In the era of precision medicine, the human ＂2nd genome＂, namely the human microbiome, is of increasing interest worldwide. Firstly, the human microbiome has been linked to various diseases including metabolic disea...In the era of precision medicine, the human ＂2nd genome＂, namely the human microbiome, is of increasing interest worldwide. Firstly, the human microbiome has been linked to various diseases including metabolic diseases, cancers, heart diseases, or brain disorders, and autoimmune diseases. Secondly, changes in the microbiome are known or hypothesized to be proxies for environmental or host phenotypical changes. Thirdly, the rational alteration of disturbed human microbial communities could possibly lead to health benefits, e.g., during disease treatment. However, studies of the human microbiome frequently involve large amounts of data,展开更多
RNAs are life＇s essential molecules with diverse functions. The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade. More...RNAs are life＇s essential molecules with diverse functions. The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade. Moreover, diversified chemical modifications as well as structural dynamics of RNAs have emerged as additional layers of gene regulatory complexity, which form new dimensions of the research on RNA epigenetics. These multiple layers of RNA epigenetics shape the transcriptomic and proteomic landscape of our cells, and in turn regulate a broad range of biological functions. To unravel the mysteries of ＂RNA world＂, we dedicate this special issue to the current advances of RNA epigenetics and beyond.展开更多
The development of genomics has greatly accelerated and even renovated the plant research. The sequencing of plant genomes has greatly facilitated the research on gene functions. The multiple released genomes further ...The development of genomics has greatly accelerated and even renovated the plant research. The sequencing of plant genomes has greatly facilitated the research on gene functions. The multiple released genomes further promote the research on genome evolution and its functional relevance. Meanwhile, the state-of-art epigenetics studies go on a genome-wide level. All these research effort would contribute to a better understanding of plants and their interactions with environment, eventually improvements in crop yield and human health.展开更多
It took 15 years, 3 billion USD, and thousands of top scientists from all over the world to complete the Human Genome Project （HGP）. Our next grand challenge in biological sciences, the worldwide Human Brain Project...It took 15 years, 3 billion USD, and thousands of top scientists from all over the world to complete the Human Genome Project （HGP）. Our next grand challenge in biological sciences, the worldwide Human Brain Project （HBP）, will be much more complex than HGP. Human brain is the most complex organ on this planet, which is also highly energy efficient. HBP mainly consists of three areas： understanding the normal brain functions, tackling major brain disorders,展开更多
文摘In the era of precision medicine, the human ＂2nd genome＂, namely the human microbiome, is of increasing interest worldwide. Firstly, the human microbiome has been linked to various diseases including metabolic diseases, cancers, heart diseases, or brain disorders, and autoimmune diseases. Secondly, changes in the microbiome are known or hypothesized to be proxies for environmental or host phenotypical changes. Thirdly, the rational alteration of disturbed human microbial communities could possibly lead to health benefits, e.g., during disease treatment. However, studies of the human microbiome frequently involve large amounts of data,
文摘RNAs are life＇s essential molecules with diverse functions. The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade. Moreover, diversified chemical modifications as well as structural dynamics of RNAs have emerged as additional layers of gene regulatory complexity, which form new dimensions of the research on RNA epigenetics. These multiple layers of RNA epigenetics shape the transcriptomic and proteomic landscape of our cells, and in turn regulate a broad range of biological functions. To unravel the mysteries of ＂RNA world＂, we dedicate this special issue to the current advances of RNA epigenetics and beyond.
文摘The development of genomics has greatly accelerated and even renovated the plant research. The sequencing of plant genomes has greatly facilitated the research on gene functions. The multiple released genomes further promote the research on genome evolution and its functional relevance. Meanwhile, the state-of-art epigenetics studies go on a genome-wide level. All these research effort would contribute to a better understanding of plants and their interactions with environment, eventually improvements in crop yield and human health.
文摘It took 15 years, 3 billion USD, and thousands of top scientists from all over the world to complete the Human Genome Project （HGP）. Our next grand challenge in biological sciences, the worldwide Human Brain Project （HBP）, will be much more complex than HGP. Human brain is the most complex organ on this planet, which is also highly energy efficient. HBP mainly consists of three areas： understanding the normal brain functions, tackling major brain disorders,
