Multivariate analysis was adopted to analyze 30 morphometrical characteristics of 121 one-year-old juvenile silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobilis) bred during the 1950s ...Multivariate analysis was adopted to analyze 30 morphometrical characteristics of 121 one-year-old juvenile silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobilis) bred during the 1950s ("the former population") and 2008 ("the current population") and collected from the middle reach of the Yangtze River. The average discriminant accuracies of the former and current silver and bighead carp population were 94.2% and 98.0%, respectively. Discriminant analysis also revealed that significant differences in morphology occurred between the former and current populations of both carp in overall characteristics. One-way analysis of variance indicated that between former and current populations, silver carp showed highly significant differences (P0.01) in twelve of their characteristics and significant differences (P0.05) in eight of their characteristics, while bighead carp showed highly significant differences (P0.01) in eight of their characteristics and significant differences (P0.05) in eight of their characteristics. Six head morphology variables of the current silver and bighead carp were significantly or highly significantly larger than the former populations; fourteen characteristics of silver carp and ten characteristics of bighead carp of the current populations, mainly reflecting truck and tail morphology, were significantly or very significantly smaller than the former populations. Our results indicate that silver and bighead carp have developed a larger head and smaller truck and tail during the last 50 years. Due to such morphological changes, it seems apparent that the heads of these fish species need to be considered in regards to human diets, particularly in relation to economic and nutritious value.展开更多
The structural and histochemical changes of the egg apparatus in the polyembryonic rice ( Oryza sativa L.), ApⅢ with the highest frequence of additional embryos among the polyembryonic rice investigated, before an...The structural and histochemical changes of the egg apparatus in the polyembryonic rice ( Oryza sativa L.), ApⅢ with the highest frequence of additional embryos among the polyembryonic rice investigated, before and after fertilization were studied and compared with those of normal and other polyembryonic rices in a similar developmental period. A total of 2 932 ovules were observed and each of them contained only a single embryo sac with a set of egg apparatus. Among 1 655 embryo sacs, there were 1 643 embryo sacs (99.27%) with one normal egg apparatus in each embryo sac, and only 12 embryo sacs (0.73%) from the remainder with 4_celled egg apparatus, i.e. two eggs and two synergids. Neither the numerous poly_egg apparatus and egg_like cells, nor the double set of embryo sacs each containing one egg apparatus and other abnormal egg apparatus in single ovary, which were reported by earlier investigators to have high frequency of embryo production in SB_1 and ApⅣ, were observed. The egg cell was located at the subterminal site of the micropylar end of embryo sac. The cytoplasm of egg cell was rich in protein materials and polysaccharide grains, which did not disappear until the division of zygote. The prominent nucleus was closely surrounded by protein and polysaccharide grains, which did not disappear until the division of zygote. No cytological difference was found between egg cells from the normal and abnormal egg apparatus. The two synergids were fully developed and situated at the upper most part of the micropylar end of the mature embryo sac. In most embryo sacs, the synergids were flask_shaped with longer necks, and a widened cap_shaped top, in close contact with the micropyle. The synergids had a well developed filiform apparatus. The characteristic appearance of the filiform apparatus as well as the cap_neck region of synergids before and after pollen tube penetration were easily distinguishable from the egg cell. The structure, the stainability with Coomassie Brilliant Blue and PAS reaction, the process of accumulation, distribution and disapperance of the cytoplasmic protein materials and polysaccharide grains of the two synergids, the persistent and rarely the receptive synergids before and after pollen tube penetration, were closely similar to those of egg cell of the same developmental stage. In comparison with normal and other polyembryonic rice reported, the size of nucleus and nucleolus and their stainability also strongly resembled those of egg cell. Based on the results observed, the main conclusions are summarized as follows: (1) the additional embryos very frequently developed in the young and mature seed of polyembryonic rice ApⅢ were produced by one or two synergids of normal egg apparatus, rarely by 4_celled egg apparatus; (2) during fertilization, the synergids, in addition to the natural specific function of introducing pollen tube and transferring sperms to egg cell and central cell, could be closely associated with the potentiality to breed one or two additional embryos; and (3) as compared with that of normal or other polyembryonic rice it is firstly disclosed that in a few embryo sacs of ApⅢ, the cytoplasmic and nuclear structure, the active anabolism and catabolism of protein and polysaccharide materials and the delayed disorganization at the mid_basal region of the receptive and persistent synergid still remained unchanged before the division of zygote. Such salient features could be the predisposition for the origin of additional embryos in ApⅢ.展开更多
The methods of moment and genetic algorithm (GA) are combined to optimize the Yagi Uda antenna array and Log periodic dipole antenna (LPDA) array. The element lengths and spacing are optimized for the Yagi Uda arra...The methods of moment and genetic algorithm (GA) are combined to optimize the Yagi Uda antenna array and Log periodic dipole antenna (LPDA) array. The element lengths and spacing are optimized for the Yagi Uda array; while the ratio factor of spacing to length as well as the ratio of length to diameter of the elements are optimized for LPDA array. The results show that the main parameters, such as gain and pattern, have been improved apparently; and the high back lobe level of LPDA can be reduced greatly, therefore, GA is a very competent method for optimizing the linear array as well as in other fields.展开更多
This paper discusses some aspects of finite element computation,such as the automatic generation of finite element ,refinement of mesh,process of node density, distribution of load,optimum design and the drawing o...This paper discusses some aspects of finite element computation,such as the automatic generation of finite element ,refinement of mesh,process of node density, distribution of load,optimum design and the drawing of stress contour, and describes the developing process of software for a planar 8 node element.展开更多
The improved current-doubler-rectifier zero-voltage-switching PWM full-bridge converter (CDR ZVS PWM FB converter) achieves ZVS for the switches in a wide load range with the use of the energy stored in the output fil...The improved current-doubler-rectifier zero-voltage-switching PWM full-bridge converter (CDR ZVS PWM FB converter) achieves ZVS for the switches in a wide load range with the use of the energy stored in the output filter inductances, and the rectifier diodes commute naturally, therefore no oscillation and voltage spike occurs. The transformer needs no special manufacture method to limit the leakage inductance. The ZVS achievement and the design considerations for the output filter inductances and the blocking capacitor are discussed for the improved CDR ZVS PWM FB converter. A 540 W prototype converter is built in the lab to verify the operational principle and design considerations for the improved converter, the experimental results are also included.展开更多
To reduce decoding delay of a communication scheme which is backward-decoding-based and achievable Chong Motani-Garg capacity bounds, a novel forward-sliding-window decoding-based communication scheme is proposed. In ...To reduce decoding delay of a communication scheme which is backward-decoding-based and achievable Chong Motani-Garg capacity bounds, a novel forward-sliding-window decoding-based communication scheme is proposed. In this scheme, if w = (w1, w2) is the message to be sent in block b, the relay will decode message w1 and generate a new message z at the end of block b, and the receiver will decode message w1 at the end of block b + 1 and decode message z and w2 at the end of block b + 2. Analysis results show that this new communication scheme can achieve the same Chong-Motani-Garg bounds and the decoding delay is only two blocks which is much shorter than that of backward decoding. Therefore, Chong-Motani-Garg bounds can be achieved by a forward decoding-based communication scheme with short decoding delay.展开更多
In this paper, a mathematical model consisting of forward and backward models is built on parallel genetic algorithms (PGAs) for fault diagnosis in a transmission power system. A new method to reduce the scale of faul...In this paper, a mathematical model consisting of forward and backward models is built on parallel genetic algorithms (PGAs) for fault diagnosis in a transmission power system. A new method to reduce the scale of fault sections is developed in the forward model and the message passing interface (MPI) approach is chosen to parallel the genetic algorithms by global sin-gle-population master-slave method (GPGAs). The proposed approach is applied to a sample system consisting of 28 sections, 84 protective relays and 40 circuit breakers. Simulation results show that the new model based on GPGAs can achieve very fast computation in online applications of large-scale power systems.展开更多
AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict prognosis.METHODS We retrospectively reviewed the records of 116 patients with he...AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict prognosis.METHODS We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma(HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffinembedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were determined.RESULTS Factors associated with poor overall survival(OS) were alpha-fetoprotein > 400 ng/m L, tumor size ≥ 5 cm, and high EP1 receptor expression, but not high COX-2 expression. Disease-free survival was not significantly different between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues(Edmondson grade Ⅰ-Ⅱ) than in poorly differentiated tissues(Edmondson grade Ⅲ-Ⅳ)(P = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue(P = 0.001).CONCLUSION COX-2 expression appears to be linked to early HCC events(initiation), while EP1 receptor expression may participate in tumor progression and predict survival.展开更多
AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal e...AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients.展开更多
Expression of the adhesion molecules, ICAM-1, VCAM-1, NCAM, CD44, CD49d (VLA-4, a chain), and CDlla (LFA-1, a chain) on mouse oocytes, and pre- and peri-implantation stage embryos was examined by quantitative indirect...Expression of the adhesion molecules, ICAM-1, VCAM-1, NCAM, CD44, CD49d (VLA-4, a chain), and CDlla (LFA-1, a chain) on mouse oocytes, and pre- and peri-implantation stage embryos was examined by quantitative indirect immunofluorescence microscopy. ICAM-1 was most strongly expressed at the oocyte stage, gradually declining almost to undetectable levels by the expanded blastocyst stage. NCAM, also expressed maximally on the oocyte, declined to undetectable levels beyond the morula stage. On the other hand, CD44 declined from highest expression at the oocyte stage to show a second maximum at the compacted 8-cell/morula. This molecule exhibited high expression around contact areas between trophecto-derm and zona pellucida during blastocyst hatching. CD49d was highly expressed in the oocyte, remained significantly expressed throughout and after blastocyst hatching was expressed on the polar trophecto-derm. Like CD44, CD49d declined to undetectable levels at the blastocyst outgrowth stage. Expression of both VCAM-1 and CDlla was undetectable throughout. The diametrical temporal expression pattern of ICAM-1 and NCAM compared to CD44 and CD49d suggest that dynamic changes in expression of adhesion molecules may be important for interaction of the embryo with the maternal cellular environment as well as for continuing development and survival of the early embryo.展开更多
Objective: To evaluate the clinical course of patients with small cell lung cancer (SCLC) as second primary malignancy. Methods: Among the 355 patients diagnosed with SCLC at Helen and Harry Gray Cancer Center of ...Objective: To evaluate the clinical course of patients with small cell lung cancer (SCLC) as second primary malignancy. Methods: Among the 355 patients diagnosed with SCLC at Helen and Harry Gray Cancer Center of Hartford Hospital Connecticut USA between 1988 and 1998, the records of 48 patients, which had been diagnosed with other malignancies before their diagnosis of SCLC, were retro- spectively reviewed. Results: Forty-eight patients (13.5%) were diagnosed with other malignancies prior to their SCLC among which 43 had documented smoking history and 93% of them (40/43) were current/former smokers. Of the 28-second primary SCLC patients who were treated with standard method, 11 (39.3%) achieved CR. 12 (42.8%) achieved PR, and the RR was 82.1%. The median survival of the 28 treated with standard method was 11.3 months (5.1-77.7 months), while that of the rest 19 untreated patients (1 of 20 was lost to follow-up) was only 2.0 months (0.5 34.0 months). There was no significant difference in the median survival and RR between 165 treated first primary SCLC (13.5 months and 77.6% respectively) and 28 treated secondary primary SCLC (11.3 months and 82.1% respectively) (P〉0.05). The patients who had prostate cancer were older and subjected to less treatments than those with skin cancer, so their survival was shorter than the latter (3.5 months vs. 15 months, P〈0.05). Conclusion: The response and survival of the treated patients with SCLC as a second malignancy showed no difference as compared to the treated ones with SCLC only. Therefore, an active medical treatment is important to relieve symptom and prolong survival of the second primary SCLC patients.展开更多
There exists an inherent difficulty in the original algorithm for the construction of Dwarf, which prevents it from constructing true Dwarfs. We explained when and why it introduces suffix redundancies into the Dwarf ...There exists an inherent difficulty in the original algorithm for the construction of Dwarf, which prevents it from constructing true Dwarfs. We explained when and why it introduces suffix redundancies into the Dwarf structure. To solve this problem, we proposed a completely new algorithm called PID. It bottom-up computes partitions of a fact table, and inserts them into the Dwarf structure. If a partition is an MSV partition, coalesce its sub-Dwarf; otherwise create necessary nodes and cells. Our performance study showed that PID is efficient. For further condensing of Dwarf, we proposed Condensed Dwarf, a more com- pressed structure, combining the strength of Dwarf and Condensed Cube. By eliminating unnecessary stores of “ALL” cells from the Dwarf structure, Condensed Dwarf could effectively reduce the size of Dwarf, especially for Dwarfs of the real world, which was illustrated by our experiments. Its query processing is still simple and, only two minor modifications to PID are required for the construction of Condensed Dwarf.展开更多
As for the backward and forward equation of nonhomogeneous(H, Q) -processes,we proof them in a new way. On the base of that, this paper gives the direct computational formalfor one dimensional distribution of the nonh...As for the backward and forward equation of nonhomogeneous(H, Q) -processes,we proof them in a new way. On the base of that, this paper gives the direct computational formalfor one dimensional distribution of the nonhomogeneous(H, Q) -process.展开更多
基金National Natural Science Foundation of China (30630051)Aquaculture E-Institute of Shanghai Universities(03E009)Shanghai Leading Academic Discipline Project(S30701)
文摘Multivariate analysis was adopted to analyze 30 morphometrical characteristics of 121 one-year-old juvenile silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobilis) bred during the 1950s ("the former population") and 2008 ("the current population") and collected from the middle reach of the Yangtze River. The average discriminant accuracies of the former and current silver and bighead carp population were 94.2% and 98.0%, respectively. Discriminant analysis also revealed that significant differences in morphology occurred between the former and current populations of both carp in overall characteristics. One-way analysis of variance indicated that between former and current populations, silver carp showed highly significant differences (P0.01) in twelve of their characteristics and significant differences (P0.05) in eight of their characteristics, while bighead carp showed highly significant differences (P0.01) in eight of their characteristics and significant differences (P0.05) in eight of their characteristics. Six head morphology variables of the current silver and bighead carp were significantly or highly significantly larger than the former populations; fourteen characteristics of silver carp and ten characteristics of bighead carp of the current populations, mainly reflecting truck and tail morphology, were significantly or very significantly smaller than the former populations. Our results indicate that silver and bighead carp have developed a larger head and smaller truck and tail during the last 50 years. Due to such morphological changes, it seems apparent that the heads of these fish species need to be considered in regards to human diets, particularly in relation to economic and nutritious value.
文摘The structural and histochemical changes of the egg apparatus in the polyembryonic rice ( Oryza sativa L.), ApⅢ with the highest frequence of additional embryos among the polyembryonic rice investigated, before and after fertilization were studied and compared with those of normal and other polyembryonic rices in a similar developmental period. A total of 2 932 ovules were observed and each of them contained only a single embryo sac with a set of egg apparatus. Among 1 655 embryo sacs, there were 1 643 embryo sacs (99.27%) with one normal egg apparatus in each embryo sac, and only 12 embryo sacs (0.73%) from the remainder with 4_celled egg apparatus, i.e. two eggs and two synergids. Neither the numerous poly_egg apparatus and egg_like cells, nor the double set of embryo sacs each containing one egg apparatus and other abnormal egg apparatus in single ovary, which were reported by earlier investigators to have high frequency of embryo production in SB_1 and ApⅣ, were observed. The egg cell was located at the subterminal site of the micropylar end of embryo sac. The cytoplasm of egg cell was rich in protein materials and polysaccharide grains, which did not disappear until the division of zygote. The prominent nucleus was closely surrounded by protein and polysaccharide grains, which did not disappear until the division of zygote. No cytological difference was found between egg cells from the normal and abnormal egg apparatus. The two synergids were fully developed and situated at the upper most part of the micropylar end of the mature embryo sac. In most embryo sacs, the synergids were flask_shaped with longer necks, and a widened cap_shaped top, in close contact with the micropyle. The synergids had a well developed filiform apparatus. The characteristic appearance of the filiform apparatus as well as the cap_neck region of synergids before and after pollen tube penetration were easily distinguishable from the egg cell. The structure, the stainability with Coomassie Brilliant Blue and PAS reaction, the process of accumulation, distribution and disapperance of the cytoplasmic protein materials and polysaccharide grains of the two synergids, the persistent and rarely the receptive synergids before and after pollen tube penetration, were closely similar to those of egg cell of the same developmental stage. In comparison with normal and other polyembryonic rice reported, the size of nucleus and nucleolus and their stainability also strongly resembled those of egg cell. Based on the results observed, the main conclusions are summarized as follows: (1) the additional embryos very frequently developed in the young and mature seed of polyembryonic rice ApⅢ were produced by one or two synergids of normal egg apparatus, rarely by 4_celled egg apparatus; (2) during fertilization, the synergids, in addition to the natural specific function of introducing pollen tube and transferring sperms to egg cell and central cell, could be closely associated with the potentiality to breed one or two additional embryos; and (3) as compared with that of normal or other polyembryonic rice it is firstly disclosed that in a few embryo sacs of ApⅢ, the cytoplasmic and nuclear structure, the active anabolism and catabolism of protein and polysaccharide materials and the delayed disorganization at the mid_basal region of the receptive and persistent synergid still remained unchanged before the division of zygote. Such salient features could be the predisposition for the origin of additional embryos in ApⅢ.
文摘The methods of moment and genetic algorithm (GA) are combined to optimize the Yagi Uda antenna array and Log periodic dipole antenna (LPDA) array. The element lengths and spacing are optimized for the Yagi Uda array; while the ratio factor of spacing to length as well as the ratio of length to diameter of the elements are optimized for LPDA array. The results show that the main parameters, such as gain and pattern, have been improved apparently; and the high back lobe level of LPDA can be reduced greatly, therefore, GA is a very competent method for optimizing the linear array as well as in other fields.
文摘This paper discusses some aspects of finite element computation,such as the automatic generation of finite element ,refinement of mesh,process of node density, distribution of load,optimum design and the drawing of stress contour, and describes the developing process of software for a planar 8 node element.
文摘The improved current-doubler-rectifier zero-voltage-switching PWM full-bridge converter (CDR ZVS PWM FB converter) achieves ZVS for the switches in a wide load range with the use of the energy stored in the output filter inductances, and the rectifier diodes commute naturally, therefore no oscillation and voltage spike occurs. The transformer needs no special manufacture method to limit the leakage inductance. The ZVS achievement and the design considerations for the output filter inductances and the blocking capacitor are discussed for the improved CDR ZVS PWM FB converter. A 540 W prototype converter is built in the lab to verify the operational principle and design considerations for the improved converter, the experimental results are also included.
基金The Free Research Fund of National Mobile Communi-cations Research Laboratory of Southeast University(No.2008B06)the Na-tional Basic Research Program of China (973 Program)(No.2007CB310603)
文摘To reduce decoding delay of a communication scheme which is backward-decoding-based and achievable Chong Motani-Garg capacity bounds, a novel forward-sliding-window decoding-based communication scheme is proposed. In this scheme, if w = (w1, w2) is the message to be sent in block b, the relay will decode message w1 and generate a new message z at the end of block b, and the receiver will decode message w1 at the end of block b + 1 and decode message z and w2 at the end of block b + 2. Analysis results show that this new communication scheme can achieve the same Chong-Motani-Garg bounds and the decoding delay is only two blocks which is much shorter than that of backward decoding. Therefore, Chong-Motani-Garg bounds can be achieved by a forward decoding-based communication scheme with short decoding delay.
基金the National Natural Science Foundation of China (No. 50677062)the New Century Excellent Talents in Uni-versity of China (No. NCET-07-0745)the Natural Science Foundation of Zhejiang Province, China (No. R107062)
文摘In this paper, a mathematical model consisting of forward and backward models is built on parallel genetic algorithms (PGAs) for fault diagnosis in a transmission power system. A new method to reduce the scale of fault sections is developed in the forward model and the message passing interface (MPI) approach is chosen to parallel the genetic algorithms by global sin-gle-population master-slave method (GPGAs). The proposed approach is applied to a sample system consisting of 28 sections, 84 protective relays and 40 circuit breakers. Simulation results show that the new model based on GPGAs can achieve very fast computation in online applications of large-scale power systems.
基金Supported by National Natural Science Foundation of China,No.81260331Key Laboratory for High-Incidence Tumor Prevention and Treatment,Ministry of Education,No.GKE2015-ZZ05
文摘AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict prognosis.METHODS We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma(HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffinembedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were determined.RESULTS Factors associated with poor overall survival(OS) were alpha-fetoprotein > 400 ng/m L, tumor size ≥ 5 cm, and high EP1 receptor expression, but not high COX-2 expression. Disease-free survival was not significantly different between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues(Edmondson grade Ⅰ-Ⅱ) than in poorly differentiated tissues(Edmondson grade Ⅲ-Ⅳ)(P = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue(P = 0.001).CONCLUSION COX-2 expression appears to be linked to early HCC events(initiation), while EP1 receptor expression may participate in tumor progression and predict survival.
基金Supported by A Grant from MURST ex 60% to GDF and CC and a grant from Nycomed Italy
文摘AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients.
文摘Expression of the adhesion molecules, ICAM-1, VCAM-1, NCAM, CD44, CD49d (VLA-4, a chain), and CDlla (LFA-1, a chain) on mouse oocytes, and pre- and peri-implantation stage embryos was examined by quantitative indirect immunofluorescence microscopy. ICAM-1 was most strongly expressed at the oocyte stage, gradually declining almost to undetectable levels by the expanded blastocyst stage. NCAM, also expressed maximally on the oocyte, declined to undetectable levels beyond the morula stage. On the other hand, CD44 declined from highest expression at the oocyte stage to show a second maximum at the compacted 8-cell/morula. This molecule exhibited high expression around contact areas between trophecto-derm and zona pellucida during blastocyst hatching. CD49d was highly expressed in the oocyte, remained significantly expressed throughout and after blastocyst hatching was expressed on the polar trophecto-derm. Like CD44, CD49d declined to undetectable levels at the blastocyst outgrowth stage. Expression of both VCAM-1 and CDlla was undetectable throughout. The diametrical temporal expression pattern of ICAM-1 and NCAM compared to CD44 and CD49d suggest that dynamic changes in expression of adhesion molecules may be important for interaction of the embryo with the maternal cellular environment as well as for continuing development and survival of the early embryo.
文摘Objective: To evaluate the clinical course of patients with small cell lung cancer (SCLC) as second primary malignancy. Methods: Among the 355 patients diagnosed with SCLC at Helen and Harry Gray Cancer Center of Hartford Hospital Connecticut USA between 1988 and 1998, the records of 48 patients, which had been diagnosed with other malignancies before their diagnosis of SCLC, were retro- spectively reviewed. Results: Forty-eight patients (13.5%) were diagnosed with other malignancies prior to their SCLC among which 43 had documented smoking history and 93% of them (40/43) were current/former smokers. Of the 28-second primary SCLC patients who were treated with standard method, 11 (39.3%) achieved CR. 12 (42.8%) achieved PR, and the RR was 82.1%. The median survival of the 28 treated with standard method was 11.3 months (5.1-77.7 months), while that of the rest 19 untreated patients (1 of 20 was lost to follow-up) was only 2.0 months (0.5 34.0 months). There was no significant difference in the median survival and RR between 165 treated first primary SCLC (13.5 months and 77.6% respectively) and 28 treated secondary primary SCLC (11.3 months and 82.1% respectively) (P〉0.05). The patients who had prostate cancer were older and subjected to less treatments than those with skin cancer, so their survival was shorter than the latter (3.5 months vs. 15 months, P〈0.05). Conclusion: The response and survival of the treated patients with SCLC as a second malignancy showed no difference as compared to the treated ones with SCLC only. Therefore, an active medical treatment is important to relieve symptom and prolong survival of the second primary SCLC patients.
基金Project (No. 20030487032) supported by the Specialized Research Fund for the Doctoral Program of Higher Education, China
文摘There exists an inherent difficulty in the original algorithm for the construction of Dwarf, which prevents it from constructing true Dwarfs. We explained when and why it introduces suffix redundancies into the Dwarf structure. To solve this problem, we proposed a completely new algorithm called PID. It bottom-up computes partitions of a fact table, and inserts them into the Dwarf structure. If a partition is an MSV partition, coalesce its sub-Dwarf; otherwise create necessary nodes and cells. Our performance study showed that PID is efficient. For further condensing of Dwarf, we proposed Condensed Dwarf, a more com- pressed structure, combining the strength of Dwarf and Condensed Cube. By eliminating unnecessary stores of “ALL” cells from the Dwarf structure, Condensed Dwarf could effectively reduce the size of Dwarf, especially for Dwarfs of the real world, which was illustrated by our experiments. Its query processing is still simple and, only two minor modifications to PID are required for the construction of Condensed Dwarf.
文摘As for the backward and forward equation of nonhomogeneous(H, Q) -processes,we proof them in a new way. On the base of that, this paper gives the direct computational formalfor one dimensional distribution of the nonhomogeneous(H, Q) -process.