using phytic acid as the special phosphorus source.Intriguingly, the presence of PO_(4)^(3-)in the form of Sn–O–P covalent bonds can act as a conductive pillar to buffer the volume expansion of Sn S while expanding its interlay spacing to allow more Na+storage, supported by both experimental and theoretical evidences. Profiting from this effect combined with microstructural metrics by loading on high pyridine N-doped reduced graphene oxide, the as-prepared material presented an unprecedented ultra-long cyclic stability even after 10,000 cycles along with high reversible capacity and excellent full-cell performances. The findings herein open up new opportunities for elevating electrochemical performances of metal sulfides and provide inspirations for the fabrication of advanced electrode materials for broad energy use.
